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Items: 1 to 50 of 180


Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.

Chow HM, Shi M, Cheng A, Gao Y, Chen G, Song X, So RWL, Zhang J, Herrup K.

Nat Neurosci. 2019 Oct 21. doi: 10.1038/s41593-019-0505-1. [Epub ahead of print]


Marine bacterial extracts as a new rich source of drugs against Alzheimer's disease.

Zhu B, Li Z, Qian PY, Herrup K.

J Neurochem. 2019 Aug 5. doi: 10.1111/jnc.14847. [Epub ahead of print]


LATE to the PART-y.

Josephs KA, Mackenzie I, Frosch MP, Bigio EH, Neumann M, Arai T, Dugger BN, Ghetti B, Grossman M, Hasegawa M, Herrup K, Holton J, Jellinger K, Lashley T, McAleese KE, Parisi JE, Revesz T, Saito Y, Vonsattel JP, Whitwell JL, Wisniewski T, Hu W.

Brain. 2019 Sep 1;142(9):e47. doi: 10.1093/brain/awz224. No abstract available.


Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences.

Song X, Ma F, Herrup K.

J Neurosci. 2019 Aug 7;39(32):6378-6394. doi: 10.1523/JNEUROSCI.0774-19.2019. Epub 2019 Jun 12.


Testing the Neuroprotective Properties of PCSO-524® Using a Neuronal Cell Cycle Suppression Assay.

Zhu B, Zhang Y, Herrup K.

Mar Drugs. 2019 Jan 24;17(2). pii: E79. doi: 10.3390/md17020079.


ATM is activated by ATP depletion and modulates mitochondrial function through NRF1.

Chow HM, Cheng A, Song X, Swerdel MR, Hart RP, Herrup K.

J Cell Biol. 2019 Mar 4;218(3):909-928. doi: 10.1083/jcb.201806197. Epub 2019 Jan 14.


The Positive Effects of Viewing Gardens for Persons with Dementia.

Goto S, Shen X, Sun M, Hamano Y, Herrup K.

J Alzheimers Dis. 2018;66(4):1705-1720. doi: 10.3233/JAD-170510.


Physiological Responses of the Youth Viewing a Japanese Garden.

Zhang Y, Liu C, Herrup K, Shi BE.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1550-1553. doi: 10.1109/EMBC.2018.8512462.


Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice.

Hui CW, Song X, Ma F, Shen X, Herrup K.

J Neuroinflammation. 2018 Nov 6;15(1):308. doi: 10.1186/s12974-018-1338-7.


DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia.

Tse KH, Cheng A, Ma F, Herrup K.

Alzheimers Dement. 2018 May;14(5):664-679. doi: 10.1016/j.jalz.2017.11.010. Epub 2018 Jan 9.


ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations.

Cheng A, Zhao T, Tse KH, Chow HM, Cui Y, Jiang L, Du S, Loy MMT, Herrup K.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E292-E301. doi: 10.1073/pnas.1716892115. Epub 2017 Dec 26.


Remote gaze tracking system for 3D environments.

Congcong Liu, Herrup K, Shi BE.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:1768-1771. doi: 10.1109/EMBC.2017.8037186.


Loopholes in the DNA contract kill neurons.

Herrup K, Tse KH, Chow HM.

Nat Neurosci. 2017 Aug 29;20(9):1192-1194. doi: 10.1038/nn.4626. No abstract available.


The Power of Traditional Design Techniques: The Effects of Viewing a Japanese Garden on Individuals With Cognitive Impairment.

Goto S, Gianfagia TJ, Munafo JP, Fujii E, Shen X, Sun M, Shi BE, Liu C, Hamano H, Herrup K.

HERD. 2017 Jul;10(4):74-86. doi: 10.1177/1937586716680064. Epub 2016 Dec 18.


Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead.

Tse KH, Herrup K.

J Neurochem. 2017 Nov;143(4):432-444. doi: 10.1111/jnc.14079. Epub 2017 Jun 21. Review.


Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.

Luo F, Herrup K, Qi X, Yang Y.

Exp Neurol. 2017 Jun;292:21-34. doi: 10.1016/j.expneurol.2017.02.015. Epub 2017 Feb 24.


Erratum to: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.

Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K.

Mol Neurodegener. 2017 Jan 12;12(1):4. doi: 10.1186/s13024-017-0151-6. No abstract available.


Family-wide Structural Characterization and Genomic Comparisons Decode the Diversity-oriented Biosynthesis of Thalassospiramides by Marine Proteobacteria.

Zhang W, Lu L, Lai Q, Zhu B, Li Z, Xu Y, Shao Z, Herrup K, Moore BS, Ross AC, Qian PY.

J Biol Chem. 2016 Dec 30;291(53):27228-27238. doi: 10.1074/jbc.M116.756858. Epub 2016 Nov 14.


The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.

Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K.

Mol Neurodegener. 2016 Aug 18;11(1):60. doi: 10.1186/s13024-016-0127-y. Erratum in: Mol Neurodegener. 2017 Jan 12;12 (1):4.


DNA damage in the oligodendrocyte lineage and its role in brain aging.

Tse KH, Herrup K.

Mech Ageing Dev. 2017 Jan;161(Pt A):37-50. doi: 10.1016/j.mad.2016.05.006. Epub 2016 May 26. Review.


Multicolor 4D Fluorescence Microscopy using Ultrathin Bessel Light Sheets.

Zhao T, Lau SC, Wang Y, Su Y, Wang H, Cheng A, Herrup K, Ip NY, Du S, Loy MM.

Sci Rep. 2016 May 18;6:26159. doi: 10.1038/srep26159.


ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity.

Vail G, Cheng A, Han YR, Zhao T, Du S, Loy MM, Herrup K, Plummer MR.

J Neurophysiol. 2016 Jul 1;116(1):201-9. doi: 10.1152/jn.00006.2016. Epub 2016 Apr 13.


Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling.

Shen X, Chen J, Li J, Kofler J, Herrup K.

eNeuro. 2016 Feb 27;3(1). pii: ENEURO.0124-15.2016. doi: 10.1523/ENEURO.0124-15.2016. eCollection 2016 Jan-Feb.


Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System.

Hui CW, Zhang Y, Herrup K.

PLoS One. 2016 Jan 20;11(1):e0147134. doi: 10.1371/journal.pone.0147134. eCollection 2016.


Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency.

Jiang D, Zhang Y, Hart RP, Chen J, Herrup K, Li J.

Brain. 2015 Dec;138(Pt 12):3520-36. doi: 10.1093/brain/awv284. Epub 2015 Oct 27.


Individual Cytokines Modulate the Neurological Symptoms of ATM Deficiency in a Region Specific Manner

Hui CW, Herrup K.

eNeuro. 2015 Aug 18;2(4). pii: ENEURO.0032-15.2015. doi: 10.1523/ENEURO.0032-15.2015. eCollection 2015 Jul-Aug.


Genomic integrity and the ageing brain.

Chow HM, Herrup K.

Nat Rev Neurosci. 2015 Nov;16(11):672-84. doi: 10.1038/nrn4020. Epub 2015 Oct 14. Review.


Correction: The Interaction of the Atm Genotype with Inflammation and Oxidative Stress.

Yang Y, Hui CW, Li J, Herrup K.

PLoS One. 2015 Jun 17;10(6):e0130645. doi: 10.1371/journal.pone.0130645. eCollection 2015.


The case for rejecting the amyloid cascade hypothesis.

Herrup K.

Nat Neurosci. 2015 Jun;18(6):794-9. doi: 10.1038/nn.4017. Review.


Neuroinflammation in Alzheimer's disease.

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP.

Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. Review.


The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death.

Zhou J, Li H, Li X, Zhang G, Niu Y, Yuan Z, Herrup K, Zhang YW, Bu G, Xu H, Zhang J.

J Neurosci. 2015 Feb 11;35(6):2624-35. doi: 10.1523/JNEUROSCI.3051-14.2015.


2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.

Alzheimer's Association National Plan Milestone Workgroup, Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC.

Alzheimers Dement. 2014 Oct;10(5 Suppl):S430-52. doi: 10.1016/j.jalz.2014.08.103.


CDK5 activator protein p25 preferentially binds and activates GSK3β.

Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup K, Zhang J.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4887-95. doi: 10.1073/pnas.1402627111. Epub 2014 Oct 20. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3313.


Differential responses of individuals with late-stage dementia to two novel environments: a multimedia room and an interior garden.

Goto S, Kamal N, Puzio H, Kobylarz F, Herrup K.

J Alzheimers Dis. 2014;42(3):985-98. doi: 10.3233/JAD-131379.


The interaction of the atm genotype with inflammation and oxidative stress.

Yang Y, Hui CW, Li J, Herrup K.

PLoS One. 2014 Jan 20;9(1):e85863. doi: 10.1371/journal.pone.0085863. eCollection 2014. Erratum in: PLoS One. 2015;10(6):e0130645.


EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

Li J, Hart RP, Mallimo EM, Swerdel MR, Kusnecov AW, Herrup K.

Nat Neurosci. 2013 Dec;16(12):1745-53. doi: 10.1038/nn.3564. Epub 2013 Oct 27. Erratum in: Nat Neurosci. 2014 Sep;17(9):1286.


Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events.

Bhaskar K, Maphis N, Xu G, Varvel NH, Kokiko-Cochran ON, Weick JP, Staugaitis SM, Cardona A, Ransohoff RM, Herrup K, Lamb BT.

Neurobiol Dis. 2014 Feb;62:273-85. doi: 10.1016/j.nbd.2013.10.007. Epub 2013 Oct 17.


Post-mitotic role of the cell cycle machinery.

Herrup K.

Curr Opin Cell Biol. 2013 Dec;25(6):711-6. doi: 10.1016/ Epub 2013 Sep 18. Review.


Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease.

Herrup K, Carrillo MC, Schenk D, Cacace A, Desanti S, Fremeau R, Bhat R, Glicksman M, May P, Swerdlow R, Van Eldik LJ, Bain LJ, Budd S.

Alzheimers Dement. 2013 Jul;9(4):452-458.e1. doi: 10.1016/j.jalz.2013.01.017.


ATM and the epigenetics of the neuronal genome.

Herrup K.

Mech Ageing Dev. 2013 Oct;134(10):434-9. doi: 10.1016/j.mad.2013.05.005. Epub 2013 May 23. Review.


The role of ATM and DNA damage in neurons: upstream and downstream connections.

Herrup K, Li J, Chen J.

DNA Repair (Amst). 2013 Aug;12(8):600-4. doi: 10.1016/j.dnarep.2013.04.012. Epub 2013 May 13.


Breaking news: thinking may be bad for DNA.

Herrup K, Chen J, Li J.

Nat Neurosci. 2013 May;16(5):518-9. doi: 10.1038/nn.3384. No abstract available.


Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation.

Yang Y, Wang H, Zhang J, Luo F, Herrup K, Bibb JA, Lu R, Miller RH.

Dev Biol. 2013 Jun 15;378(2):94-106. doi: 10.1016/j.ydbio.2013.03.023. Epub 2013 Apr 10.


The effect of garden designs on mood and heart output in older adults residing in an assisted living facility.

Goto S, Park BJ, Tsunetsugu Y, Herrup K, Miyazaki Y.

HERD. 2013 Winter;6(2):27-42.


Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.

Zhang J, Li H, Zhou T, Zhou J, Herrup K.

J Biol Chem. 2012 Jul 27;287(31):25985-94. doi: 10.1074/jbc.M112.343152. Epub 2012 May 31.


Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.

Li J, Chen J, Ricupero CL, Hart RP, Schwartz MS, Kusnecov A, Herrup K.

Nat Med. 2012 May;18(5):783-90. doi: 10.1038/nm.2709.


Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress.

Chen J, Herrup K.

PLoS One. 2012;7(3):e33177. doi: 10.1371/journal.pone.0033177. Epub 2012 Mar 8.


A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death.

Li L, Cheung T, Chen J, Herrup K.

Int J Alzheimers Dis. 2011;2011:171464. doi: 10.4061/2011/171464. Epub 2011 Sep 8.


Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia.

Li J, Chen J, Vinters HV, Gatti RA, Herrup K.

J Neurosci. 2011 May 18;31(20):7568-77. doi: 10.1523/JNEUROSCI.0778-11.2011.

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