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Items: 36


Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer.

Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell M, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB 3rd, Madani N, Sodroski J.

J Virol. 2019 Oct 15;93(21). pii: e01197-19. doi: 10.1128/JVI.01197-19. Print 2019 Nov 1.


Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.

Lai YT, Wang T, O'Dell S, Louder MK, Schön A, Cheung CSF, Chuang GY, Druz A, Lin B, McKee K, Peng D, Yang Y, Zhang B, Herschhorn A, Sodroski J, Bailer RT, Doria-Rose NA, Mascola JR, Langley DR, Kwong PD.

Nat Commun. 2019 Jan 3;10(1):47. doi: 10.1038/s41467-018-07851-1.


Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells.

Ukah OB, Puray-Chavez M, Tedbury PR, Herschhorn A, Sodroski JG, Sarafianos SG.

Viruses. 2018 Sep 30;10(10). pii: E534. doi: 10.3390/v10100534.


SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement.

Alsahafi N, Anand SP, Castillo-Menendez L, Verly MM, Medjahed H, Prévost J, Herschhorn A, Richard J, Schön A, Melillo B, Freire E, Smith AB 3rd, Sodroski J, Finzi A.

J Virol. 2018 Sep 12;92(19). pii: e01080-18. doi: 10.1128/JVI.01080-18. Print 2018 Oct 1.


Conformation-Dependent Interactions Between HIV-1 Envelope Glycoproteins and Broadly Neutralizing Antibodies.

Flemming J, Wiesen L, Herschhorn A.

AIDS Res Hum Retroviruses. 2018 Sep;34(9):794-803. doi: 10.1089/AID.2018.0102. Epub 2018 Jul 17. Review.


Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.

Nat Commun. 2018 Jan 8;9(1):158. doi: 10.1038/s41467-017-02463-7.


Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.

Schulte B, Selyutina A, Opp S, Herschhorn A, Sodroski JG, Pizzato M, Diaz-Griffero F.

Virology. 2018 Feb;515:52-65. doi: 10.1016/j.virol.2017.12.005. Epub 2017 Dec 18.


The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.

Nat Commun. 2017 Oct 19;8(1):1049. doi: 10.1038/s41467-017-01119-w. Erratum in: Nat Commun. 2018 Jan 8;9(1):158.


Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, Louder MK, Rawi R, Soumana DI, Finzi A, Herschhorn A, Madani N, Sodroski J, Freire E, Langley DR, Mascola JR, McDermott AB, Kwong PD.

Nat Chem Biol. 2017 Oct;13(10):1115-1122. doi: 10.1038/nchembio.2460. Epub 2017 Aug 21.


An entry-competent intermediate state of the HIV-1 envelope glycoproteins.

Herschhorn A, Sodroski J.

Receptors Clin Investig. 2017;4(1). pii: e1544. doi: 10.14800/rci.1544. Epub 2017 May 24.


Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein.

Nguyen HT, Madani N, Ding H, Elder E, Princiotto A, Gu C, Darby P, Alin J, Herschhorn A, Kappes JC, Mao Y, Sodroski JG.

Virol J. 2017 Feb 16;14(1):33. doi: 10.1186/s12985-017-0704-x.


Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.

Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB 3rd, Sodroski J, Finzi A.

J Virol. 2017 Feb 14;91(5). pii: e02219-16. doi: 10.1128/JVI.02219-16. Print 2017 Mar 1.


Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.

Madani N, Princiotto AM, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, Melillo B, Smith AB 3rd, Sodroski J.

J Virol. 2017 Jan 18;91(3). pii: e01880-16. doi: 10.1128/JVI.01880-16. Print 2017 Feb 1.


Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.

Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J.

mBio. 2016 Oct 25;7(5). pii: e01598-16. doi: 10.1128/mBio.01598-16.


Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140.

Go EP, Herschhorn A, Gu C, Castillo-Menendez L, Zhang S, Mao Y, Chen H, Ding H, Wakefield JK, Hua D, Liao HX, Kappes JC, Sodroski J, Desaire H.

J Virol. 2015 Aug;89(16):8245-57. doi: 10.1128/JVI.00628-15. Epub 2015 May 27.


A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.

Herschhorn A, Gu C, Espy N, Richard J, Finzi A, Sodroski JG.

Nat Chem Biol. 2014 Oct;10(10):845-52. doi: 10.1038/nchembio.1623. Epub 2014 Aug 31.


Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission.

Yen PJ, Herschhorn A, Haim H, Salas I, Gu C, Sodroski J, Gabuzda D.

J Virol. 2014 May;88(9):5014-28. doi: 10.1128/JVI.02785-13. Epub 2014 Feb 19.


The isolation of novel phage display-derived human recombinant antibodies against CCR5, the major co-receptor of HIV.

Shimoni M, Herschhorn A, Britan-Rosich Y, Kotler M, Benhar I, Hizi A.

Viral Immunol. 2013 Aug;26(4):277-90. doi: 10.1089/vim.2012.0029.


Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer.

Mao Y, Wang L, Gu C, Herschhorn A, Désormeaux A, Finzi A, Xiang SH, Sodroski JG.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12438-43. doi: 10.1073/pnas.1307382110. Epub 2013 Jun 11.


The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.

Désormeaux A, Coutu M, Medjahed H, Pacheco B, Herschhorn A, Gu C, Xiang SH, Mao Y, Sodroski J, Finzi A.

J Virol. 2013 Mar;87(5):2549-62. doi: 10.1128/JVI.03104-12. Epub 2012 Dec 19.


Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer.

Mao Y, Wang L, Gu C, Herschhorn A, Xiang SH, Haim H, Yang X, Sodroski J.

Nat Struct Mol Biol. 2012 Sep;19(9):893-9. doi: 10.1038/nsmb.2351. Epub 2012 Aug 5.


Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding.

Finzi A, Pacheco B, Xiang SH, Pancera M, Herschhorn A, Wang L, Zeng X, Desormeaux A, Kwong PD, Sodroski J.

J Virol. 2012 Sep;86(17):8974-86. doi: 10.1128/JVI.01076-12. Epub 2012 Jun 13.


An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.

Herschhorn A, Finzi A, Jones DM, Courter JR, Sugawara A, Smith AB 3rd, Sodroski JG.

PLoS One. 2011;6(11):e26731. doi: 10.1371/journal.pone.0026731. Epub 2011 Nov 1.


Structure--activity relationship studies of 1-(4-chloro-2,5-dimethoxyphenyl)-3-(3-propoxypropyl)thiourea, a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type-1.

Weitman M, Lerman K, Nudelman A, Major DT, Hizi A, Herschhorn A.

Eur J Med Chem. 2011 Feb;46(2):447-67. doi: 10.1016/j.ejmech.2010.11.003. Epub 2010 Nov 10.


Antibodies and lentiviruses that specifically recognize a T cell epitope derived from HIV-1 Nef protein and presented by HLA-C.

Herschhorn A, Marasco WA, Hizi A.

J Immunol. 2010 Dec 15;185(12):7623-32. doi: 10.4049/jimmunol.1001561. Epub 2010 Nov 12.


Reverse transcriptases can clamp together nucleic acids strands with two complementary bases at their 3'-termini for initiating DNA synthesis.

Oz-Gleenberg I, Herschhorn A, Hizi A.

Nucleic Acids Res. 2011 Feb;39(3):1042-53. doi: 10.1093/nar/gkq786. Epub 2010 Sep 28.


Retroviral reverse transcriptases.

Herschhorn A, Hizi A.

Cell Mol Life Sci. 2010 Aug;67(16):2717-47. doi: 10.1007/s00018-010-0346-2. Epub 2010 Apr 1. Review.


Retroviral reverse transcriptases (other than those of HIV-1 and murine leukemia virus): a comparison of their molecular and biochemical properties.

Hizi A, Herschhorn A.

Virus Res. 2008 Jun;134(1-2):203-20. doi: 10.1016/j.virusres.2007.12.008. Epub 2008 Mar 3. Review.


Quantitative analysis of the interactions between HIV-1 integrase and retroviral reverse transcriptases.

Herschhorn A, Oz-Gleenberg I, Hizi A.

Biochem J. 2008 May 15;412(1):163-70. doi: 10.1042/BJ20071279.


De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants.

Herschhorn A, Lerman L, Weitman M, Gleenberg IO, Nudelman A, Hizi A.

J Med Chem. 2007 May 17;50(10):2370-84. Epub 2007 Apr 26. Erratum in: J Med Chem. 2007 Jul 12;50(14):3402.


Inhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase.

Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A.

Arch Biochem Biophys. 2007 Feb 15;458(2):202-12. Epub 2006 Dec 28.


Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.

Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A.

J Biol Chem. 2005 Jun 10;280(23):21987-96. Epub 2005 Mar 23.


Recombinant human antibodies against the reverse transcriptase of human immunodeficiency virus type-1.

Herschhorn A, Admon A, Hizi A.

Biochim Biophys Acta. 2003 May 30;1648(1-2):154-63.


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