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Items: 44

1.

Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes.

Humisto A, Jokela J, Teigen K, Wahlsten M, Permi P, Sivonen K, Herfindal L.

Biochim Biophys Acta Biomembr. 2019 Jun 19. pii: S0005-2736(19)30060-4. doi: 10.1016/j.bbamem.2019.03.010. [Epub ahead of print]

PMID:
31226245
2.

Short communication: Distribution of psychotropic drugs into lipoproteins.

Serkland TT, Schjøtt J, Berg JA, Herfindal L, Riedel B, Skrede S.

Ther Drug Monit. 2019 May 23. doi: 10.1097/FTD.0000000000000660. [Epub ahead of print]

PMID:
31136418
3.

Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L.

Carpinteyro Díaz AE, Herfindal L, Rathe BA, Sletta KY, Vedeler A, Haavik S, Fossen T.

Phytochemistry. 2019 May 14;164:67-77. doi: 10.1016/j.phytochem.2019.04.014. [Epub ahead of print]

PMID:
31100654
4.

Immunoliposomes in acute myeloid leukaemia therapy. An overview of possible targets and obstacles.

Singh A, Myklebust NN, Furevik SMV, Haugse R, Herfindal L.

Curr Med Chem. 2019 May 17. doi: 10.2174/0929867326666190517114450. [Epub ahead of print]

PMID:
31099318
5.

A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae).

Haji Ibrahim AH, Herfindal L, Rathe B, Andersen HL, Almeida JRGDS, Fossen T.

Heliyon. 2019 Mar 22;5(3):e01369. doi: 10.1016/j.heliyon.2019.e01369. eCollection 2019 Mar.

6.

A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia.

Bjørnstad R, Aesoy R, Bruserud Ø, Brenner AK, Giraud F, Dowling TH, Gausdal G, Moreau P, Døskeland SO, Anizon F, Herfindal L.

Mol Cancer Ther. 2019 Mar;18(3):567-578. doi: 10.1158/1535-7163.MCT-17-1234. Epub 2019 Jan 24.

PMID:
30679386
7.

Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles.

Prandina A, Herfindal L, Radix S, Rongved P, Døskeland SO, Le Borgne M, Perret F.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):370-375. doi: 10.1080/14756366.2017.1421638.

8.

Stabilization of Human Tyrosine Hydroxylase in Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue.

Bezem MT, Johannessen FG, Jung-Kc K, Gundersen ET, Jorge-Finnigan A, Ying M, Betbeder D, Herfindal L, Martinez A.

Bioconjug Chem. 2018 Feb 21;29(2):493-502. doi: 10.1021/acs.bioconjchem.7b00807. Epub 2018 Jan 31.

PMID:
29299922
9.

Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression.

Nygaard G, Herfindal L, Asrud KS, Bjørnstad R, Kopperud RK, Oveland E, Berven FS, Myhren L, Hoivik EA, Lunde THF, Bakke M, Døskeland SO, Selheim F.

Sci Rep. 2017 Aug 18;7(1):8725. doi: 10.1038/s41598-017-08975-y.

10.

Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives.

Viktorsson EÖ, Melling Grøthe B, Aesoy R, Sabir M, Snellingen S, Prandina A, Høgmoen Åstrand OA, Bonge-Hansen T, Døskeland SO, Herfindal L, Rongved P.

Bioorg Med Chem. 2017 Apr 1;25(7):2285-2293. doi: 10.1016/j.bmc.2017.02.058. Epub 2017 Feb 28.

PMID:
28284865
11.

Toxic aromatic compounds from fruits of Narthecium ossifragum L.

Vu M, Herfindal L, Juvik OJ, Vedeler A, Haavik S, Fossen T.

Phytochemistry. 2016 Dec;132:76-85. doi: 10.1016/j.phytochem.2016.09.010. Epub 2016 Oct 6.

PMID:
27720435
12.

Zebrafish as a model system for characterization of nanoparticles against cancer.

Evensen L, Johansen PL, Koster G, Zhu K, Herfindal L, Speth M, Fenaroli F, Hildahl J, Bagherifam S, Tulotta C, Prasmickaite L, Mælandsmo GM, Snaar-Jagalska E, Griffiths G.

Nanoscale. 2016 Jan 14;8(2):862-77. doi: 10.1039/c5nr07289a.

PMID:
26648525
13.

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells.

Giraud F, Bourhis M, Ebrahimi E, Herfindal L, Choudhury RR, Bjørnstad R, Døskeland SO, Anizon F, Moreau P.

Bioorg Med Chem. 2015 Nov 15;23(22):7313-23. doi: 10.1016/j.bmc.2015.10.031. Epub 2015 Oct 24.

PMID:
26526744
14.

Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.

Kleppe R, Herfindal L, Døskeland SO.

Mar Drugs. 2015 Oct 22;13(10):6505-20. doi: 10.3390/md13106505. Review.

15.

Editorial: Toward Personalized Treatment for Acute Myeloid Leukemia.

Selheim F, Herfindal L.

Curr Pharm Biotechnol. 2016;17(1):4-5. No abstract available.

PMID:
26311133
16.

Cyanobacteria as a Source for Novel Anti-Leukemic Compounds.

Humisto A, Herfindal L, Jokela J, Karkman A, Bjørnstad R, Choudhury RR, Sivonen K.

Curr Pharm Biotechnol. 2016;17(1):78-91.

PMID:
26306745
17.

The Use of Nanocarriers in Acute Myeloid Leukaemia Therapy: Challenges and Current Status.

Sauvage F, Barratt G, Herfindal L, Vergnaud-Gauduchon J.

Curr Pharm Biotechnol. 2016;17(1):30-41. Review.

PMID:
26278525
18.

New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities.

Giraud F, Bourhis M, Nauton L, Théry V, Herfindal L, Døskeland SO, Anizon F, Moreau P.

Bioorg Chem. 2014 Dec;57:108-15. doi: 10.1016/j.bioorg.2014.09.004. Epub 2014 Sep 26.

PMID:
25305721
19.

4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.

Liu L, Jokela J, Herfindal L, Wahlsten M, Sinkkonen J, Permi P, Fewer DP, Døskeland SO, Sivonen K.

ACS Chem Biol. 2014 Nov 21;9(11):2646-55. doi: 10.1021/cb500436p. Epub 2014 Sep 25.

PMID:
25203327
20.

Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression.

Nygaard G, Herfindal L, Kopperud R, Aragay AM, Holmsen H, Døskeland SO, Kleppe R, Selheim F.

Biochem Biophys Res Commun. 2014 Jul 4;449(3):357-63. doi: 10.1016/j.bbrc.2014.05.032. Epub 2014 May 17.

PMID:
24845383
21.

Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia.

Myhren L, Nilssen IM, Nicolas V, Døskeland SO, Barratt G, Herfindal L.

Eur J Pharm Biopharm. 2014 Sep;88(1):186-93. doi: 10.1016/j.ejpb.2014.04.002. Epub 2014 Apr 18.

PMID:
24747809
22.

Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.

Herfindal L, Krakstad C, Myhren L, Hagland H, Kopperud R, Teigen K, Schwede F, Kleppe R, Døskeland SO.

PLoS One. 2014 Apr 16;9(4):e94926. doi: 10.1371/journal.pone.0094926. eCollection 2014.

23.

Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.

Liu L, Herfindal L, Jokela J, Shishido TK, Wahlsten M, Døskeland SO, Sivonen K.

Mar Drugs. 2014 Apr 3;12(4):2036-53. doi: 10.3390/md12042036.

24.

Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds.

Bouaziz Z, Issa S, Gentili J, Gratz A, Bollacke A, Kassack M, Jose J, Herfindal L, Gausdal G, Døskeland SO, Mullié C, Sonnet P, Desgrouas C, Taudon N, Valdameri G, Di Pietro A, Baitiche M, Le Borgne M.

J Enzyme Inhib Med Chem. 2015 Apr;30(2):180-8. doi: 10.3109/14756366.2014.899594. Epub 2014 Apr 3.

PMID:
24697298
25.

Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment.

Sletta H, Degnes KF, Herfindal L, Klinkenberg G, Fjærvik E, Zahlsen K, Brunsvik A, Nygaard G, Aachmann FL, Ellingsen TE, Døskeland SO, Zotchev SB.

Appl Microbiol Biotechnol. 2014 Jan;98(2):603-10. doi: 10.1007/s00253-013-5320-0. Epub 2013 Oct 26.

PMID:
24158735
26.

Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.

Herfindal L, Nygaard G, Kopperud R, Krakstad C, Døskeland SO, Selheim F.

Biochem Biophys Res Commun. 2013 Aug 9;437(4):603-8. doi: 10.1016/j.bbrc.2013.07.007. Epub 2013 Jul 12.

PMID:
23850619
27.

Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen.

Herfindal L, Myhren L, Gjertsen BT, Døskeland SO, Gausdal G.

BMC Cancer. 2013 Jul 11;13:341. doi: 10.1186/1471-2407-13-341.

28.

Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.

Gausdal G, Wergeland A, Skavland J, Nguyen E, Pendino F, Rouhee N, McCormack E, Herfindal L, Kleppe R, Havemann U, Schwede F, Bruserud O, Gjertsen BT, Lanotte M, Ségal-Bendirdjian E, Døskeland SO.

Cell Death Dis. 2013 Feb 28;4:e516. doi: 10.1038/cddis.2013.39.

29.

Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells.

Myhren LE, Nygaard G, Gausdal G, Sletta H, Teigen K, Degnes KF, Zahlsen K, Brunsvik A, Bruserud Ø, Døskeland SO, Selheim F, Herfindal L.

Mar Drugs. 2013 Jan 30;11(2):332-49. doi: 10.3390/md11020332.

30.

The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner.

Oftedal L, Myhren L, Jokela J, Gausdal G, Sivonen K, Døskeland SO, Herfindal L.

Biochim Biophys Acta. 2012 Dec;1818(12):3000-9. doi: 10.1016/j.bbamem.2012.07.015. Epub 2012 Jul 25.

31.

Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.

Jokela J, Oftedal L, Herfindal L, Permi P, Wahlsten M, Døskeland SO, Sivonen K.

PLoS One. 2012;7(7):e41222. doi: 10.1371/journal.pone.0041222. Epub 2012 Jul 19.

32.

Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1.

Herfindal L, Myhren L, Kleppe R, Krakstad C, Selheim F, Jokela J, Sivonen K, Døskeland SO.

Mol Pharm. 2011 Apr 4;8(2):360-7. doi: 10.1021/mp1002224. Epub 2011 Jan 24.

PMID:
21214185
33.

Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes.

Oftedal L, Selheim F, Wahlsten M, Sivonen K, Døskeland SO, Herfindal L.

Mar Drugs. 2010 Oct 14;8(10):2659-72. doi: 10.3390/md8102659.

34.

The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity.

Oftedal L, Skjærven KH, Coyne RT, Edvardsen B, Rohrlack T, Skulberg OM, Døskeland SO, Herfindal L.

J Ind Microbiol Biotechnol. 2011 Apr;38(4):489-501. doi: 10.1007/s10295-010-0791-9. Epub 2010 Aug 6.

35.

A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins.

Jokela J, Herfindal L, Wahlsten M, Permi P, Selheim F, Vasconçelos V, Døskeland SO, Sivonen K.

Chembiochem. 2010 Jul 26;11(11):1594-9. doi: 10.1002/cbic.201000179.

PMID:
20575133
36.

Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity.

Prestegard SK, Oftedal L, Coyne RT, Nygaard G, Skjaerven KH, Knutsen G, Døskeland SO, Herfindal L.

Mar Drugs. 2009 Nov 18;7(4):605-23. doi: 10.3390/md7040605.

37.

Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.

Jørgensen H, Degnes KF, Sletta H, Fjaervik E, Dikiy A, Herfindal L, Bruheim P, Klinkenberg G, Bredholt H, Nygård G, Døskeland SO, Ellingsen TE, Zotchev SB.

Chem Biol. 2009 Oct 30;16(10):1109-21. doi: 10.1016/j.chembiol.2009.09.014.

38.

Acyloxymethyl esterification of nodularin-R and microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells.

Herfindal L, Kasprzykowski F, Schwede F, Łankiewicz L, Fladmark KE, Łukomska J, Wahlsten M, Sivonen K, Grzonka Z, Jastorff B, Døskeland SO.

J Med Chem. 2009 Sep 24;52(18):5758-62. doi: 10.1021/jm900502e.

PMID:
19705870
39.

Antimicrobial and cytotoxic assessment of marine cyanobacteria - Synechocystis and Synechococcus.

Martins RF, Ramos MF, Herfindal L, Sousa JA, Skaerven K, Vasconcelos VM.

Mar Drugs. 2008 Jan 22;6(1):1-11.

40.

Microcystin produces disparate effects on liver cells in a dose dependent manner.

Herfindal L, Selheim F.

Mini Rev Med Chem. 2006 Mar;6(3):279-85. Review.

PMID:
16515466
41.

CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation.

Krakstad C, Herfindal L, Gjertsen BT, Bøe R, Vintermyr OK, Fladmark KE, Døskeland SO.

Cell Death Differ. 2006 Jul;13(7):1191-202. Epub 2005 Nov 25.

42.

Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast.

Selheim F, Herfindal L, Martins R, Vasconcelos V, Døskeland SO.

Aquat Toxicol. 2005 Sep 30;74(4):294-306.

PMID:
16039729
43.

A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes.

Herfindal L, Oftedal L, Selheim F, Wahlsten M, Sivonen K, Døskeland SO.

Toxicon. 2005 Sep 1;46(3):252-60.

PMID:
15990143
44.

Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells.

Bruserud Ø, Glenjen N, Gjertsen BT, Herfindal L, Døskeland SO.

Expert Opin Biol Ther. 2002 Feb;2(2):197-210. Review.

PMID:
11849119

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