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β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion.

Böni-Schnetzler M, Häuselmann SP, Dalmas E, Meier DT, Thienel C, Traub S, Schulze F, Steiger L, Dror E, Martin P, Herrera PL, Gabay C, Donath MY.

Cell Rep. 2018 Feb 13;22(7):1774-1786. doi: 10.1016/j.celrep.2018.01.063.


Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes.

van Krieken PP, Dicker A, Eriksson M, Herrera PL, Ahlgren U, Berggren PO, Ilegems E.

Sci Rep. 2017 Sep 29;7(1):12440. doi: 10.1038/s41598-017-12124-w.


Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis.

Traub S, Meier DT, Schulze F, Dror E, Nordmann TM, Goetz N, Koch N, Dalmas E, Stawiski M, Makshana V, Thorel F, Herrera PL, Böni-Schnetzler M, Donath MY.

Cell Rep. 2017 Mar 28;18(13):3192-3203. doi: 10.1016/j.celrep.2017.03.005.


Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.

da Silva Xavier G, Mondragon A, Mourougavelou V, Cruciani-Guglielmacci C, Denom J, Herrera PL, Magnan C, Rutter GA.

Diabetologia. 2017 Jun;60(6):1043-1050. doi: 10.1007/s00125-017-4242-2. Epub 2017 Mar 25.


Insulin and Glucagon: Partners for Life.

Holst JJ, Holland W, Gromada J, Lee Y, Unger RH, Yan H, Sloop KW, Kieffer TJ, Damond N, Herrera PL.

Endocrinology. 2017 Apr 1;158(4):696-701. doi: 10.1210/en.2016-1748. Review.


Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo.

Matsuoka TA, Kawashima S, Miyatsuka T, Sasaki S, Shimo N, Katakami N, Kawamori D, Takebe S, Herrera PL, Kaneto H, Stein R, Shimomura I.

Diabetes. 2017 May;66(5):1293-1300. doi: 10.2337/db16-0887. Epub 2017 Feb 21.


Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK.

Cell Metab. 2017 Mar 7;25(3):622-634. doi: 10.1016/j.cmet.2017.01.009. Epub 2017 Feb 16.


Dnmt1 activity is dispensable in δ-cells but is essential for α-cell homeostasis.

Damond N, Thorel F, Kim SK, Herrera PL.

Int J Biochem Cell Biol. 2017 Jul;88:226-235. doi: 10.1016/j.biocel.2017.01.008. Epub 2017 Jan 22.


Stress-induced adaptive islet cell identity changes.

Cigliola V, Thorel F, Chera S, Herrera PL.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:87-96. doi: 10.1111/dom.12726. Review.


Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.

Semplici F, Mondragon A, Macintyre B, Madeyski-Bengston K, Persson-Kry A, Barr S, Ramne A, Marley A, McGinty J, French P, Soedling H, Yokosuka R, Gaitan J, Lang J, Migrenne-Li S, Philippe E, Herrera PL, Magnan C, da Silva Xavier G, Rutter GA.

Diabetologia. 2016 Sep;59(9):1938-47. doi: 10.1007/s00125-016-4025-1. Epub 2016 Jun 24.


Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion.

Chera S, Herrera PL.

Curr Opin Genet Dev. 2016 Oct;40:1-10. doi: 10.1016/j.gde.2016.05.010. Epub 2016 Jun 3. Review.


Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.

Damond N, Thorel F, Moyers JS, Charron MJ, Vuguin PM, Powers AC, Herrera PL.

Elife. 2016 Apr 19;5. pii: e13828. doi: 10.7554/eLife.13828.


Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.

Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C, Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD, Stein R, Powers AC.

J Clin Invest. 2016 May 2;126(5):1857-70. doi: 10.1172/JCI83657. Epub 2016 Apr 11.


A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.

Cigliola V, Populaire C, Pierri CL, Deutsch S, Haefliger JA, Fadista J, Lyssenko V, Groop L, Rueedi R, Thorel F, Herrera PL, Meda P.

PLoS One. 2016 Mar 9;11(3):e0150880. doi: 10.1371/journal.pone.0150880. eCollection 2016.


Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.

Paul L, Walker EM, Drosos Y, Cyphert HA, Neale G, Stein R, South J, Grosveld G, Herrera PL, Sosa-Pineda B.

Diabetes. 2016 Mar;65(3):687-98. doi: 10.2337/db15-0713. Epub 2015 Dec 2.


Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.

Yang C, Loehn M, Jurczyk A, Przewozniak N, Leehy L, Herrera PL, Shultz LD, Greiner DL, Harlan DM, Bortell R.

Diabetes Metab Syndr Obes. 2015 Aug 20;8:387-98. doi: 10.2147/DMSO.S87253. eCollection 2015.


The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.

Solomou A, Meur G, Bellomo E, Hodson DJ, Tomas A, Li SM, Philippe E, Herrera PL, Magnan C, Rutter GA.

J Biol Chem. 2015 Aug 28;290(35):21432-42. doi: 10.1074/jbc.M115.645291. Epub 2015 Jul 15.


LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.

Sun G, da Silva Xavier G, Gorman T, Priest C, Solomou A, Hodson DJ, Foretz M, Viollet B, Herrera PL, Parker H, Reimann F, Gribble FM, Migrenne S, Magnan C, Marley A, Rutter GA.

Mol Metab. 2015 Jan 31;4(4):277-86. doi: 10.1016/j.molmet.2015.01.006. eCollection 2015 Apr.


Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.

Vinet L, Lamprianou S, Babič A, Lange N, Thorel F, Herrera PL, Montet X, Meda P.

Diabetologia. 2015 Feb;58(2):304-12. doi: 10.1007/s00125-014-3442-2. Epub 2014 Nov 22.


Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice.

Riley KG, Pasek RC, Maulis MF, Peek J, Thorel F, Brigstock DR, Herrera PL, Gannon M.

Diabetes. 2015 Apr;64(4):1284-98. doi: 10.2337/db14-1195. Epub 2014 Nov 12.


Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL.

Nature. 2014 Oct 23;514(7523):503-7. doi: 10.1038/nature13633. Epub 2014 Aug 20.


A standardized method for in vivo mouse pancreas imaging and semiquantitative β cell mass measurement by dual isotope SPECT.

Mathijs I, Xavier C, Peleman C, Caveliers V, Brom M, Gotthardt M, Herrera PL, Lahoutte T, Bouwens L.

Mol Imaging Biol. 2015 Feb;17(1):58-66. doi: 10.1007/s11307-014-0771-y.


Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.

Chow SZ, Speck M, Yoganathan P, Nackiewicz D, Hansen AM, Ladefoged M, Rabe B, Rose-John S, Voshol PJ, Lynn FC, Herrera PL, Müller W, Ellingsgaard H, Ehses JA.

Diabetes. 2014 Sep;63(9):2984-95. doi: 10.2337/db13-1121. Epub 2014 May 8.


Argonaute2 mediates compensatory expansion of the pancreatic β cell.

Tattikota SG, Rathjen T, McAnulty SJ, Wessels HH, Akerman I, van de Bunt M, Hausser J, Esguerra JL, Musahl A, Pandey AK, You X, Chen W, Herrera PL, Johnson PR, O'Carroll D, Eliasson L, Zavolan M, Gloyn AL, Ferrer J, Shalom-Feuerstein R, Aberdam D, Poy MN.

Cell Metab. 2014 Jan 7;19(1):122-34. doi: 10.1016/j.cmet.2013.11.015. Epub 2013 Dec 19.


Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R.

Cell Metab. 2013 Sep 3;18(3):431-44. doi: 10.1016/j.cmet.2013.08.004.


Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

Supale S, Thorel F, Merkwirth C, Gjinovci A, Herrera PL, Scorrano L, Meda P, Langer T, Maechler P.

Diabetes. 2013 Oct;62(10):3488-99. doi: 10.2337/db13-0152. Epub 2013 Jul 17.


An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.

Pitetti JL, Calvel P, Zimmermann C, Conne B, Papaioannou MD, Aubry F, Cederroth CR, Urner F, Fumel B, Crausaz M, Docquier M, Herrera PL, Pralong F, Germond M, Guillou F, Jégou B, Nef S.

Mol Endocrinol. 2013 May;27(5):814-27. doi: 10.1210/me.2012-1258. Epub 2013 Mar 21.


UCP2 regulates the glucagon response to fasting and starvation.

Allister EM, Robson-Doucette CA, Prentice KJ, Hardy AB, Sultan S, Gaisano HY, Kong D, Gilon P, Herrera PL, Lowell BB, Wheeler MB.

Diabetes. 2013 May;62(5):1623-33. doi: 10.2337/db12-0981. Epub 2013 Feb 22.


Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.

Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M.

PLoS Genet. 2013;9(1):e1003274. doi: 10.1371/journal.pgen.1003274. Epub 2013 Jan 31.


Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice.

Pitetti JL, Calvel P, Romero Y, Conne B, Truong V, Papaioannou MD, Schaad O, Docquier M, Herrera PL, Wilhelm D, Nef S.

PLoS Genet. 2013;9(1):e1003160. doi: 10.1371/journal.pgen.1003160. Epub 2013 Jan 3.


Nogo-A downregulation improves insulin secretion in mice.

Bonal CB, Baronnier DE, Pot C, Benkhoucha M, Schwab ME, Lalive PH, Herrera PL.

Diabetes. 2013 May;62(5):1443-52. doi: 10.2337/db12-0949. Epub 2012 Dec 28.


In situ electrophysiological examination of pancreatic α cells in the streptozotocin-induced diabetes model, revealing the cellular basis of glucagon hypersecretion.

Huang YC, Rupnik MS, Karimian N, Herrera PL, Gilon P, Feng ZP, Gaisano HY.

Diabetes. 2013 Feb;62(2):519-30. doi: 10.2337/db11-0786. Epub 2012 Oct 5.


The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice.

Zhang Y, Xie Z, Zhou L, Li L, Zhang H, Zhou G, Ma X, Herrera PL, Liu Z, Grusby MJ, Zhang WJ.

Gastroenterology. 2012 Jun;142(7):1571-1580.e6. doi: 10.1053/j.gastro.2012.02.043. Epub 2012 Feb 25.


Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands.

Virostko J, Henske J, Vinet L, Lamprianou S, Dai C, Radhika A, Baldwin RM, Ansari MS, Hefti F, Skovronsky D, Kung HF, Herrera PL, Peterson TE, Meda P, Powers AC.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20719-24. doi: 10.1073/pnas.1109480108. Epub 2011 Dec 5.


Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M.

Mol Endocrinol. 2011 Nov;25(11):1904-14. doi: 10.1210/me.2011-1139. Epub 2011 Sep 29.


Dicer is required for haploid male germ cell differentiation in mice.

Korhonen HM, Meikar O, Yadav RP, Papaioannou MD, Romero Y, Da Ros M, Herrera PL, Toppari J, Nef S, Kotaja N.

PLoS One. 2011;6(9):e24821. doi: 10.1371/journal.pone.0024821. Epub 2011 Sep 16.


Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Thorel F, Damond N, Chera S, Wiederkehr A, Thorens B, Meda P, Wollheim CB, Herrera PL.

Diabetes. 2011 Nov;60(11):2872-82. doi: 10.2337/db11-0876. Epub 2011 Sep 16.


Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV.

Genes Dev. 2011 Aug 15;25(16):1680-5. doi: 10.1101/gad.16875711.


Progenitor cell domains in the developing and adult pancreas.

Kopp JL, Dubois CL, Hao E, Thorel F, Herrera PL, Sander M.

Cell Cycle. 2011 Jun 15;10(12):1921-7. Epub 2011 Jun 15. Review.


In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.

Hu He KH, Lorenzo PI, Brun T, Jimenez Moreno CM, Aeberhard D, Vallejo Ortega J, Cornu M, Thorel F, Gjinovci A, Thorens B, Herrera PL, Meda P, Wollheim CB, Gauthier BR.

Diabetes. 2011 Jun;60(6):1705-15. doi: 10.2337/db10-1102. Epub 2011 Apr 26.


[Conversion of adult pancreatic alpha-cells to beta-cells in diabetic mice].

Thorel F, Herrera PL.

Med Sci (Paris). 2010 Nov;26(11):906-9. doi: 10.1051/medsci/20102611906. French. No abstract available.


β-cell regeneration: the pancreatic intrinsic faculty.

Desgraz R, Bonal C, Herrera PL.

Trends Endocrinol Metab. 2011 Jan;22(1):34-43. doi: 10.1016/j.tem.2010.09.004. Epub 2010 Nov 8. Review.


Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.

Sylvestersen KB, Herrera PL, Serup P, Rescan C.

Gene Expr Patterns. 2011 Jan-Feb;11(1-2):105-11. doi: 10.1016/j.gep.2010.10.001. Epub 2010 Oct 8.


The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression.

Ait-Lounis A, Bonal C, Seguín-Estévez Q, Schmid CD, Bucher P, Herrera PL, Durand B, Meda P, Reith W.

Diabetes. 2010 Jul;59(7):1674-85. doi: 10.2337/db09-0986. Epub 2010 Apr 22.


Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.

Thorel F, Népote V, Avril I, Kohno K, Desgraz R, Chera S, Herrera PL.

Nature. 2010 Apr 22;464(7292):1149-54. doi: 10.1038/nature08894. Epub 2010 Apr 4.


Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A, Bertolino P, Zhang CX.

Gastroenterology. 2010 May;138(5):1954-65. doi: 10.1053/j.gastro.2010.01.046. Epub 2010 Feb 2.


Transgenic and other experimental models of pancreas and islet damage.

Herrera PL.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:91-6. doi: 10.1111/j.1463-1326.2009.01104.x. Review.


Pancreatic neurogenin 3-expressing cells are unipotent islet precursors.

Desgraz R, Herrera PL.

Development. 2009 Nov;136(21):3567-74. doi: 10.1242/dev.039214. Epub 2009 Sep 30.


Insulin signaling in alpha cells modulates glucagon secretion in vivo.

Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.

Cell Metab. 2009 Apr;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007.


Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ.

J Clin Invest. 2009 Jan;119(1):125-35. doi: 10.1172/JCI26934. Epub 2008 Dec 8.

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