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The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy.

Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, Hergovich A, Höhfeld J.

Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1556-1566. doi: 10.1016/j.bbamcr.2019.07.007. Epub 2019 Jul 19.


MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer.

Gundogdu R, Hergovich A.

Cells. 2019 Jun 10;8(6). pii: E569. doi: 10.3390/cells8060569. Review.


NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells.

Keller M, Dubois F, Teulier S, Martin APJ, Levallet J, Maille E, Brosseau S, Elie N, Hergovich A, Bergot E, Camonis J, Zalcman G, Levallet G.

J Exp Clin Cancer Res. 2019 Apr 12;38(1):158. doi: 10.1186/s13046-019-1145-8.


MST1/2 Kinase Assays Using Recombinant Proteins.

Gomez M, Kulaberoglu Y, Hergovich A.

Methods Mol Biol. 2019;1893:319-331. doi: 10.1007/978-1-4939-8910-2_24.


Measuring the Kinase Activities of the LATS/NDR Protein Kinases.

Hergovich A.

Methods Mol Biol. 2019;1893:305-317. doi: 10.1007/978-1-4939-8910-2_23.


A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster.

Poon CLC, Liu W, Song Y, Gomez M, Kulaberoglu Y, Zhang X, Xu W, Veraksa A, Hergovich A, Ghabrial A, Harvey KF.

Dev Cell. 2018 Dec 3;47(5):564-575.e5. doi: 10.1016/j.devcel.2018.09.024. Epub 2018 Oct 25.


Correction: Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.

Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, Sharif AAD, Gomez M, Cascone I, Meunier B, White MA, Codogno P, Parrini MC, Camonis JH, Hergovich A.

Oncotarget. 2018 Apr 27;9(32):22870. doi: 10.18632/oncotarget.25335. eCollection 2018 Apr 27.


STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines.

Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A.

Oncotarget. 2017 Sep 11;8(45):78556-78572. doi: 10.18632/oncotarget.20833. eCollection 2017 Oct 3.


Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.

Kulaberoglu Y, Lin K, Holder M, Gai Z, Gomez M, Assefa Shifa B, Mavis M, Hoa L, Sharif AAD, Lujan C, Smith ESJ, Bjedov I, Tapon N, Wu G, Hergovich A.

Nat Commun. 2017 Sep 25;8(1):695. doi: 10.1038/s41467-017-00795-y.


The NDR/LATS protein kinases in immunology and cancer biology.

Sharif AAD, Hergovich A.

Semin Cancer Biol. 2018 Feb;48:104-114. doi: 10.1016/j.semcancer.2017.04.010. Epub 2017 Jun 1. Review.


The promise of using histone deacetylase inhibitors in combination treatment against breast cancer and other solid tumors.

Perera N, Hergovich A.

Chin Clin Oncol. 2017 Feb;6(1):9. doi: 10.21037/cco.2017.01.05. Epub 2017 Feb 6. No abstract available.


Cognitive and emotional demands of black humour processing: the role of intelligence, aggressiveness and mood.

Willinger U, Hergovich A, Schmoeger M, Deckert M, Stoettner S, Bunda I, Witting A, Seidler M, Moser R, Kacena S, Jaeckle D, Loader B, Mueller C, Auff E.

Cogn Process. 2017 May;18(2):159-167. doi: 10.1007/s10339-016-0789-y. Epub 2017 Jan 18.


YAP needs Nemo to guide a Hippo.

Hergovich A.

EMBO Rep. 2017 Jan;18(1):3-4. doi: 10.15252/embr.201643622. Epub 2016 Dec 15. No abstract available.


Hippo Signaling in Mitosis: An Updated View in Light of the MEN Pathway.

Hergovich A.

Methods Mol Biol. 2017;1505:265-277. Review.


Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer.

Flanagan JM, Wilson A, Koo C, Masrour N, Gallon J, Loomis E, Flower K, Wilhelm-Benartzi C, Hergovich A, Cunnea P, Gabra H, Braicu EI, Sehouli J, Darb-Esfahani S, Vanderstichele A, Vergote I, Kreuzinger C, Castillo-Tong DC, Wisman GBA, Berns EM, Siddiqui N, Paul J, Brown R.

Clin Cancer Res. 2017 May 1;23(9):2213-2222. doi: 10.1158/1078-0432.CCR-16-1754. Epub 2016 Sep 23.


Magic and Misdirection: The Influence of Social Cues on the Allocation of Visual Attention While Watching a Cups-and-Balls Routine.

Hergovich A, Oberfichtner B.

Front Psychol. 2016 May 31;7:761. doi: 10.3389/fpsyg.2016.00761. eCollection 2016.


Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.

Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, Sharif AA, Gomez M, Cascone I, Meunier B, White MA, Codogno P, Parrini MC, Camonis JH, Hergovich A.

Oncotarget. 2016 Jul 12;7(28):44142-44160. doi: 10.18632/oncotarget.9875. Erratum in: Oncotarget. 2018 Apr 27;9(32):22870.


The Roles of NDR Protein Kinases in Hippo Signalling.

Hergovich A.

Genes (Basel). 2016 May 18;7(5). pii: E21. doi: 10.3390/genes7050021. Review.


The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.

Hoa L, Kulaberoglu Y, Gundogdu R, Cook D, Mavis M, Gomez M, Gomez V, Hergovich A.

Cell Signal. 2016 May;28(5):488-497. doi: 10.1016/j.cellsig.2016.02.012. Epub 2016 Feb 18.


STK38 at the crossroad between autophagy and apoptosis.

Joffre C, Codogno P, Fanto M, Hergovich A, Camonis J.

Autophagy. 2016;12(3):594-5. doi: 10.1080/15548627.2015.1135283. Epub 2016 Feb 18.


RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway.

Dubois F, Keller M, Calvayrac O, Soncin F, Hoa L, Hergovich A, Parrini MC, Mazières J, Vaisse-Lesteven M, Camonis J, Levallet G, Zalcman G.

Cancer Res. 2016 Mar 15;76(6):1627-40. doi: 10.1158/0008-5472.CAN-15-1008. Epub 2016 Jan 12.


The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.

Tang F, Gill J, Ficht X, Barthlott T, Cornils H, Schmitz-Rohmer D, Hynx D, Zhou D, Zhang L, Xue G, Grzmil M, Yang Z, Hergovich A, Hollaender GA, Stein JV, Hemmings BA, Matthias P.

Sci Signal. 2015 Oct 6;8(397):ra100. doi: 10.1126/scisignal.aab2425.


The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy.

Joffre C, Dupont N, Hoa L, Gomez V, Pardo R, Gonçalves-Pimentel C, Achard P, Bettoun A, Meunier B, Bauvy C, Cascone I, Codogno P, Fanto M, Hergovich A, Camonis J.

Curr Biol. 2015 Oct 5;25(19):2479-92. doi: 10.1016/j.cub.2015.08.031. Epub 2015 Sep 17.


NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development.

Schmitz-Rohmer D, Probst S, Yang ZZ, Laurent F, Stadler MB, Zuniga A, Zeller R, Hynx D, Hemmings BA, Hergovich A.

PLoS One. 2015 Aug 25;10(8):e0136566. doi: 10.1371/journal.pone.0136566. eCollection 2015.


Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis.

Yan M, Chu L, Qin B, Wang Z, Liu X, Jin C, Zhang G, Gomez M, Hergovich A, Chen Z, He P, Gao X, Yao X.

Sci Rep. 2015 Jun 9;5:10449. doi: 10.1038/srep10449.


NDR functions as a physiological YAP1 kinase in the intestinal epithelium.

Zhang L, Tang F, Terracciano L, Hynx D, Kohler R, Bichet S, Hess D, Cron P, Hemmings BA, Hergovich A, Schmitz-Rohmer D.

Curr Biol. 2015 Feb 2;25(3):296-305. doi: 10.1016/j.cub.2014.11.054. Epub 2015 Jan 15.


Regulation of DNA damage responses and cell cycle progression by hMOB2.

Gomez V, Gundogdu R, Gomez M, Hoa L, Panchal N, O'Driscoll M, Hergovich A.

Cell Signal. 2015 Feb;27(2):326-39. doi: 10.1016/j.cellsig.2014.11.016. Epub 2014 Nov 21.


The Hippo pathway in disease and therapy: cancer and beyond.

Gomez M, Gomez V, Hergovich A.

Clin Transl Med. 2014 Jul 10;3:22. doi: 10.1186/2001-1326-3-22. eCollection 2014. Review.


Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway.

Yang R, Kong E, Jin J, Hergovich A, Püschel AW.

J Cell Sci. 2014 Aug 15;127(Pt 16):3463-76. doi: 10.1242/jcs.146696. Epub 2014 Jun 13.


hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.

Tang F, Zhang L, Xue G, Hynx D, Wang Y, Cron PD, Hundsrucker C, Hergovich A, Frank S, Hemmings BA, Schmitz-Rohmer D.

Cancer Res. 2014 Jul 15;74(14):3779-89. doi: 10.1158/0008-5472.CAN-13-3430. Epub 2014 May 28.


Constitutively active NDR1-PIF kinase functions independent of MST1 and hMOB1 signalling.

Cook D, Hoa LY, Gomez V, Gomez M, Hergovich A.

Cell Signal. 2014 Aug;26(8):1657-67. doi: 10.1016/j.cellsig.2014.04.011. Epub 2014 Apr 18.


OLA1 in centrosome biology alongside the BRCA1/BARD1 complex: looking beyond centrosomes.

Gomez V, Hergovich A.

Mol Cell. 2014 Jan 9;53(1):3-5. doi: 10.1016/j.molcel.2013.12.016. Review.


Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling.

Hergovich A.

Cell Biosci. 2013 Aug 28;3(1):32. doi: 10.1186/2045-3701-3-32.


Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.

Guilhamon P, Eskandarpour M, Halai D, Wilson GA, Feber A, Teschendorff AE, Gomez V, Hergovich A, Tirabosco R, Fernanda Amary M, Baumhoer D, Jundt G, Ross MT, Flanagan AM, Beck S.

Nat Commun. 2013;4:2166. doi: 10.1038/ncomms3166.


Generation of stable human cell lines with Tetracycline-inducible (Tet-on) shRNA or cDNA expression.

Gomez-Martinez M, Schmitz D, Hergovich A.

J Vis Exp. 2013 Mar 5;(73):e50171. doi: 10.3791/50171.


YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: implications for breast cancer.

Hergovich A.

Breast Cancer Res. 2012 Dec 5;14(6):326. doi: 10.1186/bcr3349.


Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.

Hergovich A, Hemmings BA.

Semin Cell Dev Biol. 2012 Sep;23(7):794-802. doi: 10.1016/j.semcdb.2012.04.001. Epub 2012 Apr 15. Review.


Mammalian Hippo signalling: a kinase network regulated by protein-protein interactions.

Hergovich A.

Biochem Soc Trans. 2012 Feb;40(1):124-8. doi: 10.1042/BST20110619. Review.


Intentional faking of the single category Implicit Association Test and the Implicit Association Test.

Stieger S, Göritz AS, Hergovich A, Voracek M.

Psychol Rep. 2011 Aug;109(1):219-30.


MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.

Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ.

Mol Cell Biol. 2011 Sep;31(17):3603-15. doi: 10.1128/MCB.01389-10. Epub 2011 Jul 5.


Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression.

Cornils H, Kohler RS, Hergovich A, Hemmings BA.

Cell Cycle. 2011 Jun 15;10(12):1897-904. Epub 2011 Jun 15. Review.


MOB control: reviewing a conserved family of kinase regulators.

Hergovich A.

Cell Signal. 2011 Sep;23(9):1433-40. doi: 10.1016/j.cellsig.2011.04.007. Epub 2011 Apr 21. Review.


Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.

Cornils H, Kohler RS, Hergovich A, Hemmings BA.

Mol Cell Biol. 2011 Apr;31(7):1382-95. doi: 10.1128/MCB.01216-10. Epub 2011 Jan 24.


Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.

Kohler RS, Schmitz D, Cornils H, Hemmings BA, Hergovich A.

Mol Cell Biol. 2010 Sep;30(18):4507-20. doi: 10.1128/MCB.00150-10. Epub 2010 Jul 12.


Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.

Cornils H, Stegert MR, Hergovich A, Hynx D, Schmitz D, Dirnhofer S, Hemmings BA.

Sci Signal. 2010 Jun 15;3(126):ra47. doi: 10.1126/scisignal.2000681.


TAZ-mediated crosstalk between Wnt and Hippo signaling.

Hergovich A, Hemmings BA.

Dev Cell. 2010 Apr 20;18(4):508-9. doi: 10.1016/j.devcel.2010.04.003.


The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation.

Hergovich A, Kohler RS, Schmitz D, Vichalkovski A, Cornils H, Hemmings BA.

Curr Biol. 2009 Nov 3;19(20):1692-702. doi: 10.1016/j.cub.2009.09.020.


VHL loss causes spindle misorientation and chromosome instability.

Thoma CR, Toso A, Gutbrodt KL, Reggi SP, Frew IJ, Schraml P, Hergovich A, Moch H, Meraldi P, Krek W.

Nat Cell Biol. 2009 Aug;11(8):994-1001. doi: 10.1038/ncb1912. Epub 2009 Jul 20.


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