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Items: 1 to 50 of 53

1.

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.

Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt MV, Hermanns HM, Goebeler M, Meierjohann S, Houben R, Schrama D.

J Exp Clin Cancer Res. 2019 Sep 11;38(1):397. doi: 10.1186/s13046-019-1403-9.

2.

Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases.

Kiran Gotru S, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A.

Sci Rep. 2019 Jun 6;9(1):8333. doi: 10.1038/s41598-019-44751-w.

3.

Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice.

Jahn D, Dorbath D, Schilling AK, Gildein L, Meier C, Vuille-Dit-Bille RN, Schmitt J, Kraus D, Fleet JC, Hermanns HM, Geier A.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1567-1578. doi: 10.1016/j.bbadis.2019.03.007. Epub 2019 Mar 21.

PMID:
30905785
4.

Beneficial Effects of Vitamin D Treatment in an Obese Mouse Model of Non-Alcoholic Steatohepatitis.

Jahn D, Dorbath D, Kircher S, Nier A, Bergheim I, Lenaerts K, Hermanns HM, Geier A.

Nutrients. 2019 Jan 3;11(1). pii: E77. doi: 10.3390/nu11010077.

5.

Fecal SCFAs and SCFA-producing bacteria in gut microbiome of human NAFLD as a putative link to systemic T-cell activation and advanced disease.

Rau M, Rehman A, Dittrich M, Groen AK, Hermanns HM, Seyfried F, Beyersdorf N, Dandekar T, Rosenstiel P, Geier A.

United European Gastroenterol J. 2018 Dec;6(10):1496-1507. doi: 10.1177/2050640618804444. Epub 2018 Sep 30.

6.

The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies.

Rolvering C, Zimmer AD, Ginolhac A, Margue C, Kirchmeyer M, Servais F, Hermanns HM, Hergovits S, Nazarov PV, Nicot N, Kreis S, Haan S, Behrmann I, Haan C.

J Leukoc Biol. 2018 Nov;104(5):969-985. doi: 10.1002/JLB.MA1217-495R. Epub 2018 Jul 24.

PMID:
30040142
7.

Animal models of NAFLD from a hepatologist's point of view.

Jahn D, Kircher S, Hermanns HM, Geier A.

Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):943-953. doi: 10.1016/j.bbadis.2018.06.023. Epub 2018 Jul 7. Review.

PMID:
29990551
8.

Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice.

Gotru SK, Gil-Pulido J, Beyersdorf N, Diefenbach A, Becker IC, Vögtle T, Remer K, Chubanov V, Gudermann T, Hermanns HM, Nieswandt B, Kerkau T, Zernecke A, Braun A.

J Immunol. 2018 Apr 15;200(8):2529-2534. doi: 10.4049/jimmunol.1701467. Epub 2018 Mar 26.

9.

Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function.

Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote AL, Potter SJ, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan C, Eyrich M, Hermanns HM, Geissler EK, Lutz MB.

Blood Adv. 2017 Jun 7;1(14):947-960. doi: 10.1182/bloodadvances.2017006858. eCollection 2017 Jun 13.

10.

TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.

Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):344-352. doi: 10.1161/ATVBAHA.117.310391. Epub 2017 Nov 16.

PMID:
29146750
11.

Oncostatin M induces RIG-I and MDA5 expression and enhances the double-stranded RNA response in fibroblasts.

Hergovits S, Mais C, Haan C, Costa-Pereira AP, Hermanns HM.

J Cell Mol Med. 2017 Nov;21(11):3087-3099. doi: 10.1111/jcmm.13221. Epub 2017 May 30.

12.

Interleukin-6: The dark side of liver regeneration in chronic liver disease.

Geier A, Jahn D, Hermanns HM.

Hepatology. 2017 Aug;66(2):667-668. doi: 10.1002/hep.29136. Epub 2017 Jul 4. No abstract available.

PMID:
28247995
13.

Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines.

Rolvering C, Zimmer AD, Kozar I, Hermanns HM, Letellier E, Vallar L, Nazarov PV, Nicot N, Ginolhac A, Haan S, Behrmann I, Haan C.

Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):516-526. doi: 10.1016/j.bbamcr.2016.12.006. Epub 2016 Dec 9.

14.

Non-Alcoholic Steatohepatitis: From Pathophysiology to Novel Therapies.

Jahn D, Rau M, Wohlfahrt J, Hermanns HM, Geier A.

Dig Dis. 2016;34(4):356-63. doi: 10.1159/000444547. Epub 2016 May 11.

PMID:
27170389
15.

Endocytosis of pro-inflammatory cytokine receptors and its relevance for signal transduction.

Hermanns HM, Wohlfahrt J, Mais C, Hergovits S, Jahn D, Geier A.

Biol Chem. 2016 Aug 1;397(8):695-708. doi: 10.1515/hsz-2015-0277. Review.

PMID:
27071147
16.

Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice.

Wolf K, Braun A, Haining EJ, Tseng YL, Kraft P, Schuhmann MK, Gotru SK, Chen W, Hermanns HM, Stoll G, Lesch KP, Nieswandt B.

PLoS One. 2016 Jan 22;11(1):e0147664. doi: 10.1371/journal.pone.0147664. eCollection 2016.

17.

Interferon Alpha Signalling and Its Relevance for the Upregulatory Effect of Transporter Proteins Associated with Antigen Processing (TAP) in Patients with Malignant Melanoma.

Heise R, Amann PM, Ensslen S, Marquardt Y, Czaja K, Joussen S, Beer D, Abele R, Plewnia G, Tampé R, Merk HF, Hermanns HM, Baron JM.

PLoS One. 2016 Jan 6;11(1):e0146325. doi: 10.1371/journal.pone.0146325. eCollection 2016.

18.

Farnesoid X receptor-dependent and -independent pathways mediate the transcriptional control of human fibroblast growth factor 19 by vitamin A.

Jahn D, Sutor D, Dorbath D, Weiß J, Götze O, Schmitt J, Hermanns HM, Geier A.

Biochim Biophys Acta. 2016 Feb;1859(2):381-92. doi: 10.1016/j.bbagrm.2015.12.007. Epub 2015 Dec 23.

PMID:
26723851
19.

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver.

Rau M, Schilling AK, Meertens J, Hering I, Weiss J, Jurowich C, Kudlich T, Hermanns HM, Bantel H, Beyersdorf N, Geier A.

J Immunol. 2016 Jan 1;196(1):97-105. doi: 10.4049/jimmunol.1501175. Epub 2015 Nov 30.

20.

Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice.

Chaudhari SM, Sluimer JC, Koch M, Theelen TL, Manthey HD, Busch M, Caballero-Franco C, Vogel F, Cochain C, Pelisek J, Daemen MJ, Lutz MB, Görlach A, Kissler S, Hermanns HM, Zernecke A.

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2316-25. doi: 10.1161/ATVBAHA.115.306171. Epub 2015 Sep 24.

21.

Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease.

Jahn D, Rau M, Hermanns HM, Geier A.

Cytokine Growth Factor Rev. 2015 Dec;26(6):625-35. doi: 10.1016/j.cytogfr.2015.07.016. Epub 2015 Jul 28. Review.

PMID:
26250749
22.

Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.

Hermanns HM.

Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58. doi: 10.1016/j.cytogfr.2015.07.006. Epub 2015 Jul 3. Review.

PMID:
26198770
23.

Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets.

Chen W, Thielmann I, Gupta S, Subramanian H, Stegner D, van Kruchten R, Dietrich A, Gambaryan S, Heemskerk JW, Hermanns HM, Nieswandt B, Braun A.

J Thromb Haemost. 2014 Apr;12(4):528-39. doi: 10.1111/jth.12525.

24.

IL-4 analogues with site-specific chemical modification at position 121 inhibit IL-4 and IL-13 biological activities.

Duppatla V, Gjorgjevikj M, Schmitz W, Hermanns HM, Schäfer CM, Kottmair M, Müller T, Sebald W.

Bioconjug Chem. 2014 Jan 15;25(1):52-62. doi: 10.1021/bc400307k. Epub 2013 Dec 31.

PMID:
24341642
25.

Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.

Dütting S, Vögtle T, Morowski M, Schiessl S, Schäfer CM, Watson SK, Hughes CE, Ackermann JA, Radtke D, Hermanns HM, Watson SP, Nitschke L, Nieswandt B.

Circ Res. 2014 Jan 31;114(3):444-453. doi: 10.1161/CIRCRESAHA.114.302670. Epub 2013 Nov 21.

26.

Control of gp130 expression by the mitogen-activated protein kinase ERK2.

Bonito NA, Drechsler J, Stoecker S, Carmo CR, Seckl MJ, Hermanns HM, Costa-Pereira AP.

Oncogene. 2014 Apr 24;33(17):2255-63. doi: 10.1038/onc.2013.159. Epub 2013 May 20.

PMID:
23686311
27.

The crystal structure of the protein-disulfide isomerase family member ERp27 provides insights into its substrate binding capabilities.

Kober FX, Koelmel W, Kuper J, Drechsler J, Mais C, Hermanns HM, Schindelin H.

J Biol Chem. 2013 Jan 18;288(3):2029-39. doi: 10.1074/jbc.M112.410522. Epub 2012 Nov 28.

28.

CLP36 is a negative regulator of glycoprotein VI signaling in platelets.

Gupta S, Braun A, Morowski M, Premsler T, Bender M, Nagy Z, Sickmann A, Hermanns HM, Bösl M, Nieswandt B.

Circ Res. 2012 Nov 9;111(11):1410-20. doi: 10.1161/CIRCRESAHA.112.264754. Epub 2012 Sep 5.

PMID:
22955732
29.

Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor.

Drechsler J, Grötzinger J, Hermanns HM.

PLoS One. 2012;7(8):e43155. doi: 10.1371/journal.pone.0043155. Epub 2012 Aug 22.

30.

Plasticity and cross-talk of interleukin 6-type cytokines.

Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J.

Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97. doi: 10.1016/j.cytogfr.2012.04.001. Epub 2012 May 15. Review.

PMID:
22595692
31.

Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.

Radtke S, Wüller S, Yang XP, Lippok BE, Mütze B, Mais C, de Leur HS, Bode JG, Gaestel M, Heinrich PC, Behrmann I, Schaper F, Hermanns HM.

J Cell Sci. 2010 Mar 15;123(Pt 6):947-59. doi: 10.1242/jcs.065326.

32.

Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis.

Hintzen C, Quaiser S, Pap T, Heinrich PC, Hermanns HM.

Arthritis Rheum. 2009 Jul;60(7):1932-43. doi: 10.1002/art.24602.

33.

Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression.

Hintzen C, Haan C, Tuckermann JP, Heinrich PC, Hermanns HM.

J Immunol. 2008 Nov 15;181(10):7341-9.

34.

IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma.

Heise R, Neis MM, Marquardt Y, Joussen S, Heinrich PC, Merk HF, Hermanns HM, Baron JM.

J Invest Dermatol. 2009 Jan;129(1):240-3. doi: 10.1038/jid.2008.183. Epub 2008 Jun 26. No abstract available.

35.

Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.

Hintzen C, Evers C, Lippok BE, Volkmer R, Heinrich PC, Radtke S, Hermanns HM.

J Biol Chem. 2008 Jul 11;283(28):19465-77. doi: 10.1074/jbc.M710157200. Epub 2008 Apr 22.

36.

Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis.

Neis MM, Peters B, Dreuw A, Wenzel J, Bieber T, Mauch C, Krieg T, Stanzel S, Heinrich PC, Merk HF, Bosio A, Baron JM, Hermanns HM.

J Allergy Clin Immunol. 2006 Oct;118(4):930-7. Epub 2006 Sep 1.

PMID:
17030248
37.

Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.

Stross C, Radtke S, Clahsen T, Gerlach C, Volkmer-Engert R, Schaper F, Heinrich PC, Hermanns HM.

J Biol Chem. 2006 Mar 31;281(13):8458-68. Epub 2006 Feb 2.

38.

Signaling through a mutant IFN-gamma receptor.

Costa-Pereira AP, Hermanns HM, Is'harc H, Williams TM, Watling D, Arulampalam V, Newman SJ, Heinrich PC, Kerr IM.

J Immunol. 2005 Nov 1;175(9):5958-65.

39.

Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases.

Böing I, Stross C, Radtke S, Lippok BE, Heinrich PC, Hermanns HM.

Cell Signal. 2006 Jan;18(1):50-61. Epub 2005 Jun 1.

PMID:
15935618
40.

Bow to your partner for signaling.

Hermanns HM, Müller-Newen G, Heinrich PC, Haan S.

Nat Struct Mol Biol. 2005 Jun;12(6):476-8. No abstract available.

PMID:
15933731
41.

The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.

Radtke S, Haan S, Jörissen A, Hermanns HM, Diefenbach S, Smyczek T, Schmitz-Vandeleur H, Heinrich PC, Behrmann I, Haan C.

J Biol Chem. 2005 Jul 8;280(27):25760-8. Epub 2005 May 12.

42.

The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling.

Clahsen T, Lehmann U, Stross C, Hermanns HM, Volkmer-Engert R, Schneider-Mergener J, Heinrich PC, Schaper F.

Cell Signal. 2005 May;17(5):559-69.

PMID:
15683731
43.

Interleukin-6-type cytokines upregulate expression of multidrug resistance-associated proteins in NHEK and dermal fibroblasts.

Dreuw A, Hermanns HM, Heise R, Joussen S, Rodríguez F, Marquardt Y, Jugert F, Merk HF, Heinrich PC, Baron JM.

J Invest Dermatol. 2005 Jan;124(1):28-37.

44.

Characterization of the signaling capacities of the novel gp130-like cytokine receptor.

Dreuw A, Radtke S, Pflanz S, Lippok BE, Heinrich PC, Hermanns HM.

J Biol Chem. 2004 Aug 20;279(34):36112-20. Epub 2004 Jun 11.

45.

Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F.

Biochem J. 2003 Aug 15;374(Pt 1):1-20. Review.

46.

Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling.

Greiser JS, Stross C, Heinrich PC, Behrmann I, Hermanns HM.

J Biol Chem. 2002 Jul 26;277(30):26959-65. Epub 2002 May 14.

47.

Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression.

Radtke S, Hermanns HM, Haan C, Schmitz-Van De Leur H, Gascan H, Heinrich PC, Behrmann I.

J Biol Chem. 2002 Mar 29;277(13):11297-305. Epub 2002 Jan 10.

48.

Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction.

Haan C, Is'harc H, Hermanns HM, Schmitz-Van De Leur H, Kerr IM, Heinrich PC, Grötzinger J, Behrmann I.

J Biol Chem. 2001 Oct 5;276(40):37451-8. Epub 2001 Jul 23.

49.

Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor.

Behrmann I, Hermanns HM, Haan C, Kortylewski M, Radtke S, Greiser J, Heinrich PC.

Eur Cytokine Netw. 2000 Sep;11(3):491-2. No abstract available.

50.

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