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Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.

Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF.

Biomedicines. 2018 Aug 28;6(3). pii: E90. doi: 10.3390/biomedicines6030090.


Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target.

Ma L, Chin YKY, Dekan Z, Herzig V, Yuen Chow C, Heighway J, Wing Lam S, Guillemin GJ, Alewood PF, King GF.

Biochem Pharmacol. 2018 Aug 24. pii: S0006-2952(18)30364-2. doi: 10.1016/j.bcp.2018.08.038. [Epub ahead of print]


Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.


Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.

Vanzolini KL, Ainsworth S, Bruyneel B, Herzig V, Seraus MGL, Somsen GW, Casewell NR, Cass QB, Kool J.

Toxicon. 2018 Sep 15;152:1-8. doi: 10.1016/j.toxicon.2018.06.080. Epub 2018 Jul 7.


Dipteran toxicity assays for determining the oral insecticidal activity of venoms and toxins.

Guo S, Herzig V, King GF.

Toxicon. 2018 Aug;150:297-303. doi: 10.1016/j.toxicon.2018.06.077. Epub 2018 Jun 18.


The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens.

Walker AA, Mayhew ML, Jin J, Herzig V, Undheim EAB, Sombke A, Fry BG, Meritt DJ, King GF.

Nat Commun. 2018 Feb 22;9(1):755. doi: 10.1038/s41467-018-03091-5.


ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins.

Pineda SS, Chaumeil PA, Kunert A, Kaas Q, Thang MWC, Le L, Nuhn M, Herzig V, Saez NJ, Cristofori-Armstrong B, Anangi R, Senff S, Gorse D, King GF.

Bioinformatics. 2018 Mar 15;34(6):1074-1076. doi: 10.1093/bioinformatics/btx661.


Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.


Dangerous arachnids-Fake news or reality?

Hauke TJ, Herzig V.

Toxicon. 2017 Nov;138:173-183. doi: 10.1016/j.toxicon.2017.08.024. Epub 2017 Sep 1. Review.


Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.


Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.


Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri.

Smith JJ, Herzig V, Ikonomopoulou MP, Dziemborowicz S, Bosmans F, Nicholson GM, King GF.

Toxins (Basel). 2017 May 5;9(5). pii: E155. doi: 10.3390/toxins9050155.


Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.


Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix.

Ikonomopoulou MP, Smith JJ, Herzig V, Pineda SS, Dziemborowicz S, Er SY, Durek T, Gilchrist J, Alewood PF, Nicholson GM, Bosmans F, King GF.

Toxicon. 2016 Dec 1;123:62-70. doi: 10.1016/j.toxicon.2016.10.013. Epub 2016 Oct 26.


Insecticidal activity of a recombinant knottin peptide from Loxosceles intermedia venom and recognition of these peptides as a conserved family in the genus.

Matsubara FH, Meissner GO, Herzig V, Justa HC, Dias BC, Trevisan-Silva D, Gremski LH, Gremski W, Senff-Ribeiro A, Chaim OM, King GF, Veiga SS.

Insect Mol Biol. 2017 Feb;26(1):25-34. doi: 10.1111/imb.12268. Epub 2016 Oct 15.


Create Guidelines for Characterization of Venom Peptides.

Herzig V.

Toxins (Basel). 2016 Aug 30;8(9). pii: E252. doi: 10.3390/toxins8090252.


Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.

Touchard A, Brust A, Cardoso FC, Chin YK, Herzig V, Jin AH, Dejean A, Alewood PF, King GF, Orivel J, Escoubas P.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2553-2562. doi: 10.1016/j.bbagen.2016.07.027. Epub 2016 Jul 28.


Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami.

Herzig V, Ikonomopoulou M, Smith JJ, Dziemborowicz S, Gilchrist J, Kuhn-Nentwig L, Rezende FO, Moreira LA, Nicholson GM, Bosmans F, King GF.

Sci Rep. 2016 Jul 7;6:29538. doi: 10.1038/srep29538.


Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.

Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D.

Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.


Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica.

Ariki NK, Muñoz LE, Armitage EL, Goodstein FR, George KG, Smith VL, Vetter I, Herzig V, King GF, Loening NM.

PLoS One. 2016 May 26;11(5):e0156291. doi: 10.1371/journal.pone.0156291. eCollection 2016.


Venom from the spider Araneus ventricosus is lethal to insects but inactive in vertebrates.

Liu K, Wang M, Herzig V, Liu Z, Hu W, Zhou G, Duan Z.

Toxicon. 2016 Jun 1;115:63-9. doi: 10.1016/j.toxicon.2016.03.010. Epub 2016 Mar 16.


The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a.

Herzig V, King GF.

Toxins (Basel). 2015 Oct 26;7(10):4366-80. doi: 10.3390/toxins7104366.


Weaponization of a Hormone: Convergent Recruitment of Hyperglycemic Hormone into the Venom of Arthropod Predators.

Undheim EA, Grimm LL, Low CF, Morgenstern D, Herzig V, Zobel-Thropp P, Pineda SS, Habib R, Dziemborowicz S, Fry BG, Nicholson GM, Binford GJ, Mobli M, King GF.

Structure. 2015 Jul 7;23(7):1283-92. doi: 10.1016/j.str.2015.05.003. Epub 2015 Jun 11.


Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.

Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ.

Mol Pharmacol. 2015 Aug;88(2):291-303. doi: 10.1124/mol.115.098178. Epub 2015 May 15.


Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF.

Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4.


The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop.

Bende NS, Dziemborowicz S, Herzig V, Ramanujam V, Brown GW, Bosmans F, Nicholson GM, King GF, Mobli M.

FEBS J. 2015 Mar;282(5):904-20. doi: 10.1111/febs.13189. Epub 2015 Jan 23.


A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.

Bende NS, Dziemborowicz S, Mobli M, Herzig V, Gilchrist J, Wagner J, Nicholson GM, King GF, Bosmans F.

Nat Commun. 2014 Jul 11;5:4350. doi: 10.1038/ncomms5350.


A proteomics and transcriptomics investigation of the venom from the barychelid spider Trittame loki (brush-foot trapdoor).

Undheim EA, Sunagar K, Herzig V, Kely L, Low DH, Jackson TN, Jones A, Kurniawan N, King GF, Ali SA, Antunes A, Ruder T, Fry BG.

Toxins (Basel). 2013 Dec 13;5(12):2488-503. doi: 10.3390/toxins5122488.


Analysis of intraspecific variation in venoms of Acanthophis antarcticus death adders from South Australia.

Herzig V, Kohler M, Grund KF, Reeve S, Smith AI, Hodgson WC.

J Venom Res. 2013 Aug 25;4:13-20. eCollection 2013.


Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

de Araujo AD, Herzig V, Windley MJ, Dziemborowicz S, Mobli M, Nicholson GM, Alewood PF, King GF.

Antioxid Redox Signal. 2013 Dec 1;19(16):1976-80. doi: 10.1089/ars.2013.5365. Epub 2013 Jun 19.


The insecticidal potential of venom peptides.

Smith JJ, Herzig V, King GF, Alewood PF.

Cell Mol Life Sci. 2013 Oct;70(19):3665-93. doi: 10.1007/s00018-013-1315-3. Epub 2013 Mar 23. Review.


The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels.

Bende NS, Kang E, Herzig V, Bosmans F, Nicholson GM, Mobli M, King GF.

Biochem Pharmacol. 2013 May 15;85(10):1542-54. doi: 10.1016/j.bcp.2013.02.030. Epub 2013 Mar 6.


Spider-venom peptides as bioinsecticides.

Windley MJ, Herzig V, Dziemborowicz SA, Hardy MC, King GF, Nicholson GM.

Toxins (Basel). 2012 Mar;4(3):191-227. doi: 10.3390/toxins4030191. Epub 2012 Mar 22. Review.


Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

Klint JK, Senff S, Rupasinghe DB, Er SY, Herzig V, Nicholson GM, King GF.

Toxicon. 2012 Sep 15;60(4):478-91. doi: 10.1016/j.toxicon.2012.04.337. Epub 2012 Apr 20. Review.


Spider-venom peptides as therapeutics.

Saez NJ, Senff S, Jensen JE, Er SY, Herzig V, Rash LD, King GF.

Toxins (Basel). 2010 Dec;2(12):2851-71. doi: 10.3390/toxins2122851. Epub 2010 Dec 20. Review.


TTX, cations and spider venom modify avian muscle tone in vitro.

Herzig V, Hodgson WC, Rowan EG.

J Venom Res. 2011 Jan 2;2:1-5.


ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures.

Herzig V, Wood DL, Newell F, Chaumeil PA, Kaas Q, Binford GJ, Nicholson GM, Gorse D, King GF.

Nucleic Acids Res. 2011 Jan;39(Database issue):D653-7. doi: 10.1093/nar/gkq1058. Epub 2010 Oct 29.


Flavin-cyclodextrin conjugates as catalysts of enantioselective sulfoxidations with hydrogen peroxide in aqueous media.

Mojr V, Herzig V, Buděšínský M, Cibulka R, Kraus T.

Chem Commun (Camb). 2010 Oct 28;46(40):7599-601. doi: 10.1039/c0cc02562c. Epub 2010 Sep 10.


ArachnoServer: a database of protein toxins from spiders.

Wood DL, Miljenović T, Cai S, Raven RJ, Kaas Q, Escoubas P, Herzig V, Wilson D, King GF.

BMC Genomics. 2009 Aug 13;10:375. doi: 10.1186/1471-2164-10-375.


Rigid duplex alpha-cyclodextrin reversibly connected with disulfide bonds. Synthesis and inclusion complexes.

Kumprecht L, Budesínský M, Vondrásek J, Vymetal J, Cerný J, Císarová I, Brynda J, Herzig V, Koutník P, Závada J, Kraus T.

J Org Chem. 2009 Feb 6;74(3):1082-92. doi: 10.1021/jo802139s. Erratum in: J Org Chem. 2009 Nov 6;74(21):8496.


Intersexual variations in the pharmacological properties of Coremiocnemis tropix (Araneae, Theraphosidae) spider venom.

Herzig V, Hodgson WC.

Toxicon. 2009 Feb;53(2):196-205. doi: 10.1016/j.toxicon.2008.11.002. Epub 2008 Nov 17.


Neurotoxic and insecticidal properties of venom from the Australian theraphosid spider Selenotholus foelschei.

Herzig V, Hodgson WC.

Neurotoxicology. 2008 May;29(3):471-5. doi: 10.1016/j.neuro.2008.03.002. Epub 2008 Mar 14.


Intersexual variations in Northern (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venom.

Herzig V, Khalife AA, Chong Y, Isbister GK, Currie BJ, Churchill TB, Horner S, Escoubas P, Nicholson GM, Hodgson WC.

Toxicon. 2008 Jun 1;51(7):1167-77. doi: 10.1016/j.toxicon.2008.02.001. Epub 2008 Feb 8.


[Evolution of antibiotic resistance of Streptococcus pneumoniae: results of Alsace observatory in 2005].

Gravet A, Camdessoucens G, Murbach V, Barrand P, Boucher A, Boulenc A, De Briel D, Delarbre JM, Drzewinski JC, Flipo JL, Gherardi C, Grawey I, Gueudet T, Heidt A, Herzig V, Izraelewicz D, Jehl F, Kientz P, Lantz V, Lemble C, Pierrot P, Rieder C, Riehm D, Tytgat F.

Pathol Biol (Paris). 2007 Nov;55(8-9):424-8. Epub 2007 Sep 25. French.


Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats.

Herzig V, Capuani EM, Kovar KA, Schmidt WJ.

Addict Biol. 2005 Sep;10(3):243-9.


Repeated-testing of place preference expression for evaluation of anti-craving-drug effects.

Herzig V, Schmidt WJ.

Amino Acids. 2005 May;28(3):309-17. Epub 2005 Mar 30.


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