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Items: 33

1.

Functional interactions between innate lymphoid cells and adaptive immunity.

Sonnenberg GF, Hepworth MR.

Nat Rev Immunol. 2019 Jul 26. doi: 10.1038/s41577-019-0194-8. [Epub ahead of print] Review.

PMID:
31350531
2.

Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.

Melo-Gonzalez F, Kammoun H, Evren E, Dutton EE, Papadopoulou M, Bradford BM, Tanes C, Fardus-Reid F, Swann JR, Bittinger K, Mabbott NA, Vallance BA, Willinger T, Withers DR, Hepworth MR.

J Exp Med. 2019 Apr 1;216(4):728-742. doi: 10.1084/jem.20180871. Epub 2019 Feb 27.

3.

Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells.

Penny HA, Hodge SH, Hepworth MR.

Semin Immunopathol. 2018 Jul;40(4):357-370. doi: 10.1007/s00281-018-0687-8. Epub 2018 May 8. Review.

4.

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.

Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi SM, Jacob JM, Cheng HW, Evren E, Das S, Czarnewski P, Sleiers N, Melo-Gonzalez F, Kvedaraite E, Svensson M, Scandella E, Hepworth MR, Huber S, Ludewig B, Peduto L, Villablanca EJ, Veiga-Fernandes H, Pereira JP, Flavell RA, Willinger T.

Immunity. 2018 Jan 16;48(1):120-132.e8. doi: 10.1016/j.immuni.2017.11.020.

5.

Group 3 Innate Lymphoid Cells: Communications Hubs of the Intestinal Immune System.

Withers DR, Hepworth MR.

Front Immunol. 2017 Oct 16;8:1298. doi: 10.3389/fimmu.2017.01298. eCollection 2017. Review.

6.

Innate Lymphoid Cell Regulation: Meeting the Long-Lost Cousin.

Hepworth MR.

Trends Immunol. 2017 Dec;38(12):873-874. doi: 10.1016/j.it.2017.09.003. Epub 2017 Oct 10.

PMID:
29029958
7.

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells.

Melo-Gonzalez F, Hepworth MR.

Immunology. 2017 Mar;150(3):265-275. doi: 10.1111/imm.12697. Epub 2017 Jan 3. Review.

8.

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

Monticelli LA, Buck MD, Flamar AL, Saenz SA, Tait Wojno ED, Yudanin NA, Osborne LC, Hepworth MR, Tran SV, Rodewald HR, Shah H, Cross JR, Diamond JM, Cantu E, Christie JD, Pearce EL, Artis D.

Nat Immunol. 2016 Jun;17(6):656-65. doi: 10.1038/ni.3421. Epub 2016 Apr 4.

9.

Corrigendum: CCR7-dependent trafficking of RORγ(+) ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Mackley EC, Houston S, Marriott CL, Halford EE, Lucas B, Cerovic V, Filbey KJ, Maizels RM, Hepworth MR, Sonnenberg GF, Milling S, Withers DR.

Nat Commun. 2016 Mar 29;7:11186. doi: 10.1038/ncomms11186. No abstract available.

10.

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.

Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF.

Immunity. 2016 Mar 15;44(3):634-646. doi: 10.1016/j.immuni.2016.02.019.

11.

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells.

Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF.

Nat Med. 2016 Mar;22(3):319-23. doi: 10.1038/nm.4046. Epub 2016 Feb 15.

12.

Group 3 innate lymphoid cells: regulating host-commensal bacteria interactions in inflammation and cancer.

Goc J, Hepworth MR, Sonnenberg GF.

Int Immunol. 2016 Jan;28(1):43-52. doi: 10.1093/intimm/dxv056. Epub 2015 Oct 7. Review.

13.

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.

Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, Withers DR, Hugues S, Farrar MA, Reith W, Eberl G, Baldassano RN, Laufer TM, Elson CO, Sonnenberg GF.

Science. 2015 May 29;348(6238):1031-5. doi: 10.1126/science.aaa4812. Epub 2015 Apr 23.

14.

A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation.

Ziegler T, Rausch S, Steinfelder S, Klotz C, Hepworth MR, Kühl AA, Burda PC, Lucius R, Hartmann S.

J Immunol. 2015 Feb 15;194(4):1555-64. doi: 10.4049/jimmunol.1401217. Epub 2015 Jan 14.

15.

CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Mackley EC, Houston S, Marriott CL, Halford EE, Lucas B, Cerovic V, Filbey KJ, Maizels RM, Hepworth MR, Sonnenberg GF, Milling S, Withers DR.

Nat Commun. 2015 Jan 9;6:5862. doi: 10.1038/ncomms6862. Erratum in: Nat Commun. 2016;7:11186.

16.

Frequencies of regulatory T cells in the peripheral blood of dogs with primary immune-mediated thrombocytopenia and chronic enteropathy: a pilot study.

Volkmann M, Hepworth MR, Ebner F, Rausch S, Kohn B, Hartmann S.

Vet J. 2014 Dec;202(3):630-3. doi: 10.1016/j.tvjl.2014.10.012. Epub 2014 Oct 22.

PMID:
25458882
17.

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.

Osborne LC, Monticelli LA, Nice TJ, Sutherland TE, Siracusa MC, Hepworth MR, Tomov VT, Kobuley D, Tran SV, Bittinger K, Bailey AG, Laughlin AL, Boucher JL, Wherry EJ, Bushman FD, Allen JE, Virgin HW, Artis D.

Science. 2014 Aug 1;345(6196):578-82. doi: 10.1126/science.1256942. Epub 2014 Jul 17.

18.

Therapeutic potential of larval excretory/secretory proteins of the pig whipworm Trichuris suis in allergic disease.

Ebner F, Hepworth MR, Rausch S, Janek K, Niewienda A, Kühl A, Henklein P, Lucius R, Hamelmann E, Hartmann S.

Allergy. 2014 Nov;69(11):1489-97. doi: 10.1111/all.12496. Epub 2014 Sep 6.

PMID:
25069662
19.

Regulation of the adaptive immune system by innate lymphoid cells.

Hepworth MR, Sonnenberg GF.

Curr Opin Immunol. 2014 Apr;27:75-82. doi: 10.1016/j.coi.2014.01.013. Epub 2014 Mar 3. Review.

20.

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.

Hepworth MR, Monticelli LA, Fung TC, Ziegler CG, Grunberg S, Sinha R, Mantegazza AR, Ma HL, Crawford A, Angelosanto JM, Wherry EJ, Koni PA, Bushman FD, Elson CO, Eberl G, Artis D, Sonnenberg GF.

Nature. 2013 Jun 6;498(7452):113-7. doi: 10.1038/nature12240. Epub 2013 May 22.

21.

TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.

Kim BS, Siracusa MC, Saenz SA, Noti M, Monticelli LA, Sonnenberg GF, Hepworth MR, Van Voorhees AS, Comeau MR, Artis D.

Sci Transl Med. 2013 Jan 30;5(170):170ra16. doi: 10.1126/scitranslmed.3005374.

22.

Worming our way closer to the clinic.

Hepworth MR, Hartmann S.

Int J Parasitol Drugs Drug Resist. 2012 Jul 15;2:187-90. doi: 10.1016/j.ijpddr.2012.07.001. eCollection 2012 Dec.

23.

Regulation of type 2 immunity to helminths by mast cells.

Hepworth MR, Maurer M, Hartmann S.

Gut Microbes. 2012 Sep-Oct;3(5):476-81. Epub 2012 Aug 15. Review.

24.

Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines.

Hepworth MR, Daniłowicz-Luebert E, Rausch S, Metz M, Klotz C, Maurer M, Hartmann S.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6644-9. doi: 10.1073/pnas.1112268109. Epub 2012 Apr 9.

25.

IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology.

Stange J, Hepworth MR, Rausch S, Zajic L, Kühl AA, Uyttenhove C, Renauld JC, Hartmann S, Lucius R.

J Immunol. 2012 Mar 1;188(5):2410-8. doi: 10.4049/jimmunol.1102062. Epub 2012 Jan 20.

26.

A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages.

Klotz C, Ziegler T, Figueiredo AS, Rausch S, Hepworth MR, Obsivac N, Sers C, Lang R, Hammerstein P, Lucius R, Hartmann S.

PLoS Pathog. 2011 Jan 6;7(1):e1001248. doi: 10.1371/journal.ppat.1001248.

27.

A matter of timing: early, not chronic phase intestinal nematode infection restrains control of a concurrent enteric protozoan infection.

Rausch S, Held J, Stange J, Lendner M, Hepworth MR, Klotz C, Lucius R, Pogonka T, Hartmann S.

Eur J Immunol. 2010 Oct;40(10):2804-15. doi: 10.1002/eji.201040306.

28.

Looking into the future of Trichuris suis therapy.

Hepworth MR, Hamelmann E, Lucius R, Hartmann S.

J Allergy Clin Immunol. 2010 Mar;125(3):767-8; author reply 768-9. doi: 10.1016/j.jaci.2009.11.041. Epub 2010 Feb 11. No abstract available.

PMID:
20153034
29.

The role of sex hormones in the development of Th2 immunity in a gender-biased model of Trichuris muris infection.

Hepworth MR, Hardman MJ, Grencis RK.

Eur J Immunol. 2010 Feb;40(2):406-16. doi: 10.1002/eji.200939589.

30.

Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells.

Rausch S, Huehn J, Loddenkemper C, Hepworth MR, Klotz C, Sparwasser T, Hamann A, Lucius R, Hartmann S.

Eur J Immunol. 2009 Nov;39(11):3066-77. doi: 10.1002/eji.200939644.

31.

Disruption of Th2 immunity results in a gender-specific expansion of IL-13 producing accessory NK cells during helminth infection.

Hepworth MR, Grencis RK.

J Immunol. 2009 Sep 15;183(6):3906-14. doi: 10.4049/jimmunol.0900577. Epub 2009 Aug 19.

32.

IL-33, a potent inducer of adaptive immunity to intestinal nematodes.

Humphreys NE, Xu D, Hepworth MR, Liew FY, Grencis RK.

J Immunol. 2008 Feb 15;180(4):2443-9.

33.

Effect of glycosylphosphatidylinositol (GPI)-phospholipase D overexpression on GPI metabolism.

Mann KJ, Hepworth MR, Raikwar NS, Deeg MA, Sevlever D.

Biochem J. 2004 Mar 1;378(Pt 2):641-8.

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