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Items: 1 to 50 of 179

1.

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model.

Sacher C, Blume T, Beyer L, Peters F, Eckenweber F, Sgobio C, Deussing M, Albert NL, Unterrainer M, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Brzak I, Neumann U, Saito T, Saido TC, Bartenstein P, Rominger A, Herms J, Brendel M.

J Nucl Med. 2019 Jul 13. pii: jnumed.119.227322. doi: 10.2967/jnumed.119.227322. [Epub ahead of print]

PMID:
31302633
2.

Bevacizumab reduces toxicity of reirradiation in recurrent high-grade glioma.

Fleischmann DF, Jenn J, Corradini S, Ruf V, Herms J, Forbrig R, Unterrainer M, Thon N, Kreth FW, Belka C, Niyazi M.

Radiother Oncol. 2019 Jun 25;138:99-105. doi: 10.1016/j.radonc.2019.06.009. [Epub ahead of print]

PMID:
31252301
3.

Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice.

Sgobio C, Sun L, Ding J, Herms J, Lovinger DM, Cai H.

Sci Rep. 2019 Mar 19;9(1):4857. doi: 10.1038/s41598-019-41091-7.

4.

In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model.

Marinković P, Blumenstock S, Goltstein PM, Korzhova V, Peters F, Knebl A, Herms J.

Brain. 2019 Apr 1;142(4):1051-1062. doi: 10.1093/brain/awz035.

PMID:
30847469
5.

Translational control in brain pathologies: biological significance and therapeutic opportunities.

Delaidelli A, Jan A, Herms J, Sorensen PH.

Acta Neuropathol. 2019 Apr;137(4):535-555. doi: 10.1007/s00401-019-01971-8. Epub 2019 Feb 9. Review.

PMID:
30739199
6.

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Pottier C, Ren Y, Perkerson RB 3rd, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL 3rd, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R.

Acta Neuropathol. 2019 Jun;137(6):879-899. doi: 10.1007/s00401-019-01962-9. Epub 2019 Feb 9.

PMID:
30739198
7.

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR.

Nat Med. 2019 Mar;25(3):529. doi: 10.1038/s41591-019-0378-6.

PMID:
30718908
8.

ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR.

Nat Med. 2019 Mar;25(3):496-506. doi: 10.1038/s41591-018-0336-8. Epub 2019 Jan 28. Erratum in: Nat Med. 2019 Feb 4;:.

PMID:
30692699
9.

In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria.

Montagna E, Crux S, Luckner M, Herber J, Colombo AV, Marinković P, Tahirovic S, Lichtenthaler SF, Wanner G, Müller UC, Sgobio C, Herms J.

Glia. 2019 May;67(5):985-998. doi: 10.1002/glia.23584. Epub 2019 Jan 22.

PMID:
30667091
10.

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C.

Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7.

11.

Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation.

Brendel M, Jaworska A, Overhoff F, Blume T, Probst F, Gildehaus FJ, Bartenstein P, Haass C, Bohrmann B, Herms J, Willem M, Rominger A.

Theranostics. 2018 Sep 9;8(18):4957-4968. doi: 10.7150/thno.27868. eCollection 2018.

12.

Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study.

Blume T, Focke C, Peters F, Deussing M, Albert NL, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Ozmen L, Baumann K, Bartenstein P, Rominger A, Herms J, Brendel M.

J Neuroinflammation. 2018 Nov 6;15(1):307. doi: 10.1186/s12974-018-1347-6.

13.

Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice.

Focke C, Blume T, Zott B, Shi Y, Deussing M, Peters F, Schmidt C, Kleinberger G, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Ozmen L, Baumann K, Dorostkar MM, Haass C, Adelsberger H, Herms J, Rominger A, Brendel M.

J Nucl Med. 2019 Apr;60(4):548-554. doi: 10.2967/jnumed.118.217703. Epub 2018 Sep 27.

PMID:
30262517
14.

Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study.

Unterrainer M, Fleischmann DF, Diekmann C, Vomacka L, Lindner S, Vettermann F, Brendel M, Wenter V, Ertl-Wagner B, Herms J, Wetzel C, Rupprecht R, Tonn JC, Belka C, Bartenstein P, Niyazi M, Albert NL.

Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):580-590. doi: 10.1007/s00259-018-4166-1. Epub 2018 Sep 22.

PMID:
30244386
15.

Label-free 3D-CLEM Using Endogenous Tissue Landmarks.

Luckner M, Burgold S, Filser S, Scheungrab M, Niyaz Y, Hummel E, Wanner G, Herms J.

iScience. 2018 Aug 31;6:92-101. doi: 10.1016/j.isci.2018.07.012. Epub 2018 Jul 20.

16.

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.

Xiang X, Piers TM, Wefers B, Zhu K, Mallach A, Brunner B, Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C.

Mol Neurodegener. 2018 Sep 6;13(1):49. doi: 10.1186/s13024-018-0280-6.

17.

BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines.

Blume T, Filser S, Jaworska A, Blain JF, Koenig G, Moschke K, Lichtenthaler SF, Herms J.

Front Aging Neurosci. 2018 Jul 26;10:229. doi: 10.3389/fnagi.2018.00229. eCollection 2018.

18.

The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP).

Rammes G, Seeser F, Mattusch K, Zhu K, Haas L, Kummer M, Heneka M, Herms J, Parsons CG.

Neuropharmacology. 2018 Sep 15;140:184-192. doi: 10.1016/j.neuropharm.2018.07.021. Epub 2018 Aug 11.

PMID:
30016667
19.

The USP8 mutational status may predict long-term remission in patients with Cushing's disease.

Albani A, Pérez-Rivas LG, Dimopoulou C, Zopp S, Colón-Bolea P, Roeber S, Honegger J, Flitsch J, Rachinger W, Buchfelder M, Stalla GK, Herms J, Reincke M, Theodoropoulou M.

Clin Endocrinol (Oxf). 2018 Jun 29. doi: 10.1111/cen.13802. [Epub ahead of print]

PMID:
29957855
20.

Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function.

Zhu K, Peters F, Filser S, Herms J.

Biol Psychiatry. 2018 Oct 1;84(7):478-487. doi: 10.1016/j.biopsych.2018.04.022. Epub 2018 Jun 23. Review.

PMID:
29945719
21.

Tcf4 regulates dendritic spine density and morphology in the adult brain.

Crux S, Herms J, Dorostkar MM.

PLoS One. 2018 Jun 22;13(6):e0199359. doi: 10.1371/journal.pone.0199359. eCollection 2018.

22.

Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology.

Brendel M, Yousefi BH, Blume T, Herz M, Focke C, Deussing M, Peters F, Lindner S, von Ungern-Sternberg B, Drzezga A, Bartenstein P, Haass C, Okamura N, Herms J, Yakushev I, Rominger A.

Front Aging Neurosci. 2018 Jun 7;10:174. doi: 10.3389/fnagi.2018.00174. eCollection 2018.

23.

Data on specificity of [18F]GE180 uptake for TSPO expression in rodent brain and myocardium.

Deussing M, Blume T, Vomacka L, Mahler C, Focke C, Todica A, Unterrainer M, Albert NL, Lindner S, von Ungern-Sternberg B, Baumann K, Zwergal A, Bartenstein P, Herms J, Rominger A, Brendel M.

Data Brief. 2018 May 5;19:331-336. doi: 10.1016/j.dib.2018.04.133. eCollection 2018 Aug.

24.

Correction to: Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status.

Unterrainer M, Winkelmann I, Suchorska B, Giese A, Wenter V, Kreth FW, Herms J, Bartenstein P, Tonn JC, Albert NL.

Eur J Nucl Med Mol Imaging. 2018 Jun;45(6):1078. doi: 10.1007/s00259-018-3991-6.

PMID:
29541813
25.

Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status.

Unterrainer M, Winkelmann I, Suchorska B, Giese A, Wenter V, Kreth FW, Herms J, Bartenstein P, Tonn JC, Albert NL.

Eur J Nucl Med Mol Imaging. 2018 Jul;45(7):1242-1249. doi: 10.1007/s00259-018-3969-4. Epub 2018 Feb 27. Erratum in: Eur J Nucl Med Mol Imaging. 2018 Mar 15;:.

PMID:
29487977
26.

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology.

Peters F, Salihoglu H, Rodrigues E, Herzog E, Blume T, Filser S, Dorostkar M, Shimshek DR, Brose N, Neumann U, Herms J.

Acta Neuropathol. 2018 May;135(5):695-710. doi: 10.1007/s00401-017-1804-9. Epub 2018 Jan 11.

27.

Coupling between physiological TSPO expression in brain and myocardium allows stabilization of late-phase cerebral [18F]GE180 PET quantification.

Deussing M, Blume T, Vomacka L, Mahler C, Focke C, Todica A, Unterrainer M, Albert NL, Lindner S, von Ungern-Sternberg B, Baumann K, Zwergal A, Bartenstein P, Herms J, Rominger A, Brendel M.

Neuroimage. 2018 Jan 15;165:83-91. doi: 10.1016/j.neuroimage.2017.10.006. Epub 2017 Oct 5.

PMID:
28988133
28.

Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex.

Ahlfeld J, Filser S, Schmidt F, Wefers AK, Merk DJ, Glaß R, Herms J, Schüller U.

Sci Rep. 2017 Jul 21;7(1):6137. doi: 10.1038/s41598-017-06150-x.

29.

Chip-on-the-tip compact flexible endoscopic epifluorescence video-microscope for in-vivo imaging in medicine and biomedical research.

Matz G, Messerschmidt B, Göbel W, Filser S, Betz CS, Kirsch M, Uckermann O, Kunze M, Flämig S, Ehrhardt A, Irion KM, Haack M, Dorostkar MM, Herms J, Gross H.

Biomed Opt Express. 2017 Jun 20;8(7):3329-3342. doi: 10.1364/BOE.8.003329. eCollection 2017 Jul 1.

30.

Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study.

Brendel M, Focke C, Blume T, Peters F, Deussing M, Probst F, Jaworska A, Overhoff F, Albert N, Lindner S, von Ungern-Sternberg B, Bartenstein P, Haass C, Kleinberger G, Herms J, Rominger A.

J Nucl Med. 2017 Dec;58(12):1984-1990. doi: 10.2967/jnumed.117.195107. Epub 2017 Jul 13.

31.

In vivo imaging of retinal neurodegeneration at the single cell level in humans.

Herms J, Schön C.

Brain. 2017 Jun 1;140(6):1542-1543. doi: 10.1093/brain/awx100. No abstract available.

PMID:
28549130
32.

The Role of APP in Structural Spine Plasticity.

Montagna E, Dorostkar MM, Herms J.

Front Mol Neurosci. 2017 May 10;10:136. doi: 10.3389/fnmol.2017.00136. eCollection 2017. Review.

33.

Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex.

Blumenstock S, Rodrigues EF, Peters F, Blazquez-Llorca L, Schmidt F, Giese A, Herms J.

EMBO Mol Med. 2017 May;9(5):716-731. doi: 10.15252/emmm.201607305.

34.

Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis.

Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, Herms J, Haass C, Rominger A.

Front Aging Neurosci. 2017 Jan 31;9:8. doi: 10.3389/fnagi.2017.00008. eCollection 2017.

35.

Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD).

Rammes G, Mattusch C, Wulff M, Seeser F, Kreuzer M, Zhu K, Deussing JM, Herms J, Parsons CG.

Neuropharmacology. 2017 Sep 1;123:100-115. doi: 10.1016/j.neuropharm.2017.02.003. Epub 2017 Feb 4.

PMID:
28174113
36.

High plasticity of axonal pathology in Alzheimer's disease mouse models.

Blazquez-Llorca L, Valero-Freitag S, Rodrigues EF, Merchán-Pérez Á, Rodríguez JR, Dorostkar MM, DeFelipe J, Herms J.

Acta Neuropathol Commun. 2017 Feb 7;5(1):14. doi: 10.1186/s40478-017-0415-y.

37.

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J.

Biol Psychiatry. 2018 Mar 1;83(5):428-437. doi: 10.1016/j.biopsych.2016.12.023. Epub 2016 Dec 26.

38.

In Vivo Imaging of Tau Aggregates in the Mouse Retina.

Schön C, Herms J.

Methods Mol Biol. 2017;1523:361-368.

PMID:
27975264
39.

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis.

Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Müller UC, Herms J.

EMBO J. 2016 Oct 17;35(20):2213-2222. Epub 2016 Aug 29.

40.

Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors.

Ovsepian SV, Blazquez-Llorca L, Freitag SV, Rodrigues EF, Herms J.

Cereb Cortex. 2017 Oct 1;27(10):4733-4749. doi: 10.1093/cercor/bhw267.

PMID:
27600841
41.

Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice.

Overhoff F, Brendel M, Jaworska A, Korzhova V, Delker A, Probst F, Focke C, Gildehaus FJ, Carlsen J, Baumann K, Haass C, Bartenstein P, Herms J, Rominger A.

Front Neurosci. 2016 Feb 29;10:45. doi: 10.3389/fnins.2016.00045. eCollection 2016.

42.

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models.

Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, Van Leuven F, Okamura N, Herms J, Rominger A.

J Nucl Med. 2016 May;57(5):792-8. doi: 10.2967/jnumed.115.163493. Epub 2016 Feb 11.

43.

Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study.

Brendel M, Probst F, Jaworska A, Overhoff F, Korzhova V, Albert NL, Beck R, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Kleinberger G, Haass C, Herms J, Rominger A.

J Nucl Med. 2016 Jun;57(6):954-60. doi: 10.2967/jnumed.115.167858. Epub 2016 Feb 18.

44.

Dendritic Spine Pathology in Neurodegenerative Diseases.

Herms J, Dorostkar MM.

Annu Rev Pathol. 2016 May 23;11:221-50. doi: 10.1146/annurev-pathol-012615-044216. Epub 2016 Feb 22. Review.

PMID:
26907528
45.

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.

Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S.

Hum Mol Genet. 2016 Mar 15;25(6):1165-75. doi: 10.1093/hmg/ddv639. Epub 2016 Jan 5.

PMID:
26740549
46.

Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease.

Zou C, Shi Y, Ohli J, Schüller U, Dorostkar MM, Herms J.

Acta Neuropathol. 2016 Feb;131(2):235-246. doi: 10.1007/s00401-015-1527-8. Epub 2016 Jan 2.

47.

Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET.

Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A.

Mol Psychiatry. 2015 Oct;20(10):1141. doi: 10.1038/mp.2015.146. No abstract available.

PMID:
26401838
48.

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.

49.

Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities.

Dorostkar MM, Zou C, Blazquez-Llorca L, Herms J.

Acta Neuropathol. 2015 Jul;130(1):1-19. doi: 10.1007/s00401-015-1449-5. Epub 2015 Jun 11. Review.

50.

Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment.

Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A.

Mol Psychiatry. 2015 Oct;20(10):1179-87. doi: 10.1038/mp.2015.74. Epub 2015 Jun 9.

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