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Items: 1 to 50 of 272

1.

Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.

König S, Pace S, Pein H, Heinekamp T, Kramer J, Romp E, Straßburger M, Troisi F, Proschak A, Dworschak J, Scherlach K, Rossi A, Sautebin L, Haeggström JZ, Hertweck C, Brakhage AA, Gerstmeier J, Proschak E, Werz O.

Cell Chem Biol. 2019 Jan 17. pii: S2451-9456(19)30001-7. doi: 10.1016/j.chembiol.2019.01.001. [Epub ahead of print]

PMID:
30745237
2.

A Unique Biosynthetic Pathway in Bloom-Forming Cyanobacterial Genus Microcystis Jointly Assembles Cytotoxic Aeruginoguanidines and Microguanidines.

Pancrace C, Ishida K, Briand E, Gatte Pichi D, Weiz AR, Guljamow A, Scalvenzi T, Sassoon N, Hertweck C, Dittmann E, Gugger M.

ACS Chem Biol. 2018 Dec 17. doi: 10.1021/acschembio.8b00918. [Epub ahead of print]

PMID:
30556994
3.

A Pair of Bacterial Siderophores Releases and Traps an Intercellular Signal Molecule: An Unusual Case of Natural Nitrone Bioconjugation.

Trottmann F, Franke J, Ishida K, García-Altares M, Hertweck C.

Angew Chem Int Ed Engl. 2019 Jan 2;58(1):200-204. doi: 10.1002/anie.201811131. Epub 2018 Dec 4.

PMID:
30375753
4.

Publisher Correction: Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria.

Mahler L, Wink K, Beulig RJ, Scherlach K, Tovar M, Zang E, Martin K, Hertweck C, Belder D, Roth M.

Sci Rep. 2018 Oct 23;8(1):15859. doi: 10.1038/s41598-018-34069-4.

5.

Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites.

Fischer J, Müller SY, Netzker T, Jäger N, Gacek-Matthews A, Scherlach K, Stroe MC, García-Altares M, Pezzini F, Schoeler H, Reichelt M, Gershenzon J, Krespach MK, Shelest E, Schroeckh V, Valiante V, Heinzel T, Hertweck C, Strauss J, Brakhage AA.

Elife. 2018 Oct 12;7. pii: e40969. doi: 10.7554/eLife.40969.

6.

Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria.

Niehs SP, Scherlach K, Hertweck C.

Org Biomol Chem. 2018 Sep 26;16(37):8345-8352. doi: 10.1039/c8ob01515e.

PMID:
30209475
7.

Genome Editing Reveals Novel Thiotemplated Assembly of Polythioamide Antibiotics in Anaerobic Bacteria.

Dunbar KL, Büttner H, Molloy EM, Dell M, Kumpfmüller J, Hertweck C.

Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14080-14084. doi: 10.1002/anie.201807970. Epub 2018 Oct 3.

PMID:
30193003
8.

Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria.

Mahler L, Wink K, Beulig RJ, Scherlach K, Tovar M, Zang E, Martin K, Hertweck C, Belder D, Roth M.

Sci Rep. 2018 Aug 30;8(1):13087. doi: 10.1038/s41598-018-31263-2. Erratum in: Sci Rep. 2018 Oct 23;8(1):15859.

9.

Unexpected Bacterial Origin of the Antibiotic Icosalide: Two-Tailed Depsipeptide Assembly in Multifarious Burkholderia Symbionts.

Dose B, Niehs SP, Scherlach K, Flórez LV, Kaltenpoth M, Hertweck C.

ACS Chem Biol. 2018 Sep 21;13(9):2414-2420. doi: 10.1021/acschembio.8b00600. Epub 2018 Sep 4.

PMID:
30160099
10.

Genomics-Driven Discovery of a Symbiont-Specific Cyclopeptide from Bacteria Residing in the Rice Seedling Blight Fungus.

Niehs SP, Dose B, Scherlach K, Roth M, Hertweck C.

Chembiochem. 2018 Oct 18;19(20):2167-2172. doi: 10.1002/cbic.201800400. Epub 2018 Oct 2.

PMID:
30113119
11.

Enzymatic Amide Tailoring Promotes Retro-Aldol Amino Acid Conversion To Form the Antifungal Agent Aspirochlorine.

Tsunematsu Y, Maeda N, Yokoyama M, Chankhamjon P, Watanabe K, Scherlach K, Hertweck C.

Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14051-14054. doi: 10.1002/anie.201806740. Epub 2018 Sep 24.

PMID:
30109903
12.

Reconstitution of Enzymatic Carbon-Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis.

Scharf DH, Dworschak JD, Chankhamjon P, Scherlach K, Heinekamp T, Brakhage AA, Hertweck C.

ACS Chem Biol. 2018 Sep 21;13(9):2508-2512. doi: 10.1021/acschembio.8b00413. Epub 2018 Aug 17.

PMID:
30075079
13.

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system.

Hermenau R, Ishida K, Gama S, Hoffmann B, Pfeifer-Leeg M, Plass W, Mohr JF, Wichard T, Saluz HP, Hertweck C.

Nat Chem Biol. 2018 Sep;14(9):841-843. doi: 10.1038/s41589-018-0101-9. Epub 2018 Jul 30.

PMID:
30061716
14.

Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing.

Kloss F, Neuwirth T, Haensch VG, Hertweck C.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14476-14481. doi: 10.1002/anie.201805961. Epub 2018 Aug 16.

PMID:
30001481
15.

Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway.

Litomska A, Ishida K, Dunbar KL, Boettger M, Coyne S, Hertweck C.

Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11574-11578. doi: 10.1002/anie.201804158. Epub 2018 Aug 2.

PMID:
29947149
16.

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles.

Flórez LV, Scherlach K, Miller IJ, Rodrigues A, Kwan JC, Hertweck C, Kaltenpoth M.

Nat Commun. 2018 Jun 26;9(1):2478. doi: 10.1038/s41467-018-04955-6.

17.

On-Line Polyketide Cyclization into Diverse Medium-Sized Lactones by a Specialized Ketosynthase Domain.

Sundaram S, Kim HJ, Bauer R, Thongkongkaew T, Heine D, Hertweck C.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11223-11227. doi: 10.1002/anie.201804991. Epub 2018 Jul 24.

PMID:
29897642
18.

Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen.

Heine D, Holmes NA, Worsley SF, Santos ACA, Innocent TM, Scherlach K, Patrick EH, Yu DW, Murrell JC, Vieria PC, Boomsma JJ, Hertweck C, Hutchings MI, Wilkinson B.

Nat Commun. 2018 Jun 7;9(1):2208. doi: 10.1038/s41467-018-04520-1.

19.

A giant type I polyketide synthase participates in zygospore maturation in Chlamydomonas reinhardtii.

Heimerl N, Hommel E, Westermann M, Meichsner D, Lohr M, Hertweck C, Grossman AR, Mittag M, Sasso S.

Plant J. 2018 Jul;95(2):268-281. doi: 10.1111/tpj.13948. Epub 2018 Jun 5.

PMID:
29729034
20.

Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species.

Thongkongkaew T, Ding W, Bratovanov E, Oueis E, Garcı A-Altares MA, Zaburannyi N, Harmrolfs K, Zhang Y, Scherlach K, Müller R, Hertweck C.

ACS Chem Biol. 2018 May 18;13(5):1370-1379. doi: 10.1021/acschembio.8b00221. Epub 2018 May 2.

PMID:
29669203
21.

Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells.

Aiyar P, Schaeme D, García-Altares M, Carrasco Flores D, Dathe H, Hertweck C, Sasso S, Mittag M.

Nat Commun. 2017 Nov 24;8(1):1756. doi: 10.1038/s41467-017-01547-8.

22.

Antimicrobial discovery inspired by ecological interactions.

Molloy EM, Hertweck C.

Curr Opin Microbiol. 2017 Oct;39:121-127. doi: 10.1016/j.mib.2017.09.006. Epub 2017 Nov 21. Review.

PMID:
29169087
23.

High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome.

Guljamow A, Kreische M, Ishida K, Liaimer A, Altermark B, Bähr L, Hertweck C, Ehwald R, Dittmann E.

Appl Environ Microbiol. 2017 Sep 22. pii: AEM.01510-17. doi: 10.1128/AEM.01510-17. [Epub ahead of print]

24.

Mediators of mutualistic microbe-microbe interactions.

Scherlach K, Hertweck C.

Nat Prod Rep. 2018 Apr 25;35(4):303-308. doi: 10.1039/c7np00035a.

PMID:
28884173
25.

A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore.

Brandenburger E, Gressler M, Leonhardt R, Lackner G, Habel A, Hertweck C, Brock M, Hoffmeister D.

Appl Environ Microbiol. 2017 Aug 25. pii: AEM.01478-17. doi: 10.1128/AEM.01478-17. [Epub ahead of print]

26.

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.

Kugel S, Baunach M, Baer P, Ishida-Ito M, Sundaram S, Xu Z, Groll M, Hertweck C.

Nat Commun. 2017 Jun 15;8:15804. doi: 10.1038/ncomms15804.

27.

Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.

Marion A, Groll M, Scharf DH, Scherlach K, Glaser M, Sievers H, Schuster M, Hertweck C, Brakhage AA, Antes I, Huber EM.

ACS Chem Biol. 2017 Jul 21;12(7):1874-1882. doi: 10.1021/acschembio.6b00847. Epub 2017 Jun 6.

PMID:
28525266
28.

Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism.

Flórez LV, Scherlach K, Gaube P, Ross C, Sitte E, Hermes C, Rodrigues A, Hertweck C, Kaltenpoth M.

Nat Commun. 2017 Apr 28;8:15172. doi: 10.1038/ncomms15172.

29.

Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase.

Brandt P, García-Altares M, Nett M, Hertweck C, Hoffmeister D.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5937-5941. doi: 10.1002/anie.201700767. Epub 2017 Apr 25.

PMID:
28440038
30.

Enzymatic Carbon-Sulfur Bond Formation in Natural Product Biosynthesis.

Dunbar KL, Scharf DH, Litomska A, Hertweck C.

Chem Rev. 2017 Apr 26;117(8):5521-5577. doi: 10.1021/acs.chemrev.6b00697. Epub 2017 Apr 18. Review.

31.

Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus.

Valiante V, Mattern DJ, Schüffler A, Horn F, Walther G, Scherlach K, Petzke L, Dickhaut J, Guthke R, Hertweck C, Nett M, Thines E, Brakhage AA.

ACS Chem Biol. 2017 May 19;12(5):1227-1234. doi: 10.1021/acschembio.7b00003. Epub 2017 Mar 15.

PMID:
28233494
32.

Symbiont-Derived Antimicrobials Contribute to the Control of the Lepidopteran Gut Microbiota.

Shao Y, Chen B, Sun C, Ishida K, Hertweck C, Boland W.

Cell Chem Biol. 2017 Jan 19;24(1):66-75. doi: 10.1016/j.chembiol.2016.11.015.

33.

Zincophorin - biosynthesis in Streptomyces griseus and antibiotic properties.

Walther E, Boldt S, Kage H, Lauterbach T, Martin K, Roth M, Hertweck C, Sauerbrei A, Schmidtke M, Nett M.

GMS Infect Dis. 2016 Nov 28;4:Doc08. doi: 10.3205/id000026. eCollection 2016.

34.

Biomimetic Thioesters as Probes for Enzymatic Assembly Lines: Synthesis, Applications, and Challenges.

Franke J, Hertweck C.

Cell Chem Biol. 2016 Oct 20;23(10):1179-1192. doi: 10.1016/j.chembiol.2016.08.014. Epub 2016 Sep 29. Review.

35.

A functional link between hyphal maintenance and quorum sensing in Candida albicans.

Polke M, Sprenger M, Scherlach K, Albán-Proaño MC, Martin R, Hertweck C, Hube B, Jacobsen ID.

Mol Microbiol. 2017 Feb;103(4):595-617. doi: 10.1111/mmi.13526. Epub 2016 Oct 11.

36.

Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme.

Chankhamjon P, Tsunematsu Y, Ishida-Ito M, Sasa Y, Meyer F, Boettger-Schmidt D, Urbansky B, Menzel KD, Scherlach K, Watanabe K, Hertweck C.

Angew Chem Int Ed Engl. 2016 Sep 19;55(39):11955-9. doi: 10.1002/anie.201604516. Epub 2016 Aug 25.

PMID:
27559694
37.

From Powerful Review Articles to Research Breakthroughs.

Kostic M, Crews CM, Hertweck C, Shokat K, Suga H.

Cell Chem Biol. 2016 Aug 18;23(8):883-4. doi: 10.1016/j.chembiol.2016.08.002. No abstract available.

38.

A widespread bacterial phenazine forms S-conjugates with biogenic thiols and crosslinks proteins.

Heine D, Sundaram S, Beudert M, Martin K, Hertweck C.

Chem Sci. 2016 Aug 1;7(8):4848-4855. doi: 10.1039/c6sc00503a. Epub 2016 Apr 14.

39.

Structural investigation of the lipopolysaccharide O-chain isolated from Burkholderia fungorum strain DSM 17061.

De Felice A, Di Lorenzo F, Scherlach K, Ross C, Silipo A, Hertweck C, Molinaro A.

Carbohydr Res. 2016 Oct 4;433:31-5. doi: 10.1016/j.carres.2016.07.008. Epub 2016 Jul 9.

PMID:
27434832
40.

Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802: A Competitor of Fungus-Growing Termite Cultivars.

Guo H, Kreuzenbeck NB, Otani S, Garcia-Altares M, Dahse HM, Weigel C, Aanen DK, Hertweck C, Poulsen M, Beemelmanns C.

Org Lett. 2016 Jul 15;18(14):3338-41. doi: 10.1021/acs.orglett.6b01437. Epub 2016 Jun 24.

PMID:
27341414
41.

A Non-canonical Melanin Biosynthesis Pathway Protects Aspergillus terreus Conidia from Environmental Stress.

Geib E, Gressler M, Viediernikova I, Hillmann F, Jacobsen ID, Nietzsche S, Hertweck C, Brock M.

Cell Chem Biol. 2016 May 19;23(5):587-597. doi: 10.1016/j.chembiol.2016.03.014. Epub 2016 Apr 28.

42.

Our Advisors, Our Ambassadors, Our Editorial Board Members.

Kostic M, Crews CM, Hertweck C, Shokat K, Suga H.

Cell Chem Biol. 2016 Mar 17;23(3):311-2. doi: 10.1016/j.chembiol.2016.03.004. No abstract available.

43.

Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides.

Ueberschaar N, Meyer F, Dahse HM, Hertweck C.

Chem Commun (Camb). 2016 Apr 7;52(27):4894-7. doi: 10.1039/c6cc00890a. Epub 2016 Mar 14.

PMID:
26974406
44.

Voices of Chemical Biology: Charting the Next Decade.

Kostic M, Crews CM, Hertweck C, Shokat K, Suga H.

Cell Chem Biol. 2016 Feb 18;23(2):199. doi: 10.1016/j.chembiol.2016.02.006. No abstract available.

45.

Cell Chemical Biology: Home of Exciting Chemical Biology.

Kostic M, Crews CM, Hertweck C, Shokat K, Suga H.

Cell Chem Biol. 2016 Jan 21;23(1):1-2. doi: 10.1016/j.chembiol.2016.01.001. No abstract available.

46.

Food preparation with mucoralean fungi: A potential biosafety issue?

Dolatabadi S, Scherlach K, Figge M, Hertweck C, Dijksterhuis J, Menken SB, de Hoog GS.

Fungal Biol. 2016 Mar;120(3):393-401. doi: 10.1016/j.funbio.2015.12.001. Epub 2015 Dec 19.

PMID:
26895868
47.

Daldionin, an Unprecedented Binaphthyl Derivative, and Diverse Polyketide Congeners from a Fungal Orchid Endophyte.

Barnes EC, Jumpathong J, Lumyong S, Voigt K, Hertweck C.

Chemistry. 2016 Mar 18;22(13):4551-5. doi: 10.1002/chem.201504005. Epub 2016 Feb 16.

PMID:
26880363
48.

On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems.

Sundaram S, Hertweck C.

Curr Opin Chem Biol. 2016 Apr;31:82-94. doi: 10.1016/j.cbpa.2016.01.012. Epub 2016 Feb 8. Review.

PMID:
26859622
49.

A Fivefold Parallelized Biosynthetic Process Secures Chlorination of Armillaria mellea (Honey Mushroom) Toxins.

Wick J, Heine D, Lackner G, Misiek M, Tauber J, Jagusch H, Hertweck C, Hoffmeister D.

Appl Environ Microbiol. 2015 Dec 11;82(4):1196-1204. doi: 10.1128/AEM.03168-15. Print 2016 Feb 15.

50.

Bacaryolanes A-C, Rare Bacterial Caryolanes from a Mangrove Endophyte.

Ding L, Goerls H, Dornblut K, Lin W, Maier A, Fiebig HH, Hertweck C.

J Nat Prod. 2015 Dec 24;78(12):2963-7. doi: 10.1021/acs.jnatprod.5b00674. Epub 2015 Nov 27.

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