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Items: 48


A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites.

McCormick B, Craig HE, Chu JY, Carlin LM, Canel M, Wollweber F, Toivakka M, Michael M, Astier AL, Norton L, Lilja J, Felton JM, Sasaki T, Ivaska J, Hers I, Dransfield I, Rossi AG, Vermeren S.

J Immunol. 2019 Sep 15;203(6):1579-1588. doi: 10.4049/jimmunol.1900443. Epub 2019 Aug 19.


Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function.

Moore SF, Smith NR, Blair TA, Durrant TN, Hers I.

Sci Rep. 2019 Feb 6;9(1):1468. doi: 10.1038/s41598-018-37012-9.


Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation.

Blair TA, Moore SF, Walsh TG, Hutchinson JL, Durrant TN, Anderson KE, Poole AW, Hers I.

Cell Signal. 2018 Oct;50:111-120. doi: 10.1016/j.cellsig.2018.05.005. Epub 2018 May 21.


Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis.

Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW.

JCI Insight. 2018 May 17;3(10). pii: 99062. doi: 10.1172/jci.insight.99062. eCollection 2018 May 17.


In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ, Anderson KE, Stephens LR, Hawkins PT, Marshall AJ, Moore SF, Hers I.

Blood Adv. 2017 Jun 13;1(14):918-932. doi: 10.1182/bloodadvances.2017005173.


Integrin αIIbβ3 outside-in signaling.

Durrant TN, van den Bosch MT, Hers I.

Blood. 2017 Oct 5;130(14):1607-1619. doi: 10.1182/blood-2017-03-773614. Epub 2017 Aug 9. Review.


Temporal contribution of the platelet body and balloon to thrombin generation.

Agbani EO, Hers I, Poole AW.

Haematologica. 2017 Oct;102(10):e379-e381. doi: 10.3324/haematol.2017.166819. Epub 2017 Jul 13. No abstract available.


Membrane Ballooning in Aggregated Platelets is Synchronised and Mediates a Surge in Microvesiculation.

Agbani EO, Williams CM, Hers I, Poole AW.

Sci Rep. 2017 Jun 5;7(1):2770. doi: 10.1038/s41598-017-02933-4.


The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.

Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I.

J Biol Chem. 2017 Feb 3;292(5):1691-1704. doi: 10.1074/jbc.M116.746867. Epub 2016 Nov 30.


Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.

Williams CM, Savage JS, Harper MT, Moore SF, Hers I, Poole AW.

Platelets. 2016 Jun;27(4):286-94. doi: 10.3109/09537104.2015.1100282. Epub 2015 Nov 20.


Coordinated Membrane Ballooning and Procoagulant Spreading in Human Platelets.

Agbani EO, van den Bosch MT, Brown E, Williams CM, Mattheij NJ, Cosemans JM, Collins PW, Heemskerk JW, Hers I, Poole AW.

Circulation. 2015 Oct 13;132(15):1414-24. doi: 10.1161/CIRCULATIONAHA.114.015036. Epub 2015 Sep 1.


Circulating primers enhance platelet function and induce resistance to antiplatelet therapy.

Blair TA, Moore SF, Hers I.

J Thromb Haemost. 2015 Aug;13(8):1479-93. doi: 10.1111/jth.13022. Epub 2015 Jun 25.


Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4-deficient platelets.

Harper MT, van den Bosch MT, Hers I, Poole AW.

Blood. 2015 May 7;125(19):3034-6. doi: 10.1182/blood-2014-12-618439. No abstract available.


Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.

Moore SF, Williams CM, Brown E, Blair TA, Harper MT, Coward RJ, Poole AW, Hers I.

Cardiovasc Res. 2015 Jul 1;107(1):9-19. doi: 10.1093/cvr/cvv132. Epub 2015 Apr 22.


Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal.

Chen MZ, Hudson CA, Vincent EE, de Berker DA, May MT, Hers I, Dayan CM, Andrews RC, Tavaré JM.

PLoS One. 2015 Apr 13;10(4):e0120084. doi: 10.1371/journal.pone.0120084. eCollection 2015.


Is JAK2V617F finally off the hook?

Hers I, Poole AW.

Blood. 2014 Aug 14;124(7):992-3. doi: 10.1182/blood-2014-07-583856. No abstract available.


Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming.

Blair TA, Moore SF, Williams CM, Poole AW, Vanhaesebroeck B, Hers I.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1681-8. doi: 10.1161/ATVBAHA.114.303954. Epub 2014 Jun 5.


Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor.

Vincent EE, Elder DJ, Curwen J, Kilgour E, Hers I, Tavaré JM.

PLoS One. 2013 Jun 24;8(6):e66963. doi: 10.1371/journal.pone.0066963. Print 2013.


Absence of platelet phenotype in mice lacking the motor protein myosin Va.

Harper MT, van den Bosch MT, Hers I, Poole AW.

PLoS One. 2013;8(1):e53239. doi: 10.1371/journal.pone.0053239. Epub 2013 Jan 18.


Munc13-4 is critical for thrombosis through regulating release of ADP from platelets.

Savage JS, Williams CM, Konopatskaya O, Hers I, Harper MT, Poole AW.

J Thromb Haemost. 2013 Apr;11(4):771-5. doi: 10.1111/jth.12138. No abstract available.


Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse.

Hale LJ, Welsh GI, Perks CM, Hurcombe JA, Moore S, Hers I, Saleem MA, Mathieson PW, Murphy AJ, Jeansson M, Holly JM, Hardouin SN, Coward RJ.

J Pathol. 2013 May;230(1):95-106. doi: 10.1002/path.4165. Epub 2013 Mar 21.


Dysfunction of the PI3 kinase/Rap1/integrin α(IIb)β(3) pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia.

Moore SF, Hunter RW, Harper MT, Savage JS, Siddiq S, Westbury SK, Poole AW, Mumford AD, Hers I.

Blood. 2013 Feb 14;121(7):1209-19. doi: 10.1182/blood-2012-05-431288. Epub 2012 Dec 13.


Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.

Moore SF, van den Bosch MT, Hunter RW, Sakamoto K, Poole AW, Hers I.

J Biol Chem. 2013 Feb 8;288(6):3918-28. doi: 10.1074/jbc.M112.429936. Epub 2012 Dec 13.


Akt signalling in health and disease.

Hers I, Vincent EE, Tavaré JM.

Cell Signal. 2011 Oct;23(10):1515-27. doi: 10.1016/j.cellsig.2011.05.004. Epub 2011 May 17. Review.


mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected].

Moore SF, Hunter RW, Hers I.

J Biol Chem. 2011 Jul 15;286(28):24553-60. doi: 10.1074/jbc.M110.202341. Epub 2011 May 18. Erratum in: J Biol Chem. 2011 Sep 2;286(35):31062.


Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function.

Hunter RW, Hers I.

J Thromb Haemost. 2009 Dec;7(12):2123-30. doi: 10.1111/j.1538-7836.2009.03637.x. Epub 2009 Oct 8.


Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.

Hunter RW, Mackintosh C, Hers I.

J Biol Chem. 2009 May 1;284(18):12339-48. doi: 10.1074/jbc.M807536200. Epub 2009 Mar 4.


Understanding the therapeutic action of recombinant factor VIIa in platelet disorders.

Hers I, Mumford A.

Platelets. 2008 Dec;19(8):571-81. doi: 10.1080/09537100802406653. Review.


The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB.

Hunter RW, Harper MT, Hers I.

J Thromb Haemost. 2008 Nov;6(11):1923-32. doi: 10.1111/j.1538-7836.2008.03140.x. Epub 2008 Aug 28.


Regulation of small GTP-binding proteins by insulin.

Welsh GI, Hers I, Wherlock M, Tavaré JM.

Biochem Soc Trans. 2006 Apr;34(Pt 2):209-12. Review.


Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.

Hers I, Wherlock M, Homma Y, Yagisawa H, Tavaré JM.

J Biol Chem. 2006 Feb 24;281(8):4762-70. Epub 2005 Dec 6.


Role of protein kinase B in insulin-regulated glucose uptake.

Welsh GI, Hers I, Berwick DC, Dell G, Wherlock M, Birkin R, Leney S, Tavaré JM.

Biochem Soc Trans. 2005 Apr;33(Pt 2):346-9. Review.


Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM, Cooke FT, Tavaré JM.

J Cell Sci. 2004 Dec 1;117(Pt 25):5985-93. Epub 2004 Nov 16.


PKC-interacting proteins: from function to pharmacology.

Poole AW, Pula G, Hers I, Crosby D, Jones ML.

Trends Pharmacol Sci. 2004 Oct;25(10):528-35. Review.


Evaluation of soil gas sampling and analysis techniques at a former petrochemical plant site.

Hers I, Li L, Hannam S.

Environ Technol. 2004 Jul;25(7):847-60.


The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.

Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM.

J Biol Chem. 2002 Sep 13;277(37):33895-900. Epub 2002 Jul 9.


The use of indoor air measurements to evaluate intrusion of subsurface VOC vapors into buildings.

Hers I, Zapf-Gilje R, Li L, Atwater J.

J Air Waste Manag Assoc. 2001 Sep;51(9):1318-31.


Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.

Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP.

Blood. 2000 Dec 15;96(13):4246-53.


Inhibition of platelet integrin alpha(IIb)beta(3) by peptides that interfere with protein kinases and the beta(3) tail.

Hers I, Donath J, Litjens PE, van Willigen G, Akkerman JW.

Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1651-60.


Evidence against a direct role of the integrin alpha2beta1 in collagen-induced tyrosine phosphorylation in human platelets.

Hers I, Berlanga O, Tiekstra MJ, Kamiguti AS, Theakston RD, Watson SP.

Eur J Biochem. 2000 Apr;267(7):2088-97.


Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alphaIIbbeta3 exposure.

Hers I, Donath J, van Willigen G, Akkerman JW.

Arterioscler Thromb Vasc Biol. 1998 Mar;18(3):404-14.


Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit.

van Willigen G, Hers I, Gorter G, Akkerman JW.

Biochem J. 1996 Mar 15;314 ( Pt 3):769-79.

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