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Serious, Severe, Sepsis.

Herwald H, Egesten A.

J Innate Immun. 2020;12(2):129-130. doi: 10.1159/000505623. Epub 2020 Jan 31. No abstract available.


Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor.

Persson ST, Ekström S, Papareddy P, Herwald H.

J Innate Immun. 2019 Sep 27:1-14. doi: 10.1159/000502959. [Epub ahead of print]


A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection.

Papareddy P, Rossnagel M, Doreen Hollwedel F, Kilic G, Veerla S, Naudin C, Smeds E, Westman J, Martinez-Martinez I, Egesten A, de la Morena-Barrio ME, Corral J, Linder A, Artoni A, Abbattista M, Novembrino C, Herbert Brakebusch C, Martinelli I, Kasetty G, Herwald H.

Nat Microbiol. 2019 Dec;4(12):2442-2455. doi: 10.1038/s41564-019-0559-6. Epub 2019 Sep 23.


Tackling the Pros and Cons of Inflammation.

Herwald H, Egesten A.

J Innate Immun. 2019;11(6):445-446. doi: 10.1159/000502353. Epub 2019 Aug 30. No abstract available.


Renal clearance of heparin-binding protein and elimination during renal replacement therapy: Studies in ICU patients and healthy volunteers.

Samuelsson L, Tydén J, Herwald H, Hultin M, Walldén J, Steinvall I, Sjöberg F, Johansson J.

PLoS One. 2019 Aug 29;14(8):e0221813. doi: 10.1371/journal.pone.0221813. eCollection 2019.


The Extracellular Matrix: Reloaded Revolutions.

Egesten A, Herwald H.

J Innate Immun. 2019;11(4):301-302. doi: 10.1159/000500357. Epub 2019 Jun 5. No abstract available.


Innate immunity - a clinical perspective.

Egesten A, Gordon S, Herwald H.

J Intern Med. 2019 May;285(5):477-478. doi: 10.1111/joim.12898. Epub 2019 Apr 16. No abstract available.


Another Brick in the Wall.

Herwald H, Egesten A.

J Innate Immun. 2019;11(2):109-110. doi: 10.1159/000498950. Epub 2019 Feb 26. No abstract available.


Catch Me if You Can or Actors on the Run.

Egesten A, Herwald H.

J Innate Immun. 2019;11(1):1-2. doi: 10.1159/000495685. Epub 2018 Dec 11. No abstract available.


Early depletion of contact system in patients with sepsis: a prospective matched control observational study.

Berkestedt I, Andersson P, Herwald H, Valik JK, Sörensen O, Bodelsson M.

APMIS. 2018 Dec;126(12):892-898. doi: 10.1111/apm.12898. Epub 2018 Nov 5.


Osteopontin protects against pneumococcal infection in a murine model of allergic airway inflammation.

Kasetty G, Bhongir RKV, Papareddy P, Tufvesson E, Stenberg H, Bjermer L, Hultgårdh-Nilsson A, Herwald H, Egesten A.

Allergy. 2019 Apr;74(4):663-674. doi: 10.1111/all.13646. Epub 2018 Nov 19.


Journal of Innate Immunity Ten Years Later.

Egesten A, Herwald H.

J Innate Immun. 2018;10(5-6):363-364. doi: 10.1159/000494683. Epub 2018 Oct 25. No abstract available.


Heparin-Binding Protein Release Is Strongly Induced by Leptospira Species and Is a Candidate for an Early Diagnostic Marker of Human Leptospirosis.

Vieira ML, Persson S, Lopes-Ferreira M, Romero EC, Kirchgatter K, Nascimento ALTO, Herwald H.

J Infect Dis. 2019 Feb 23;219(6):996-1006. doi: 10.1093/infdis/jiy589.


Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation.

Kenne E, Rasmuson J, Renné T, Vieira ML, Müller-Esterl W, Herwald H, Lindbom L.

FASEB J. 2019 Feb;33(2):2599-2609. doi: 10.1096/fj.201801329R. Epub 2018 Oct 3.


TFPI-2 Protects Against Gram-Negative Bacterial Infection.

Ali MN, Kasetty G, Elvén M, Alyafei S, Jovic S, Egesten A, Herwald H, Schmidtchen A, Papareddy P.

Front Immunol. 2018 Sep 11;9:2072. doi: 10.3389/fimmu.2018.02072. eCollection 2018.


Heparin-binding protein in ventilator-induced lung injury.

Tydén J, Larsson N, Lehtipalo S, Herwald H, Hultin M, Walldén J, Behndig AF, Johansson J.

Intensive Care Med Exp. 2018 Sep 10;6(1):33. doi: 10.1186/s40635-018-0198-x.


Osteopontin protects against lung injury caused by extracellular histones.

Kasetty G, Papareddy P, Bhongir RKV, Ali MN, Mori M, Wygrecka M, Erjefält JS, Hultgårdh-Nilsson A, Palmberg L, Herwald H, Egesten A.

Mucosal Immunol. 2019 Jan;12(1):39-50. doi: 10.1038/s41385-018-0079-3. Epub 2018 Aug 16.


Selected Biomarkers Correlate with the Origin and Severity of Sepsis.

Holub M, Džupová O, Růžková M, Stráníková A, Bartáková E, Máca J, Beneš J, Herwald H, Beran O.

Mediators Inflamm. 2018 Mar 27;2018:7028267. doi: 10.1155/2018/7028267. eCollection 2018.


A fibrin biofilm covers blood clots and protects from microbial invasion.

Macrae FL, Duval C, Papareddy P, Baker SR, Yuldasheva N, Kearney KJ, McPherson HR, Asquith N, Konings J, Casini A, Degen JL, Connell SD, Philippou H, Wolberg AS, Herwald H, Ariëns RA.

J Clin Invest. 2018 Aug 1;128(8):3356-3368. doi: 10.1172/JCI98734. Epub 2018 Jun 25.


Heparin-binding protein as a biomarker of post-injury sepsis in trauma patients.

Halldorsdottir HD, Eriksson J, Persson BP, Herwald H, Lindbom L, Weitzberg E, Oldner A.

Acta Anaesthesiol Scand. 2018 Aug;62(7):962-973. doi: 10.1111/aas.13107. Epub 2018 Mar 22.


Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production.

Westman J, Chakrakodi B, Snäll J, Mörgelin M, Bruun Madsen M, Hyldegaard O, Neumann A, Frick IM, Norrby-Teglund A, Björck L, Herwald H.

Front Immunol. 2018 Feb 22;9:236. doi: 10.3389/fimmu.2018.00236. eCollection 2018.


Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice.

Wang Y, Luo L, Braun OÖ, Westman J, Madhi R, Herwald H, Mörgelin M, Thorlacius H.

Sci Rep. 2018 Mar 5;8(1):4020. doi: 10.1038/s41598-018-22156-5.


An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and Innate immunity.

Papareddy P, Kasetty G, Alyafei S, Smeds E, Salo-Ahen OMH, Hansson SR, Egesten A, Herwald H.

Virulence. 2018 Dec 31;9(1):724-737. doi: 10.1080/21505594.2018.1441589.


Globular C1q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function.

Anders E, Nebel D, Westman J, Herwald H, Nilsson BO, Svensson D.

Biochem J. 2018 Feb 23;475(4):775-786. doi: 10.1042/BCJ20170857.


Leptospira interrogans outer membrane protein LipL21 is a potent inhibitor of neutrophil myeloperoxidase.

Vieira ML, Teixeira AF, Pidde G, Ching ATC, Tambourgi DV, Nascimento ALTO, Herwald H.

Virulence. 2018 Jan 1;9(1):414-425. doi: 10.1080/21505594.2017.1407484.


Comprehensive Mass Spectrometric Survey of Streptococcus pyogenes Subcellular Proteomes.

Wilk L, Happonen L, Malmström J, Herwald H.

J Proteome Res. 2018 Jan 5;17(1):600-617. doi: 10.1021/acs.jproteome.7b00701. Epub 2017 Dec 4.


Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).

Neumann A, Papareddy P, Westman J, Hyldegaard O, Snäll J, Norrby-Teglund A, Herwald H.

J Innate Immun. 2018;10(1):30-43. doi: 10.1159/000480386. Epub 2017 Oct 17.


Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein.

Persson ST, Hauri S, Malmström J, Herwald H.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12792. Epub 2017 Oct 19.


Paracelsus, poison, and colistin.

Herwald H.

Thromb Haemost. 2017 Aug 30;117(9):1661. doi: 10.1160/TH17-08-0537. Epub 2017 Aug 11. No abstract available.


The Nonantibiotic Macrolide EM703 Improves Survival in a Model of Quinolone-Treated Pseudomonas aeruginosa Airway Infection.

Kasetty G, Bhongir RKV, Papareddy P, Herwald H, Egesten A.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e02761-16. doi: 10.1128/AAC.02761-16. Print 2017 Sep.


Visions and the Progress of Science.

Egesten A, Herwald H.

J Innate Immun. 2017;9(4):331-332. doi: 10.1159/000478280. Epub 2017 Jun 22. No abstract available.


Extracellular nucleic acids in immunity and cardiovascular responses: between alert and disease.

Preissner KT, Herwald H.

Thromb Haemost. 2017 Jun 27;117(7):1272-1282. doi: 10.1160/TH-16-11-0858. Epub 2017 Jun 8. Review.


Heparin-binding protein as a biomarker of acute kidney injury in critical illness.

Tydén J, Herwald H, Hultin M, Walldén J, Johansson J.

Acta Anaesthesiol Scand. 2017 Aug;61(7):797-803. doi: 10.1111/aas.12913. Epub 2017 Jun 5.


A rapid method for selecting suitable animal species for studying pathogen interactions with plasma protein ligands in vivo.

Naudin C, Schumski A, Salo-Ahen OMH, Herwald H, Smeds E.

Microb Biotechnol. 2017 May;10(3):657-665. doi: 10.1111/1751-7915.12601. Epub 2017 Feb 7.


Cells of Innate and Adaptive Immunity: A Matter of Class?

Herwald H, Egesten A.

J Innate Immun. 2017;9(2):109-110. doi: 10.1159/000457176. Epub 2017 Feb 2. No abstract available.


Intracellular Clearance by Nobel Laureates.

Herwald H, Egesten A.

J Innate Immun. 2017;9(1):1-2. doi: 10.1159/000453127. Epub 2016 Dec 7. No abstract available.


DNA-fragmentation is a source of bactericidal activity against Pseudomonas aeruginosa.

Bhongir RK, Kasetty G, Papareddy P, Mörgelin M, Herwald H, Egesten A.

Biochem J. 2017 Feb 1;474(3):411-425. doi: 10.1042/BCJ20160706. Epub 2016 Oct 26.


On PAMPs and DAMPs.

Herwald H, Egesten A.

J Innate Immun. 2016;8(5):427-8. doi: 10.1159/000448437. Epub 2016 Aug 13. No abstract available.


Modulation of Hemostatic and Inflammatory Responses by Leptospira Spp.

Vieira ML, Naudin C, Mörgelin M, Romero EC, Nascimento AL, Herwald H.

PLoS Negl Trop Dis. 2016 May 11;10(5):e0004713. doi: 10.1371/journal.pntd.0004713. eCollection 2016 May.


The Origin of a Paradigm.

Herwald H, Egesten A.

J Innate Immun. 2016;8(3):221-2. doi: 10.1159/000445282. Epub 2016 Apr 28. No abstract available.


Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure.

Tydén J, Herwald H, Sjöberg F, Johansson J.

PLoS One. 2016 Mar 23;11(3):e0152035. doi: 10.1371/journal.pone.0152035. eCollection 2016.


Gone with the Wind--Innate Immunity and Airway Inflammation.

Herwald H, Egesten A.

J Innate Immun. 2016;8(2):109-10. doi: 10.1159/000444614. Epub 2016 Mar 1. No abstract available.


Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release.

Snäll J, Linnér A, Uhlmann J, Siemens N, Ibold H, Janos M, Linder A, Kreikemeyer B, Herwald H, Johansson L, Norrby-Teglund A.

Sci Rep. 2016 Feb 18;6:21288. doi: 10.1038/srep21288.


Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics.

Malmström E, Kilsgård O, Hauri S, Smeds E, Herwald H, Malmström L, Malmström J.

Nat Commun. 2016 Jan 6;7:10261. doi: 10.1038/ncomms10261.


Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics.

Gela A, Bhongir RK, Mori M, Keenan P, Mörgelin M, Erjefält JS, Herwald H, Egesten A, Kasetty G.

PLoS One. 2016 Jan 5;11(1):e0146192. doi: 10.1371/journal.pone.0146192. eCollection 2016.


Nobel Parasites in the Kingdom of Invertebrates.

Herwald H, Egesten A.

J Innate Immun. 2016;8(1):1-2. doi: 10.1159/000443137. Epub 2015 Dec 23. No abstract available.


Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

Westman J, Papareddy P, Dahlgren MW, Chakrakodi B, Norrby-Teglund A, Smeds E, Linder A, Mörgelin M, Johansson-Lindbom B, Egesten A, Herwald H.

PLoS Pathog. 2015 Dec 8;11(12):e1005319. doi: 10.1371/journal.ppat.1005319. eCollection 2015 Dec.


[Sepsis--the unknown public disease of our time].

Mellhammar L, Kander T, Christensson B, Herwald H, Egesten A, Larsson A, Sjölin J, Brink M, Mehle C, Hanberger H, Gårdlund B, Oldner A, Källman J, Linder A.

Lakartidningen. 2015 Nov 17;112. pii: DSAI. Swedish. No abstract available.


LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).

Svensson D, Wilk L, Mörgelin M, Herwald H, Nilsson BO.

Biochem J. 2016 Jan 1;473(1):87-98. doi: 10.1042/BJ20150798. Epub 2015 Oct 27.


Vigilant keratinocytes trigger pathogen-associated molecular pattern signaling in response to streptococcal M1 protein.

Persson ST, Wilk L, Mörgelin M, Herwald H.

Infect Immun. 2015 Dec;83(12):4673-81. doi: 10.1128/IAI.00887-15. Epub 2015 Sep 28.

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