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Items: 24


The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory Formation.

Webb WM, Irwin AB, Pepin ME, Henderson BW, Huang V, Butler AA, Herskowitz JH, Wende AR, Cash AE, Lubin FD.

Biol Psychiatry. 2019 Jun 12. pii: S0006-3223(19)31415-5. doi: 10.1016/j.biopsych.2019.05.022. [Epub ahead of print]


Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.

Greathouse KM, Henderson BW, Gentry EG, Herskowitz JH.

Behav Brain Res. 2019 Nov 5;373:112083. doi: 10.1016/j.bbr.2019.112083. Epub 2019 Jul 11.


Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid.

Henderson BW, Greathouse KM, Ramdas R, Walker CK, Rao TC, Bach SV, Curtis KA, Day JJ, Mattheyses AL, Herskowitz JH.

Sci Signal. 2019 Jun 25;12(587). pii: eaaw9318. doi: 10.1126/scisignal.aaw9318.


Klotho deficiency affects the spine morphology and network synchronization of neurons.

Vo HT, Phillips ML, Herskowitz JH, King GD.

Mol Cell Neurosci. 2019 Jul;98:1-11. doi: 10.1016/j.mcn.2019.04.002. Epub 2019 Apr 13.


Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging.

Boros BD, Greathouse KM, Gearing M, Herskowitz JH.

Neurobiol Aging. 2019 Jan;73:92-103. doi: 10.1016/j.neurobiolaging.2018.09.003. Epub 2018 Sep 21.


Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.

Greathouse KM, Boros BD, Deslauriers JF, Henderson BW, Curtis KA, Gentry EG, Herskowitz JH.

Brain Struct Funct. 2018 Dec;223(9):4227-4241. doi: 10.1007/s00429-018-1748-4. Epub 2018 Sep 8.


α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons.

Froula JM, Henderson BW, Gonzalez JC, Vaden JH, Mclean JW, Wu Y, Banumurthy G, Overstreet-Wadiche L, Herskowitz JH, Volpicelli-Daley LA.

Acta Neuropathol Commun. 2018 May 1;6(1):35. doi: 10.1186/s40478-018-0537-x.


Dendritic spines provide cognitive resilience against Alzheimer's disease.

Boros BD, Greathouse KM, Gentry EG, Curtis KA, Birchall EL, Gearing M, Herskowitz JH.

Ann Neurol. 2017 Oct;82(4):602-614. doi: 10.1002/ana.25049. Epub 2017 Oct 22.


Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain.

Henderson BW, Gentry EG, Rush T, Troncoso JC, Thambisetty M, Montine TJ, Herskowitz JH.

J Neurochem. 2016 Aug;138(4):525-31. doi: 10.1111/jnc.13688. Epub 2016 Jul 1.


ROCK1 and ROCK2 inhibition alters dendritic spine morphology in hippocampal neurons.

Swanger SA, Mattheyses AL, Gentry EG, Herskowitz JH.

Cell Logist. 2016 Jan 19;5(4):e1133266. eCollection 2015 Oct-Dec.


Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.

Gentry EG, Henderson BW, Arrant AE, Gearing M, Feng Y, Riddle NC, Herskowitz JH.

J Neurosci. 2016 Jan 27;36(4):1316-23. doi: 10.1523/JNEUROSCI.2336-15.2016.


Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.

Herskowitz JH, Feng Y, Mattheyses AL, Hales CM, Higginbotham LA, Duong DM, Montine TJ, Troncoso JC, Thambisetty M, Seyfried NT, Levey AI, Lah JJ.

J Neurosci. 2013 Dec 4;33(49):19086-98. doi: 10.1523/JNEUROSCI.2508-13.2013.


AAV2 production with optimized N/P ratio and PEI-mediated transfection results in low toxicity and high titer for in vitro and in vivo applications.

Huang X, Hartley AV, Yin Y, Herskowitz JH, Lah JJ, Ressler KJ.

J Virol Methods. 2013 Nov;193(2):270-7. doi: 10.1016/j.jviromet.2013.06.008. Epub 2013 Jun 19.


RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells.

Pranski EL, Dalal NV, Sanford CV, Herskowitz JH, Gearing M, Lazo C, Miller GW, Lah JJ, Levey AI, Betarbet RS.

Neurobiol Dis. 2013 Jun;54:264-79. doi: 10.1016/j.nbd.2012.12.018. Epub 2013 Jan 11.


Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brains.

Sager KL, Wuu J, Herskowitz JH, Mufson EJ, Levey AI, Lah JJ.

PLoS One. 2012;7(8):e40527. doi: 10.1371/journal.pone.0040527. Epub 2012 Aug 21.


Asparaginyl endopeptidase cleaves TDP-43 in brain.

Herskowitz JH, Gozal YM, Duong DM, Dammer EB, Gearing M, Ye K, Lah JJ, Peng J, Levey AI, Seyfried NT.

Proteomics. 2012 Aug;12(15-16):2455-63. doi: 10.1002/pmic.201200006.


GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production.

Herskowitz JH, Offe K, Deshpande A, Kahn RA, Levey AI, Lah JJ.

Mol Biol Cell. 2012 Jul;23(14):2645-57. doi: 10.1091/mbc.E12-01-0014. Epub 2012 May 23.


Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.

Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS.

J Neuroinflammation. 2012 Apr 16;9:67. doi: 10.1186/1742-2094-9-67.


Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.

Seyfried NT, Gozal YM, Donovan LE, Herskowitz JH, Dammer EB, Xia Q, Ku L, Chang J, Duong DM, Rees HD, Cooper DS, Glass JD, Gearing M, Tansey MG, Lah JJ, Feng Y, Levey AI, Peng J.

J Proteome Res. 2012 May 4;11(5):2721-38. doi: 10.1021/pr2010814. Epub 2012 Apr 4.


Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.

Herskowitz JH, Seyfried NT, Gearing M, Kahn RA, Peng J, Levey AI, Lah JJ.

J Biol Chem. 2011 Feb 25;286(8):6117-27. doi: 10.1074/jbc.M110.167239. Epub 2010 Dec 8.


Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.

Herskowitz JH, Seyfried NT, Duong DM, Xia Q, Rees HD, Gearing M, Peng J, Lah JJ, Levey AI.

J Proteome Res. 2010 Dec 3;9(12):6368-79. doi: 10.1021/pr100666c. Epub 2010 Oct 22.


The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation.

Siegel AM, Herskowitz JH, Speck SH.

PLoS Pathog. 2008 Apr 4;4(4):e1000039. doi: 10.1371/journal.ppat.1000039.


Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection.

Herskowitz JH, Siegel AM, Jacoby MA, Speck SH.

J Virol. 2008 Apr;82(7):3295-310. doi: 10.1128/JVI.02234-07. Epub 2008 Jan 30.


The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells.

Herskowitz JH, Jacoby MA, Speck SH.

J Virol. 2005 Feb;79(4):2261-73. Erratum in: J Virol. 2011 Mar;85(6):3041. Herskowitz, Jeremy [corrected to Herskowitz, Jeremy H].

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