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Items: 32

1.

Telomeres Increasingly Develop Aberrant Structures in Aging Humans.

Boccardi V, Cari L, Nocentini G, Riccardi C, Cecchetti R, Ruggiero C, Arosio B, Paolisso G, Herbig U, Mecocci P.

J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):230-235. doi: 10.1093/gerona/gly257.

PMID:
30388200
2.

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts.

Razdan N, Vasilopoulos T, Herbig U.

Aging Cell. 2018 Dec;17(6):e12838. doi: 10.1111/acel.12838. Epub 2018 Sep 22.

3.

Understanding the evolving phenotype of vascular complications in telomere biology disorders.

Higgs C, Crow YJ, Adams DM, Chang E, Hayes D Jr, Herbig U, Huang JN, Himes R, Jajoo K, Johnson FB, Reynolds SD, Yonekawa Y, Armanios M, Boulad F, DiNardo CD, Dufour C, Goldman FD, Khan S, Kratz C, Myers KC, Raghu G, Alter BP, Aubert G, Bhala S, Cowen EW, Dror Y, El-Youssef M, Friedman B, Giri N, Helms Guba L, Khincha PP, Lin TF, Longhurst H, McReynolds LJ, Nelson A, Olson T, Pariser A, Perona R, Sasa G, Schratz K, Simonetto DA, Townsley D, Walsh M, Stevens K, Agarwal S, Bertuch AA, Savage SA; Clinical Care Consortium for Telomere-associated Ailments (CCCTAA).

Angiogenesis. 2019 Feb;22(1):95-102. doi: 10.1007/s10456-018-9640-7. Epub 2018 Aug 25.

PMID:
30168024
4.

Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.

Zhang G, Wu LW, Mender I, Barzily-Rokni M, Hammond MR, Ope O, Cheng C, Vasilopoulos T, Randell S, Sadek N, Beroard A, Xiao M, Tian T, Tan J, Saeed U, Sugarman E, Krepler C, Brafford P, Sproesser K, Murugan S, Somasundaram R, Garman B, Wubbenhorst B, Woo J, Yin X, Liu Q, Frederick DT, Miao B, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Kwong LN, Amaravadi RK, Lu Y, Boland GM, Wei Z, Nathanson K, Herbig U, Mills GB, Flaherty KT, Herlyn M, Shay JW.

Clin Cancer Res. 2018 Oct 1;24(19):4771-4784. doi: 10.1158/1078-0432.CCR-17-2773. Epub 2018 Mar 21.

5.

Detection of Dysfunctional Telomeres in Oncogene-Induced Senescence.

Patel PL, Herbig U.

Methods Mol Biol. 2017;1534:69-78.

PMID:
27812868
6.

Shorter telomere length in Europeans than in Africans due to polygenetic adaptation.

Hansen ME, Hunt SC, Stone RC, Horvath K, Herbig U, Ranciaro A, Hirbo J, Beggs W, Reiner AP, Wilson JG, Kimura M, De Vivo I, Chen MM, Kark JD, Levy D, Nyambo T, Tishkoff SA, Aviv A.

Hum Mol Genet. 2016 Jun 1;25(11):2324-2330. Epub 2016 Mar 2.

7.

Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence.

Patel PL, Suram A, Mirani N, Bischof O, Herbig U.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5024-33. doi: 10.1073/pnas.1602379113. Epub 2016 Aug 8.

8.

Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.

Boccardi V, Razdan N, Kaplunov J, Mundra JJ, Kimura M, Aviv A, Herbig U.

Aging Cell. 2015 Jun;14(3):372-81. doi: 10.1111/acel.12289. Epub 2015 Feb 14.

9.

DCAF4, a novel gene associated with leucocyte telomere length.

Mangino M, Christiansen L, Stone R, Hunt SC, Horvath K, Eisenberg DT, Kimura M, Petersen I, Kark JD, Herbig U, Reiner AP, Benetos A, Codd V, Nyholt DR, Sinnreich R, Christensen K, Nassar H, Hwang SJ, Levy D, Bataille V, Fitzpatrick AL, Chen W, Berenson GS, Samani NJ, Martin NG, Tishkoff S, Schork NJ, Kyvik KO, DalgÄrd C, Spector TD, Aviv A.

J Med Genet. 2015 Mar;52(3):157-62. doi: 10.1136/jmedgenet-2014-102681. Epub 2015 Jan 26.

10.

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

Rossiello F, Herbig U, Longhese MP, Fumagalli M, d'Adda di Fagagna F.

Curr Opin Genet Dev. 2014 Jun;26:89-95. doi: 10.1016/j.gde.2014.06.009. Epub 2014 Aug 11. Review.

11.

The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses.

Suram A, Herbig U.

Aging Cell. 2014 Oct;13(5):780-6. doi: 10.1111/acel.12246. Epub 2014 Jul 18. Review.

12.

Tracking and fixed ranking of leukocyte telomere length across the adult life course.

Benetos A, Kark JD, Susser E, Kimura M, Sinnreich R, Chen W, Steenstrup T, Christensen K, Herbig U, von Bornemann Hjelmborg J, Srinivasan SR, Berenson GS, Labat C, Aviv A.

Aging Cell. 2013 Aug;12(4):615-21. doi: 10.1111/acel.12086. Epub 2013 May 27.

13.

Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage.

Zhang P, Herbig U, Coffman F, Lambert MW.

Nucleic Acids Res. 2013 May 1;41(10):5321-40. doi: 10.1093/nar/gkt235. Epub 2013 Apr 9.

14.

Telomerase gene therapy: a novel approach to combat aging.

Boccardi V, Herbig U.

EMBO Mol Med. 2012 Aug;4(8):685-7. doi: 10.1002/emmm.201200246. Epub 2012 May 15. No abstract available.

15.

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.

Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U.

EMBO J. 2012 Jun 29;31(13):2839-51. doi: 10.1038/emboj.2012.132. Epub 2012 May 8.

16.

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.

Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F.

Nat Cell Biol. 2012 Mar 18;14(4):355-65. doi: 10.1038/ncb2466. Erratum in: Nat Cell Biol. 2012 May;14(5):555.

17.

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells.

Benhamed M, Herbig U, Ye T, Dejean A, Bischof O.

Nat Cell Biol. 2012 Feb 26;14(3):266-75. doi: 10.1038/ncb2443.

18.

Telomere dynamics in keloids.

Granick M, Kimura M, Kim S, Daniali L, Cao X, Herbig U, Aviv A.

Eplasty. 2011 Mar 16;11:e15.

19.

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.

Badie S, Escandell JM, Bouwman P, Carlos AR, Thanasoula M, Gallardo MM, Suram A, Jaco I, Benitez J, Herbig U, Blasco MA, Jonkers J, Tarsounas M.

Nat Struct Mol Biol. 2010 Dec;17(12):1461-9. doi: 10.1038/nsmb.1943. Epub 2010 Nov 14.

20.

Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress.

Kovalenko OA, Kaplunov J, Herbig U, Detoledo S, Azzam EI, Santos JH.

PLoS One. 2010 May 25;5(5):e10812. doi: 10.1371/journal.pone.0010812.

21.

Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.

Levy D, Neuhausen SL, Hunt SC, Kimura M, Hwang SJ, Chen W, Bis JC, Fitzpatrick AL, Smith E, Johnson AD, Gardner JP, Srinivasan SR, Schork N, Rotter JI, Herbig U, Psaty BM, Sastrasinh M, Murray SS, Vasan RS, Province MA, Glazer NL, Lu X, Cao X, Kronmal R, Mangino M, Soranzo N, Spector TD, Berenson GS, Aviv A.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9293-8. doi: 10.1073/pnas.0911494107. Epub 2010 Apr 26.

22.

A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction.

Kovalenko OA, Caron MJ, Ulema P, Medrano C, Thomas AP, Kimura M, Bonini MG, Herbig U, Santos JH.

Aging Cell. 2010 Apr;9(2):203-19. doi: 10.1111/j.1474-9726.2010.00551.x.

23.

Accumulation of senescent cells in mitotic tissue of aging primates.

Jeyapalan JC, Ferreira M, Sedivy JM, Herbig U.

Mech Ageing Dev. 2007 Jan;128(1):36-44. Epub 2006 Nov 20.

24.

Cellular senescence in aging primates.

Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM.

Science. 2006 Mar 3;311(5765):1257. Epub 2006 Feb 2.

25.

Regulation of growth arrest in senescence: telomere damage is not the end of the story.

Herbig U, Sedivy JM.

Mech Ageing Dev. 2006 Jan;127(1):16-24. Epub 2005 Oct 17. Review.

PMID:
16229875
26.
28.

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts.

Wei W, Herbig U, Wei S, Dutriaux A, Sedivy JM.

EMBO Rep. 2003 Nov;4(11):1061-6. Epub 2003 Oct 17.

29.
30.

The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.

Herbig U, Marlar CA, Fanning E.

Mol Biol Cell. 1999 Aug;10(8):2631-45.

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