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Items: 26

1.

Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons.

Roberts BL, Bennett BJ, Bennett CM, Carroll JM, Dalbøge LS, Hall C, Hassouneh W, Heppner KM, Kirigiti MA, Lindsley SR, Tennant KG, True CA, Whittle A, Wolf AC, Roberts CT Jr, Tang-Christensen M, Sleeman MW, Cowley MA, Grove KL, Kievit P.

Mol Metab. 2019 Aug;26:18-29. doi: 10.1016/j.molmet.2019.06.001. Epub 2019 Jun 8.

2.

Targeting FXR and FGF19 to Treat Metabolic Diseases-Lessons Learned From Bariatric Surgery.

Bozadjieva N, Heppner KM, Seeley RJ.

Diabetes. 2018 Sep;67(9):1720-1728. doi: 10.2337/dbi17-0007. Review.

3.

FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys.

Andersen B, Straarup EM, Heppner KM, Takahashi DL, Raffaele V, Dissen GA, Lewandowski K, Bödvarsdottir TB, Raun K, Grove KL, Kievit P.

Int J Obes (Lond). 2018 Jun;42(6):1151-1160. doi: 10.1038/s41366-018-0080-7. Epub 2018 Jun 11.

4.

GLP-1R Signaling Directly Activates Arcuate Nucleus Kisspeptin Action in Brain Slices but Does not Rescue Luteinizing Hormone Inhibition in Ovariectomized Mice During Negative Energy Balance.

Heppner KM, Baquero AF, Bennett CM, Lindsley SR, Kirigiti MA, Bennett B, Bosch MA, Mercer AJ, Rønnekleiv OK, True C, Grove KL, Smith MS.

eNeuro. 2017 Jan 20;4(1). pii: ENEURO.0198-16.2016. doi: 10.1523/ENEURO.0198-16.2016. eCollection 2017 Jan-Feb.

5.

Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice.

Heppner KM, Marks S, Holland J, Ottaway N, Smiley D, Dimarchi R, Perez-Tilve D.

Diabetologia. 2015 Sep;58(9):2124-32. doi: 10.1007/s00125-015-3651-3. Epub 2015 Jun 7.

6.

GLP-1 based therapeutics: simultaneously combating T2DM and obesity.

Heppner KM, Perez-Tilve D.

Front Neurosci. 2015 Mar 20;9:92. doi: 10.3389/fnins.2015.00092. eCollection 2015. Review.

7.

Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain.

Heppner KM, Kirigiti M, Secher A, Paulsen SJ, Buckingham R, Pyke C, Knudsen LB, Vrang N, Grove KL.

Endocrinology. 2015 Jan;156(1):255-67. doi: 10.1210/en.2014-1675.

8.

Mechanisms in endocrinology: regulation of glucose metabolism by the ghrelin system: multiple players and multiple actions.

Heppner KM, Tong J.

Eur J Endocrinol. 2014 Jul;171(1):R21-32. doi: 10.1530/EJE-14-0183. Epub 2014 Apr 8. Review.

PMID:
24714083
9.

GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats.

Habegger KM, Heppner KM, Amburgy SE, Ottaway N, Holland J, Raver C, Bartley E, Müller TD, Pfluger PT, Berger J, Toure M, Benoit SC, Dimarchi RD, Perez-Tilve D, D'Alessio DA, Seeley RJ, Tschöp MH.

Diabetes. 2014 Feb;63(2):505-13. doi: 10.2337/db13-0511. Epub 2013 Nov 1.

10.

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.

Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.

11.

Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia.

Habegger KM, Al-Massadi O, Heppner KM, Myronovych A, Holland J, Berger J, Yi CX, Gao Y, Lehti M, Ottaway N, Amburgy S, Raver C, Müller TD, Pfluger PT, Kohli R, Perez-Tilve D, Seeley RJ, Tschöp MH.

Gut. 2014 Aug;63(8):1238-46. doi: 10.1136/gutjnl-2013-304583. Epub 2013 Oct 9.

12.

Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors.

Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tschöp MH, Sandoval DA, Perez-Tilve D.

Diabetes. 2014 Jan;63(1):122-31. doi: 10.2337/db13-0414. Epub 2013 Sep 23.

13.

GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats.

Habegger KM, Kirchner H, Yi CX, Heppner KM, Sweeney D, Ottaway N, Holland J, Amburgy S, Raver C, Krishna R, Müller TD, Perez-Tilve D, Pfluger PT, Obici S, DiMarchi RD, D'Alessio DA, Seeley RJ, Tschöp MH.

Diabetes. 2013 Sep;62(9):3261-7. doi: 10.2337/db13-0117. Epub 2013 Jun 17.

14.

Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background.

Kirchner H, Heppner KM, Holland J, Kabra D, Tschöp MH, Pfluger PT.

PLoS One. 2013 Apr 22;8(4):e61822. doi: 10.1371/journal.pone.0061822. Print 2013.

15.

Fibroblast growth factor 21 mediates specific glucagon actions.

Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH.

Diabetes. 2013 May;62(5):1453-63. doi: 10.2337/db12-1116. Epub 2013 Jan 10.

16.

p62 links β-adrenergic input to mitochondrial function and thermogenesis.

Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH.

J Clin Invest. 2013 Jan;123(1):469-78. doi: 10.1172/JCI64209. Epub 2012 Dec 21.

17.

Ghrelin in the control of energy, lipid, and glucose metabolism.

Heppner KM, Müller TD, Tong J, Tschöp MH.

Methods Enzymol. 2012;514:249-60. doi: 10.1016/B978-0-12-381272-8.00015-5.

PMID:
22975057
18.

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.

Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D.

Diabetes. 2012 Nov;61(11):2753-62. doi: 10.2337/db11-1556. Epub 2012 Aug 28.

19.

Acylation type determines ghrelin's effects on energy homeostasis in rodents.

Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH.

Endocrinology. 2012 Oct;153(10):4687-95. Epub 2012 Aug 3.

20.

The role of ghrelin-octanoyl-acyl-transferase in thermoregulation.

Heppner KM, Müller TD, Kirchner H, Perez-Tilve D, Pfluger PT, Tschöp MH, Hofmann SM.

J Endocrinol Invest. 2013 Mar;36(3):180-4. doi: 10.3275/8388. Epub 2012 Apr 23.

PMID:
22526011
21.

The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction.

Yi CX, Heppner KM, Kirchner H, Tong J, Bielohuby M, Gaylinn BD, Müller TD, Bartley E, Davis HW, Zhao Y, Joseph A, Kruthaupt T, Ottaway N, Kabra D, Habegger KM, Benoit SC, Bidlingmaier M, Thorner MO, Perez-Tilve D, Tschöp MH, Pfluger PT.

PLoS One. 2012;7(2):e32100. doi: 10.1371/journal.pone.0032100. Epub 2012 Feb 21.

22.

The role of ghrelin in the control of energy balance.

Kirchner H, Heppner KM, Tschöp MH.

Handb Exp Pharmacol. 2012;(209):161-84. doi: 10.1007/978-3-642-24716-3_7. Review.

PMID:
22249814
23.

Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity.

Pfluger PT, Castañeda TR, Heppner KM, Strassburg S, Kruthaupt T, Chaudhary N, Halem H, Culler MD, Datta R, Burget L, Tschöp MH, Nogueiras R, Perez-Tilve D.

Physiol Behav. 2011 Nov 30;105(1):52-61. doi: 10.1016/j.physbeh.2011.04.025. Epub 2011 Apr 28.

PMID:
21554896
24.

The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism.

Heppner KM, Tong J, Kirchner H, Nass R, Tschöp MH.

Curr Opin Endocrinol Diabetes Obes. 2011 Feb;18(1):50-5. doi: 10.1097/MED.0b013e328341e1d3. Review.

PMID:
21150588
25.

The metabolic actions of glucagon revisited.

Habegger KM, Heppner KM, Geary N, Bartness TJ, DiMarchi R, Tschöp MH.

Nat Rev Endocrinol. 2010 Dec;6(12):689-97. doi: 10.1038/nrendo.2010.187. Epub 2010 Oct 19. Review.

26.

Glucagon regulation of energy metabolism.

Heppner KM, Habegger KM, Day J, Pfluger PT, Perez-Tilve D, Ward B, Gelfanov V, Woods SC, DiMarchi R, Tschöp M.

Physiol Behav. 2010 Jul 14;100(5):545-8. doi: 10.1016/j.physbeh.2010.03.019. Epub 2010 Apr 8. Review.

PMID:
20381509

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