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Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.

Hoch E, Levy M, Hershfinkel M, Sekler I.

Int J Mol Sci. 2020 Jan 22;21(3). pii: E734. doi: 10.3390/ijms21030734.


Rare-variant pathogenicity triage and inclusion of synonymous variants improves analysis of disease associations of orphan G protein-coupled receptors.

Dershem R, Metpally RPR, Jeffreys K, Krishnamurthy S, Smelser DT, Hershfinkel M; Regeneron Genetics Center, Carey DJ, Robishaw JD, Breitwieser GE.

J Biol Chem. 2019 Nov 29;294(48):18109-18121. doi: 10.1074/jbc.RA119.009253. Epub 2019 Oct 18.


Corrigendum to "ZnR/GPR39 upregulation of K+/Cl--cotransporter 3 in tamoxifen resistant breast cancer cells" [Cell Calcium 81 (2019) 12-20].

Mero M, Asraf H, Sekler I, Taylor KM, Hershfinkel M.

Cell Calcium. 2019 Nov;83:102077. doi: 10.1016/j.ceca.2019.102077. Epub 2019 Sep 10. No abstract available.


ZnR/GPR39 upregulation of K+/Cl--cotransporter 3 in tamoxifen resistant breast cancer cells.

Mero M, Asraf H, Sekler I, Taylor KM, Hershfinkel M.

Cell Calcium. 2019 Jul;81:12-20. doi: 10.1016/j.ceca.2019.05.005. Epub 2019 May 22. Erratum in: Cell Calcium. 2019 Nov;83:102077.


Zinc transporter 10 (ZnT10)-dependent extrusion of cellular Mn2+ is driven by an active Ca2+-coupled exchange.

Levy M, Elkoshi N, Barber-Zucker S, Hoch E, Zarivach R, Hershfinkel M, Sekler I.

J Biol Chem. 2019 Apr 12;294(15):5879-5889. doi: 10.1074/jbc.RA118.006816. Epub 2019 Feb 12.


How cellular Zn2+ signaling drives physiological functions.

Levaot N, Hershfinkel M.

Cell Calcium. 2018 Nov;75:53-63. doi: 10.1016/j.ceca.2018.08.004. Epub 2018 Aug 18. Review.


Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth.

Ventura-Bixenshpaner H, Asraf H, Chakraborty M, Elkabets M, Sekler I, Taylor KM, Hershfinkel M.

Sci Rep. 2018 May 25;8(1):8119. doi: 10.1038/s41598-018-26459-5.


The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease.

Hershfinkel M.

Int J Mol Sci. 2018 Feb 1;19(2). pii: E439. doi: 10.3390/ijms19020439. Review.


Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity.

Reffatto V, Rasinger JD, Carroll TS, Ganay T, Lundebye AK, Sekler I, Hershfinkel M, Hogstrand C.

Arch Toxicol. 2018 Mar;92(3):1189-1203. doi: 10.1007/s00204-017-2119-2. Epub 2017 Nov 25.


Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins.

Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5167-E5176. doi: 10.1073/pnas.1703623114. Epub 2017 Jun 13.


Mitochondria control store-operated Ca2+ entry through Na+ and redox signals.

Ben-Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk JA, Zhou Y, Motiani RK, Gueguinou M, Hempel N, Hershfinkel M, Gill DL, Trebak M, Sekler I.

EMBO J. 2017 Mar 15;36(6):797-815. doi: 10.15252/embj.201592481. Epub 2017 Feb 20.


The zinc sensing receptor, ZnR/GPR39, in health and disease.

Sunuwar L, Gilad D, Hershfinkel M.

Front Biosci (Landmark Ed). 2017 Mar 1;22:1469-1492. Review.


Identification of residues that control Li+ versus Na+ dependent Ca2+ exchange at the transport site of the mitochondrial NCLX.

Roy S, Dey K, Hershfinkel M, Ohana E, Sekler I.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):997-1008. doi: 10.1016/j.bbamcr.2017.01.011. Epub 2017 Jan 24.


The Zn2+-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss.

Sunuwar L, Asraf H, Donowitz M, Sekler I, Hershfinkel M.

Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):947-960. doi: 10.1016/j.bbadis.2017.01.009. Epub 2017 Jan 16.


Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration.

Li Y, Andereggen L, Yuki K, Omura K, Yin Y, Gilbert HY, Erdogan B, Asdourian MS, Shrock C, de Lima S, Apfel UP, Zhuo Y, Hershfinkel M, Lippard SJ, Rosenberg PA, Benowitz L.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E209-E218. doi: 10.1073/pnas.1616811114. Epub 2017 Jan 3.


Correction to 'The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis'.

Sunuwar L, Medini M, Cohen L, Sekler I, Hershfinkel M.

Philos Trans R Soc Lond B Biol Sci. 2016 Sep 19;371(1703). pii: 20160331. doi: 10.1098/rstb.2016.0331. No abstract available.


Amyloid β attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2+ , ERK1/2 and Clusterin signaling in neurons.

Abramovitch-Dahan C, Asraf H, Bogdanovic M, Sekler I, Bush AI, Hershfinkel M.

J Neurochem. 2016 Oct;139(2):221-233. doi: 10.1111/jnc.13760. Epub 2016 Sep 15.


PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons.

Kostic M, Ludtmann MH, Bading H, Hershfinkel M, Steer E, Chu CT, Abramov AY, Sekler I.

Cell Rep. 2015 Oct 13;13(2):376-86. doi: 10.1016/j.celrep.2015.08.079. Epub 2015 Oct 1.


Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.

Ganay T, Asraf H, Aizenman E, Bogdanovic M, Sekler I, Hershfinkel M.

J Neurochem. 2015 Dec;135(5):897-907. doi: 10.1111/jnc.13367. Epub 2015 Oct 22.


Seashells by the zinc shore: a meeting report of the International Society for Zinc Biology, Asilomar, CA 2014.

Hershfinkel M, Ford D, Kelleher S, Aizenman E.

Metallomics. 2015 Sep;7(9):1299-304. doi: 10.1039/c5mt90029h. No abstract available.


Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol.

Asraf H, Avunie-Masala R, Hershfinkel M, Gheber L.

PLoS One. 2015 Jun 2;10(6):e0129255. doi: 10.1371/journal.pone.0129255. eCollection 2015.


Life after the birth of the mitochondrial Na+/Ca2+ exchanger, NCLX.

Nita LI, Hershfinkel M, Sekler I.

Sci China Life Sci. 2015 Jan;58(1):59-65. doi: 10.1007/s11427-014-4789-9. Epub 2015 Jan 10. Review.


A crosstalk between Na⁺ channels, Na⁺/K⁺ pump and mitochondrial Na⁺ transporters controls glucose-dependent cytosolic and mitochondrial Na⁺ signals.

Nita II, Hershfinkel M, Lewis EC, Sekler I.

Cell Calcium. 2015 Feb;57(2):69-75. doi: 10.1016/j.ceca.2014.12.007. Epub 2014 Dec 18.


Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.

Gilad D, Shorer S, Ketzef M, Friedman A, Sekler I, Aizenman E, Hershfinkel M.

Neurobiol Dis. 2015 Sep;81:4-13. doi: 10.1016/j.nbd.2014.12.020. Epub 2015 Jan 3.


Nitric oxide signaling modulates synaptic inhibition in the superior paraolivary nucleus (SPN) via cGMP-dependent suppression of KCC2.

Yassin L, Radtke-Schuller S, Asraf H, Grothe B, Hershfinkel M, Forsythe ID, Kopp-Scheinpflug C.

Front Neural Circuits. 2014 Jun 17;8:65. doi: 10.3389/fncir.2014.00065. eCollection 2014.


Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria.

Nita II, Hershfinkel M, Kantor C, Rutter GA, Lewis EC, Sekler I.

FASEB J. 2014 Aug;28(8):3301-12. doi: 10.1096/fj.13-248161. Epub 2014 Apr 9.


The ZnR/GPR39 interacts with the CaSR to enhance signaling in prostate and salivary epithelia.

Asraf H, Salomon S, Nevo A, Sekler I, Mayer D, Hershfinkel M.

J Cell Physiol. 2014 Jul;229(7):868-77. doi: 10.1002/jcp.24514.


Impact of S100A8/A9 expression on prostate cancer progression in vitro and in vivo.

Grebhardt S, Müller-Decker K, Bestvater F, Hershfinkel M, Mayer D.

J Cell Physiol. 2014 May;229(5):661-71. doi: 10.1002/jcp.24489.


Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.

Perez-Rosello T, Anderson CT, Schopfer FJ, Zhao Y, Gilad D, Salvatore SR, Freeman BA, Hershfinkel M, Aizenman E, Tzounopoulos T.

J Neurosci. 2013 May 29;33(22):9259-72. doi: 10.1523/JNEUROSCI.0237-13.2013. Erratum in: J Neurosci. 2014 May 21;34(21):7394.


The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.

Nita II, Hershfinkel M, Fishman D, Ozeri E, Rutter GA, Sensi SL, Khananshvili D, Lewis EC, Sekler I.

PLoS One. 2012;7(10):e46649. doi: 10.1371/journal.pone.0046649. Epub 2012 Oct 8.


Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39).

Cohen L, Asraf H, Sekler I, Hershfinkel M.

J Biol Chem. 2012 Sep 28;287(40):33339-50. Epub 2012 Aug 9.


Molecular identity and functional properties of the mitochondrial Na+/Ca2+ exchanger.

Palty R, Hershfinkel M, Sekler I.

J Biol Chem. 2012 Sep 14;287(38):31650-7. doi: 10.1074/jbc.R112.355867. Epub 2012 Jul 20. Review.


Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin.

Cohen L, Azriel-Tamir H, Arotsker N, Sekler I, Hershfinkel M.

PLoS One. 2012;7(4):e35482. doi: 10.1371/journal.pone.0035482. Epub 2012 Apr 24.


Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.

Hoch E, Lin W, Chai J, Hershfinkel M, Fu D, Sekler I.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7202-7. doi: 10.1073/pnas.1200362109. Epub 2012 Apr 23.


SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro.

Saadi RA, He K, Hartnett KA, Kandler K, Hershfinkel M, Aizenman E.

Neuroscience. 2012 May 17;210:38-46. doi: 10.1016/j.neuroscience.2012.03.001. Epub 2012 Mar 7.


The neurophysiology and pathology of brain zinc.

Sensi SL, Paoletti P, Koh JY, Aizenman E, Bush AI, Hershfinkel M.

J Neurosci. 2011 Nov 9;31(45):16076-85. doi: 10.1523/JNEUROSCI.3454-11.2011. Review.


Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.

Chorin E, Vinograd O, Fleidervish I, Gilad D, Herrmann S, Sekler I, Aizenman E, Hershfinkel M.

J Neurosci. 2011 Sep 7;31(36):12916-26. doi: 10.1523/JNEUROSCI.2205-11.2011.


Zinc bells rang in Jerusalem!

Hershfinkel M, Aizenman E, Andrews G, Sekler I.

Sci Signal. 2010 Jul 6;3(129):mr2. doi: 10.1126/scisignal.3129mr2.


Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair.

Sharir H, Zinger A, Nevo A, Sekler I, Hershfinkel M.

J Biol Chem. 2010 Aug 20;285(34):26097-106. doi: 10.1074/jbc.M110.107490. Epub 2010 Jun 3.


Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc.

Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, Sekler I, Silverman WF.

J Cell Physiol. 2010 Sep;224(3):567-74. doi: 10.1002/jcp.22168.


NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.

Palty R, Silverman WF, Hershfinkel M, Caporale T, Sensi SL, Parnis J, Nolte C, Fishman D, Shoshan-Barmatz V, Herrmann S, Khananshvili D, Sekler I.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):436-41. doi: 10.1073/pnas.0908099107. Epub 2009 Dec 15.


The lipophilic zinc chelator DP-b99 prevents zinc induced neuronal death.

Barkalifa R, Hershfinkel M, Friedman JE, Kozak A, Sekler I.

Eur J Pharmacol. 2009 Sep 15;618(1-3):15-21. doi: 10.1016/j.ejphar.2009.07.019. Epub 2009 Jul 19.


Intracellular zinc inhibits KCC2 transporter activity.

Hershfinkel M, Kandler K, Knoch ME, Dagan-Rabin M, Aras MA, Abramovitch-Dahan C, Sekler I, Aizenman E.

Nat Neurosci. 2009 Jun;12(6):725-7. doi: 10.1038/nn.2316. Epub 2009 May 10.


Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter.

Ohana E, Hoch E, Keasar C, Kambe T, Yifrach O, Hershfinkel M, Sekler I.

J Biol Chem. 2009 Jun 26;284(26):17677-86. doi: 10.1074/jbc.M109.007203. Epub 2009 Apr 14.


Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules.

Kaisman-Elbaz T, Sekler I, Fishman D, Karol N, Forberg M, Kahn N, Hershfinkel M, Silverman WF.

J Cell Physiol. 2009 Jul;220(1):222-9. doi: 10.1002/jcp.21754.


Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus.

Besser L, Chorin E, Sekler I, Silverman WF, Atkin S, Russell JT, Hershfinkel M.

J Neurosci. 2009 Mar 4;29(9):2890-901. doi: 10.1523/JNEUROSCI.5093-08.2009.


Glutamate regulates the activity of topoisomerase I in mouse cerebellum.

Zehorai E, Eitan E, Hershfinkel M, Sekler I, Priel E.

Mol Neurobiol. 2008 Dec;38(3):242-52. doi: 10.1007/s12035-008-8044-x. Epub 2008 Nov 4.


Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells.

Fedida-Metula S, Elhyany S, Tsory S, Segal S, Hershfinkel M, Sekler I, Fishman D.

Carcinogenesis. 2008 Aug;29(8):1546-54. doi: 10.1093/carcin/bgn146. Epub 2008 Jun 25.


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