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Clinical epidemiology of COPD - Insights from 10 years of the COPDGene study.

Maselli DJ, Bhatt SP, Anzueto A, Bowler RP, DeMeo DL, Diaz AA, Dransfield MT, Fawzy A, Foreman MG, Hanania NA, Hersh CP, Kim V, Kinney GL, Putcha N, Wan ES, Wells JM, Westney GE, Young KA, Silverman EK, Han MK, Make BJ.

Chest. 2019 May 30. pii: S0012-3692(19)31128-6. doi: 10.1016/j.chest.2019.04.135. [Epub ahead of print] Review.


It's more than low BMI: prevalence of cachexia and associated mortality in COPD.

McDonald MN, Wouters EFM, Rutten E, Casaburi R, Rennard SI, Lomas DA, Bamman M, Celli B, Agusti A, Tal-Singer R, Hersh CP, Dransfield M, Silverman EK.

Respir Res. 2019 May 22;20(1):100. doi: 10.1186/s12931-019-1073-3.


Unsupervised discovery of phenotype specific multi-omics networks.

Shi WJ, Zhuang Y, Russell PH, Hobbs BD, Parker MM, Castaldi PJ, Rudra P, Vestal B, Hersh CP, Saba LM, Kechris K.

Bioinformatics. 2019 Apr 8. pii: btz226. doi: 10.1093/bioinformatics/btz226. [Epub ahead of print]


RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD.

Morrow JD, Chase RP, Parker MM, Glass K, Seo M, Divo M, Owen CA, Castaldi P, DeMeo DL, Silverman EK, Hersh CP.

Respir Res. 2019 Apr 2;20(1):65. doi: 10.1186/s12931-019-1032-z.


Pharmacogenomics of chronic obstructive pulmonary disease.

Hersh CP.

Expert Rev Respir Med. 2019 May;13(5):459-470. doi: 10.1080/17476348.2019.1601559. Epub 2019 Apr 8.


Genetic Advances in COPD: Insights from COPDGene.

Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK.

Am J Respir Crit Care Med. 2019 Mar 25. doi: 10.1164/rccm.201808-1455SO. [Epub ahead of print]


Combined FEV1 and FVC Bronchodilator Response, Exacerbations, and Mortality in COPD.

Fortis S, Comellas A, Make BJ, Hersh CP, Bodduluri S, Georgopoulos D, Kim V, Criner GJ, Dransfield MT, Bhatt SP.

Ann Am Thorac Soc. 2019 Mar 25. doi: 10.1513/AnnalsATS.201809-601OC. [Epub ahead of print]


Novel Data Transformations for RNA-seq Differential Expression Analysis.

Zhang Z, Yu D, Seo M, Hersh CP, Weiss ST, Qiu W.

Sci Rep. 2019 Mar 18;9(1):4820. doi: 10.1038/s41598-019-41315-w.


Omics and the Search for Blood Biomarkers in COPD: Insights from COPDGene.

Regan EA, Hersh CP, Castaldi PJ, DeMeo DL, Silverman EK, Crapo JD, Bowler RP.

Am J Respir Cell Mol Biol. 2019 Mar 15. doi: 10.1165/rcmb.2018-0245PS. [Epub ahead of print]


Found in Translation: Multi-omics Assessment of the COPD-Lung Cancer Interaction.

Christenson S, Hersh CP.

Am J Respir Crit Care Med. 2019 Feb 12. doi: 10.1164/rccm.201901-0156ED. [Epub ahead of print] No abstract available.


Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis.

Faner R, Morrow JD, Casas-Recasens S, Cloonan SM, Noell G, López-Giraldo A, Tal-Singer R, Miller BE, Silverman EK, Agustí A, Hersh CP.

Respir Res. 2019 Jan 8;20(1):5. doi: 10.1186/s12931-018-0965-y.


High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report.

Hersh CP, Adcock IM, Celedón JC, Cho MH, Christiani DC, Himes BE, Kaminski N, Mathias RA, Meyers DA, Quackenbush J, Redline S, Steiling KA, Tabor HK, Tobin MD, Wurfel MM, Yang IV, Koppelman GH.

Ann Am Thorac Soc. 2019 Jan;16(1):1-16. doi: 10.1513/AnnalsATS.201810-716WS.


An evolutionarily conserved non-synonymous SNP in a leucine-rich repeat domain determines anthracnose resistance in watermelon.

Jang YJ, Seo M, Hersh CP, Rhee SJ, Kim Y, Lee GP.

Theor Appl Genet. 2019 Feb;132(2):473-488. doi: 10.1007/s00122-018-3235-y. Epub 2018 Nov 16.


A Network Analysis of Biomarkers for Type 2 Diabetes.

Huang T, Glass K, Zeleznik OA, Kang JH, Ivey KL, Sonawane AR, Birmann BM, Hersh CP, Hu FB, Tworoger SS.

Diabetes. 2019 Feb;68(2):281-290. doi: 10.2337/db18-0892. Epub 2018 Nov 8.


Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study.

Hayden LP, Cho MH, Raby BA, Beaty TH, Silverman EK, Hersh CP; COPDGene Investigators.

Respir Res. 2018 Oct 29;19(1):209. doi: 10.1186/s12931-018-0890-0.


Alpha-1 Antitrypsin Deficiency as an Incidental Finding in Clinical Genetic Testing.

Hersh CP, Campbell EJ, Scott LR, Raby BA.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):246-248. doi: 10.1164/rccm.201809-1679LE. No abstract available.


Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease.

Seo M, Qiu W, Bailey W, Criner GJ, Dransfield MT, Fuhlbrigge AL, Reilly JJ, Scholand MB, Castaldi P, Chase R, Parker M, Saferali A, Yun JH, Crapo JD, Cho MH, Beaty TH, Silverman EK, Hersh CP.

J Mol Med (Berl). 2018 Dec;96(12):1375-1385. doi: 10.1007/s00109-018-1708-8. Epub 2018 Oct 23.


Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution.

Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ; COPDGene investigators, by Core Units:, ECLIPSE Investigators:, GenKOLS Investigators:.

Am J Respir Cell Mol Biol. 2019 Apr;60(4):388-398. doi: 10.1165/rcmb.2018-0110OC.



Yun JH, Hersh CP.

J Allergy Clin Immunol. 2018 Dec;142(6):2013-2014. doi: 10.1016/j.jaci.2018.07.043. Epub 2018 Oct 10. No abstract available.


Clinical Approach to the Therapy of Asthma-COPD Overlap.

Maselli DJ, Hardin M, Christenson SA, Hanania NA, Hersh CP, Adams SG, Anzueto A, Peters JI, Han MK, Martinez FJ.

Chest. 2019 Jan;155(1):168-177. doi: 10.1016/j.chest.2018.07.028. Epub 2018 Aug 2. Review.


Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.

Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH.

Hum Mol Genet. 2018 Nov 1;27(21):3801-3812. doi: 10.1093/hmg/ddy269.


Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.

Lutz SM, Frederiksen B, Begum F, McDonald MN, Cho MH, Hobbs BD, Parker MM, DeMeo DL, Hersh CP, Ehringer MA, Young K, Jiang L, Foreman MG, Kinney GL, Make BJ, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH, Hokanson JE; ECLIPSE and COPDGene Investigators.

Nicotine Tob Res. 2019 May 21;21(6):714-722. doi: 10.1093/ntr/nty095.


Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.

Yun JH, Lamb A, Chase R, Singh D, Parker MM, Saferali A, Vestbo J, Tal-Singer R, Castaldi PJ, Silverman EK, Hersh CP; COPDGene and ECLIPSE Investigators.

J Allergy Clin Immunol. 2018 Jun;141(6):2037-2047.e10. doi: 10.1016/j.jaci.2018.04.010. Epub 2018 Apr 28.


Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease.

Ross JC, Castaldi PJ, Cho MH, Hersh CP, Rahaghi FN, Sánchez-Ferrero GV, Parker MM, Litonjua AA, Sparrow D, Dy JG, Silverman EK, Washko GR, San José Estépar R.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1033-1042. doi: 10.1164/rccm.201707-1405OC.


Integrative genomics identifies new genes associated with severe COPD and emphysema.

Sakornsakolpat P, Morrow JD, Castaldi PJ, Hersh CP, Bossé Y, Silverman EK, Manichaikul A, Cho MH.

Respir Res. 2018 Mar 22;19(1):46. doi: 10.1186/s12931-018-0744-9.


Features of COPD as Predictors of Lung Cancer.

Carr LL, Jacobson S, Lynch DA, Foreman MG, Flenaugh EL, Hersh CP, Sciurba FC, Wilson DO, Sieren JC, Mulhall P, Kim V, Kinsey CM, Bowler RP.

Chest. 2018 Jun;153(6):1326-1335. doi: 10.1016/j.chest.2018.01.049. Epub 2018 Feb 13.


Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease.

Morrow JD, Cho MH, Platig J, Zhou X, DeMeo DL, Qiu W, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Silverman EK, Hersh CP.

Hum Genomics. 2018 Jan 15;12(1):1. doi: 10.1186/s40246-018-0132-z.


Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci.

Morrow JD, Glass K, Cho MH, Hersh CP, Pinto-Plata V, Celli B, Marchetti N, Criner G, Bueno R, Washko G, Choi AMK, Quackenbush J, Silverman EK, DeMeo DL.

Am J Respir Crit Care Med. 2018 May 15;197(10):1275-1284. doi: 10.1164/rccm.201707-1434OC.


Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study.

Hayden LP, Hardin ME, Qiu W, Lynch DA, Strand MJ, van Beek EJ, Crapo JD, Silverman EK, Hersh CP; COPDGene Investigators(∗).

Chest. 2018 Feb;153(2):368-377. doi: 10.1016/j.chest.2017.11.038. Epub 2017 Dec 15.


Chest computed tomography-derived low fat-free mass index and mortality in COPD.

McDonald MN, Diaz AA, Rutten E, Lutz SM, Harmouche R, San Jose Estepar R, Kinney G, Hokanson JE, Gower BA, Wouters EFM, Rennard SI, Hersh CP, Casaburi R, Dransfield MT, Silverman EK, Washko GR.

Eur Respir J. 2017 Dec 14;50(6). pii: 1701134. doi: 10.1183/13993003.01134-2017. Print 2017 Dec.


Estimating drivers of cell state transitions using gene regulatory network models.

Schlauch D, Glass K, Hersh CP, Silverman EK, Quackenbush J.

BMC Syst Biol. 2017 Dec 13;11(1):139. doi: 10.1186/s12918-017-0517-y.


Diagnosing alpha-1 antitrypsin deficiency: the first step in precision medicine.

Hersh CP.

F1000Res. 2017 Nov 27;6:2049. doi: 10.12688/f1000research.12399.1. eCollection 2017. Review.


Meta-analysis of peripheral blood gene expression modules for COPD phenotypes.

Reinhold D, Morrow JD, Jacobson S, Hu J, Ringel B, Seibold MA, Hersh CP, Kechris KJ, Bowler RP.

PLoS One. 2017 Oct 9;12(10):e0185682. doi: 10.1371/journal.pone.0185682. eCollection 2017.


RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking.

Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ.

BMC Med Genomics. 2017 Oct 6;10(1):58. doi: 10.1186/s12920-017-0295-9.


Subtyping Chronic Obstructive Pulmonary Disease Using Peripheral Blood Proteomics.

Zarei S, Mirtar A, Morrow JD, Castaldi PJ, Belloni P, Hersh CP.

Chronic Obstr Pulm Dis. 2017 Feb 8;4(2):97-108. doi: 10.15326/jcopdf.4.2.2016.0147.


Whole-Genome Sequencing in Common Respiratory Diseases. Ready, Set, Go!

Hersh CP, Vachani A.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):121-122. doi: 10.1164/rccm.201703-0479ED. No abstract available.


Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts.

Castaldi PJ, Benet M, Petersen H, Rafaels N, Finigan J, Paoletti M, Marike Boezen H, Vonk JM, Bowler R, Pistolesi M, Puhan MA, Anto J, Wauters E, Lambrechts D, Janssens W, Bigazzi F, Camiciottoli G, Cho MH, Hersh CP, Barnes K, Rennard S, Boorgula MP, Dy J, Hansel NN, Crapo JD, Tesfaigzi Y, Agusti A, Silverman EK, Garcia-Aymerich J.

Thorax. 2017 Nov;72(11):998-1006. doi: 10.1136/thoraxjnl-2016-209846. Epub 2017 Jun 21.


Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease.

Obeidat M, Nie Y, Chen V, Shannon CP, Andiappan AK, Lee B, Rotzschke O, Castaldi PJ, Hersh CP, Fishbane N, Ng RT, McManus B, Miller BE, Rennard S, Paré PD, Sin DD.

Respir Res. 2017 Apr 24;18(1):72. doi: 10.1186/s12931-017-0558-1.


Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups.

Foreman MG, Wilson C, DeMeo DL, Hersh CP, Beaty TH, Cho MH, Ziniti J, Curran-Everett D, Criner G, Hokanson JE, Brantly M, Rouhani FN, Sandhaus RA, Crapo JD, Silverman EK; Genetic Epidemiology of COPD (COPDGene) Investigators * .

Ann Am Thorac Soc. 2017 Aug;14(8):1280-1287. doi: 10.1513/AnnalsATS.201611-838OC.


Screening for interaction effects in gene expression data.

Castaldi PJ, Cho MH, Liang L, Silverman EK, Hersh CP, Rice K, Aschard H.

PLoS One. 2017 Mar 16;12(3):e0173847. doi: 10.1371/journal.pone.0173847. eCollection 2017.


Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue.

Morrow JD, Zhou X, Lao T, Jiang Z, DeMeo DL, Cho MH, Qiu W, Cloonan S, Pinto-Plata V, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Choi AM, Silverman EK, Hersh CP.

Sci Rep. 2017 Mar 13;7:44232. doi: 10.1038/srep44232.


Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways.

Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):47-58. doi: 10.1165/rcmb.2016-0328OC.


Gene-based segregation method for identifying rare variants in family-based sequencing studies.

Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH.

Genet Epidemiol. 2017 May;41(4):309-319. doi: 10.1002/gepi.22037. Epub 2017 Feb 13.


Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.

McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK.

J Cachexia Sarcopenia Muscle. 2017 Jun;8(3):428-436. doi: 10.1002/jcsm.12171. Epub 2017 Jan 2.


Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study.

Wells JM, Estepar RS, McDonald MN, Bhatt SP, Diaz AA, Bailey WC, Jacobson FL, Dransfield MT, Washko GR, Make BJ, Casaburi R, van Beek EJ, Hoffman EA, Sciurba FC, Crapo JD, Silverman EK, Hersh CP; COPDGene Investigators.

BMC Pulm Med. 2016 Dec 1;16(1):169.


Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.

Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL; COPDGene and Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points Investigators.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):332-341. doi: 10.1165/rcmb.2016-0172OC.


Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL; COPDGene and ECLIPSE Investigators.

Am J Respir Crit Care Med. 2017 Mar 15;195(6):757-771. doi: 10.1164/rccm.201605-0997OC.


DNA methylation profiling in human lung tissue identifies genes associated with COPD.

Morrow JD, Cho MH, Hersh CP, Pinto-Plata V, Celli B, Marchetti N, Criner G, Bueno R, Washko G, Glass K, Choi AMK, Quackenbush J, Silverman EK, DeMeo DL.

Epigenetics. 2016 Oct 2;11(10):730-739. doi: 10.1080/15592294.2016.1226451. Epub 2016 Nov 1.


Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O'Neal WK, Bowler RP; SPIROMICS Research Group; COPDGene Investigators.

PLoS Genet. 2016 Aug 17;12(8):e1006011. doi: 10.1371/journal.pgen.1006011. eCollection 2016 Aug.


Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis.

Hayden LP, Cho MH, McDonald MN, Crapo JD, Beaty TH, Silverman EK, Hersh CP; COPDGene Investigators *.

Am J Respir Cell Mol Biol. 2017 Jan;56(1):20-28. doi: 10.1165/rcmb.2016-0101OC.

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