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Critical reflection about socioeconomic inequalities among White young men from poor and working-class backgrounds.

Hershberg RM, Johnson SK.

Dev Psychol. 2019 Mar;55(3):562-573. doi: 10.1037/dev0000587.


Characterization of Factors Affecting the Detection Limit of EGFR p.T790M in Circulating Tumor DNA.

Fahoum I, Forer R, Volodarsky D, Vulih I, Bick T, Sarji S, Bamberger Z, Ben-Izhak O, Sabo E, Hershberg R, Hershkovitz D.

Technol Cancer Res Treat. 2018 Jan 1;17:1533033818793653. doi: 10.1177/1533033818793653.


Effect of Adding Motolimod to Standard Combination Chemotherapy and Cetuximab Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck: The Active8 Randomized Clinical Trial.

Ferris RL, Saba NF, Gitlitz BJ, Haddad R, Sukari A, Neupane P, Morris JC, Misiukiewicz K, Bauman JE, Fenton M, Jimeno A, Adkins DR, Schneider CJ, Sacco AG, Shirai K, Bowles DW, Gibson M, Nwizu T, Gottardo R, Manjarrez KL, Dietsch GN, Bryan JK, Hershberg RM, Cohen EEW.

JAMA Oncol. 2018 Nov 1;4(11):1583-1588. doi: 10.1001/jamaoncol.2018.1888.


The Codon Usage of Lowly Expressed Genes Is Subject to Natural Selection.

Yannai A, Katz S, Hershberg R.

Genome Biol Evol. 2018 Apr 1;10(5):1237-1246. doi: 10.1093/gbe/evy084.


Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.

Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL.

J Immunol. 2018 May 1;200(9):3244-3258. doi: 10.4049/jimmunol.1701733. Epub 2018 Apr 2.


Development and Pilot Testing of a Bilingual Environmental Health Assessment Tool to Promote Asthma-friendly Childcares.

Evans-Agnew RA, Postma J, Camacho AO, Hershberg RM, Trujilio E, Tinajera M.

Prog Community Health Partnersh. 2018;12(1):35-44. doi: 10.1353/cpr.2018.0004.


TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells.

Dang Y, Rutnam ZJ, Dietsch G, Lu H, Yang Y, Hershberg R, Disis ML.

J Leukoc Biol. 2018 Jan;103(1):157-164. doi: 10.1002/JLB.5AB0217-070R. Epub 2017 Dec 14.


Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals.

Shayan G, Kansy BA, Gibson SP, Srivastava RM, Bryan JK, Bauman JE, Ohr J, Kim S, Duvvuri U, Clump DA, Heron DE, Johnson JT, Hershberg RM, Ferris RL.

Clin Cancer Res. 2018 Jan 1;24(1):62-72. doi: 10.1158/1078-0432.CCR-17-0357. Epub 2017 Oct 23.


Horizontally Acquired Genes Are Often Shared between Closely Related Bacterial Species.

Bolotin E, Hershberg R.

Front Microbiol. 2017 Aug 25;8:1536. doi: 10.3389/fmicb.2017.01536. eCollection 2017.


Similar levels of gene content variation observed for Pseudomonas syringae populations extracted from single and multiple host species.

Karasov TL, Barrett L, Hershberg R, Bergelson J.

PLoS One. 2017 Sep 7;12(9):e0184195. doi: 10.1371/journal.pone.0184195. eCollection 2017.


Is the Scoutreach Initiative of Boy Scouts of America Linked to Character Development among Socioeconomically, Racially, and Ethnically Diverse Youth?: Initial Explorations.

Wang J, Champine RB, Ferris KA, Hershberg RM, Warren DJ, Burkhard BM, Su S, Lerner RM.

J Youth Adolesc. 2017 Oct;46(10):2230-2240. doi: 10.1007/s10964-017-0710-8. Epub 2017 Jun 29.


Antibiotic-Independent Adaptive Effects of Antibiotic Resistance Mutations.

Hershberg R.

Trends Genet. 2017 Aug;33(8):521-528. doi: 10.1016/j.tig.2017.05.003. Epub 2017 Jun 16. Review.


A phase 2, randomized, double-blind, placebo- controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or persistent ovarian cancer: a Gynecologic Oncology Group partners study.

Monk BJ, Brady MF, Aghajanian C, Lankes HA, Rizack T, Leach J, Fowler JM, Higgins R, Hanjani P, Morgan M, Edwards R, Bradley W, Kolevska T, Foukas P, Swisher EM, Anderson KS, Gottardo R, Bryan JK, Newkirk M, Manjarrez KL, Mannel RS, Hershberg RM, Coukos G.

Ann Oncol. 2017 May 1;28(5):996-1004. doi: 10.1093/annonc/mdx049.


Rapid Genetic Adaptation during the First Four Months of Survival under Resource Exhaustion.

Avrani S, Bolotin E, Katz S, Hershberg R.

Mol Biol Evol. 2017 Jul 1;34(7):1758-1769. doi: 10.1093/molbev/msx118.


Human host range of Mycobacterium tuberculosis.

Hershberg R.

Nat Genet. 2016 Nov 29;48(12):1453-1454. doi: 10.1038/ng.3724.


Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN.

Chow LQM, Morishima C, Eaton KD, Baik CS, Goulart BH, Anderson LN, Manjarrez KL, Dietsch GN, Bryan JK, Hershberg RM, Disis ML, Martins RG.

Clin Cancer Res. 2017 May 15;23(10):2442-2450. doi: 10.1158/1078-0432.CCR-16-1934. Epub 2016 Nov 3.


Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.

van Haren SD, Dowling DJ, Foppen W, Christensen D, Andersen P, Reed SG, Hershberg RM, Baden LR, Levy O.

J Immunol. 2016 Dec 1;197(11):4413-4424. Epub 2016 Oct 28.


Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy.

Monk BJ, Facciabene A, Brady WE, Aghajanian CA, Fracasso PM, Walker JL, Lankes HA, Manjarrez KL, Danet-Desnoyers GH, Bell-McGuinn KM, McCourt CK, Malykhin A, Hershberg RM, Coukos G.

Clin Cancer Res. 2017 Apr 15;23(8):1955-1966. doi: 10.1158/1078-0432.CCR-16-1453. Epub 2016 Oct 4.


Character Development within Youth Development Programs: Exploring Multiple Dimensions of Activity Involvement.

Lynch AD, Ferris KA, Burkhard B, Wang J, Hershberg RM, Lerner RM.

Am J Community Psychol. 2016 Mar;57(1-2):73-86. doi: 10.1002/ajcp.12035. Epub 2016 Mar 28.


The Somatic Nature of Cancer Allows It to Affect Highly Constrained Genes.

Ostrow SL, Hershberg R.

Genome Biol Evol. 2016 Jun 3;8(5):1614-20. doi: 10.1093/gbe/evw110.


The Human Vaccines Project: A roadmap for cancer vaccine development.

Romero P, Banchereau J, Bhardwaj N, Cockett M, Disis ML, Dranoff G, Gilboa E, Hammond SA, Hershberg R, Korman AJ, Kvistborg P, Melief C, Mellman I, Palucka AK, Redchenko I, Robins H, Sallusto F, Schenkelberg T, Schoenberger S, Sosman J, Türeci Ö, Van den Eynde B, Koff W, Coukos G.

Sci Transl Med. 2016 Apr 13;8(334):334ps9. doi: 10.1126/scitranslmed.aaf0685. Review.


VTX-1463, a novel TLR-8 agonist, attenuates nasal congestion after ragweed challenge in sensitized beagle dogs.

Royer CM, Rudolph K, Dietsch GN, Hershberg RM, Barrett EG.

Immun Inflamm Dis. 2015 Dec 7;4(1):45-51. doi: 10.1002/iid3.91. eCollection 2016 Mar.


Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity.

Dietsch GN, Lu H, Yang Y, Morishima C, Chow LQ, Disis ML, Hershberg RM.

PLoS One. 2016 Feb 29;11(2):e0148764. doi: 10.1371/journal.pone.0148764. eCollection 2016.


Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection.

Ostrow SL, Simon E, Prinz E, Bick T, Shentzer T, Nagawkar SS, Sabo E, Ben-Izhak O, Hershberg R, Hershkovitz D.

Sci Rep. 2016 Feb 23;6:21927. doi: 10.1038/srep21927.


Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma.

Swisher EM, Harrell MI, Norquist BM, Walsh T, Brady M, Lee M, Hershberg R, Kalli KR, Lankes H, Konnick EQ, Pritchard CC, Monk BJ, Chan JK, Burger R, Kaufmann SH, Birrer MJ.

JAMA Oncol. 2016 Mar;2(3):370-2. doi: 10.1001/jamaoncol.2015.6053.


Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination.

Fatehchand K, Ren L, Elavazhagan S, Fang H, Mo X, Vasilakos JP, Dietsch GN, Hershberg RM, Tridandapani S, Butchar JP.

J Biol Chem. 2016 Feb 19;291(8):3895-904. doi: 10.1074/jbc.M115.701151. Epub 2015 Dec 22.


Early Child Social-Emotional Problems and Child Obesity: Exploring the Protective Role of a Primary Care-Based General Parenting Intervention.

Gross RS, Briggs RD, Hershberg RS, Silver EJ, Velazco NK, Hauser NR, Racine AD.

J Dev Behav Pediatr. 2015 Oct;36(8):594-604. doi: 10.1097/DBP.0000000000000212.


Mutation--The Engine of Evolution: Studying Mutation and Its Role in the Evolution of Bacteria.

Hershberg R.

Cold Spring Harb Perspect Biol. 2015 Sep 1;7(9):a018077. doi: 10.1101/cshperspect.a018077. Review.


Developmental Trajectories of Youth Character: A Five-Wave Longitudinal Study of Cub Scouts and Non-Scout Boys.

Wang J, Ferris KA, Hershberg RM, Lerner RM.

J Youth Adolesc. 2015 Dec;44(12):2359-73. doi: 10.1007/s10964-015-0340-y. Epub 2015 Aug 18.


Gene Loss Dominates As a Source of Genetic Variation within Clonal Pathogenic Bacterial Species.

Bolotin E, Hershberg R.

Genome Biol Evol. 2015 Jul 10;7(8):2173-87. doi: 10.1093/gbe/evv135.


Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337).

Dietsch GN, Randall TD, Gottardo R, Northfelt DW, Ramanathan RK, Cohen PA, Manjarrez KL, Newkirk M, Bryan JK, Hershberg RM.

Clin Cancer Res. 2015 Dec 15;21(24):5445-52. doi: 10.1158/1078-0432.CCR-15-0578. Epub 2015 Jul 7.


Prokaryotic nucleotide composition is shaped by both phylogeny and the environment.

Reichenberger ER, Rosen G, Hershberg U, Hershberg R.

Genome Biol Evol. 2015 Apr 9;7(5):1380-9. doi: 10.1093/gbe/evv063.


Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.

Elavazhagan S, Fatehchand K, Santhanam V, Fang H, Ren L, Gautam S, Reader B, Mo X, Cheney C, Briercheck E, Vasilakos JP, Dietsch GN, Hershberg RM, Caligiuri M, Byrd JC, Butchar JP, Tridandapani S.

J Immunol. 2015 Mar 15;194(6):2786-95. doi: 10.4049/jimmunol.1402316. Epub 2015 Feb 9.


A phase I dose-finding study of the novel Toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma.

Northfelt DW, Ramanathan RK, Cohen PA, Von Hoff DD, Weiss GJ, Dietsch GN, Manjarrez KL, Randall TD, Hershberg RM.

Clin Cancer Res. 2014 Jul 15;20(14):3683-91. doi: 10.1158/1078-0432.CCR-14-0392. Epub 2014 May 7.


Cancer evolution is associated with pervasive positive selection on globally expressed genes.

Ostrow SL, Barshir R, DeGregori J, Yeger-Lotem E, Hershberg R.

PLoS Genet. 2014 Mar 6;10(3):e1004239. doi: 10.1371/journal.pgen.1004239. eCollection 2014 Mar.


Illuminating trajectories of adolescent thriving and contribution through the words of youth: qualitative findings from the 4-H Study of Positive Youth Development.

Hershberg RM, DeSouza LM, Warren AE, Lerner JV, Lerner RM.

J Youth Adolesc. 2014 Jun;43(6):950-70. doi: 10.1007/s10964-014-0102-2. Epub 2014 Feb 21.


Beyond the deficit model: bullying and trajectories of character virtues in adolescence.

Hilliard LJ, Bowers EP, Greenman KN, Hershberg RM, Geldhof GJ, Glickman SA, Lerner JV, Lerner RM.

J Youth Adolesc. 2014 Jun;43(6):991-1003. doi: 10.1007/s10964-014-0094-y. Epub 2014 Feb 16.


Elevated mutagenesis does not explain the increased frequency of antibiotic resistant mutants in starved aging colonies.

Katz S, Hershberg R.

PLoS Genet. 2013 Nov;9(11):e1003968. doi: 10.1371/journal.pgen.1003968. Epub 2013 Nov 14.


POGO-DB--a database of pairwise-comparisons of genomes and conserved orthologous genes.

Lan Y, Morrison JC, Hershberg R, Rosen GL.

Nucleic Acids Res. 2014 Jan;42(Database issue):D625-32. doi: 10.1093/nar/gkt1094. Epub 2013 Nov 5.


Strong purifying selection at synonymous sites in D. melanogaster.

Lawrie DS, Messer PW, Hershberg R, Petrov DA.

PLoS Genet. 2013 May;9(5):e1003527. doi: 10.1371/journal.pgen.1003527. Epub 2013 May 30.


TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross-priming of EGFR-specific CD8+ T cells.

Stephenson RM, Lim CM, Matthews M, Dietsch G, Hershberg R, Ferris RL.

Cancer Immunol Immunother. 2013 Aug;62(8):1347-57. doi: 10.1007/s00262-013-1437-3. Epub 2013 May 18.


The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O.

PLoS One. 2013;8(3):e58164. doi: 10.1371/journal.pone.0058164. Epub 2013 Mar 4.


On the limitations of using ribosomal genes as references for the study of codon usage: a rebuttal.

Hershberg R, Petrov DA.

PLoS One. 2012;7(12):e49060. doi: 10.1371/journal.pone.0049060. Epub 2012 Dec 20.


Lineage targeted MHC-II transgenic mice demonstrate the role of dendritic cells in bacterial-driven colitis.

Maggio-Price L, Seamons A, Bielefeldt-Ohmann H, Zeng W, Brabb T, Ware C, Lei M, Hershberg RM.

Inflamm Bowel Dis. 2013 Jan;19(1):174-84. doi: 10.1002/ibd.23000.


VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC.

Lu H, Dietsch GN, Matthews MA, Yang Y, Ghanekar S, Inokuma M, Suni M, Maino VC, Henderson KE, Howbert JJ, Disis ML, Hershberg RM.

Clin Cancer Res. 2012 Jan 15;18(2):499-509. doi: 10.1158/1078-0432.CCR-11-1625. Epub 2011 Nov 29.


Evidence that mutation is universally biased towards AT in bacteria.

Hershberg R, Petrov DA.

PLoS Genet. 2010 Sep 9;6(9):e1001115. doi: 10.1371/journal.pgen.1001115.


General rules for optimal codon choice.

Hershberg R, Petrov DA.

PLoS Genet. 2009 Jul;5(7):e1000556. doi: 10.1371/journal.pgen.1000556. Epub 2009 Jul 10.

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