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Items: 45


The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.

Rouault AAJ, Rosselli-Murai LK, Hernandez CC, Gimenez LE, Tall GG, Sebag JA.

Sci Signal. 2020 Jan 7;13(613). pii: eaax4569. doi: 10.1126/scisignal.aax4569.


Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies.

Hernandez CC, XiangWei W, Hu N, Shen D, Shen W, Lagrange AH, Zhang Y, Dai L, Ding C, Sun Z, Hu J, Zhu H, Jiang Y, Macdonald RL.

Brain. 2019 Jul 1;142(7):1938-1954. doi: 10.1093/brain/awz123.


A structural look at GABAA receptor mutations linked to epilepsy syndromes.

Hernandez CC, Macdonald RL.

Brain Res. 2019 Jul 1;1714:234-247. doi: 10.1016/j.brainres.2019.03.004. Epub 2019 Mar 7. Review.


Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains.

Choveau FS, De la Rosa V, Bierbower SM, Hernandez CC, Shapiro MS.

J Biol Chem. 2018 Dec 14;293(50):19411-19428. doi: 10.1074/jbc.RA118.005401. Epub 2018 Oct 22.


G protein-coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7.1.

Carrington SJ, Hernandez CC, Swale DR, Aluko OA, Denton JS, Cone RD.

J Biol Chem. 2018 Nov 16;293(46):17739-17753. doi: 10.1074/jbc.RA118.003238. Epub 2018 Sep 26.


X-ray powder diffraction and other analyses of cellulose nanocrystals obtained from corn straw by chemical treatments.

Hernandez CC, Ferreira FF, Rosa DS.

Carbohydr Polym. 2018 Aug 1;193:39-44. doi: 10.1016/j.carbpol.2018.03.085. Epub 2018 Mar 27.


CTCF-KDM4A complex correlates with histone modifications that negatively regulate CHD5 gene expression in cancer cell lines.

Guerra-Calderas L, González-Barrios R, Patiño CC, Alcaraz N, Salgado-Albarrán M, de León DC, Hernández CC, Sánchez-Pérez Y, Maldonado-Martínez HA, De la Rosa-Velazquez IA, Vargas-Romero F, Herrera LA, García-Carrancá A, Soto-Reyes E.

Oncotarget. 2018 Mar 30;9(24):17028-17042. doi: 10.18632/oncotarget.24798. eCollection 2018 Mar 30.


A Missense Mutation A384P Associated with Human Hyperekplexia Reveals a Desensitization Site of Glycine Receptors.

Wang CH, Hernandez CC, Wu J, Zhou N, Hsu HY, Shen ML, Wang YC, Macdonald RL, Wu DC.

J Neurosci. 2018 Mar 14;38(11):2818-2831. doi: 10.1523/JNEUROSCI.0674-16.2018. Epub 2018 Feb 13.


GABA A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy.

Hernandez CC, Zhang Y, Hu N, Shen D, Shen W, Liu X, Kong W, Jiang Y, Macdonald RL.

Sci Rep. 2017 Nov 21;7(1):15903. doi: 10.1038/s41598-017-16010-3.


Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor.

Hernández CC, Burgos CF, Gajardo AH, Silva-Grecchi T, Gavilan J, Toledo JR, Fuentealba J.

Neural Regen Res. 2017 Sep;12(9):1381-1389. doi: 10.4103/1673-5374.215240. Review.


Altered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome.

Hernandez CC, Kong W, Hu N, Zhang Y, Shen W, Jackson L, Liu X, Jiang Y, Macdonald RL.

eNeuro. 2017 Feb 10;4(1). pii: ENEURO.0251-16.2017. doi: 10.1523/ENEURO.0251-16.2017. eCollection 2017 Jan-Feb.


Correction: Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.

Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL.

PLoS One. 2016 Nov 21;11(11):e0167264. doi: 10.1371/journal.pone.0167264. eCollection 2016.


De novo GABRG2 mutations associated with epileptic encephalopathies.

Shen D, Hernandez CC, Shen W, Hu N, Poduri A, Shiedley B, Rotenberg A, Datta AN, Leiz S, Patzer S, Boor R, Ramsey K, Goldberg E, Helbig I, Ortiz-Gonzalez XR, Lemke JR, Marsh ED, Macdonald RL.

Brain. 2017 Jan;140(1):49-67. doi: 10.1093/brain/aww272. Epub 2016 Nov 17.


A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy.

Ishii A, Kang JQ, Schornak CC, Hernandez CC, Shen W, Watkins JC, Macdonald RL, Hirose S.

J Med Genet. 2017 Mar;54(3):202-211. doi: 10.1136/jmedgenet-2016-104083. Epub 2016 Oct 27.


Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.

Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL.

PLoS One. 2016 Sep 13;11(9):e0162883. doi: 10.1371/journal.pone.0162883. eCollection 2016. Erratum in: PLoS One. 2016 Nov 21;11(11):e0167264.



Janve VS, Hernandez CC, Verdier KM, Hu N, Macdonald RL.

Ann Neurol. 2016 Aug;80(2):312-3. doi: 10.1002/ana.24701. Epub 2016 Jun 24. No abstract available.


Epileptic encephalopathy de novo GABRB mutations impair γ-aminobutyric acid type A receptor function.

Janve VS, Hernandez CC, Verdier KM, Hu N, Macdonald RL.

Ann Neurol. 2016 May;79(5):806-825. doi: 10.1002/ana.24631.


Three epilepsy-associated GABRG2 missense mutations at the γ+/β- interface disrupt GABAA receptor assembly and trafficking by similar mechanisms but to different extents.

Huang X, Hernandez CC, Hu N, Macdonald RL.

Neurobiol Dis. 2014 Aug;68:167-79. doi: 10.1016/j.nbd.2014.04.015. Epub 2014 May 4.


Co-expression of γ2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor β2 subunits.

Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL.

Neurochem Res. 2014 Jun;39(6):1088-103. doi: 10.1007/s11064-013-1187-9. Epub 2013 Nov 12.


Traumatic cardiac arrest: should advanced life support be initiated?

Leis CC, Hernández CC, Blanco MJ, Paterna PC, Hernández Rde E, Torres EC.

J Trauma Acute Care Surg. 2013 Feb;74(2):634-8. doi: 10.1097/TA.0b013e31827d5d3c.


Impaired surface αβγ GABA(A) receptor expression in familial epilepsy due to a GABRG2 frameshift mutation.

Tian M, Mei D, Freri E, Hernandez CC, Granata T, Shen W, Macdonald RL, Guerrini R.

Neurobiol Dis. 2013 Feb;50:135-41. doi: 10.1016/j.nbd.2012.10.008. Epub 2012 Oct 13.


The GABRG2 nonsense mutation, Q40X, associated with Dravet syndrome activated NMD and generated a truncated subunit that was partially rescued by aminoglycoside-induced stop codon read-through.

Huang X, Tian M, Hernandez CC, Hu N, Macdonald RL.

Neurobiol Dis. 2012 Oct;48(1):115-23. doi: 10.1016/j.nbd.2012.06.013. Epub 2012 Jun 30.


Pore determinants of KCNQ3 K+ current expression.

Choveau FS, Hernandez CC, Bierbower SM, Shapiro MS.

Biophys J. 2012 Jun 6;102(11):2489-98. doi: 10.1016/j.bpj.2012.04.018. Epub 2012 Jun 5. Erratum in: Biophys J. 2013 May 7;104(9):2110-1.


GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating.

Gurba KN, Hernandez CC, Hu N, Macdonald RL.

J Biol Chem. 2012 Apr 6;287(15):12083-97. doi: 10.1074/jbc.M111.332528. Epub 2012 Feb 2.


The GABRA6 mutation, R46W, associated with childhood absence epilepsy, alters 6β22 and 6β2 GABA(A) receptor channel gating and expression.

Hernandez CC, Gurba KN, Hu N, Macdonald RL.

J Physiol. 2011 Dec 1;589(Pt 23):5857-78. doi: 10.1113/jphysiol.2011.218883. Epub 2011 Sep 19.


Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating.

Lo WY, Lagrange AH, Hernandez CC, Harrison R, Dell A, Haslam SM, Sheehan JH, Macdonald RL.

J Biol Chem. 2010 Oct 8;285(41):31348-61. doi: 10.1074/jbc.M110.151449. Epub 2010 Jul 16.


Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels.

Bal M, Zhang J, Hernandez CC, Zaika O, Shapiro MS.

J Neurosci. 2010 Feb 10;30(6):2311-23. doi: 10.1523/JNEUROSCI.5175-09.2010.


Modulation of spontaneous and GABA-evoked tonic alpha4beta3delta and alpha4beta3gamma2L GABAA receptor currents by protein kinase A.

Tang X, Hernandez CC, Macdonald RL.

J Neurophysiol. 2010 Feb;103(2):1007-19. doi: 10.1152/jn.00801.2009. Epub 2009 Nov 25.


Affinity for phosphatidylinositol 4,5-bisphosphate determines muscarinic agonist sensitivity of Kv7 K+ channels.

Hernandez CC, Falkenburger B, Shapiro MS.

J Gen Physiol. 2009 Nov;134(5):437-48. doi: 10.1085/jgp.200910313.


Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity.

Zaika O, Hernandez CC, Bal M, Tolstykh GP, Shapiro MS.

Biophys J. 2008 Dec;95(11):5121-37. doi: 10.1529/biophysj.108.137604. Epub 2008 Sep 12.


Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.

Bal M, Zhang J, Zaika O, Hernandez CC, Shapiro MS.

J Biol Chem. 2008 Nov 7;283(45):30668-76. doi: 10.1074/jbc.M805216200. Epub 2008 Sep 11.


A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels.

Hernandez CC, Zaika O, Shapiro MS.

J Gen Physiol. 2008 Sep;132(3):361-81. doi: 10.1085/jgp.200810007.


Autoantibodies enhance agonist action and binding to cardiac muscarinic receptors in chronic Chagas' disease.

Hernandez CC, Nascimento JH, Chaves EA, Costa PC, Masuda MO, Kurtenbach E, Campos DE Carvalho AC, Gimenez LE.

J Recept Signal Transduct Res. 2008;28(4):375-401. doi: 10.1080/10799890802262319 .


Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit.

Miceli F, Soldovieri MV, Hernandez CC, Shapiro MS, Annunziato L, Taglialatela M.

Biophys J. 2008 Sep;95(5):2254-64. doi: 10.1529/biophysj.107.128371. Epub 2008 May 30.


Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications.

Hernandez CC, Zaika O, Tolstykh GP, Shapiro MS.

J Physiol. 2008 Apr 1;586(7):1811-21. doi: 10.1113/jphysiol.2007.148304. Epub 2008 Jan 31. Review.


Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions.

Soldovieri MV, Cilio MR, Miceli F, Bellini G, Miraglia del Giudice E, Castaldo P, Hernandez CC, Shapiro MS, Pascotto A, Annunziato L, Taglialatela M.

J Neurosci. 2007 May 2;27(18):4919-28.


Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing.

Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, Shapiro MS.

EMBO J. 2006 Oct 18;25(20):4996-5004. Epub 2006 Oct 5.


Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.

Rocha NN, Garcia S, Giménez LE, Hernández CC, Senra JF, Lima RS, Cyrino F, Bouskela E, Soares MB, Ribeiro dos Santos R, Campos de Carvalho AC.

Parasitology. 2006 Dec;133(Pt 6):729-37. Epub 2006 Sep 18.


Human antibodies with muscarinic activity modulate ventricular repolarization: basis for electrical disturbance.

Medei E, Pedrosa RC, Benchimol Barbosa PR, Costa PC, Hernández CC, Chaves EA, Linhares V, Masuda MO, Nascimento JH, Campos de Carvalho AC.

Int J Cardiol. 2007 Feb 14;115(3):373-80. Epub 2006 Aug 1.


Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease.

Ribeiro AL, Giménez LE, Hernández CC, de Carvalho AC, Teixeira MM, Guedes VC, Barros MV, Lombardi F, Rocha MO.

Int J Cardiol. 2007 Apr 12;117(1):59-63. Epub 2006 Jul 21.


DNA immunizations with M2 muscarinic and beta1 adrenergic receptor coding plasmids impair cardiac function in mice.

Giménez LE, Hernández CC, Mattos EC, Brandão IT, Olivieri B, Campelo RP, Araújo-Jorge T, Silva CL, Campos de Carvalho AC, Kurtenbach E.

J Mol Cell Cardiol. 2005 May;38(5):703-14.


Human chagasic IgGs bind to cardiac muscarinic receptors and impair L-type Ca2+ currents.

Hernández CC, Barcellos LC, Giménez LE, Cabarcas RA, Garcia S, Pedrosa RC, Nascimento JH, Kurtenbach E, Masuda MO, Campos de Carvalho AC.

Cardiovasc Res. 2003 Apr 1;58(1):55-65.


Kallikreins and kininogens in saliva and plasma of patients presenting with rheumatoid arthritis.

Hernández CC, Donadi EA, Reis ML.

Scand J Rheumatol. 2002;31(1):38-40.


Kininogen-kallikrein-kinin system in plasma and saliva of patients with Sjögren's syndrome.

Hernández CC, Donadi EA, Reis ML.

J Rheumatol. 1998 Dec;25(12):2381-4.


[Prevalence of retained 3rd molars in the students at the School of Dentistry, ISCM, Havana, during 1975-76, 1976-77 and 1977-78 academic years].

Hernandez CC, del Valle Ruiz M, Cuellar Lomba D.

Rev Cubana Estomatol. 1983 May-Aug;20(2):161-7. Spanish. No abstract available.


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