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Items: 1 to 50 of 120

1.

Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implications for Biofilm Formation.

Mahasenan KV, Batuecas MT, De Benedetti S, Kim C, Rana N, Lee M, Hesek D, Fisher JF, Sanz-Aparicio J, Hermoso JA, Mobashery S.

ACS Chem Biol. 2020 Jan 17;15(1):189-196. doi: 10.1021/acschembio.9b00754. Epub 2020 Jan 7.

PMID:
31877028
2.

Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division.

Alcorlo M, Dik DA, De Benedetti S, Mahasenan KV, Lee M, Domínguez-Gil T, Hesek D, Lastochkin E, López D, Boggess B, Mobashery S, Hermoso JA.

Nat Commun. 2019 Dec 5;10(1):5567. doi: 10.1038/s41467-019-13354-4.

3.

Disulfide Engineered Lipase to Enhance the Catalytic Activity: A Structure-Based Approach on BTL2.

Godoy CA, Klett J, Di Geronimo B, Hermoso JA, Guisán JM, Carrasco-López C.

Int J Mol Sci. 2019 Oct 23;20(21). pii: E5245. doi: 10.3390/ijms20215245.

4.

Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin.

Flydal MI, Alcorlo-Pagés M, Johannessen FG, Martínez-Caballero S, Skjærven L, Fernandez-Leiro R, Martinez A, Hermoso JA.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11229-11234. doi: 10.1073/pnas.1902639116. Epub 2019 May 22.

5.

Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase.

Revuelto A, Ruiz-Santaquiteria M, de Lucio H, Gamo A, Carriles AA, Gutiérrez KJ, Sánchez-Murcia PA, Hermoso JA, Gago F, Camarasa MJ, Jiménez-Ruiz A, Velázquez S.

ACS Infect Dis. 2019 Jun 14;5(6):873-891. doi: 10.1021/acsinfecdis.8b00355. Epub 2019 Apr 23.

PMID:
30983322
6.

Cold-induced aldimine bond cleavage by Tris in Bacillus subtilis alanine racemase.

Bernardo-García N, Sánchez-Murcia PA, Espaillat A, Martínez-Caballero S, Cava F, Hermoso JA, Gago F.

Org Biomol Chem. 2019 Apr 24;17(17):4350-4358. doi: 10.1039/c9ob00223e.

PMID:
30977502
7.

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.

Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02637-18. doi: 10.1128/AAC.02637-18. Print 2019 May.

8.

Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae.

Rued BE, Alcorlo M, Edmonds KA, Martínez-Caballero S, Straume D, Fu Y, Bruce KE, Wu H, Håvarstein LS, Hermoso JA, Winkler ME, Giedroc DP.

mBio. 2019 Jan 29;10(1). pii: e02622-18. doi: 10.1128/mBio.02622-18.

9.

A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.

Dik DA, Batuecas MT, Lee M, Mahasenan KV, Marous DR, Lastochkin E, Fisher JF, Hermoso JA, Mobashery S.

Biochemistry. 2018 Oct 23;57(42):6090-6098. doi: 10.1021/acs.biochem.8b00800. Epub 2018 Oct 10.

PMID:
30256085
10.

Exploiting distant homologues for phasing through the generation of compact fragments, local fold refinement and partial solution combination.

Millán C, Sammito MD, McCoy AJ, Nascimento AFZ, Petrillo G, Oeffner RD, Domínguez-Gil T, Hermoso JA, Read RJ, Usón I.

Acta Crystallogr D Struct Biol. 2018 Apr 1;74(Pt 4):290-304. doi: 10.1107/S2059798318001365. Epub 2018 Apr 3.

11.

Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa.

Lee M, Batuecas MT, Tomoshige S, Domínguez-Gil T, Mahasenan KV, Dik DA, Hesek D, Millán C, Usón I, Lastochkin E, Hermoso JA, Mobashery S.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4393-4398. doi: 10.1073/pnas.1801298115. Epub 2018 Apr 9.

12.

Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.

Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S.

Sci Rep. 2018 Mar 7;8(1):4110. doi: 10.1038/s41598-018-22527-y.

13.

Structural insights into the binding and catalytic mechanisms of the Listeria monocytogenes bacteriophage glycosyl hydrolase PlyP40.

Romero P, Bartual SG, Schmelcher M, Glück C, Hermoso JA, Loessner MJ.

Mol Microbiol. 2018 Apr;108(2):128-142. doi: 10.1111/mmi.13922. Epub 2018 Mar 6.

14.

Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.

Bernardo-García N, Mahasenan KV, Batuecas MT, Lee M, Hesek D, Petráčková D, Doubravová L, Branny P, Mobashery S, Hermoso JA.

ACS Chem Biol. 2018 Mar 16;13(3):694-702. doi: 10.1021/acschembio.7b00817. Epub 2018 Jan 30.

PMID:
29357220
15.

Deciphering how Cpl-7 cell wall-binding repeats recognize the bacterial peptidoglycan.

Bustamante N, Iglesias-Bexiga M, Bernardo-García N, Silva-Martín N, García G, Campanero-Rhodes MA, García E, Usón I, Buey RM, García P, Hermoso JA, Bruix M, Menéndez M.

Sci Rep. 2017 Nov 28;7(1):16494. doi: 10.1038/s41598-017-16392-4.

16.

X-ray Structure of Catenated Lytic Transglycosylase SltB1.

Domínguez-Gil T, Molina R, Dik DA, Spink E, Mobashery S, Hermoso JA.

Biochemistry. 2017 Dec 5;56(48):6317-6320. doi: 10.1021/acs.biochem.7b00932. Epub 2017 Nov 16.

17.

Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus.

Bartual SG, Alcorlo M, Martínez-Caballero S, Molina R, Hermoso JA.

Int J Med Microbiol. 2018 Aug;308(6):692-704. doi: 10.1016/j.ijmm.2017.10.003. Epub 2017 Oct 27. Review.

PMID:
29100886
18.

A single amino acid polymorphism in the glycosyltransferase CpsK defines four Streptococcus suis serotypes.

Roy D, Athey TBT, Auger JP, Goyette-Desjardins G, Van Calsteren MR, Takamatsu D, Okura M, Teatero S, Alcorlo M, Hermoso JA, Segura M, Gottschalk M, Fittipaldi N.

Sci Rep. 2017 Jun 22;7(1):4066. doi: 10.1038/s41598-017-04403-3.

19.

Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.

Acebrón I, Mahasenan KV, De Benedetti S, Lee M, Artola-Recolons C, Hesek D, Wang H, Hermoso JA, Mobashery S.

J Am Chem Soc. 2017 May 24;139(20):6795-6798. doi: 10.1021/jacs.7b01626. Epub 2017 May 10.

20.

Carbohydrate recognition and lysis by bacterial peptidoglycan hydrolases.

Alcorlo M, Martínez-Caballero S, Molina R, Hermoso JA.

Curr Opin Struct Biol. 2017 Jun;44:87-100. doi: 10.1016/j.sbi.2017.01.001. Epub 2017 Jan 19. Review.

PMID:
28109980
21.

Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2017 Feb 8;139(5):2102-2110. doi: 10.1021/jacs.6b12565. Epub 2017 Jan 27.

22.

Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa.

Dik DA, Domínguez-Gil T, Lee M, Hesek D, Byun B, Fishovitz J, Boggess B, Hellman LM, Fisher JF, Hermoso JA, Mobashery S.

J Am Chem Soc. 2017 Feb 1;139(4):1448-1451. doi: 10.1021/jacs.6b12819. Epub 2017 Jan 17.

23.

Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis.

Gutiérrez-Fernández J, Saleh M, Alcorlo M, Gómez-Mejía A, Pantoja-Uceda D, Treviño MA, Voß F, Abdullah MR, Galán-Bartual S, Seinen J, Sánchez-Murcia PA, Gago F, Bruix M, Hammerschmidt S, Hermoso JA.

Sci Rep. 2016 Dec 5;6:38094. doi: 10.1038/srep38094.

24.

Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa.

Lee M, Domínguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S.

ACS Chem Biol. 2016 Oct 21;11(10):2936. Epub 2016 Sep 6. No abstract available.

PMID:
27599239
25.

Renew or die: The molecular mechanisms of peptidoglycan recycling and antibiotic resistance in Gram-negative pathogens.

Domínguez-Gil T, Molina R, Alcorlo M, Hermoso JA.

Drug Resist Updat. 2016 Sep;28:91-104. doi: 10.1016/j.drup.2016.07.002. Epub 2016 Jul 29. Review.

PMID:
27620957
26.

Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa.

Domínguez-Gil T, Lee M, Acebrón-Avalos I, Mahasenan KV, Hesek D, Dik DA, Byun B, Lastochkin E, Fisher JF, Mobashery S, Hermoso JA.

Structure. 2016 Oct 4;24(10):1729-1741. doi: 10.1016/j.str.2016.07.019. Epub 2016 Sep 8.

27.

Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria.

Rivera I, Molina R, Lee M, Mobashery S, Hermoso JA.

Microb Drug Resist. 2016 Sep;22(6):470-6. doi: 10.1089/mdr.2016.0083. Epub 2016 Jun 21. Review.

28.

Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa.

Lee M, Domínguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S.

ACS Chem Biol. 2016 Jun 17;11(6):1525-31. doi: 10.1021/acschembio.6b00194. Epub 2016 Apr 11. Erratum in: ACS Chem Biol. 2016 Oct 21;11(10 ):2936.

29.

Structural insights into the synthesis of FMN in prokaryotic organisms.

Herguedas B, Lans I, Sebastián M, Hermoso JA, Martínez-Júlvez M, Medina M.

Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2526-42. doi: 10.1107/S1399004715019641. Epub 2015 Nov 27.

PMID:
26627660
30.

Synthesis of a heterogeneous artificial metallolipase with chimeric catalytic activity.

Filice M, Romero O, Gutiérrez-Fernández J, de Las Rivas B, Hermoso JA, Palomo JM.

Chem Commun (Camb). 2015 Jun 7;51(45):9324-7. doi: 10.1039/c5cc02450a.

PMID:
25960359
31.
32.

Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.

Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2015 Feb 11;137(5):1738-41. doi: 10.1021/jacs.5b00056. Epub 2015 Feb 2.

33.

Structural basis for selective recognition of endogenous and microbial polysaccharides by macrophage receptor SIGN-R1.

Silva-Martín N, Bartual SG, Ramírez-Aportela E, Chacón P, Park CG, Hermoso JA.

Structure. 2014 Nov 4;22(11):1595-606.

34.

Crystal structures of Ophiostoma piceae sterol esterase: structural insights into activation mechanism and product release.

Gutiérrez-Fernández J, Vaquero ME, Prieto A, Barriuso J, Martínez MJ, Hermoso JA.

J Struct Biol. 2014 Sep;187(3):215-222. doi: 10.1016/j.jsb.2014.07.007. Epub 2014 Aug 7.

35.

Comparative study of two GH19 chitinase-like proteins from Hevea brasiliensis, one exhibiting a novel carbohydrate-binding domain.

Martínez-Caballero S, Cano-Sánchez P, Mares-Mejía I, Díaz-Sánchez AG, Macías-Rubalcava ML, Hermoso JA, Rodríguez-Romero A.

FEBS J. 2014 Oct;281(19):4535-54. doi: 10.1111/febs.12962. Epub 2014 Sep 6.

36.

Structure of the pneumococcal l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB.

Abdullah MR, Gutiérrez-Fernández J, Pribyl T, Gisch N, Saleh M, Rohde M, Petruschka L, Burchhardt G, Schwudke D, Hermoso JA, Hammerschmidt S.

Mol Microbiol. 2014 Sep;93(6):1183-206. doi: 10.1111/mmi.12729. Epub 2014 Aug 14.

37.

Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

Fishovitz J, Hermoso JA, Chang M, Mobashery S.

IUBMB Life. 2014 Aug;66(8):572-7. doi: 10.1002/iub.1289. Epub 2014 Jul 14. Review.

38.

Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli.

Artola-Recolons C, Lee M, Bernardo-García N, Blázquez B, Hesek D, Bartual SG, Mahasenan KV, Lastochkin E, Pi H, Boggess B, Meindl K, Usón I, Fisher JF, Mobashery S, Hermoso JA.

ACS Chem Biol. 2014 Sep 19;9(9):2058-66. doi: 10.1021/cb500439c. Epub 2014 Jul 10.

39.

Structure solution with ARCIMBOLDO using fragments derived from distant homology models.

Sammito M, Meindl K, de Ilarduya IM, Millán C, Artola-Recolons C, Hermoso JA, Usón I.

FEBS J. 2014 Sep;281(18):4029-45. doi: 10.1111/febs.12897. Epub 2014 Sep 6.

40.

Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics.

Fishovitz J, Rojas-Altuve A, Otero LH, Dawley M, Carrasco-López C, Chang M, Hermoso JA, Mobashery S.

J Am Chem Soc. 2014 Jul 16;136(28):9814-7. doi: 10.1021/ja5030657. Epub 2014 Jul 2.

41.

A complement to the modern crystallographer's toolbox: caged gadolinium complexes with versatile binding modes.

Stelter M, Molina R, Jeudy S, Kahn R, Abergel C, Hermoso JA.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1506-16. doi: 10.1107/S1399004714005483. Epub 2014 May 23.

PMID:
24914962
42.

Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor.

Ferreira P, Villanueva R, Martínez-Júlvez M, Herguedas B, Marcuello C, Fernandez-Silva P, Cabon L, Hermoso JA, Lostao A, Susin SA, Medina M.

Biochemistry. 2014 Jul 1;53(25):4204-15. doi: 10.1021/bi500343r. Epub 2014 Jun 20.

PMID:
24914854
43.

Structural basis of PcsB-mediated cell separation in Streptococcus pneumoniae.

Bartual SG, Straume D, Stamsås GA, Muñoz IG, Alfonso C, Martínez-Ripoll M, Håvarstein LS, Hermoso JA.

Nat Commun. 2014 May 8;5:3842. doi: 10.1038/ncomms4842.

44.

Peptidoglycan remodeling by the coordinated action of multispecific enzymes.

Alvarez L, Espaillat A, Hermoso JA, de Pedro MA, Cava F.

Microb Drug Resist. 2014 Jun;20(3):190-8. doi: 10.1089/mdr.2014.0047. Epub 2014 May 5. Review.

45.

Getting CAD in shape: the atomic structure of human dihydroorotase domain.

Hermoso JA.

Structure. 2014 Feb 4;22(2):179-81. doi: 10.1016/j.str.2014.01.005.

46.

Structural basis for the broad specificity of a new family of amino-acid racemases.

Espaillat A, Carrasco-López C, Bernardo-García N, Pietrosemoli N, Otero LH, Álvarez L, de Pedro MA, Pazos F, Davis BM, Waldor MK, Hermoso JA, Cava F.

Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):79-90. doi: 10.1107/S1399004713024838. Epub 2013 Dec 24.

47.

Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

Fulde M, Bernardo-García N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S.

Thromb Haemost. 2014 Mar 3;111(3):401-16. doi: 10.1160/TH13-05-0421. Epub 2013 Nov 7.

PMID:
24196407
48.

Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence.

Saleh M, Bartual SG, Abdullah MR, Jensch I, Asmat TM, Petruschka L, Pribyl T, Gellert M, Lillig CH, Antelmann H, Hermoso JA, Hammerschmidt S.

EMBO Mol Med. 2013 Dec;5(12):1852-70. doi: 10.1002/emmm.201202435. Epub 2013 Oct 18.

49.

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.

Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-López C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16808-13. doi: 10.1073/pnas.1300118110. Epub 2013 Oct 1.

50.

Crystal structures of CbpF complexed with atropine and ipratropium reveal clues for the design of novel antimicrobials against Streptococcus pneumoniae.

Silva-Martín N, Retamosa MG, Maestro B, Bartual SG, Rodes MJ, García P, Sanz JM, Hermoso JA.

Biochim Biophys Acta. 2014 Jan;1840(1):129-35. doi: 10.1016/j.bbagen.2013.09.006. Epub 2013 Sep 11.

PMID:
24036328

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