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Items: 17


Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.

Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S.

J Mol Biol. 2019 Aug 9;431(17):3146-3156. doi: 10.1016/j.jmb.2019.06.012. Epub 2019 Jun 24.


Dimerization quality control via ubiquitylation.

Herhaus L, Dikic I.

Science. 2018 Oct 12;362(6411):151-152. doi: 10.1126/science.aav1391. No abstract available.


Ubiquitin-induced phase separation of p62/SQSTM1.

Herhaus L, Dikic I.

Cell Res. 2018 Apr;28(4):389-390. doi: 10.1038/s41422-018-0030-x. No abstract available.


Regulation of Salmonella-host cell interactions via the ubiquitin system.

Herhaus L, Dikic I.

Int J Med Microbiol. 2018 Jan;308(1):176-184. doi: 10.1016/j.ijmm.2017.11.003. Epub 2017 Nov 6. Review.


Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I.

Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66.


Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I.

Nat Commun. 2017 Jan 13;8:14004. doi: 10.1038/ncomms14004.


Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.

Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4039-44. doi: 10.1073/pnas.1523926113. Epub 2016 Mar 30.


Expanding the ubiquitin code through post-translational modification.

Herhaus L, Dikic I.

EMBO Rep. 2015 Sep;16(9):1071-83. doi: 10.15252/embr.201540891. Epub 2015 Aug 12. Review.


Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9.

Rojas-Fernandez A, Herhaus L, Macartney T, Lachaud C, Hay RT, Sapkota GP.

Sci Rep. 2015 Apr 29;5:9811. doi: 10.1038/srep09811.


Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.

Herhaus L, Perez-Oliva AB, Cozza G, Gourlay R, Weidlich S, Campbell DG, Pinna LA, Sapkota GP.

Sci Signal. 2015 Apr 14;8(372):ra35. doi: 10.1126/scisignal.aaa0441.


Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).

Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS.

J Med Chem. 2015 Jan 8;58(1):183-96. doi: 10.1021/jm500480k. Epub 2014 Jul 30.


The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways.

Herhaus L, Sapkota GP.

Cell Signal. 2014 Oct;26(10):2186-92. doi: 10.1016/j.cellsig.2014.06.012. Epub 2014 Jul 5. Review.


USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.

Herhaus L, Al-Salihi MA, Dingwell KS, Cummins TD, Wasmus L, Vogt J, Ewan R, Bruce D, Macartney T, Weidlich S, Smith JC, Sapkota GP.

Open Biol. 2014 May;4(5):140065. doi: 10.1098/rsob.140065.


Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.

Vogt J, Dingwell KS, Herhaus L, Gourlay R, Macartney T, Campbell D, Smith JC, Sapkota GP.

Open Biol. 2014 Feb 19;4:130210. doi: 10.1098/rsob.130210.


OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.

Herhaus L, Al-Salihi M, Macartney T, Weidlich S, Sapkota GP.

Nat Commun. 2013;4:2519. doi: 10.1038/ncomms3519.


USP11 augments TGFβ signalling by deubiquitylating ALK5.

Al-Salihi MA, Herhaus L, Macartney T, Sapkota GP.

Open Biol. 2012 Jun;2(6):120063. doi: 10.1098/rsob.120063.


Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

Al-Salihi MA, Herhaus L, Sapkota GP.

Open Biol. 2012 May;2(5):120082. doi: 10.1098/rsob.120082. Review.

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