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Items: 1 to 50 of 288

1.

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models.

Eichner LJ, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU.

Cell Metab. 2018 Nov 5. pii: S1550-4131(18)30637-5. doi: 10.1016/j.cmet.2018.10.005. [Epub ahead of print]

PMID:
30415923
2.

Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis.

Wolff G, Taranko AE, Meln I, Weinmann J, Sijmonsma T, Lerch S, Heide D, Billeter AT, Tews D, Krunic D, Fischer-Posovszky P, Müller-Stich BP, Herzig S, Grimm D, Heikenwälder M, Kao WW, Vegiopoulos A.

Mol Metab. 2018 Oct 23. pii: S2212-8778(18)30837-8. doi: 10.1016/j.molmet.2018.10.007. [Epub ahead of print]

3.

Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes.

Higareda-Almaraz JC, Karbiener M, Giroud M, Pauler FM, Gerhalter T, Herzig S, Scheideler M.

BMC Genomics. 2018 Nov 3;19(1):794. doi: 10.1186/s12864-018-5173-0.

4.

Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.

Görgülü K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, Kowalska M, Stevanovic M, Wörmann SM, Wartmann T, Zhao Y, Halangk W, Voronina S, Tepikin A, Schlitter AM, Steiger K, Artati A, Adamski J, Aichler M, Walch A, Jastroch M, Hartleben G, Mantzoros CS, Weichert W, Schmid RM, Herzig S, Krüger A, Sainz B Jr, Lesina M, Algül H.

Gastroenterology. 2018 Oct 5. pii: S0016-5085(18)35087-X. doi: 10.1053/j.gastro.2018.09.053. [Epub ahead of print]

PMID:
30296435
5.

Reply to "In Reference to 'Improving the Safety of Opioid Use for Acute Noncancer Pain in Hospitalized Adults: A Consensus Statement from the Society of Hospital Medicine'".

Herzig SJ, Mosher HJ, Calcaterra SL, Nuckols TK.

J Hosp Med. 2018 Sep;13(10):728. doi: 10.12788/jhm.3058. No abstract available.

PMID:
30261091
6.

Web Exclusive. Annals for Hospitalists Inpatient Notes - Managing Acute Pain in the Hospital in the Face of the Opioid Crisis.

Herzig SJ.

Ann Intern Med. 2018 Sep 18;169(6):HO2-HO3. doi: 10.7326/M18-2295. No abstract available.

PMID:
30242421
7.

Development of perceived pharmacological deficits of medical students and alumni supports claim for continuous and more application-oriented education.

Johannsen W, Frings B, Herzig S, Matthes J.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Sep 7. doi: 10.1007/s00210-018-1563-8. [Epub ahead of print]

PMID:
30194456
8.

Comparative secretome analyses of primary murine white and brown adipocytes reveal novel adipokines.

Ali Khan A, Hansson J, Weber P, Foehr S, Krijgsveld J, Herzig S, Scheideler M.

Mol Cell Proteomics. 2018 Aug 22. pii: mcp.RA118.000704. doi: 10.1074/mcp.RA118.000704. [Epub ahead of print]

9.

De novo NAD+ biosynthetic impairment in acute kidney injury in humans.

Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM.

Nat Med. 2018 Sep;24(9):1351-1359. doi: 10.1038/s41591-018-0138-z. Epub 2018 Aug 20.

PMID:
30127395
10.

Longitudinal Trends and Variation in Antipsychotic Use in Older Adults After Cardiac Surgery.

Kim DH, Mahesri M, Bateman BT, Huybrechts KF, Inouye SK, Marcantonio ER, Herzig SJ, Ely EW, Pisani MA, Levin R, Avorn J.

J Am Geriatr Soc. 2018 Aug;66(8):1491-1498. doi: 10.1111/jgs.15418. Epub 2018 Aug 19.

PMID:
30125337
11.

Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.

Bayindir-Buchhalter I, Wolff G, Lerch S, Sijmonsma T, Schuster M, Gronych J, Billeter AT, Babaei R, Krunic D, Ketscher L, Spielmann N, Hrabe de Angelis M, Ruas JL, Müller-Stich BP, Heikenwalder M, Lichter P, Herzig S, Vegiopoulos A.

EMBO Mol Med. 2018 Aug;10(8). pii: e8613. doi: 10.15252/emmm.201708613.

12.

Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression.

Bartels P, Yu D, Huang H, Hu Z, Herzig S, Soong TW.

Biophys J. 2018 Jul 3;115(1):163. doi: 10.1016/j.bpj.2018.06.001. No abstract available.

13.

Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance.

Maida A, Zota A, Vegiopoulos A, Appak-Baskoy S, Augustin HG, Heikenwalder M, Herzig S, Rose AJ.

J Nutr Biochem. 2018 Jul;57:189-196. doi: 10.1016/j.jnutbio.2018.03.027. Epub 2018 Apr 7.

PMID:
29751292
14.

Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression.

Bartels P, Yu D, Huang H, Hu Z, Herzig S, Soong TW.

Biophys J. 2018 May 8;114(9):2095-2106. doi: 10.1016/j.bpj.2018.03.029. Erratum in: Biophys J. 2018 Jul 3;115(1):163.

PMID:
29742403
15.

Preventability of Early Versus Late Hospital Readmissions in a National Cohort of General Medicine Patients.

Graham KL, Auerbach AD, Schnipper JL, Flanders SA, Kim CS, Robinson EJ, Ruhnke GW, Thomas LR, Kripalani S, Vasilevskis EE, Fletcher GS, Sehgal NJ, Lindenauer PK, Williams MV, Metlay JP, Davis RB, Yang J, Marcantonio ER, Herzig SJ.

Ann Intern Med. 2018 Jun 5;168(11):766-774. doi: 10.7326/M17-1724. Epub 2018 May 1.

PMID:
29710243
16.

Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis.

Babaei R, Schuster M, Meln I, Lerch S, Ghandour RA, Pisani DF, Bayindir-Buchhalter I, Marx J, Wu S, Schoiswohl G, Billeter AT, Krunic D, Mauer J, Lee YH, Granneman JG, Fischer L, Müller-Stich BP, Amri EZ, Kershaw EE, Heikenwälder M, Herzig S, Vegiopoulos A.

Sci Signal. 2018 Apr 24;11(527). pii: eaai7838. doi: 10.1126/scisignal.aai7838.

PMID:
29692363
17.

Improving the Safety of Opioid Use for Acute Noncancer Pain in Hospitalized Adults: A Consensus Statement From the Society of Hospital Medicine.

Herzig SJ, Mosher HJ, Calcaterra SL, Jena AB, Nuckols TK.

J Hosp Med. 2018 Apr;13(4):263-271. doi: 10.12788/jhm.2980.

PMID:
29624189
18.

Safe Opioid Prescribing for Acute Noncancer Pain in Hospitalized Adults: A Systematic Review of Existing Guidelines.

Herzig SJ, Calcaterra SL, Mosher HJ, Ronan MV, Groningen NV, Shek L, Loffredo A, Keller M, Jena AB, Nuckols TK.

J Hosp Med. 2018 Apr;13(4):256-262. doi: 10.12788/jhm.2979.

PMID:
29624188
19.

Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast.

Zemva J, Pfaff D, Groener JB, Fleming T, Herzig S, Teleman A, Nawroth PP, Tyedmers J.

Exp Clin Endocrinol Diabetes. 2018 Feb 8. doi: 10.1055/s-0043-122382. [Epub ahead of print]

PMID:
29421830
20.

High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans.

Riedinger C, Mendler M, Schlotterer A, Fleming T, Okun J, Hammes HP, Herzig S, Nawroth PP.

J Biol Chem. 2018 Mar 30;293(13):4845-4859. doi: 10.1074/jbc.M117.805879. Epub 2018 Feb 2.

PMID:
29414769
21.

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart.

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A.

Circulation. 2018 Jun 12;137(24):2592-2608. doi: 10.1161/CIRCULATIONAHA.117.029733. Epub 2018 Jan 20.

PMID:
29353241
22.

The Evaluation of Medical Inpatients Who Are Admitted on Long-term Opioid Therapy for Chronic Pain.

Mosher H, Herzig SJ, Danovitch I, Boutsicaris C, Hassamal S, Wittnebel K, Dashti A, Nuckols T.

J Hosp Med. 2018 Apr;13(4):249-255. doi: 10.12788/jhm.2889. Epub 2017 Dec 6.

PMID:
29240853
23.

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.

Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J.

Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11.

PMID:
29227474
24.

Antipsychotics and the Risk of Aspiration Pneumonia in Individuals Hospitalized for Nonpsychiatric Conditions: A Cohort Study.

Herzig SJ, LaSalvia MT, Naidus E, Rothberg MB, Zhou W, Gurwitz JH, Marcantonio ER.

J Am Geriatr Soc. 2017 Dec;65(12):2580-2586. doi: 10.1111/jgs.15066. Epub 2017 Nov 2.

PMID:
29095482
25.

The Diagnostic Yield of Noninvasive Microbiologic Sputum Sampling in a Cohort of Patients with Clinically Diagnosed Hospital-Acquired Pneumonia.

Naidus EL, Lasalvia MT, Marcantonio ER, Herzig SJ.

J Hosp Med. 2018 Jan 1;13(1):34-37. doi: 10.12788/jhm.2868. Epub 2017 Oct 18.

PMID:
29073317
26.

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.

Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, Christian S, Hess-Stumpp H, Augustin HG, Müller-Decker K, Nawroth PP, Herzig S, Berriel Diaz M.

Cell Metab. 2017 Dec 5;26(6):842-855.e5. doi: 10.1016/j.cmet.2017.09.018. Epub 2017 Oct 19.

PMID:
29056512
27.

Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.

Kumar V, Fleming T, Terjung S, Gorzelanny C, Gebhardt C, Agrawal R, Mall MA, Ranzinger J, Zeier M, Madhusudhan T, Ranjan S, Isermann B, Liesz A, Deshpande D, Häring HU, Biswas SK, Reynolds PR, Hammes HP, Peperkok R, Angel P, Herzig S, Nawroth PP.

Nucleic Acids Res. 2017 Oct 13;45(18):10595-10613. doi: 10.1093/nar/gkx705.

28.

AMPK: guardian of metabolism and mitochondrial homeostasis.

Herzig S, Shaw RJ.

Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135. doi: 10.1038/nrm.2017.95. Epub 2017 Oct 4. Review.

29.

Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes.

Scheideler M, Herzig S, Georgiadi A.

Horm Mol Biol Clin Investig. 2017 Aug 29;31(2). pii: /j/hmbci.2017.31.issue-2/hmbci-2017-0043/hmbci-2017-0043.xml. doi: 10.1515/hmbci-2017-0043. Review.

PMID:
28850545
30.

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux.

Zemva J, Fink CA, Fleming TH, Schmidt L, Loft A, Herzig S, Knieß RA, Mayer M, Bukau B, Nawroth PP, Tyedmers J.

Redox Biol. 2017 Oct;13:674-686. doi: 10.1016/j.redox.2017.08.007. Epub 2017 Aug 12.

31.

A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage.

Niopek K, Üstünel BE, Seitz S, Sakurai M, Zota A, Mattijssen F, Wang X, Sijmonsma T, Feuchter Y, Gail AM, Leuchs B, Niopek D, Staufer O, Brune M, Sticht C, Gretz N, Müller-Decker K, Hammes HP, Nawroth P, Fleming T, Conkright MD, Blüher M, Zeigerer A, Herzig S, Berriel Diaz M.

Cell Rep. 2017 Aug 8;20(6):1422-1434. doi: 10.1016/j.celrep.2017.07.023.

32.

Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution.

Maida A, Chan JSK, Sjøberg KA, Zota A, Schmoll D, Kiens B, Herzig S, Rose AJ.

Mol Metab. 2017 Jun 24;6(8):873-881. doi: 10.1016/j.molmet.2017.06.009. eCollection 2017 Aug.

33.

Adipose tissue: between the extremes.

Vegiopoulos A, Rohm M, Herzig S.

EMBO J. 2017 Jul 14;36(14):1999-2017. doi: 10.15252/embj.201696206. Epub 2017 Jun 16. Review.

34.

A multi-centre student survey on weighing disciplines in medical curricula - a pilot study.

Dafsari HS, Herzig S, Matthes J.

GMS J Med Educ. 2017 May 15;34(2):Doc24. doi: 10.3205/zma001101. eCollection 2017.

35.

The prescription talk - an approach to teach patient-physician conversation about drug prescription to medical students.

Hauser K, Koerfer A, Niehaus M, Albus C, Herzig S, Matthes J.

GMS J Med Educ. 2017 May 15;34(2):Doc18. doi: 10.3205/zma001095. eCollection 2017.

36.

Let's burn whatever you have: mitofusin 2 metabolically re-wires brown adipose tissue.

Scheideler M, Herzig S.

EMBO Rep. 2017 Jul;18(7):1039-1040. doi: 10.15252/embr.201744341. Epub 2017 May 24. No abstract available.

37.

Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic.

Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, Yong TF, Wong YP, Hu Z, Huang H, Zhang G, Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S, Soong TW.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4288-E4295. doi: 10.1073/pnas.1617205114. Epub 2017 May 10.

38.

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.

Brings S, Fleming T, Freichel M, Muckenthaler MU, Herzig S, Nawroth PP.

Int J Mol Sci. 2017 May 5;18(5). pii: E984. doi: 10.3390/ijms18050984. Review.

39.

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis.

Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C.

Nat Med. 2017 May;23(5):623-630. doi: 10.1038/nm.4316. Epub 2017 Apr 17.

40.

ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy.

Sulaj A, Kopf S, Gröne E, Gröne HJ, Hoffmann S, Schleicher E, Häring HU, Schwenger V, Herzig S, Fleming T, Nawroth PP, von Bauer R.

J Diabetes Complications. 2017 Jun;31(6):1058-1065. doi: 10.1016/j.jdiacomp.2017.01.002. Epub 2017 Jan 21.

PMID:
28325697
41.

Physician Perspectives on Readmission.

Herzig SJ, Auerbach AD.

J Gen Intern Med. 2017 Jul;32(7):731. doi: 10.1007/s11606-017-4025-y. No abstract available.

42.

Nondirected Testing for Inpatients With Severe Liver Injury.

Tapper EB, Herzig SJ.

J Hosp Med. 2017 Mar;12(3):184-187. doi: 10.12788/jhm.2705. Review. No abstract available.

PMID:
28272597
43.

Perceived Safety and Value of Inpatient "Very Important Person" Services.

Allen-Dicker J, Auerbach A, Herzig SJ.

J Hosp Med. 2017 Mar;12(3):177-179. doi: 10.12788/jhm.2701.

PMID:
28272595
44.

Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells.

Morgenstern J, Fleming T, Schumacher D, Eckstein V, Freichel M, Herzig S, Nawroth P.

J Biol Chem. 2017 Feb 24;292(8):3224-3238. doi: 10.1074/jbc.M116.760132. Epub 2016 Dec 12.

45.

Biological Mechanisms for the Effect of Obesity on Cancer Risk: Experimental Evidence.

Berriel Diaz M, Herzig S, Schafmeier T.

Recent Results Cancer Res. 2016;208:219-242. Review.

PMID:
27909910
46.

Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.

Ekim Üstünel B, Friedrich K, Maida A, Wang X, Krones-Herzig A, Seibert O, Sommerfeld A, Jones A, Sijmonsma TP, Sticht C, Gretz N, Fleming T, Nawroth PP, Stremmel W, Rose AJ, Berriel-Diaz M, Blüher M, Herzig S.

Nat Commun. 2016 Nov 9;7:13267. doi: 10.1038/ncomms13267.

47.

ACDD4 score: A simple tool for assessing risk of pneumonia after stroke.

Kumar S, Marchina S, Massaro J, Feng W, Lahoti S, Selim M, Herzig SJ.

J Neurol Sci. 2017 Jan 15;372:399-402. doi: 10.1016/j.jns.2016.10.050. Epub 2016 Nov 1.

PMID:
27823836
48.

Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study.

Kharabian Masouleh S, Herzig S, Klose L, Roggenhofer E, Tenckhoff H, Kaiser T, Thöne-Otto A, Wiese M, Berg T, Schroeter ML, Margulies DS, Villringer A.

J Viral Hepat. 2017 Mar;24(3):216-225. doi: 10.1111/jvh.12634. Epub 2016 Nov 4.

PMID:
27813284
49.

Reply to "Antipsychotics: Mortality Risk Themselves?"

Herzig SJ, Marcantonio ER.

J Am Geriatr Soc. 2016 Nov;64(11):2400. doi: 10.1111/jgs.14506. Epub 2016 Oct 26. No abstract available.

50.

Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.

Mendler M, Riedinger C, Schlotterer A, Volk N, Fleming T, Herzig S, Nawroth PP, Morcos M.

J Diabetes Complications. 2017 Feb;31(2):304-310. doi: 10.1016/j.jdiacomp.2016.09.014. Epub 2016 Oct 1.

PMID:
27776915

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