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Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side.

Prieto-Bermejo R, Romo-González M, Pérez-Fernández A, Ijurko C, Hernández-Hernández Á.

J Exp Clin Cancer Res. 2018 Jun 26;37(1):125. doi: 10.1186/s13046-018-0797-0. Review.


MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.

Shibuya H, Hernández-Hernández A, Morimoto A, Negishi L, Höög C, Watanabe Y.

Cell. 2018 May 3;173(4):1058. doi: 10.1016/j.cell.2018.04.025. No abstract available.


Paraptosis in human glioblastoma cell line induced by curcumin.

Garrido-Armas M, Corona JC, Escobar ML, Torres L, Ordóñez-Romero F, Hernández-Hernández A, Arenas-Huertero F.

Toxicol In Vitro. 2018 Sep;51:63-73. doi: 10.1016/j.tiv.2018.04.014. Epub 2018 Apr 30.


Sexual dimorphism in the width of the mouse synaptonemal complex.

Agostinho A, Kouznetsova A, Hernández-Hernández A, Bernhem K, Blom H, Brismar H, Höög C.

J Cell Sci. 2018 Mar 6;131(5). pii: jcs212548. doi: 10.1242/jcs.212548.


Mesenchymal stromal cells (MSC) from JAK2+ myeloproliferative neoplasms differ from normal MSC and contribute to the maintenance of neoplastic hematopoiesis.

Ramos TL, Sánchez-Abarca LI, Rosón-Burgo B, Redondo A, Rico A, Preciado S, Ortega R, Rodríguez C, Muntión S, Hernández-Hernández Á, De Las Rivas J, González M, González Porras JR, Del Cañizo C, Sánchez-Guijo F.

PLoS One. 2017 Aug 10;12(8):e0182470. doi: 10.1371/journal.pone.0182470. eCollection 2017.


The Importance of NADPH Oxidases and Redox Signaling in Angiogenesis.

Prieto-Bermejo R, Hernández-Hernández A.

Antioxidants (Basel). 2017 May 13;6(2). pii: E32. doi: 10.3390/antiox6020032. Review.


Antimicrobial and anti-inflammatory activities, wound-healing effectiveness and chemical characterization of the latex of Jatropha neopauciflora Pax.

Hernandez-Hernandez AB, Alarcon-Aguilar FJ, Almanza-Perez JC, Nieto-Yañez O, Olivares-Sanchez JM, Duran-Diaz A, Rodriguez-Monroy MA, Canales-Martinez MM.

J Ethnopharmacol. 2017 May 23;204:1-7. doi: 10.1016/j.jep.2017.04.003. Epub 2017 Apr 6.


HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target?

Ramos TL, Sánchez-Abarca LI, Redondo A, Hernández-Hernández Á, Almeida AM, Puig N, Rodríguez C, Ortega R, Preciado S, Rico A, Muntión S, Porras JRG, Del Cañizo C, Sánchez-Guijo F.

Oncotarget. 2017 Apr 25;8(17):28187-28202. doi: 10.18632/oncotarget.15969.


Study of the interplay between N-graphene defects and small Pd clusters for enhanced hydrogen storage via a spill-over mechanism.

Rangel E, Sansores E, Vallejo E, Hernández-Hernández A, López-Pérez PA.

Phys Chem Chem Phys. 2016 Dec 7;18(48):33158-33170.


Friendship Concept and Community Network Structure among Elementary School and University Students.

Hernández-Hernández AM, Viga-de Alva D, Huerta-Quintanilla R, Canto-Lugo E, Laviada-Molina H, Molina-Segui F.

PLoS One. 2016 Oct 19;11(10):e0164886. doi: 10.1371/journal.pone.0164886. eCollection 2016.


The DARC-CD82 axis discloses bone marrow macrophages as guardians of long-term hematopoietic stem cells quiescence.

Pérez-Fernández A, Hernández-Hernández Á.

Stem Cell Investig. 2016 Sep 1;3:44. doi: 10.21037/sci.2016.08.07. eCollection 2016. No abstract available.


CTCF contributes in a critical way to spermatogenesis and male fertility.

Hernández-Hernández A, Lilienthal I, Fukuda N, Galjart N, Höög C.

Sci Rep. 2016 Jun 27;6:28355. doi: 10.1038/srep28355.


High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation.

Agostinho A, Manneberg O, van Schendel R, Hernández-Hernández A, Kouznetsova A, Blom H, Brismar H, Höög C.

EMBO Rep. 2016 Jun;17(6):901-13. doi: 10.15252/embr.201642030. Epub 2016 May 11.


[Percutaneous coronary intervention in Navarre. Outcomes of a low volume centre].

Artaiz M, Salterain N, Fernández Montero A, Hernández-Hernández A, Canepa Leite JP, Calabuig Nogués J.

An Sist Sanit Navar. 2016 Apr 29;39(1):87-97. doi: 10.4321/S1137-6627/2016000100010. Spanish.


The central element of the synaptonemal complex in mice is organized as a bilayered junction structure.

Hernández-Hernández A, Masich S, Fukuda T, Kouznetsova A, Sandin S, Daneholt B, Höög C.

J Cell Sci. 2016 Jun 1;129(11):2239-49. doi: 10.1242/jcs.182477. Epub 2016 Apr 21.


The width of the lateral element of the synaptonemal complex is determined by a multilayered organization of its components.

Ortiz R, Kouznetsova A, Echeverría-Martínez OM, Vázquez-Nin GH, Hernández-Hernández A.

Exp Cell Res. 2016 May 15;344(1):22-29. doi: 10.1016/j.yexcr.2016.03.025. Epub 2016 Apr 29.


ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated secretion.

López-Benito S, Lillo C, Hernández-Hernández Á, Chao MV, Arévalo JC.

J Cell Sci. 2016 May 1;129(9):1866-77. doi: 10.1242/jcs.184168. Epub 2016 Mar 10.


Changes in the expression of LIMP-2 during cerulein-induced pancreatitis in rats: Effect of inhibition of leukocyte infiltration, cAMP and MAPKs early on in its development.

García-Hernández V, Sarmiento N, Sánchez-Bernal C, Coveñas R, Hernández-Hernández A, Calvo JJ, Sánchez-Yagüe J.

Int J Biochem Cell Biol. 2016 Mar;72:109-117. doi: 10.1016/j.biocel.2016.01.010. Epub 2016 Jan 18.


MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry.

L Ramos T, Sánchez-Abarca LI, Muntión S, Preciado S, Puig N, López-Ruano G, Hernández-Hernández Á, Redondo A, Ortega R, Rodríguez C, Sánchez-Guijo F, del Cañizo C.

Cell Commun Signal. 2016 Jan 12;14:2. doi: 10.1186/s12964-015-0124-8.



Hernández-Hernández AB, Alarcón-Aguilar FJ, Jiménez-Estrada M, Hernández-Portilla LB, Flores-Ortiz CM, Rodríguez-Monroy MA, Canales-Martínez M.

Afr J Tradit Complement Altern Med. 2016 Nov 23;14(1):32-42. doi: 10.21010/ajtcam.v14i1.4505. eCollection 2017.


Better Adherence to the Mediterranean Diet Could Mitigate the Adverse Consequences of Obesity on Cardiovascular Disease: The SUN Prospective Cohort.

Eguaras S, Toledo E, Hernández-Hernández A, Cervantes S, Martínez-González MA.

Nutrients. 2015 Nov 5;7(11):9154-62. doi: 10.3390/nu7115457.


Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project.

Hernandez-Hernandez A, Gea A, Ruiz-Canela M, Toledo E, Beunza JJ, Bes-Rastrollo M, Martinez-Gonzalez MA.

Nutrients. 2015 Nov 5;7(11):9116-26. doi: 10.3390/nu7115456.


MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.

Shibuya H, Hernández-Hernández A, Morimoto A, Negishi L, Höög C, Watanabe Y.

Cell. 2015 Nov 19;163(5):1252-1266. doi: 10.1016/j.cell.2015.10.030. Epub 2015 Nov 5. Erratum in: Cell. 2018 May 3;173(4):1058.


PTPN13 and β-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche.

López-Ruano G, Prieto-Bermejo R, Ramos TL, San-Segundo L, Sánchez-Abarca LI, Sánchez-Guijo F, Pérez-Simón JA, Sánchez-Yagüe J, Llanillo M, Hernández-Hernández Á.

Stem Cell Reports. 2015 Oct 13;5(4):516-31. doi: 10.1016/j.stemcr.2015.08.003. Epub 2015 Sep 3.


Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the SUN Cohort.

Ramallal R, Toledo E, Martínez-González MA, Hernández-Hernández A, García-Arellano A, Shivappa N, Hébert JR, Ruiz-Canela M.

PLoS One. 2015 Sep 4;10(9):e0135221. doi: 10.1371/journal.pone.0135221. eCollection 2015.


Enhanced antitumour drug delivery to cholangiocarcinoma through the apical sodium-dependent bile acid transporter (ASBT).

Lozano E, Monte MJ, Briz O, Hernández-Hernández A, Banales JM, Marin JJ, Macias RI.

J Control Release. 2015 Oct 28;216:93-102. doi: 10.1016/j.jconrel.2015.08.022. Epub 2015 Aug 14.


Do endothelial cells belong to the primitive stem leukemic clone in CML? Role of extracellular vesicles.

Ramos TL, Sánchez-Abarca LI, López-Ruano G, Muntión S, Preciado S, Hernández-Ruano M, Rosado B, de las Heras N, Chillón MC, Hernández-Hernández Á, González M, Sánchez-Guijo F, Del Cañizo C.

Leuk Res. 2015 Aug;39(8):921-4. doi: 10.1016/j.leukres.2015.05.014. Epub 2015 Jun 11.


[Costs of appendicitis treatment by diagnosis-related groups in a third-level pediatric hospital].

Tlacuilo-Parra A, Hernández-Hernández A, Venegas-Dávalos M, Gutiérrez-Hermosillo V, Guevara-Gutiérrez E, Ambriz-González G.

Cir Cir. 2014 Nov-Dec;82(6):628-36. Spanish.


Modeling body mass variation: incorporating social influence into calculations of caloric intake and energy expenditure.

Hernández-Hernández AM, Huerta-Quintanilla R.

PLoS One. 2014 Nov 4;9(11):e111709. doi: 10.1371/journal.pone.0111709. eCollection 2014.


PTPN13 regulates cellular signalling and β-catenin function during megakaryocytic differentiation.

Sardina JL, López-Ruano G, Prieto-Bermejo R, Sánchez-Sánchez B, Pérez-Fernández A, Sánchez-Abarca LI, Pérez-Simón JA, Quintales L, Sánchez-Yagüe J, Llanillo M, Antequera F, Hernández-Hernández A.

Biochim Biophys Acta. 2014 Dec;1843(12):2886-99. doi: 10.1016/j.bbamcr.2014.08.014. Epub 2014 Sep 3.


The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.

Romero-Pozuelo J, Dason JS, Mansilla A, Baños-Mateos S, Sardina JL, Chaves-Sanjuán A, Jurado-Gómez J, Santana E, Atwood HL, Hernández-Hernández Á, Sánchez-Barrena MJ, Ferrús A.

J Cell Sci. 2014 Oct 1;127(Pt 19):4246-59. doi: 10.1242/jcs.152603. Epub 2014 Jul 29.


Merotelic attachments allow alignment and stabilization of chromatids in meiosis II oocytes.

Kouznetsova A, Hernández-Hernández A, Höög C.

Nat Commun. 2014 Jul 9;5:4409. doi: 10.1038/ncomms5409.


NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.

Sánchez-Sánchez B, Gutiérrez-Herrero S, López-Ruano G, Prieto-Bermejo R, Romo-González M, Llanillo M, Pandiella A, Guerrero C, Miguel JF, Sánchez-Guijo F, Del Cañizo C, Hernández-Hernández A.

Clin Cancer Res. 2014 Aug 1;20(15):4014-25. doi: 10.1158/1078-0432.CCR-13-3044. Epub 2014 May 15.


STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.

Fukuda T, Fukuda N, Agostinho A, Hernández-Hernández A, Kouznetsova A, Höög C.

EMBO J. 2014 Jun 2;33(11):1243-55. doi: 10.1002/embj.201387329. Epub 2014 May 5.


Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.

Ishiguro K, Kim J, Shibuya H, Hernández-Hernández A, Suzuki A, Fukagawa T, Shioi G, Kiyonari H, Li XC, Schimenti J, Höög C, Watanabe Y.

Genes Dev. 2014 Mar 15;28(6):594-607. doi: 10.1101/gad.237313.113. Epub 2014 Mar 3.


The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis.

Fukuda N, Fukuda T, Sinnamon J, Hernandez-Hernandez A, Izadi M, Raju CS, Czaplinski K, Percipalle P.

PLoS Genet. 2013;9(10):e1003858. doi: 10.1371/journal.pgen.1003858. Epub 2013 Oct 17.


Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.

Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G.

Mol Syst Biol. 2013 Oct 1;9:692. doi: 10.1038/msb.2013.50.


Changes of the nucleolus architecture in absence of the nuclear factor CTCF.

Hernández-Hernández A, Soto-Reyes E, Ortiz R, Arriaga-Canon C, Echeverría-Martinez OM, Vázquez-Nin GH, Recillas-Targa F.

Cytogenet Genome Res. 2012;136(2):89-96. doi: 10.1159/000335752. Epub 2012 Jan 25.


Comparative antioxidant capacities of quercetin and butylated hydroxyanisole in cholesterol-modified erythrocytes damaged by tert-butylhydroperoxide.

Sánchez-Gallego JI, López-Revuelta A, Hernández-Hernández A, Sardina JL, López-Ruano G, Sánchez-Yagüe J, Llanillo M.

Food Chem Toxicol. 2011 Sep;49(9):2212-21. doi: 10.1016/j.fct.2011.06.014. Epub 2011 Jun 25.


A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.

Schramm S, Fraune J, Naumann R, Hernandez-Hernandez A, Höög C, Cooke HJ, Alsheimer M, Benavente R.

PLoS Genet. 2011 May;7(5):e1002088. doi: 10.1371/journal.pgen.1002088. Epub 2011 May 26.


Reactive oxygen species: are they important for haematopoiesis?

Sardina JL, López-Ruano G, Sánchez-Sánchez B, Llanillo M, Hernández-Hernández A.

Crit Rev Oncol Hematol. 2012 Mar;81(3):257-74. doi: 10.1016/j.critrevonc.2011.03.005. Epub 2011 Apr 19. Review.


Upper gastrointestinal bleeding: risk factors for mortality in two urban centres in Latin America.

Morales Uribe CH, Sierra Sierra S, Hernández Hernández AM, Arango Durango AF, López GA.

Rev Esp Enferm Dig. 2011 Jan;103(1):20-4.


CDDO-Im, an antitumor molecule that also improves platetet production.

Sardina JL, López-Ruano G, Sánchez-Sánchez B, Hernández-Hernández A.

Leuk Res. 2011 Apr;35(4):427-8. doi: 10.1016/j.leukres.2010.10.011. Epub 2010 Nov 12. No abstract available.


p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation.

Sardina JL, López-Ruano G, Sánchez-Abarca LI, Pérez-Simón JA, Gaztelumendi A, Trigueros C, Llanillo M, Sánchez-Yagüe J, Hernández-Hernández A.

Cell Death Differ. 2010 Dec;17(12):1842-54. doi: 10.1038/cdd.2010.67. Epub 2010 Jun 4.


Membrane cholesterol contents modify the protective effects of quercetin and rutin on integrity and cellular viability in oxidized erythrocytes.

Sánchez-Gallego JI, López-Revuelta A, Sardina JL, Hernández-Hernández A, Sánchez-Yagüe J, Llanillo M.

Free Radic Biol Med. 2010 May 15;48(10):1444-54. doi: 10.1016/j.freeradbiomed.2010.02.034. Epub 2010 Mar 3.


[Barriers and Facilitators in the Recruitment and Retention of Heterosexual Couples for Preventive Interventions.]

Hernández-Hernández AL, Perez-Jimenez D.

Interam J Psychol. 2010;44(1):19-27. Spanish.


Synaptonemal complex stability depends on repressive histone marks of the lateral element-associated repeat sequences.

Hernández-Hernández A, Ortiz R, Ubaldo E, Martínez OM, Vázquez-Nin GH, Recillas-Targa F.

Chromosoma. 2010 Feb;119(1):41-58. doi: 10.1007/s00412-009-0243-3. Epub 2009 Oct 9.


Chromatin structure contribution to the synaptonemal complex formation.

Hernández-Hernández A, Vázquez-Nin GH, Echeverría OM, Recillas-Targa F.

Cell Mol Life Sci. 2009 Apr;66(7):1198-208. doi: 10.1007/s00018-008-8584-2. Review.


Erythrocyte and platelet phospholipid fatty acids as markers of advanced non-small cell lung cancer: comparison with serum levels of sialic acid, TPS and Cyfra 21-1.

de Castro J, Rodríguez MC, Martínez-Zorzano VS, Hernández-Hernández A, Llanillo M, Sánchez-Yagüe J.

Cancer Invest. 2008 May;26(4):407-18. doi: 10.1080/07357900701788114.


Changes in the expression and dynamics of SHP-1 and SHP-2 during cerulein-induced acute pancreatitis in rats.

Sarmiento N, Sánchez-Bernal C, Ayra M, Pérez N, Hernández-Hernández A, Calvo JJ, Sánchez-Yagüe J.

Biochim Biophys Acta. 2008 Apr;1782(4):271-9. doi: 10.1016/j.bbadis.2008.01.005. Epub 2008 Feb 9.

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