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Mechanical stress compromises multicomponent efflux complexes in bacteria.

Genova LA, Roberts MF, Wong YC, Harper CE, Santiago AG, Fu B, Srivastava A, Jung W, Wang LM, Krzemiński Ł, Mao X, Sun X, Hui CY, Chen P, Hernandez CJ.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25462-25467. doi: 10.1073/pnas.1909562116. Epub 2019 Nov 26.


Bone-inspired microarchitectures achieve enhanced fatigue life.

Torres AM, Trikanad AA, Aubin CA, Lambers FM, Luna M, Rimnac CM, Zavattieri P, Hernandez CJ.

Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24457-24462. doi: 10.1073/pnas.1905814116. Epub 2019 Nov 18.


PINK1 Silencing Modifies Dendritic Spine Dynamics of Mouse Hippocampal Neurons.

Hernández CJ, Báez-Becerra C, Contreras-Zárate MJ, Arboleda H, Arboleda G.

J Mol Neurosci. 2019 Dec;69(4):570-579. doi: 10.1007/s12031-019-01385-x. Epub 2019 Sep 5.


Disruption of the Gut Microbiome Increases the Risk of Periprosthetic Joint Infection in Mice.

Hernandez CJ, Yang X, Ji G, Niu Y, Sethuraman AS, Koressel J, Shirley M, Fields MW, Chyou S, Li TM, Luna M, Callahan RL, Ross FP, Lu TT, Brito IL, Carli AV, Bostrom MPG.

Clin Orthop Relat Res. 2019 Nov;477(11):2588-2598. doi: 10.1097/CORR.0000000000000851.


The microbial metagenome and bone tissue composition in mice with microbiome-induced reductions in bone strength.

Guss JD, Taylor E, Rouse Z, Roubert S, Higgins CH, Thomas CJ, Baker SP, Vashishth D, Donnelly E, Shea MK, Booth SL, Bicalho RC, Hernandez CJ.

Bone. 2019 Oct;127:146-154. doi: 10.1016/j.bone.2019.06.010. Epub 2019 Jun 14.


Immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome-mediated metabolic syndrome.

Mosquera MJ, Kim S, Zhou H, Jing TT, Luna M, Guss JD, Reddy P, Lai K, Leifer CA, Brito IL, Hernandez CJ, Singh A.

Sci Adv. 2019 Mar 27;5(3):eaav9788. doi: 10.1126/sciadv.aav9788. eCollection 2019 Mar.


Altered Tissue Composition, Microarchitecture, and Mechanical Performance in Cancellous Bone From Men With Type 2 Diabetes Mellitus.

Hunt HB, Torres AM, Palomino PM, Marty E, Saiyed R, Cohn M, Jo J, Warner S, Sroga GE, King KB, Lane JM, Vashishth D, Hernandez CJ, Donnelly E.

J Bone Miner Res. 2019 Jul;34(7):1191-1206. doi: 10.1002/jbmr.3711. Epub 2019 May 17.


The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis.

Guss JD, Ziemian SN, Luna M, Sandoval TN, Holyoak DT, Guisado GG, Roubert S, Callahan RL, Brito IL, van der Meulen MCH, Goldring SR, Hernandez CJ.

Osteoarthritis Cartilage. 2019 Jan;27(1):129-139. doi: 10.1016/j.joca.2018.07.020. Epub 2018 Sep 18.


Can quantitative computed tomography detect bone morphological changes associated with catastrophic proximal sesamoid bone fracture in Thoroughbred racehorses?

Cresswell EN, McDonough SP, Palmer SE, Hernandez CJ, Reesink HL.

Equine Vet J. 2019 Jan;51(1):123-130. doi: 10.1111/evj.12965. Epub 2018 Jun 1.


Current Options and Emerging Biomaterials for Periprosthetic Joint Infection.

Levack AE, Cyphert EL, Bostrom MP, Hernandez CJ, von Recum HA, Carli AV.

Curr Rheumatol Rep. 2018 Apr 30;20(6):33. doi: 10.1007/s11926-018-0742-4. Review.


Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.

Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD.

Hum Mol Genet. 2018 Jul 1;27(13):2225-2243. doi: 10.1093/hmg/ddy128.


Bone marrow lesions in osteoarthritis: What lies beneath.

Alliston T, Hernandez CJ, Findlay DM, Felson DT, Kennedy OD.

J Orthop Res. 2018 Jul;36(7):1818-1825. doi: 10.1002/jor.23844. Epub 2018 May 22. Review.


Bone Mechanical Function and the Gut Microbiota.

Hernandez CJ.

Adv Exp Med Biol. 2017;1033:249-270. doi: 10.1007/978-3-319-66653-2_12. Review.


The Microbiome and Bone and Joint Disease.

Hernandez CJ.

Curr Rheumatol Rep. 2017 Nov 4;19(12):77. doi: 10.1007/s11926-017-0705-1. Review.


An in vivo model of a mechanically-induced bone marrow lesion.

Matheny JB, Goff MG, Pownder SL, Koff MF, Hayashi K, Yang X, Bostrom MPG, van der Meulen MCH, Hernandez CJ.

J Biomech. 2017 Nov 7;64:258-261. doi: 10.1016/j.jbiomech.2017.09.020. Epub 2017 Oct 13.


STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells.

Garrido-Tapia M, Hernández CJ, Ascui G, Kramm K, Morales M, Ga Rate V, Zúñiga R, Bustamante M, Aguillón JC, Catala N D, Ribeiro CH, Molina MAC.

Immunobiology. 2017 Nov;222(11):1043-1051. doi: 10.1016/j.imbio.2017.05.009. Epub 2017 May 23.


Mechanically induced bone formation is not sensitive to local osteocyte density in rat vertebral cancellous bone.

Cresswell EN, Nguyen TM, Horsfield MW, Alepuz AJ, Metzger TA, Niebur GL, Hernandez CJ.

J Orthop Res. 2018 Feb;36(2):672-681. doi: 10.1002/jor.23606. Epub 2017 Jun 2.


Romosozumab Treatment Converts Trabecular Rods into Trabecular Plates in Male Cynomolgus Monkeys.

Matheny JB, Torres AM, Ominsky MS, Hernandez CJ.

Calcif Tissue Int. 2017 Jul;101(1):82-91. doi: 10.1007/s00223-017-0258-3. Epub 2017 Feb 28.


Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.

Guss JD, Horsfield MW, Fontenele FF, Sandoval TN, Luna M, Apoorva F, Lima SF, Bicalho RC, Singh A, Ley RE, van der Meulen MC, Goldring SR, Hernandez CJ.

J Bone Miner Res. 2017 Jun;32(6):1343-1353. doi: 10.1002/jbmr.3114. Epub 2017 Mar 27.


Understanding Bone Strength Is Not Enough.

Hernandez CJ, van der Meulen MC.

J Bone Miner Res. 2017 Jun;32(6):1157-1162. doi: 10.1002/jbmr.3078. Epub 2017 Feb 7.


Links Between the Microbiome and Bone.

Hernandez CJ, Guss JD, Luna M, Goldring SR.

J Bone Miner Res. 2016 Sep;31(9):1638-46. doi: 10.1002/jbmr.2887. Epub 2016 Jul 26. Review.


Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure.

Torres AM, Matheny JB, Keaveny TM, Taylor D, Rimnac CM, Hernandez CJ.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2892-7. doi: 10.1073/pnas.1520539113. Epub 2016 Feb 29.


Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients.

Ribeiro CH, Kramm K, Gálvez-Jirón F, Pola V, Bustamante M, Contreras HR, Sabag A, Garrido-Tapia M, Hernández CJ, Zúñiga R, Collazo N, Sotelo PH, Morales C, Mercado L, Catalán D, Aguillón JC, Molina MC.

Oncol Rep. 2016 Mar;35(3):1309-17. doi: 10.3892/or.2015.4510. Epub 2015 Dec 23.


Spatial relationships between bone formation and mechanical stress within cancellous bone.

Cresswell EN, Goff MG, Nguyen TM, Lee WX, Hernandez CJ.

J Biomech. 2016 Jan 25;49(2):222-8. doi: 10.1016/j.jbiomech.2015.12.011. Epub 2015 Dec 11.


Finite element models predict the location of microdamage in cancellous bone following uniaxial loading.

Goff MG, Lambers FM, Sorna RM, Keaveny TM, Hernandez CJ.

J Biomech. 2015 Nov 26;48(15):4142-8. doi: 10.1016/j.jbiomech.2015.10.023. Epub 2015 Oct 26.


Fatigue-induced microdamage in cancellous bone occurs distant from resorption cavities and trabecular surfaces.

Goff MG, Lambers FM, Nguyen TM, Sung J, Rimnac CM, Hernandez CJ.

Bone. 2015 Oct;79:8-14. doi: 10.1016/j.bone.2015.05.020. Epub 2015 May 22.


The effects of tensile-compressive loading mode and microarchitecture on microdamage in human vertebral cancellous bone.

Lambers FM, Bouman AR, Tkachenko EV, Keaveny TM, Hernandez CJ.

J Biomech. 2014 Nov 28;47(15):3605-12.


The effects of misalignment during in vivo loading of bone: techniques to detect the proximity of objects in three-dimensional models.

Goff MG, Chang KL, Litts EN, Hernandez CJ.

J Biomech. 2014 Sep 22;47(12):3156-61. doi: 10.1016/j.jbiomech.2014.06.016. Epub 2014 Jun 21.


Quantitative relationships between microdamage and cancellous bone strength and stiffness.

Hernandez CJ, Lambers FM, Widjaja J, Chapa C, Rimnac CM.

Bone. 2014 Sep;66:205-13. doi: 10.1016/j.bone.2014.05.023. Epub 2014 Jun 11.


A microfluidic platform for profiling biomechanical properties of bacteria.

Sun X, Weinlandt WD, Patel H, Wu M, Hernandez CJ.

Lab Chip. 2014 Jul 21;14(14):2491-8. doi: 10.1039/c3lc51428e.


Theoretical consideration of the effect of drug holidays on BMD and tissue age.

Hernandez CJ, Lopez HK, Lane JM.

Osteoporos Int. 2014 May;25(5):1577-84. doi: 10.1007/s00198-014-2653-1. Epub 2014 Feb 26.


Microdamage caused by fatigue loading in human cancellous bone: relationship to reductions in bone biomechanical performance.

Lambers FM, Bouman AR, Rimnac CM, Hernandez CJ.

PLoS One. 2013 Dec 30;8(12):e83662. doi: 10.1371/journal.pone.0083662. eCollection 2013.


Anti-resorptive agents reduce the size of resorption cavities: a three-dimensional dynamic bone histomorphometry study.

Matheny JB, Slyfield CR, Tkachenko EV, Lin I, Ehlert KM, Tomlinson RE, Wilson DL, Hernandez CJ.

Bone. 2013 Nov;57(1):277-83. doi: 10.1016/j.bone.2013.08.018. Epub 2013 Aug 26.


Biomechanical effects of simulated resorption cavities in cancellous bone across a wide range of bone volume fractions.

Easley SK, Chang MT, Shindich D, Hernandez CJ, Keaveny TM.

J Bone Miner Res. 2012 Sep;27(9):1927-35. doi: 10.1002/jbmr.1657.


Three-dimensional characterization of resorption cavity size and location in human vertebral trabecular bone.

Goff MG, Slyfield CR, Kummari SR, Tkachenko EV, Fischer SE, Yi YH, Jekir MG, Keaveny TM, Hernandez CJ.

Bone. 2012 Jul;51(1):28-37. doi: 10.1016/j.bone.2012.03.028. Epub 2012 Apr 3.


Mechanical failure begins preferentially near resorption cavities in human vertebral cancellous bone under compression.

Slyfield CR, Tkachenko EV, Fischer SE, Ehlert KM, Yi IH, Jekir MG, O'Brien RG, Keaveny TM, Hernandez CJ.

Bone. 2012 Jun;50(6):1281-7. doi: 10.1016/j.bone.2012.02.636. Epub 2012 Mar 9.


Ectopic expression of SOX9 in osteoblasts alters bone mechanical properties.

Liang B, Cotter MM, Chen D, Hernandez CJ, Zhou G.

Calcif Tissue Int. 2012 Feb;90(2):76-89. doi: 10.1007/s00223-011-9550-9. Epub 2011 Dec 6.


Irradiation does not modify mechanical properties of cancellous bone under compression.

Hernandez CJ, Ramsey DS, Dux SJ, Chu EH, Rimnac CM.

Clin Orthop Relat Res. 2012 Sep;470(9):2488-95. doi: 10.1007/s11999-011-2148-8.


Human evolution and osteoporosis-related spinal fractures.

Cotter MM, Loomis DA, Simpson SW, Latimer B, Hernandez CJ.

PLoS One. 2011;6(10):e26658. doi: 10.1371/journal.pone.0026658. Epub 2011 Oct 19.


Three-dimensional dynamic bone histomorphometry.

Slyfield CR, Tkachenko EV, Wilson DL, Hernandez CJ.

J Bone Miner Res. 2012 Feb;27(2):486-95. doi: 10.1002/jbmr.553.


Surface contaminants inhibit osseointegration in a novel murine model.

Bonsignore LA, Colbrunn RW, Tatro JM, Messerschmitt PJ, Hernandez CJ, Goldberg VM, Stewart MC, Greenfield EM.

Bone. 2011 Nov;49(5):923-30. doi: 10.1016/j.bone.2011.07.013. Epub 2011 Jul 23.


Survival after lung metastasectomy for colorectal cancer: importance of previous liver metastasis as a prognostic factor.

Zabaleta J, Aguinagalde B, Fuentes MG, Bazterargui N, Izquierdo JM, Hernández CJ, Enriquez-Navascués JM, Emparanza JI.

Eur J Surg Oncol. 2011 Sep;37(9):786-90. doi: 10.1016/j.ejso.2011.05.014. Epub 2011 Jul 2.


Near-terminal creep damage does not substantially influence fatigue life under physiological loading.

Stern LC, Brinkman JG, Furmanski J, Rimnac CM, Hernandez CJ.

J Biomech. 2011 Jul 7;44(10):1995-8. doi: 10.1016/j.jbiomech.2011.04.039. Epub 2011 May 18.


[Review and update of the prognostic factors in lung metastasis surgery].

Zabaleta J, Aguinagalde B, Fuentes MG, Izquierdo JM, Hernández CJ, Emparanza JI.

Cir Esp. 2011 Apr;89(4):243-8. doi: 10.1016/j.ciresp.2010.12.006. Epub 2011 Feb 24. Spanish.


Interleukin 10 decreases MICA expression on melanoma cell surface.

Serrano AE, Menares-Castillo E, Garrido-Tapia M, Ribeiro CH, Hernández CJ, Mendoza-Naranjo A, Gatica-Andrades M, Valenzuela-Diaz R, Zúñiga R, López MN, Salazar-Onfray F, Aguillón JC, Molina MC.

Immunol Cell Biol. 2011 Mar;89(3):447-57. doi: 10.1038/icb.2010.100. Epub 2010 Aug 17.


[Acute mediastinitis as a complication of H1N1 influenza].

Zabaleta J, Aguinagalde B, Izquierdo JM, Hernández CJ.

Arch Bronconeumol. 2010 Jul;46(7):398. doi: 10.1016/j.arbres.2010.03.008. Epub 2010 May 12. Spanish. No abstract available.


Alterations in damage processes in dense cancellous bone following gamma-radiation sterilization.

Dux SJ, Ramsey D, Chu EH, Rimnac CM, Hernandez CJ.

J Biomech. 2010 May 28;43(8):1509-13. doi: 10.1016/j.jbiomech.2010.01.042. Epub 2010 Feb 20.


Three-dimensional surface texture visualization of bone tissue through epifluorescence-based serial block face imaging.

Slyfield CR Jr, Niemeyer KE, Tkachenko EV, Tomlinson RE, Steyer GG, Patthanacharoenphon CG, Kazakia GJ, Wilson DL, Hernandez CJ.

J Microsc. 2009 Oct;236(1):52-9. doi: 10.1111/j.1365-2818.2009.03204.x.


Trabecular microarchitecture of hominoid thoracic vertebrae.

Cotter MM, Simpson SW, Latimer BM, Hernandez CJ.

Anat Rec (Hoboken). 2009 Aug;292(8):1098-106. doi: 10.1002/ar.20932.


Trabecular microfracture precedes cortical shell failure in the rat caudal vertebra under cyclic overloading.

Kummari SR, Davis AJ, Vega LA, Ahn N, Cassinelli EH, Hernandez CJ.

Calcif Tissue Int. 2009 Aug;85(2):127-33. doi: 10.1007/s00223-009-9257-3. Epub 2009 Jun 2.


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