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Items: 24


Humanized Mouse Models for the Study of Hepatitis C and Host Interactions.

Yong KSM, Her Z, Chen Q.

Cells. 2019 Jun 17;8(6). pii: E604. doi: 10.3390/cells8060604. Review.


Enterovirus A71 Infection Activates Human Immune Responses and Induces Pathological Changes in Humanized Mice.

Ke Y, Liu WN, Her Z, Liu M, Tan SY, Tan YW, Chan XY, Fan Y, Huang EK, Chen H, En Chang KT, Chan JKY, Hann Chu JJ, Chen Q.

J Virol. 2019 Jan 17;93(3). pii: e01066-18. doi: 10.1128/JVI.01066-18. Print 2019 Feb 1.


Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system.

Yong KSM, Ng JHJ, Her Z, Hey YY, Tan SY, Tan WWS, Irac SE, Liu M, Chan XY, Gunawan M, Foo RJH, Low DHW, Mendenhall IH, Chionh YT, Dutertre CA, Chen Q, Wang LF.

Sci Rep. 2018 Mar 16;8(1):4726. doi: 10.1038/s41598-018-22899-1.


Humanized Mice as Unique Tools for Human-Specific Studies.

Yong KSM, Her Z, Chen Q.

Arch Immunol Ther Exp (Warsz). 2018 Aug;66(4):245-266. doi: 10.1007/s00005-018-0506-x. Epub 2018 Feb 7. Review.


Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity.

Lum FM, Couderc T, Chia BS, Ong RY, Her Z, Chow A, Leo YS, Kam YW, Rénia L, Lecuit M, Ng LFP.

Sci Rep. 2018 Jan 30;8(1):1860. doi: 10.1038/s41598-018-20305-4.


A Novel Human Systemic Lupus Erythematosus Model in Humanised Mice.

Gunawan M, Her Z, Liu M, Tan SY, Chan XY, Tan WWS, Dharmaraaja S, Fan Y, Ong CB, Loh E, Chang KTE, Tan TC, Chan JKY, Chen Q.

Sci Rep. 2017 Nov 30;7(1):16642. doi: 10.1038/s41598-017-16999-7.


An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia.

Her Z, Yong KSM, Paramasivam K, Tan WWS, Chan XY, Tan SY, Liu M, Fan Y, Linn YC, Hui KM, Surana U, Chen Q.

J Hematol Oncol. 2017 Oct 6;10(1):162. doi: 10.1186/s13045-017-0532-x.


Hepatitis C virus mediated chronic inflammation and tumorigenesis in the humanised immune system and liver mouse model.

Zheng Z, Sze CW, Keng CT, Al-Haddawi M, Liu M, Tan SY, Kwek HL, Her Z, Chan XY, Barnwal B, Loh E, Chang KTE, Tan TC, Tan YJ, Chen Q.

PLoS One. 2017 Sep 8;12(9):e0184127. doi: 10.1371/journal.pone.0184127. eCollection 2017.


Fingolimod treatment abrogates chikungunya virus-induced arthralgia.

Teo TH, Chan YH, Lee WW, Lum FM, Amrun SN, Her Z, Rajarethinam R, Merits A, Rötzschke O, Rénia L, Ng LF.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaal1333. doi: 10.1126/scitranslmed.aal1333.


Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection.

Her Z, Kam YW, Gan VC, Lee B, Thein TL, Tan JJ; SIgN Immunomonitoring Platform, Lee LK, Fink K, Lye DC, Rénia L, Leo YS, Ng LF.

J Infect Dis. 2017 Jan 1;215(1):42-51. doi: 10.1093/infdis/jiw494. Epub 2016 Oct 17.


Early clearance of Chikungunya virus in children is associated with a strong innate immune response.

Simarmata D, Ng DC, Kam YW, Lee B, Sum MS, Her Z, Chow A, Leo YS, Cardosa J, Perera D, Ooi MH, Ng LF.

Sci Rep. 2016 May 16;6:26097. doi: 10.1038/srep26097.


Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.

Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow P, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Chen Q, Abastado JP, Chew V.

Gut. 2017 Feb;66(2):342-351. doi: 10.1136/gutjnl-2015-310814. Epub 2015 Dec 15.


Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells.

Burrack KS, Tan JJ, McCarthy MK, Her Z, Berger JN, Ng LF, Morrison TE.

PLoS Pathog. 2015 Oct 5;11(10):e1005191. doi: 10.1371/journal.ppat.1005191. eCollection 2015 Oct.


Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.

Teo TH, Her Z, Tan JJ, Lum FM, Lee WW, Chan YH, Ong RY, Kam YW, Leparc-Goffart I, Gallian P, Rénia L, de Lamballerie X, Ng LF.

J Virol. 2015 Aug;89(15):7955-69. doi: 10.1128/JVI.00909-15. Epub 2015 May 20.


Expanding regulatory T cells alleviates chikungunya virus-induced pathology in mice.

Lee WW, Teo TH, Her Z, Lum FM, Kam YW, Haase D, Rénia L, Rötzschke O, Ng LF.

J Virol. 2015 Aug 1;89(15):7893-7904. Epub 2015 May 20.


Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response.

Her Z, Teng TS, Tan JJ, Teo TH, Kam YW, Lum FM, Lee WW, Gabriel C, Melchiotti R, Andiappan AK, Lulla V, Lulla A, Win MK, Chow A, Biswas SK, Leo YS, Lecuit M, Merits A, Rénia L, Ng LF.

EMBO Mol Med. 2015 Jan;7(1):24-41. doi: 10.15252/emmm.201404459.


Neutrophils: neglected players in viral diseases.

Gabriel C, Her Z, Ng LF.

DNA Cell Biol. 2013 Dec;32(12):665-75. doi: 10.1089/dna.2013.2211. Epub 2013 Nov 15. Review.


Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection.

Herrero LJ, Sheng KC, Jian P, Taylor A, Her Z, Herring BL, Chow A, Leo YS, Hickey MJ, Morand EF, Ng LF, Bucala R, Mahalingam S.

Arthritis Rheum. 2013 Oct;65(10):2724-36. doi: 10.1002/art.38090.


Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection.

Kam YW, Simarmata D, Chow A, Her Z, Teng TS, Ong EK, Rénia L, Leo YS, Ng LF.

J Infect Dis. 2012 Apr 1;205(7):1147-54. doi: 10.1093/infdis/jis033. Epub 2012 Mar 1.


Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor.

Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF.

J Infect Dis. 2011 Jan 15;203(2):149-57. doi: 10.1093/infdis/jiq042.


Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response.

Her Z, Malleret B, Chan M, Ong EK, Wong SC, Kwek DJ, Tolou H, Lin RT, Tambyah PA, Rénia L, Ng LF.

J Immunol. 2010 May 15;184(10):5903-13. doi: 10.4049/jimmunol.0904181. Epub 2010 Apr 19.


Chikungunya: a bending reality.

Her Z, Kam YW, Lin RT, Ng LF.

Microbes Infect. 2009 Dec;11(14-15):1165-76. doi: 10.1016/j.micinf.2009.09.004. Epub 2009 Sep 10. Review.


IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.

Ng LF, Chow A, Sun YJ, Kwek DJ, Lim PL, Dimatatac F, Ng LC, Ooi EE, Choo KH, Her Z, Kourilsky P, Leo YS.

PLoS One. 2009;4(1):e4261. doi: 10.1371/journal.pone.0004261. Epub 2009 Jan 21.


Ecology and transmission of Listeria monocytogenes infecting ruminants and in the farm environment.

Nightingale KK, Schukken YH, Nightingale CR, Fortes ED, Ho AJ, Her Z, Grohn YT, McDonough PL, Wiedmann M.

Appl Environ Microbiol. 2004 Aug;70(8):4458-67.

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