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Items: 1 to 50 of 57

1.

Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome.

Knebel B, Fahlbusch P, Dille M, Wahlers N, Hartwig S, Jacob S, Kettel U, Schiller M, Herebian D, Koellmer C, Lehr S, Müller-Wieland D, Kotzka J.

Front Cell Dev Biol. 2019 Oct 25;7:248. doi: 10.3389/fcell.2019.00248. eCollection 2019.

2.

iRhom2 inhibits bile duct obstruction-induced liver fibrosis.

Sundaram B, Behnke K, Belancic A, Al-Salihi MA, Thabet Y, Polz R, Pellegrino R, Zhuang Y, Shinde PV, Xu HC, Vasilevska J, Longerich T, Herebian D, Mayatepek E, Bock HH, May P, Kordes C, Aghaeepour N, Mak TW, Keitel V, Häussinger D, Scheller J, Pandyra AA, Lang KS, Lang PA.

Sci Signal. 2019 Oct 29;12(605). pii: eaax1194. doi: 10.1126/scisignal.aax1194.

PMID:
31662486
3.

Highly Elevated Plasma γ-Glutamyltransferase Elevations: A Trait Caused by γ-Glutamyltransferase 1 Transmembrane Mutations.

De Grandi A, Franzini M, Rosipal Š, Rosipal R, Debreova M, Corti A, Ruetzler-Dichtl E, Scholl-Bürgi S, Paolicchi A, Pompella A, Emdin M, Zampa G, Witt H, Zoller H, Tilg H, Mayatepek E, Herebian D, Pramstaller PP, Müller T, Janecke AR.

Hepatology. 2019 Sep 13. doi: 10.1002/hep.30944. [Epub ahead of print] No abstract available.

PMID:
31520399
4.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

Zhuang Y, Xu HC, Shinde PV, Warfsmann J, Vasilevska J, Sundaram B, Behnke K, Huang J, Hoell JI, Borkhardt A, Pfeffer K, Taha MS, Herebian D, Mayatepek E, Brenner D, Ahmadian MR, Keitel V, Wieczorek D, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Gut. 2019 Aug 13. pii: gutjnl-2019-318215. doi: 10.1136/gutjnl-2019-318215. [Epub ahead of print]

5.

Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration.

Preising MN, Görg B, Friedburg C, Qvartskhava N, Budde BS, Bonus M, Toliat MR, Pfleger C, Altmüller J, Herebian D, Beyer M, Zöllner HJ, Wittsack HJ, Schaper J, Klee D, Zechner U, Nürnberg P, Schipper J, Schnitzler A, Gohlke H, Lorenz B, Häussinger D, Bolz HJ.

FASEB J. 2019 Oct;33(10):11507-11527. doi: 10.1096/fj.201900914RR. Epub 2019 Jul 25.

PMID:
31345061
6.

Evaluation of lipoprotein-associated phospholipase A2 as a marker for renal microvasculopathy in adolescents with Type 1 diabetes.

Seyfarth J, Herebian D, Reinauer C, Baechle C, Roden M, Holl RW, Reinehr T, Mayatepek E, Meissner T, Rosenbauer J.

Diabet Med. 2019 Jul 23. doi: 10.1111/dme.14086. [Epub ahead of print]

PMID:
31335994
7.

Quantification of fetal steroids in nails of neonates to quantify prenatal stress and growth restriction.

Schmelter V, Antonaci L, Fröhlich S, Herebian D, Verde P, Heil M, Hoehn T.

Biol Psychol. 2019 Jan;140:81-85. doi: 10.1016/j.biopsycho.2018.12.001. Epub 2018 Dec 10.

PMID:
30543835
8.

Transplanted Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Support Liver Regeneration in Gunn Rats.

Spitzhorn LS, Kordes C, Megges M, Sawitza I, Götze S, Reichert D, Schulze-Matz P, Graffmann N, Bohndorf M, Wruck W, Köhler JP, Herebian D, Mayatepek E, Oreffo ROC, Häussinger D, Adjaye J.

Stem Cells Dev. 2018 Nov 20. doi: 10.1089/scd.2018.0010. [Epub ahead of print]

PMID:
30280963
9.

Laminin-521 promotes quiescence in isolated stellate cells from rat liver.

Rohn F, Kordes C, Castoldi M, Götze S, Poschmann G, Stühler K, Herebian D, Benk AS, Geiger F, Zhang T, Spatz JP, Häussinger D.

Biomaterials. 2018 Oct;180:36-51. doi: 10.1016/j.biomaterials.2018.07.008. Epub 2018 Jul 7.

PMID:
30014965
10.

Anti-inflammatory consequences of bile acid accumulation in virus-infected bile duct ligated mice.

Rattay S, Graf D, Kislat A, Homey B, Herebian D, Häussinger D, Hengel H, Zimmermann A, Schupp AK.

PLoS One. 2018 Jun 28;13(6):e0199863. doi: 10.1371/journal.pone.0199863. eCollection 2018.

11.

Blue Diaper Syndrome and PCSK1 Mutations.

Distelmaier F, Herebian D, Atasever C, Beck-Woedl S, Mayatepek E, Strom TM, Haack TB.

Pediatrics. 2018 Apr;141(Suppl 5):S501-S505. doi: 10.1542/peds.2017-0548.

12.

4-Hydroxybenzoic acid restores CoQ10 biosynthesis in human COQ2 deficiency.

Herebian D, Seibt A, Smits SHJ, Rodenburg RJ, Mayatepek E, Distelmaier F.

Ann Clin Transl Neurol. 2017 Oct 17;4(12):902-908. doi: 10.1002/acn3.486. eCollection 2017 Dec.

13.

Bypassing human CoQ10 deficiency.

Herebian D, López LC, Distelmaier F.

Mol Genet Metab. 2018 Mar;123(3):289-291. doi: 10.1016/j.ymgme.2017.12.008. Epub 2017 Dec 9.

PMID:
29246431
14.

An extract from the Atlantic brown algae Saccorhiza polyschides counteracts diet-induced obesity in mice via a gut related multi-factorial mechanisms.

Huebbe P, Nikolai S, Schloesser A, Herebian D, Campbell G, Glüer CC, Zeyner A, Demetrowitsch T, Schwarz K, Metges CC, Roeder T, Schultheiss G, Ipharraguerre IR, Rimbach G.

Oncotarget. 2017 May 23;8(43):73501-73515. doi: 10.18632/oncotarget.18113. eCollection 2017 Sep 26.

15.

Hepatitis B virus surface proteins accelerate cholestatic injury and tumor progression in Abcb4-knockout mice.

Zahner D, Glimm H, Matono T, Churin Y, Herebian D, Mayatepek E, Köhler K, Gattenlöhner S, Stinn A, Tschuschner A, Roderfeld M, Roeb E.

Oncotarget. 2017 Feb 2;8(32):52560-52570. doi: 10.18632/oncotarget.15003. eCollection 2017 Aug 8.

16.

Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation.

Ellinger P, Stindt J, Dröge C, Sattler K, Stross C, Kluge S, Herebian D, Smits SHJ, Burdelski M, Schulz-Jürgensen S, Ballauff A, Schulte Am Esch J, Mayatepek E, Häussinger D, Kubitz R, Schmitt L.

World J Gastroenterol. 2017 Aug 7;23(29):5295-5303. doi: 10.3748/wjg.v23.i29.5295.

17.

TNFα induced up-regulation of Na+,K+,2Cl- cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity.

Pozdeev VI, Lang E, Görg B, Bidmon HJ, Shinde PV, Kircheis G, Herebian D, Pfeffer K, Lang F, Häussinger D, Lang KS, Lang PA.

Sci Rep. 2017 Aug 11;7(1):7938. doi: 10.1038/s41598-017-07640-8.

18.

Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks.

Matz P, Wruck W, Fauler B, Herebian D, Mielke T, Adjaye J.

Sci Rep. 2017 Jul 24;7(1):6294. doi: 10.1038/s41598-017-06546-9.

19.

Coexisting variants in OSTM1 and MANEAL cause a complex neurodegenerative disorder with NBIA-like brain abnormalities.

Herebian D, Alhaddad B, Seibt A, Schwarzmayr T, Danhauser K, Klee D, Harmsen S, Meitinger T, Strom TM, Schulz A, Mayatepek E, Haack TB, Distelmaier F.

Eur J Hum Genet. 2017 Sep;25(9):1092-1095. doi: 10.1038/ejhg.2017.96. Epub 2017 Jun 14.

20.

Detection of 6-demethoxyubiquinone in CoQ10 deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

Herebian D, Seibt A, Smits SHJ, Bünning G, Freyer C, Prokisch H, Karall D, Wredenberg A, Wedell A, López LC, Mayatepek E, Distelmaier F.

Mol Genet Metab. 2017 Jul;121(3):216-223. doi: 10.1016/j.ymgme.2017.05.012. Epub 2017 May 20.

PMID:
28552678
21.

NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood.

Kremer LS, Danhauser K, Herebian D, Petkovic Ramadža D, Piekutowska-Abramczuk D, Seibt A, Müller-Felber W, Haack TB, Płoski R, Lohmeier K, Schneider D, Klee D, Rokicki D, Mayatepek E, Strom TM, Meitinger T, Klopstock T, Pronicka E, Mayr JA, Baric I, Distelmaier F, Prokisch H.

Am J Hum Genet. 2016 Oct 6;99(4):894-902. doi: 10.1016/j.ajhg.2016.07.018. Epub 2016 Sep 8.

22.

Bile Acid-Induced Suicidal Erythrocyte Death.

Lang E, Pozdeev VI, Gatidis S, Qadri SM, Häussinger D, Kubitz R, Herebian D, Mayatepek E, Lang F, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;38(4):1500-9. doi: 10.1159/000443091. Epub 2016 Apr 7.

23.

Cooperative role of lymphotoxin β receptor and tumor necrosis factor receptor p55 in murine liver regeneration.

Sorg UR, Behnke K, Degrandi D, Reich M, Keitel V, Herebian D, Deenen R, Beyer M, Schultze JL, Köhrer K, Gabbert HE, Mayatepek E, Häussinger D, Pfeffer K.

J Hepatol. 2016 May;64(5):1108-1117. doi: 10.1016/j.jhep.2015.12.006. Epub 2015 Dec 19.

PMID:
26708145
24.

Renal response to short- and long-term exercise in very-long-chain acyl-CoA dehydrogenase-deficient (VLCAD(-/-)) mice.

Tucci S, Krogmann A, Herebian D, Spiekerkoetter U.

Mol Cell Pediatr. 2014 Dec;1(1):5. doi: 10.1186/s40348-014-0005-z. Epub 2014 Oct 2.

25.

Caenorhabditis elegans ATAD-3 modulates mitochondrial iron and heme homeostasis.

van den Ecker D, Hoffmann M, Müting G, Maglioni S, Herebian D, Mayatepek E, Ventura N, Distelmaier F.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):389-94. doi: 10.1016/j.bbrc.2015.09.143. Epub 2015 Sep 30.

PMID:
26427876
26.

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.

Reich M, Deutschmann K, Sommerfeld A, Klindt C, Kluge S, Kubitz R, Ullmer C, Knoefel WT, Herebian D, Mayatepek E, Häussinger D, Keitel V.

Gut. 2016 Mar;65(3):487-501. doi: 10.1136/gutjnl-2015-309458. Epub 2015 Sep 29.

PMID:
26420419
27.

Bile acids induce hepatic differentiation of mesenchymal stem cells.

Sawitza I, Kordes C, Götze S, Herebian D, Häussinger D.

Sci Rep. 2015 Aug 25;5:13320. doi: 10.1038/srep13320.

28.

Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9.

Danhauser K, Herebian D, Haack TB, Rodenburg RJ, Strom TM, Meitinger T, Klee D, Mayatepek E, Prokisch H, Distelmaier F.

Eur J Hum Genet. 2016 Mar;24(3):450-4. doi: 10.1038/ejhg.2015.133. Epub 2015 Jun 17.

29.

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.

Qvartskhava N, Lang PA, Görg B, Pozdeev VI, Ortiz MP, Lang KS, Bidmon HJ, Lang E, Leibrock CB, Herebian D, Bode JG, Lang F, Häussinger D.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5521-6. doi: 10.1073/pnas.1423968112. Epub 2015 Apr 13.

30.

Two Case Reports of Successful Treatment of Cholestasis With Steroids in Patients With PFIC-2.

Engelmann G, Wenning D, Herebian D, Sander O, Dröge C, Kluge S, Kubitz R.

Pediatrics. 2015 May;135(5):e1326-32. doi: 10.1542/peds.2014-2376. Epub 2015 Apr 6.

31.

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.

Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen MS, Stožer A, Wnendt S, Piemonti L, Köhler M, Ferrer J, Thorens B, Schliess F, Rupnik MS, Heise T, Berggren PO, Klöcker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E.

Nat Med. 2015 Apr;21(4):363-72. doi: 10.1038/nm.3822. Epub 2015 Mar 16.

PMID:
25774850
32.

Hepatic stellate cells contribute to progenitor cells and liver regeneration.

Kordes C, Sawitza I, Götze S, Herebian D, Häussinger D.

J Clin Invest. 2014 Dec;124(12):5503-15. doi: 10.1172/JCI74119. Epub 2014 Nov 17.

33.

Conjugated bilirubin triggers anemia by inducing erythrocyte death.

Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C, Orth HM, Klindt C, Schuier M, Keitel V, Reich M, Liu G, Schmidt S, Xu HC, Qadri SM, Herebian D, Pandyra AA, Mayatepek E, Gulbins E, Lang F, Häussinger D, Lang KS, Föller M, Lang PA.

Hepatology. 2015 Jan;61(1):275-84. doi: 10.1002/hep.27338. Epub 2014 Nov 24.

34.

Functional studies of 18 heterologously expressed medium-chain acyl-CoA dehydrogenase (MCAD) variants.

Koster KL, Sturm M, Herebian D, Smits SH, Spiekerkoetter U.

J Inherit Metab Dis. 2014 Nov;37(6):917-28. doi: 10.1007/s10545-014-9732-5. Epub 2014 Jun 26.

PMID:
24966162
35.

Monounsaturated 14:1n-9 and 16:1n-9 fatty acids but not 18:1n-9 induce apoptosis and necrosis in murine HL-1 cardiomyocytes.

Hoffmann L, Seibt A, Herebian D, Spiekerkoetter U.

Lipids. 2014 Jan;49(1):25-37. doi: 10.1007/s11745-013-3865-4. Epub 2013 Nov 27.

PMID:
24281896
36.

A novel mutation within a transmembrane helix of the bile salt export pump (BSEP, ABCB11) with delayed development of cirrhosis.

Stindt J, Ellinger P, Weissenberger K, Dröge C, Herebian D, Mayatepek E, Homey B, Braun S, Schulte am Esch J, Horacek M, Canbay A, Schmitt L, Häussinger D, Kubitz R.

Liver Int. 2013 Nov;33(10):1527-35. doi: 10.1111/liv.12217. Epub 2013 Jun 12.

PMID:
23758865
37.

Long-term dietary effects on substrate selection and muscle fiber type in very-long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice.

Tucci S, Pearson S, Herebian D, Spiekerkoetter U.

Biochim Biophys Acta. 2013 Apr;1832(4):509-16. doi: 10.1016/j.bbadis.2013.01.006. Epub 2013 Jan 9.

38.

HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion.

Donner MG, Topp SA, Cebula P, Krienen A, Gehrmann T, Sommerfeld A, Reinehr R, Macher A, Herebian D, Mayatepek E, Pannen BH, Knoefel WT, Häussinger D.

Biol Chem. 2013 Jan;394(1):97-112. doi: 10.1515/hsz-2012-0153.

PMID:
23096566
39.

Functional effects of different medium-chain acyl-CoA dehydrogenase genotypes and identification of asymptomatic variants.

Sturm M, Herebian D, Mueller M, Laryea MD, Spiekerkoetter U.

PLoS One. 2012;7(9):e45110. doi: 10.1371/journal.pone.0045110. Epub 2012 Sep 17.

40.
41.

Single dose NTBC-treatment of hereditary tyrosinemia type I.

Schlune A, Thimm E, Herebian D, Spiekerkoetter U.

J Inherit Metab Dis. 2012 Sep;35(5):831-6. doi: 10.1007/s10545-012-9450-9. Epub 2012 Feb 4.

PMID:
22307209
42.

Neurocognitive outcome in patients with hypertyrosinemia type I after long-term treatment with NTBC.

Thimm E, Richter-Werkle R, Kamp G, Molke B, Herebian D, Klee D, Mayatepek E, Spiekerkoetter U.

J Inherit Metab Dis. 2012 Mar;35(2):263-8. doi: 10.1007/s10545-011-9394-5. Epub 2011 Nov 9.

PMID:
22069142
43.

Genetic variants of the bile salt export pump: inducers and modifiers of liver diseases.

Kubitz R, Brinkmeyer C, Sagir A, Herebian D, Häussinger D.

Dig Dis. 2011;29(1):89-92. doi: 10.1159/000324140. Epub 2011 Jun 17.

PMID:
21691112
44.

Increase of CSF tyrosine and impaired serotonin turnover in tyrosinemia type I.

Thimm E, Herebian D, Assmann B, Klee D, Mayatepek E, Spiekerkoetter U.

Mol Genet Metab. 2011 Feb;102(2):122-5. doi: 10.1016/j.ymgme.2010.11.003. Epub 2010 Nov 10.

PMID:
21112803
45.

Simultaneous LC-MS/MS determination of phenylbutyrate, phenylacetate benzoate and their corresponding metabolites phenylacetylglutamine and hippurate in blood and urine.

Laryea MD, Herebian D, Meissner T, Mayatepek E.

J Inherit Metab Dis. 2010 Dec;33 Suppl 3:S321-8. doi: 10.1007/s10545-010-9172-9. Epub 2010 Aug 7.

PMID:
20694517
46.

Pre-exercise medium-chain triglyceride application prevents acylcarnitine accumulation in skeletal muscle from very-long-chain acyl-CoA-dehydrogenase-deficient mice.

Primassin S, Tucci S, Herebian D, Seibt A, Hoffmann L, ter Veld F, Spiekerkoetter U.

J Inherit Metab Dis. 2010 Jun;33(3):237-46. doi: 10.1007/s10545-010-9105-7. Epub 2010 May 6.

PMID:
20446112
47.

Identification of NTBC metabolites in urine from patients with hereditary tyrosinemia type 1 using two different mass spectrometric platforms: triple stage quadrupole and LTQ-Orbitrap.

Herebian D, Lamshöft M, Mayatepek E, Spiekerkoetter U.

Rapid Commun Mass Spectrom. 2010 Mar;24(6):791-800. doi: 10.1002/rcm.4451.

PMID:
20187082
48.

A novel tandem mass spectrometry method for rapid confirmation of medium- and very long-chain acyl-CoA dehydrogenase deficiency in newborns.

ter Veld F, Mueller M, Kramer S, Haussmann U, Herebian D, Mayatepek E, Laryea MD, Primassin S, Spiekerkoetter U.

PLoS One. 2009 Jul 30;4(7):e6449. doi: 10.1371/journal.pone.0006449.

49.

Metabolite analysis in Curcuma domestica using various GC-MS and LC-MS separation and detection techniques.

Herebian D, Choi JH, Abd El-Aty AM, Shim JH, Spiteller M.

Biomed Chromatogr. 2009 Sep;23(9):951-65. doi: 10.1002/bmc.1207.

PMID:
19358151
50.

Liquid chromatography tandem mass spectrometry method for the quantitation of NTBC (2-(nitro-4-trifluoromethylbenzoyl)1,3-cyclohexanedione) in plasma of tyrosinemia type 1 patients.

Herebian D, Spiekerkötter U, Lamshöft M, Thimm E, Laryea M, Mayatepek E.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1453-9. doi: 10.1016/j.jchromb.2009.03.014. Epub 2009 Mar 17.

PMID:
19345648

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