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Items: 37


The inositol-requiring enzyme 1 (IRE1α) RNAse inhibitor, 4µ8C, is also a potent cellular antioxidant.

Chan SMH, Lowe MP, Bernard A, Miller AA, Herbert TP.

Biochem J. 2018 Mar 9;475(5):923-929. doi: 10.1042/BCJ20170678.


3',4'-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice.

Lau YS, Mustafa MR, Choy KW, Chan SMH, Potocnik S, Herbert TP, Woodman OL.

Sci Rep. 2018 Jan 29;8(1):1818. doi: 10.1038/s41598-018-19584-8.


Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response.

Chan SMH, Lau YS, Miller AA, Ku JM, Potocnik S, Ye JM, Woodman OL, Herbert TP.

Endocrinology. 2017 Oct 1;158(10):3162-3173. doi: 10.1210/en.2016-1879.


The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells.

Chan SMH, Zhao X, Elfowiris A, Ratnam C, Herbert TP.

Biochimie. 2017 Jul;138:156-167. doi: 10.1016/j.biochi.2017.04.018. Epub 2017 May 4.


Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21.

Jo E, Li S, Liang Q, Zhang X, Wang H, Herbert TP, Jenkins TA, Xu A, Ye JM.

PLoS One. 2017 Apr 19;12(4):e0173676. doi: 10.1371/journal.pone.0173676. eCollection 2017.


A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

Herbert TP, Laybutt DR.

Diabetes. 2016 Jun;65(6):1472-80. doi: 10.2337/db15-1633. Review.


Endoplasmic reticulum stress up-regulates Nedd4-2 to induce autophagy.

Wang H, Sun RQ, Camera D, Zeng XY, Jo E, Chan SM, Herbert TP, Molero JC, Ye JM.

FASEB J. 2016 Jul;30(7):2549-56. doi: 10.1096/fj.201500119. Epub 2016 Mar 28.


System-L amino acid transporters play a key role in pancreatic β-cell signalling and function.

Cheng Q, Beltran VD, Chan SM, Brown JR, Bevington A, Herbert TP.

J Mol Endocrinol. 2016 Apr;56(3):175-87. doi: 10.1530/JME-15-0212. Epub 2015 Dec 8.


Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.

Johnson CE, Hunt DK, Wiltshire M, Herbert TP, Sampson JR, Errington RJ, Davies DM, Tee AR.

Mol Oncol. 2015 Mar;9(3):675-88. doi: 10.1016/j.molonc.2014.11.005. Epub 2014 Nov 22.


Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1.

Xie J, El Sayed NM, Qi C, Zhao X, Moore CE, Herbert TP.

J Mol Endocrinol. 2014 Aug;53(1):105-15. doi: 10.1530/JME-13-0200.


ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes.

Omikorede O, Qi C, Gorman T, Chapman P, Yu A, Smith DM, Herbert TP.

Nutr Diabetes. 2013 Oct 21;3:e93. doi: 10.1038/nutd.2013.35.


Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells.

Chen C, Cano M, Wang JJ, Li J, Huang C, Yu Q, Herbert TP, Handa JT, Zhang SX.

Antioxid Redox Signal. 2014 May 10;20(14):2091-106. doi: 10.1089/ars.2013.5240. Epub 2013 Dec 17.


Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.

Barlow AD, Nicholson ML, Herbert TP.

Diabetes. 2013 Aug;62(8):2674-82. doi: 10.2337/db13-0106. Review.


Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.

Selway J, Rigatti R, Storey N, Lu J, Willars GB, Herbert TP.

PLoS One. 2012;7(3):e33004. doi: 10.1371/journal.pone.0033004. Epub 2012 Mar 7.


Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2).

Barlow AD, Xie J, Moore CE, Campbell SC, Shaw JA, Nicholson ML, Herbert TP.

Diabetologia. 2012 May;55(5):1355-65. doi: 10.1007/s00125-012-2475-7.


The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.

Xie J, Herbert TP.

Cell Mol Life Sci. 2012 Apr;69(8):1289-304. doi: 10.1007/s00018-011-0874-4. Epub 2011 Nov 9. Review.


Molecular mechanisms of muscarinic acetylcholine receptor-stimulated increase in cytosolic free Ca(2+) concentration and ERK1/2 activation in the MIN6 pancreatic β-cell line.

Selway JL, Moore CE, Mistry R, John Challiss RA, Herbert TP.

Acta Diabetol. 2012 Aug;49(4):277-89. doi: 10.1007/s00592-011-0314-9. Epub 2011 Aug 11.


cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

Xie J, Ponuwei GA, Moore CE, Willars GB, Tee AR, Herbert TP.

Cell Signal. 2011 Dec;23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. Epub 2011 Jul 6.


PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells.

Moore CE, Omikorede O, Gomez E, Willars GB, Herbert TP.

Mol Endocrinol. 2011 Feb;25(2):315-26. doi: 10.1210/me.2010-0309. Epub 2010 Dec 30.


Identification of cAMP-dependent kinase as a third in vivo ribosomal protein S6 kinase in pancreatic beta-cells.

Moore CE, Xie J, Gomez E, Herbert TP.

J Mol Biol. 2009 Jun 12;389(3):480-94. doi: 10.1016/j.jmb.2009.04.020. Epub 2009 Apr 16.


Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle.

Evans K, Nasim Z, Brown J, Clapp E, Amin A, Yang B, Herbert TP, Bevington A.

J Am Soc Nephrol. 2008 Nov;19(11):2119-29. doi: 10.1681/ASN.2007101108. Epub 2008 Jul 23.


PERK in the life and death of the pancreatic beta-cell.

Herbert TP.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1205-7. Review.


Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells.

Evans K, Nasim Z, Brown J, Butler H, Kauser S, Varoqui H, Erickson JD, Herbert TP, Bevington A.

J Am Soc Nephrol. 2007 May;18(5):1426-36. Epub 2007 Apr 11.


Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic beta-cells.

Greenman IC, Gomez E, Moore CE, Herbert TP.

J Endocrinol. 2007 Jan;192(1):179-87.


The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites.

Herbert TP, Tee AR, Proud CG.

J Biol Chem. 2002 Mar 29;277(13):11591-6. Epub 2002 Jan 17.


Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.

Wicksteed B, Herbert TP, Alarcon C, Lingohr MK, Moss LG, Rhodes CJ.

J Biol Chem. 2001 Jun 22;276(25):22553-8. Epub 2001 Apr 10.


Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.

Herbert TP, Fåhraeus R, Prescott A, Lane DP, Proud CG.

Curr Biol. 2000 Jun 29;10(13):793-6.


Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T, Feener EP, Herbert TP, Rhodes CJ, King GL.

Circulation. 2000 Feb 15;101(6):676-81.


Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.

Köhler M, Norgren S, Berggren PO, Fredholm BB, Larsson O, Rhodes CJ, Herbert TP, Luthman H.

FEBS Lett. 1998 Dec 11;441(1):97-102.


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