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Characterization and optimization of the novel TRPM2 antagonist tatM2NX.

Cruz-Torres I, Backos DS, Herson PS.

Mol Pharmacol. 2019 Nov 26. pii: mol.119.117549. doi: 10.1124/mol.119.117549. [Epub ahead of print]


Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice.

Chalmers NE, Yonchek J, Steklac KE, Ramsey M, Bayer KU, Herson PS, Quillinan N.

Mol Neurobiol. 2019 Sep 13. doi: 10.1007/s12035-019-01765-9. [Epub ahead of print]


Probing the Local Magnetic Structure of the [FeIII (Tp)(CN)3 ]- Building Block Via Solid-State NMR Spectroscopy, Polarized Neutron Diffraction, and First-Principle Calculations.

De S, Flambard A, Garnier D, Herson P, Köhler FH, Mondal A, Costuas K, Gillon B, Lescouëzec R, Le Guennic B, Gendron F.

Chemistry. 2019 Sep 18;25(52):12120-12136. doi: 10.1002/chem.201902239. Epub 2019 Aug 28.


Influence of Time to Transport to a Higher Level Facility on the Clinical Outcomes of US Combat Casualties with TBI: A Multicenter 7-Year Study.

Maddry JK, Arana AA, Perez CA, Medellin KL, Paciocco JA, Mora AG, Holder WG, Davis WT, Herson P, Bebarta VS.

Mil Med. 2019 Jul 23. pii: usz178. doi: 10.1093/milmed/usz178. [Epub ahead of print]


Reversal of Global Ischemia-Induced Cognitive Dysfunction by Delayed Inhibition of TRPM2 Ion Channels.

Dietz RM, Cruz-Torres I, Orfila JE, Patsos OP, Shimizu K, Chalmers N, Deng G, Tiemeier E, Quillinan N, Herson PS.

Transl Stroke Res. 2019 Jun 28. doi: 10.1007/s12975-019-00712-z. [Epub ahead of print]


Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions.

Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9208-9213. doi: 10.1073/pnas.1902227116. Epub 2019 Apr 22.


Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice.

Dingman AL, Rodgers KM, Dietz RM, Hickey SP, Frazier AP, Clevenger AC, Yonchek JC, Traystman RJ, Macklin WB, Herson PS.

Dev Neurosci. 2019 Mar 12:1-16. doi: 10.1159/000496200. [Epub ahead of print]


Experimental pediatric stroke shows age-specific recovery of cognition and role of hippocampal Nogo-A receptor signaling.

Orfila JE, Dietz RM, Rodgers KM, Dingman A, Patsos OP, Cruz-Torres I, Grewal H, Strnad F, Schroeder C, Herson PS.

J Cereb Blood Flow Metab. 2019 Feb 14:271678X19828581. doi: 10.1177/0271678X19828581. [Epub ahead of print]


Circulating heparan sulfate fragments mediate septic cognitive dysfunction.

Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP.

J Clin Invest. 2019 Apr 1;129(4):1779-1784. doi: 10.1172/JCI124485. Epub 2019 Mar 18.


Age-associated hippocampal volume changes in childhood arterial ischemic stroke.

Ritchey Z, Mirsky DM, Weitzenkamp D, Bernard TJ, Herson PS, Stence NV.

Childs Nerv Syst. 2019 Feb;35(2):295-300. doi: 10.1007/s00381-018-4021-5. Epub 2018 Dec 8.


Single dose of 17β-estradiol provides transient neuroprotection in female juvenile mice after cardiac-arrest and cardiopulmonary resuscitation.

Quillinan N, Dingman AL, Deng G, Tatum S, Orfila JE, Clevenger AC, Klawitter J, Traystman RJ, Herson PS.

Neurochem Int. 2019 Jul;127:80-86. doi: 10.1016/j.neuint.2018.11.013. Epub 2018 Nov 22.


Cofilin-actin rod formation in neuronal processes after brain ischemia.

Won SJ, Minnella AM, Wu L, Eun CH, Rome E, Herson PS, Shaw AE, Bamburg JR, Swanson RA.

PLoS One. 2018 Oct 16;13(10):e0198709. doi: 10.1371/journal.pone.0198709. eCollection 2018.


Sex differences in stroke: Challenges and opportunities.

Bushnell CD, Chaturvedi S, Gage KR, Herson PS, Hurn PD, Jiménez MC, Kittner SJ, Madsen TE, McCullough LD, McDermott M, Reeves MJ, Rundek T.

J Cereb Blood Flow Metab. 2018 Dec;38(12):2179-2191. doi: 10.1177/0271678X18793324. Epub 2018 Aug 17. Review.


Cardiac Arrest Induces Ischemic Long-Term Potentiation of Hippocampal CA1 Neurons That Occludes Physiological Long-Term Potentiation.

Orfila JE, McKinnon N, Moreno M, Deng G, Chalmers N, Dietz RM, Herson PS, Quillinan N.

Neural Plast. 2018 Apr 26;2018:9275239. doi: 10.1155/2018/9275239. eCollection 2018.


Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia.

Rodgers KM, Ahrendsen JT, Patsos OP, Strnad FA, Yonchek JC, Traystman RJ, Macklin WB, Herson PS.

Neuroscience. 2018 Jun 1;380:1-13. doi: 10.1016/j.neuroscience.2018.03.045. Epub 2018 Apr 9.


Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation.

Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU.

Sci Rep. 2018 Apr 3;8(1):5448. doi: 10.1038/s41598-018-23779-4.


Juvenile cerebral ischemia reveals age-dependent BDNF-TrkB signaling changes: Novel mechanism of recovery and therapeutic intervention.

Dietz RM, Orfila JE, Rodgers KM, Patsos OP, Deng G, Chalmers N, Quillinan N, Traystman RJ, Herson PS.

J Cereb Blood Flow Metab. 2018 Dec;38(12):2223-2235. doi: 10.1177/0271678X18766421. Epub 2018 Apr 3.


Endogenous Sex Steroids Dampen Neuroinflammation and Improve Outcome of Traumatic Brain Injury in Mice.

Clevenger AC, Kim H, Salcedo E, Yonchek JC, Rodgers KM, Orfila JE, Dietz RM, Quillinan N, Traystman RJ, Herson PS.

J Mol Neurosci. 2018 Mar;64(3):410-420. doi: 10.1007/s12031-018-1038-x. Epub 2018 Feb 15.


Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone.

Gould EA, Busquet N, Shepherd D, Dietz RM, Herson PS, Simoes de Souza FM, Li A, George NM, Restrepo D, Macklin WB.

Elife. 2018 Feb 13;7. pii: e34783. doi: 10.7554/eLife.34783.


Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke.

Orfila JE, Grewal H, Dietz RM, Strnad F, Shimizu T, Moreno M, Schroeder C, Yonchek J, Rodgers KM, Dingman A, Bernard TJ, Quillinan N, Macklin WB, Traystman RJ, Herson PS.

J Cereb Blood Flow Metab. 2019 Jun;39(6):1005-1014. doi: 10.1177/0271678X17750761. Epub 2017 Dec 28.


More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series).

Oshima K, Haeger SM, Hippensteel JA, Herson PS, Schmidt EP.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217745786. doi: 10.1177/2045893217745786.


The role of T-type calcium channels in the subiculum: to burst or not to burst?

Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM.

J Physiol. 2017 Oct 1;595(19):6327-6348. doi: 10.1113/JP274565. Epub 2017 Aug 18.


Enhanced Fibrinolysis with Magnetically Powered Colloidal Microwheels.

Tasci TO, Disharoon D, Schoeman RM, Rana K, Herson PS, Marr DWM, Neeves KB.

Small. 2017 Sep;13(36). doi: 10.1002/smll.201700954. Epub 2017 Jul 18.


Predicting Progression of Intracranial Arteriopathies in Childhood Stroke With Vessel Wall Imaging.

Stence NV, Pabst LL, Hollatz AL, Mirsky DM, Herson PS, Poisson S, Traystman RJ, Bernard TJ.

Stroke. 2017 Aug;48(8):2274-2277. doi: 10.1161/STROKEAHA.117.017922. Epub 2017 Jul 5.


Long-term depression in Purkinje neurons is persistently impaired following cardiac arrest and cardiopulmonary resuscitation in mice.

Quillinan N, Deng G, Shimizu K, Cruz-Torres I, Schroeder C, Traystman RJ, Herson PS.

J Cereb Blood Flow Metab. 2017 Aug;37(8):3053-3064. doi: 10.1177/0271678X16683691. Epub 2016 Dec 19.


Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest.

Deng G, Orfila JE, Dietz RM, Moreno-Garcia M, Rodgers KM, Coultrap SJ, Quillinan N, Traystman RJ, Bayer KU, Herson PS.

Cell Rep. 2017 Jan 31;18(5):1109-1117. doi: 10.1016/j.celrep.2017.01.011.


EEG power as a biomarker to predict the outcome after cardiac arrest and cardiopulmonary resuscitation induced global ischemia.

Weitzel LR, Sampath D, Shimizu K, White AM, Herson PS, Raol YH.

Life Sci. 2016 Nov 15;165:21-25. doi: 10.1016/j.lfs.2016.09.007. Epub 2016 Sep 15.


Neuropathophysiology of Brain Injury.

Quillinan N, Herson PS, Traystman RJ.

Anesthesiol Clin. 2016 Sep;34(3):453-64. doi: 10.1016/j.anclin.2016.04.011. Review.


Juvenile striatal white matter is resistant to ischemia-induced damage.

Ahrendsen JT, Grewal HS, Hickey SP, Culp CM, Gould EA, Shimizu T, Strnad FA, Traystman RJ, Herson PS, Macklin WB.

Glia. 2016 Nov;64(11):1972-86. doi: 10.1002/glia.23036. Epub 2016 Jul 27.


Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke.

Kelly KK, MacPherson AM, Grewal H, Strnad F, Jones JW, Yu J, Pierzchalski K, Kane MA, Herson PS, Siegenthaler JA.

BMC Neurosci. 2016 Jul 15;17(1):49. doi: 10.1186/s12868-016-0284-5.


Sex-Related Differences in the Risk of Hospital-Acquired Sepsis and Pneumonia Post Acute Ischemic Stroke.

Colbert JF, Traystman RJ, Poisson SN, Herson PS, Ginde AA.

J Stroke Cerebrovasc Dis. 2016 Oct;25(10):2399-404. doi: 10.1016/j.jstrokecerebrovasdis.2016.06.008. Epub 2016 Jun 28.


Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia.

Shimizu T, Dietz RM, Cruz-Torres I, Strnad F, Garske AK, Moreno M, Venna VR, Quillinan N, Herson PS.

Exp Neurol. 2016 Sep;283(Pt A):151-6. doi: 10.1016/j.expneurol.2016.06.015. Epub 2016 Jun 15.


Therapeutic hypothermia protects against ischemia-induced impairment of synaptic plasticity following juvenile cardiac arrest in sex-dependent manner.

Dietz RM, Deng G, Orfila JE, Hui X, Traystman RJ, Herson PS.

Neuroscience. 2016 Jun 14;325:132-41. doi: 10.1016/j.neuroscience.2016.03.052. Epub 2016 Mar 29.


Surface-enabled propulsion and control of colloidal microwheels.

Tasci TO, Herson PS, Neeves KB, Marr DW.

Nat Commun. 2016 Jan 4;7:10225. doi: 10.1038/ncomms10225.


Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.

Shimizu K, Quillinan N, Orfila JE, Herson PS.

Exp Neurol. 2016 Jan;275 Pt 1:78-83. doi: 10.1016/j.expneurol.2015.10.014. Epub 2015 Oct 30.


Sex Steroids Do Not Modulate TRPM2-Mediated Injury in Females following Middle Cerebral Artery Occlusion(1,2,3).

Quillinan N, Grewal H, Klawitter J, Herson PS.

eNeuro. 2014 Nov 12;1(1). pii: ENEURO.0022-14.2014. doi: 10.1523/ENEURO.0022-14.2014. eCollection 2014 Nov-Dec.


Clinical indicators of paraplegia underplay universal spinal cord neuronal injury from transient aortic occlusion.

Bell MT, Puskas F, Bennett DT, Cleveland JC Jr, Herson PS, Mares JM, Meng X, Weyant MJ, Fullerton DA, Brett Reece T.

Brain Res. 2015 Aug 27;1618:55-60. doi: 10.1016/j.brainres.2015.04.053. Epub 2015 May 22.


Arginase I release from activated neutrophils induces peripheral immunosuppression in a murine model of stroke.

Sippel TR, Shimizu T, Strnad F, Traystman RJ, Herson PS, Waziri A.

J Cereb Blood Flow Metab. 2015 Oct;35(10):1657-63. doi: 10.1038/jcbfm.2015.103. Epub 2015 May 13.


(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation.

Grace PM, Shimizu K, Strand KA, Rice KC, Deng G, Watkins LR, Herson PS.

Brain Behav Immun. 2015 Aug;48:115-22. doi: 10.1016/j.bbi.2015.03.005. Epub 2015 Mar 13.


Alpha-2 agonist attenuates ischemic injury in spinal cord neurons.

Freeman KA, Puskas F, Bell MT, Mares JM, Foley LS, Weyant MJ, Cleveland JC Jr, Fullerton DA, Meng X, Herson PS, Reece TB.

J Surg Res. 2015 May 1;195(1):21-8. doi: 10.1016/j.jss.2014.12.033. Epub 2014 Dec 23.


Animal models of stroke: translational potential at present and in 2050.

Herson PS, Traystman RJ.

Future Neurol. 2014 Sep;9(5):541-551.


Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia.

Quillinan N, Grewal H, Deng G, Shimizu K, Yonchek JC, Strnad F, Traystman RJ, Herson PS.

Neuroscience. 2015 Jan 22;284:555-65. doi: 10.1016/j.neuroscience.2014.10.033. Epub 2014 Oct 24.


Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation.

Deng G, Carter J, Traystman RJ, Wagner DH, Herson PS.

J Neuroimmunol. 2014 Sep 15;274(1-2):132-40. doi: 10.1016/j.jneuroim.2014.07.009. Epub 2014 Jul 22.


Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation.

Orfila JE, Shimizu K, Garske AK, Deng G, Maylie J, Traystman RJ, Quillinan N, Adelman JP, Herson PS.

Eur J Neurosci. 2014 Oct;40(8):3179-88. doi: 10.1111/ejn.12683. Epub 2014 Jul 31.


Extracranial hypothermia during cardiac arrest and cardiopulmonary resuscitation is neuroprotective in vivo.

Hutchens MP, Fujiyoshi T, Koerner IP, Herson PS.

Ther Hypothermia Temp Manag. 2014 Jun;4(2):79-87. doi: 10.1089/ther.2014.0003. Epub 2014 May 27.


Androgens and stroke: good, bad or indifferent?

Quillinan N, Deng G, Grewal H, Herson PS.

Exp Neurol. 2014 Sep;259:10-5. doi: 10.1016/j.expneurol.2014.02.004. Epub 2014 Feb 8. Review.


Misleading results: translational challenges.

Traystman RJ, Herson PS.

Science. 2014 Jan 24;343(6169):369-70. doi: 10.1126/science.343.6169.369. No abstract available.


Sex stratified neuronal cultures to study ischemic cell death pathways.

Fairbanks SL, Vest R, Verma S, Traystman RJ, Herson PS.

J Vis Exp. 2013 Dec 9;(82):e50758. doi: 10.3791/50758.


A novel mouse model of pediatric cardiac arrest and cardiopulmonary resuscitation reveals age-dependent neuronal sensitivities to ischemic injury.

Deng G, Yonchek JC, Quillinan N, Strnad FA, Exo J, Herson PS, Traystman RJ.

J Neurosci Methods. 2014 Jan 30;222:34-41. doi: 10.1016/j.jneumeth.2013.10.015. Epub 2013 Nov 2.


Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury.

Bell MT, Puskas F, Agoston VA, Cleveland JC Jr, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TB.

Circulation. 2013 Sep 10;128(11 Suppl 1):S152-6. doi: 10.1161/CIRCULATIONAHA.112.000024.


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