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Items: 14

1.

Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy.

Peyser BD, Hermone A, Salamoun JM, Burnett JC, Hollingshead MG, McGrath CF, Gussio R, Wipf P.

Mol Cancer Ther. 2019 Oct;18(10):1765-1774. doi: 10.1158/1535-7163.MCT-19-0185. Epub 2019 Jul 24.

PMID:
31341033
2.

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.

Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P.

Org Biomol Chem. 2017 May 16;15(19):4096-4114. doi: 10.1039/c7ob00526a.

3.
4.

A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.

Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Cheng EH, Hsieh JJ.

Cancer Res. 2012 Feb 1;72(3):736-46. doi: 10.1158/0008-5472.CAN-11-2584. Epub 2011 Dec 13.

5.

Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.

Burnett JC, Wang C, Nuss JE, Nguyen TL, Hermone AR, Schmidt JJ, Gussio R, Wipf P, Bavari S.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5811-3. doi: 10.1016/j.bmcl.2009.01.111. Epub 2009 Feb 13.

PMID:
19703771
6.

Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore.

Hermone AR, Burnett JC, Nuss JE, Tressler LE, Nguyen TL, Solaja BA, Vennerstrom JL, Schmidt JJ, Wipf P, Bavari S, Gussio R.

ChemMedChem. 2008 Dec;3(12):1905-12. doi: 10.1002/cmdc.200800241.

PMID:
19006141
7.

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.

Burnett JC, Opsenica D, Sriraghavan K, Panchal RG, Ruthel G, Hermone AR, Nguyen TL, Kenny TA, Lane DJ, McGrath CF, Schmidt JJ, Vennerstrom JL, Gussio R, Solaja BA, Bavari S.

J Med Chem. 2007 May 3;50(9):2127-36. Epub 2007 Apr 7.

PMID:
17417831
8.

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.

Burnett JC, Ruthel G, Stegmann CM, Panchal RG, Nguyen TL, Hermone AR, Stafford RG, Lane DJ, Kenny TA, McGrath CF, Wipf P, Stahl AM, Schmidt JJ, Gussio R, Brunger AT, Bavari S.

J Biol Chem. 2007 Feb 16;282(7):5004-14. Epub 2006 Nov 8.

9.

A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.

Nguyen TL, McGrath C, Hermone AR, Burnett JC, Zaharevitz DW, Day BW, Wipf P, Hamel E, Gussio R.

J Med Chem. 2005 Sep 22;48(19):6107-16. Erratum in: J Med Chem. 2005 Dec 1;48(24):7917.

PMID:
16162011
10.

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

Nguyen TL, Schoehn G, Weissenhorn W, Hermone AR, Burnett JC, Panchal RG, McGrath C, Zaharevitz DW, Aman MJ, Gussio R, Bavari S.

J Struct Biol. 2005 Jul;151(1):30-40.

PMID:
15908231
11.

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Burnett JC, Schmidt JJ, McGrath CF, Nguyen TL, Hermone AR, Panchal RG, Vennerstrom JL, Kodukula K, Zaharevitz DW, Gussio R, Bavari S.

Bioorg Med Chem. 2005 Jan 17;13(2):333-41.

PMID:
15598556
12.

Identification of small molecule inhibitors of anthrax lethal factor.

Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, Liddington RC, Gussio R, Bavari S.

Nat Struct Mol Biol. 2004 Jan;11(1):67-72. Epub 2003 Dec 29.

PMID:
14718925
13.

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S.

Biochem Biophys Res Commun. 2003 Oct 10;310(1):84-93.

PMID:
14511652
14.

Free-energy simulations of the retinal cis --> trans isomerization in bacteriorhodopsin.

Hermone A, Kuczera K.

Biochemistry. 1998 Mar 3;37(9):2843-53.

PMID:
9485435

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