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Items: 14


A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.

Gerez JA, Prymaczok NC, Rockenstein E, Herrmann US, Schwarz P, Adame A, Enchev RI, Courtheoux T, Boersema PJ, Riek R, Peter M, Aguzzi A, Masliah E, Picotti P.

Sci Transl Med. 2019 Jun 5;11(495). pii: eaau6722. doi: 10.1126/scitranslmed.aau6722.


Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

Leske H, Hornemann S, Herrmann US, Zhu C, Dametto P, Li B, Laferriere F, Polymenidou M, Pelczar P, Reimann RR, Schwarz P, Rushing EJ, Wüthrich K, Aguzzi A.

PLoS One. 2017 Feb 16;12(2):e0170503. doi: 10.1371/journal.pone.0170503. eCollection 2017.


A neuroprotective role for microglia in prion diseases.

Zhu C, Herrmann US, Falsig J, Abakumova I, Nuvolone M, Schwarz P, Frauenknecht K, Rushing EJ, Aguzzi A.

J Exp Med. 2016 May 30;213(6):1047-59. doi: 10.1084/jem.20151000. Epub 2016 May 16.


Differential Toxicity of Antibodies to the Prion Protein.

Reimann RR, Sonati T, Hornemann S, Herrmann US, Arand M, Hawke S, Aguzzi A.

PLoS Pathog. 2016 Jan 28;12(1):e1005401. doi: 10.1371/journal.ppat.1005401. eCollection 2016 Jan.


Structure-based drug design identifies polythiophenes as antiprion compounds.

Herrmann US, Schütz AK, Shirani H, Huang D, Saban D, Nuvolone M, Li B, Ballmer B, Åslund AK, Mason JJ, Rushing E, Budka H, Nyström S, Hammarström P, Böckmann A, Caflisch A, Meier BH, Nilsson KP, Hornemann S, Aguzzi A.

Sci Transl Med. 2015 Aug 5;7(299):299ra123. doi: 10.1126/scitranslmed.aab1923.


Correction: Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.

Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T.

PLoS Pathog. 2015 Apr 14;11(4):e1004808. doi: 10.1371/journal.ppat.1004808. eCollection 2015 Apr.


Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.

Zhu C, Herrmann US, Li B, Abakumova I, Moos R, Schwarz P, Rushing EJ, Colonna M, Aguzzi A.

Neurobiol Aging. 2015 May;36(5):1994-2003. doi: 10.1016/j.neurobiolaging.2015.02.019. Epub 2015 Feb 27.


Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.

Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A.

PLoS Pathog. 2015 Feb 24;11(2):e1004662. doi: 10.1371/journal.ppat.1004662. eCollection 2015 Feb. Erratum in: PLoS Pathog. 2015 Apr;11(4):e1004808.


Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP.

Dametto P, Lakkaraju AK, Bridel C, Villiger L, O'Connor T, Herrmann US, Pelczar P, Rülicke T, McHugh D, Adili A, Aguzzi A.

PLoS One. 2015 Feb 6;10(2):e0117412. doi: 10.1371/journal.pone.0117412. eCollection 2015.


The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.

Sonati T, Reimann RR, Falsig J, Baral PK, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann US, Wieland B, Swayampakula M, Rahman MH, Das D, Kav N, Riek R, Liberski PP, James MN, Aguzzi A.

Nature. 2013 Sep 5;501(7465):102-6. doi: 10.1038/nature12402. Epub 2013 Jul 31.


Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures.

Falsig J, Sonati T, Herrmann US, Saban D, Li B, Arroyo K, Ballmer B, Liberski PP, Aguzzi A.

PLoS Pathog. 2012;8(11):e1002985. doi: 10.1371/journal.ppat.1002985. Epub 2012 Nov 1.


EEG correlation and power during maintenance of wakefulness test after sleep-deprivation.

Gast H, Schindler K, Rummel C, Herrmann US, Roth C, Hess CW, Mathis J.

Clin Neurophysiol. 2011 Oct;122(10):2025-31. doi: 10.1016/j.clinph.2011.03.003. Epub 2011 Apr 6.


Sleepiness is not always perceived before falling asleep in healthy, sleep-deprived subjects.

Herrmann US, Hess CW, Guggisberg AG, Roth C, Gugger M, Mathis J.

Sleep Med. 2010 Sep;11(8):747-51. doi: 10.1016/j.sleep.2010.03.015. Epub 2010 Jul 31.


The functional relationship between yawning and vigilance.

Guggisberg AG, Mathis J, Herrmann US, Hess CW.

Behav Brain Res. 2007 Apr 16;179(1):159-66. Epub 2007 Feb 3.


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