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Items: 1 to 50 of 139

1.

Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3.

Houtman J, Freitag K, Gimber N, Schmoranzer J, Heppner FL, Jendrach M.

EMBO J. 2019 Feb 15;38(4). pii: e99430. doi: 10.15252/embj.201899430. Epub 2019 Jan 7.

PMID:
30617086
2.

Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies.

Çakmak-Görür N, Radke J, Rhein S, Schumann E, Willimsky G, Heppner FL, Blankenstein T, Pezzutto A.

Leukemia. 2019 Jan 3. doi: 10.1038/s41375-018-0330-7. [Epub ahead of print] No abstract available.

PMID:
30607022
3.

Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain.

Robson JP, Wagner B, Glitzner E, Heppner FL, Steinkellner T, Khan D, Petritsch C, Pollak DD, Sitte HH, Sibilia M.

FEBS J. 2018 Sep;285(17):3175-3196. doi: 10.1111/febs.14603. Epub 2018 Aug 4.

4.

CNS myeloid cells critically regulate heat hyperalgesia.

Kälin S, Miller KR, Kälin RE, Jendrach M, Witzel C, Heppner FL.

J Clin Invest. 2018 Jul 2;128(7):2774-2786. doi: 10.1172/JCI95305. Epub 2018 May 21.

5.

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, Lelios I, Heppner FL, Kipnis J, Merkler D, Greter M, Becher B.

Immunity. 2018 Mar 20;48(3):599. doi: 10.1016/j.immuni.2018.02.014. No abstract available.

PMID:
29562204
6.

Architectural B-cell organization in skeletal muscle identifies subtypes of dermatomyositis.

Radke J, Koll R, Preuße C, Pehl D, Todorova K, Schönemann C, Allenbach Y, Aronica E, de Visser M, Heppner FL, Weis J, Doostkam S, Maisonobe T, Benveniste O, Goebel HH, Stenzel W.

Neurol Neuroimmunol Neuroinflamm. 2018 Mar 6;5(3):e451. doi: 10.1212/NXI.0000000000000451. eCollection 2018 May.

7.

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA).

Burwinkel M, Lutzenberger M, Heppner FL, Schulz-Schaeffer W, Baier M.

Acta Neuropathol Commun. 2018 Mar 5;6(1):23. doi: 10.1186/s40478-018-0511-7.

8.

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, Lelios I, Heppner FL, Kipnis J, Merkler D, Greter M, Becher B.

Immunity. 2018 Feb 20;48(2):380-395.e6. doi: 10.1016/j.immuni.2018.01.011. Epub 2018 Feb 6. Erratum in: Immunity. 2018 Mar 20;48(3):599.

9.

Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus.

Papageorgiou IE, Valous NA, Lahrmann B, Janova H, Klaft ZJ, Koch A, Schneider UC, Vajkoczy P, Heppner FL, Grabe N, Halama N, Heinemann U, Kann O.

Glia. 2018 May;66(5):920-933. doi: 10.1002/glia.23292. Epub 2018 Jan 19.

PMID:
29350438
10.

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.

Amulic B, Knackstedt SL, Abu Abed U, Deigendesch N, Harbort CJ, Caffrey BE, Brinkmann V, Heppner FL, Hinds PW, Zychlinsky A.

Dev Cell. 2017 Nov 20;43(4):449-462.e5. doi: 10.1016/j.devcel.2017.10.013. Epub 2017 Nov 2.

11.

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O.

Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008.

12.

Phospho-AXL is widely expressed in glioblastoma and associated with significant shorter overall survival.

Onken J, Vajkoczy P, Torka R, Hempt C, Patsouris V, Heppner FL, Radke J.

Oncotarget. 2017 Jun 13;8(31):50403-50414. doi: 10.18632/oncotarget.18468. eCollection 2017 Aug 1.

13.

Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice.

Wagner LK, Gilling KE, Schormann E, Kloetzel PM, Heppner FL, Krüger E, Prokop S.

Acta Neuropathol Commun. 2017 Jun 24;5(1):52. doi: 10.1186/s40478-017-0453-5.

14.

Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity.

Kühnen P, Handke D, Waterland RA, Hennig BJ, Silver M, Fulford AJ, Dominguez-Salas P, Moore SE, Prentice AM, Spranger J, Hinney A, Hebebrand J, Heppner FL, Walzer L, Grötzinger C, Gromoll J, Wiegand S, Grüters A, Krude H.

Cell Metab. 2016 Sep 13;24(3):502-509. doi: 10.1016/j.cmet.2016.08.001. Epub 2016 Aug 25.

15.

Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH).

Atangana E, Schneider UC, Blecharz K, Magrini S, Wagner J, Nieminen-Kelhä M, Kremenetskaia I, Heppner FL, Engelhardt B, Vajkoczy P.

Transl Stroke Res. 2017 Apr;8(2):144-156. doi: 10.1007/s12975-016-0485-3. Epub 2016 Aug 1.

PMID:
27477569
16.

High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia.

Baufeld C, Osterloh A, Prokop S, Miller KR, Heppner FL.

Acta Neuropathol. 2016 Sep;132(3):361-75. doi: 10.1007/s00401-016-1595-4. Epub 2016 Jul 8.

17.

MGMT Promoter Methylation and BRAF V600E Mutations Are Helpful Markers to Discriminate Pleomorphic Xanthoastrocytoma from Giant Cell Glioblastoma.

Lohkamp LN, Schinz M, Gehlhaar C, Guse K, Thomale UW, Vajkoczy P, Heppner FL, Koch A.

PLoS One. 2016 Jun 2;11(6):e0156422. doi: 10.1371/journal.pone.0156422. eCollection 2016.

18.

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors.

Brandenburg S, Müller A, Turkowski K, Radev YT, Rot S, Schmidt C, Bungert AD, Acker G, Schorr A, Hippe A, Miller K, Heppner FL, Homey B, Vajkoczy P.

Acta Neuropathol. 2016 Mar;131(3):365-78. doi: 10.1007/s00401-015-1529-6. Epub 2015 Dec 30.

PMID:
26718201
19.

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice.

Prokop S, Miller KR, Drost N, Handrick S, Mathur V, Luo J, Wegner A, Wyss-Coray T, Heppner FL.

J Exp Med. 2015 Oct 19;212(11):1811-8. doi: 10.1084/jem.20150479. Epub 2015 Oct 12.

20.

A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance.

Dietel M, Jöhrens K, Laffert MV, Hummel M, Bläker H, Pfitzner BM, Lehmann A, Denkert C, Darb-Esfahani S, Lenze D, Heppner FL, Koch A, Sers C, Klauschen F, Anagnostopoulos I.

Cancer Gene Ther. 2015 Sep;22(9):417-30. doi: 10.1038/cgt.2015.39. Epub 2015 Sep 11. Review.

PMID:
26358176
21.

Genome wide DNA copy number analysis in cholangiocarcinoma using high resolution molecular inversion probe single nucleotide polymorphism assay.

Arnold A, Bahra M, Lenze D, Bradtmöller M, Guse K, Gehlhaar C, Bläker H, Heppner FL, Koch A.

Exp Mol Pathol. 2015 Oct;99(2):344-53. doi: 10.1016/j.yexmp.2015.08.003. Epub 2015 Aug 8.

PMID:
26260902
22.

Conserved size and periodicity of pyramidal patches in layer 2 of medial/caudal entorhinal cortex.

Naumann RK, Ray S, Prokop S, Las L, Heppner FL, Brecht M.

J Comp Neurol. 2016 Mar 1;524(4):783-806. doi: 10.1002/cne.23865. Epub 2015 Sep 9.

23.

Immune attack: the role of inflammation in Alzheimer disease.

Heppner FL, Ransohoff RM, Becher B.

Nat Rev Neurosci. 2015 Jun;16(6):358-72. doi: 10.1038/nrn3880. Review.

PMID:
25991443
24.

Microglia inflict delayed brain injury after subarachnoid hemorrhage.

Schneider UC, Davids AM, Brandenburg S, Müller A, Elke A, Magrini S, Atangana E, Turkowski K, Finger T, Gutenberg A, Gehlhaar C, Brück W, Heppner FL, Vajkoczy P.

Acta Neuropathol. 2015 Aug;130(2):215-31. doi: 10.1007/s00401-015-1440-1. Epub 2015 May 9.

PMID:
25956409
25.

The most fulminant course of the Marburg variant of multiple sclerosis-autopsy findings.

Nunes JC, Radbruch H, Walz R, Lin K, Stenzel W, Prokop S, Koch A, Heppner FL.

Mult Scler. 2015 Apr;21(4):485-7. doi: 10.1177/1352458514537366. Epub 2014 Jun 2.

PMID:
25824955
26.

Hypothalamic innate immune reaction in obesity.

Kälin S, Heppner FL, Bechmann I, Prinz M, Tschöp MH, Yi CX.

Nat Rev Endocrinol. 2015 Jun;11(6):339-51. doi: 10.1038/nrendo.2015.48. Epub 2015 Mar 31. Review.

PMID:
25824676
27.

Proximal weakness in a patient with MALT lymphoma: a case report and discussion of possible pathogenesis.

Nunes JC, Rinnenthal JL, Allenbach Y, Lenze D, Hummel M, Jöhrens K, Walz R, Goebel HH, Heppner FL, Stenzel W.

Neuropathol Appl Neurobiol. 2015 Aug;41(5):686-9. doi: 10.1111/nan.12234. Epub 2015 May 19. No abstract available.

PMID:
25763887
28.

Nuclear actin aggregation is a hallmark of anti-synthetase syndrome-induced dysimmune myopathy.

Stenzel W, Preuße C, Allenbach Y, Pehl D, Junckerstorff R, Heppner FL, Nolte K, Aronica E, Kana V, Rushing E, Schneider U, Claeys KG, Benveniste O, Weis J, Goebel HH.

Neurology. 2015 Mar 31;84(13):1346-54. doi: 10.1212/WNL.0000000000001422. Epub 2015 Mar 6.

29.

Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis.

Preusse C, Goebel HH, Pehl D, Rinnenthal JL, Kley RA, Allenbach Y, Heppner FL, Vorgerd M, Authier FJ, Gherardi R, Stenzel W.

Neuropathol Appl Neurobiol. 2015 Dec;41(7):952-63. doi: 10.1111/nan.12231. Epub 2015 May 19.

PMID:
25711697
30.

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling.

Hu F, Dzaye O, Hahn A, Yu Y, Scavetta RJ, Dittmar G, Kaczmarek AK, Dunning KR, Ricciardelli C, Rinnenthal JL, Heppner FL, Lehnardt S, Synowitz M, Wolf SA, Kettenmann H.

Neuro Oncol. 2015 Feb;17(2):200-10. doi: 10.1093/neuonc/nou324. Epub 2014 Dec 1.

31.

The lymphoid follicle variant of dermatomyositis.

Radke J, Pehl D, Aronica E, Schonenberg-Meinema D, Schneider U, Heppner FL, de Visser M, Goebel HH, Stenzel W.

Neurol Neuroimmunol Neuroinflamm. 2014 Jul 28;1(2):e19. doi: 10.1212/NXI.0000000000000019. eCollection 2014 Aug.

32.

The evolution of the anaplastic cerebellar liponeurocytoma: case report and review of the literature.

Radke J, Gehlhaar C, Lenze D, Capper D, Bock A, Heppner FL, Jödicke A, Koch A.

Clin Neuropathol. 2015 Jan-Feb;34(1):19-25. doi: 10.5414/NP300783. Review.

PMID:
25250652
33.

An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates.

Johansson LBG, Simon R, Bergström G, Eriksson M, Prokop S, Mandenius CF, Heppner FL, Åslund AKO, Nilsson KPR.

Biosens Bioelectron. 2015 Jan 15;63:204-211. doi: 10.1016/j.bios.2014.07.042. Epub 2014 Jul 24.

34.

Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.

Barucker C, Harmeier A, Weiske J, Fauler B, Albring KF, Prokop S, Hildebrand P, Lurz R, Heppner FL, Huber O, Multhaup G.

J Biol Chem. 2014 Jul 18;289(29):20182-91. doi: 10.1074/jbc.M114.564690. Epub 2014 May 30.

35.

A paucisymptomatic neuromuscular disease mimicking type III 5q-SMA with complex rearrangements in the SMN gene.

Lohkamp LN, von Au K, Goebel HH, Kress W, Grieben U, Drossel K, Garbes L, Wirth B, Heppner FL, Stenzel W.

J Child Neurol. 2014 Feb;29(2):254-9. doi: 10.1177/0883073813511858. Epub 2013 Dec 11.

PMID:
24334346
36.

Inflammatory myopathy with abundant macrophages (IMAM): the immunology revisited.

Rinnenthal JL, Goebel HH, Preuße C, Lebenheim L, Schumann M, Moos V, Schneider T, Heppner FL, Stenzel W.

Neuromuscul Disord. 2014 Feb;24(2):151-5. doi: 10.1016/j.nmd.2013.11.004. Epub 2013 Nov 18.

PMID:
24314585
37.

Microglia actions in Alzheimer’s disease.

Prokop S, Miller KR, Heppner FL.

Acta Neuropathol. 2013 Oct;126(4):461-77. Review.

PMID:
24224195
38.

Novel γ-sarcoglycan-mutation affects cardiac function and N-terminal dystrophin expression.

Schröder NW, Grieben U, Prokop S, Dekomien G, Epplen JT, Heppner FL, Goebel HH, Stenzel W.

Muscle Nerve. 2014 Jan;49(1):144-5. doi: 10.1002/mus.23981. Epub 2013 Dec 3. No abstract available.

PMID:
23929688
39.

Microglia as dynamic and essential components of the amyloid hypothesis.

Gandy S, Heppner FL.

Neuron. 2013 May 22;78(4):575-7. doi: 10.1016/j.neuron.2013.05.007. No abstract available.

40.

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology.

Krabbe G, Halle A, Matyash V, Rinnenthal JL, Eom GD, Bernhardt U, Miller KR, Prokop S, Kettenmann H, Heppner FL.

PLoS One. 2013;8(4):e60921. doi: 10.1371/journal.pone.0060921. Epub 2013 Apr 8.

41.

Enhanced acute immune response in IL-12p35-/- mice is followed by accelerated distinct repair mechanisms in Staphylococcus aureus-induced murine brain abscess.

Held J, Preuße C, Döser A, Richter L, Heppner FL, Stenzel W.

J Infect Dis. 2013 Sep 1;208(5):749-60. doi: 10.1093/infdis/jit126. Epub 2013 Mar 26.

PMID:
23532102
42.

Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits.

Nyström S, Psonka-Antonczyk KM, Ellingsen PG, Johansson LB, Reitan N, Handrick S, Prokop S, Heppner FL, Wegenast-Braun BM, Jucker M, Lindgren M, Stokke BT, Hammarström P, Nilsson KP.

ACS Chem Biol. 2013;8(6):1128-33. doi: 10.1021/cb4000376. Epub 2013 Mar 29.

PMID:
23521783
43.

Combined temozolomide and sunitinib treatment leads to better tumour control but increased vascular resistance in O6-methylguanine methyltransferase-methylated gliomas.

Czabanka M, Bruenner J, Parmaksiz G, Broggini T, Topalovic M, Bayerl SH, Auf G, Kremenetskaia I, Nieminen M, Jabouille A, Mueller S, Harms U, Harms C, Koch A, Heppner FL, Vajkoczy P.

Eur J Cancer. 2013 Jun;49(9):2243-52. doi: 10.1016/j.ejca.2013.02.019. Epub 2013 Mar 14.

PMID:
23499430
44.

Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance.

Dietel M, Jöhrens K, Laffert M, Hummel M, Bläker H, Müller BM, Lehmann A, Denkert C, Heppner FL, Koch A, Sers C, Anagnostopoulos I.

Cancer Gene Ther. 2013 Apr;20(4):211-21. doi: 10.1038/cgt.2013.13. Epub 2013 Mar 15. Review.

PMID:
23492822
45.

Enhanced fluorescent assignment of protein aggregates by an oligothiophene-porphyrin-based amyloid ligand.

Arja K, Sjölander D, Åslund A, Prokop S, Heppner FL, Konradsson P, Lindgren M, Hammarström P, Åslund KO, Nilsson KP.

Macromol Rapid Commun. 2013 May 14;34(9):723-30. doi: 10.1002/marc.201200817. Epub 2013 Mar 7.

PMID:
23468206
46.

Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies.

Klingstedt T, Blechschmidt C, Nogalska A, Prokop S, Häggqvist B, Danielsson O, Engel WK, Askanas V, Heppner FL, Nilsson KP.

Chembiochem. 2013 Mar 18;14(5):607-16. doi: 10.1002/cbic.201200731. Epub 2013 Feb 28.

47.

Juvenile autophagic vacuolar myopathy - a new entity or variant?

Stenzel W, Nishino I, von Moers A, Kadry MA, Glaeser D, Heppner FL, Goebel HH.

Neuropathol Appl Neurobiol. 2013 Jun;39(4):449-53. doi: 10.1111/nan.12018. No abstract available.

PMID:
23324055
48.

Calcified myocardial necrosis in pediatric patients after cardiopulmonary resuscitation.

Buschmann CT, Stenzel W, Martin H, Heppner FL, Guddat SS, Tsokos M.

Forensic Sci Med Pathol. 2013 Dec;9(4):543-50. doi: 10.1007/s12024-012-9400-8. Epub 2012 Dec 22.

PMID:
23264200
49.

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.

Vom Berg J, Prokop S, Miller KR, Obst J, Kälin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL.

Nat Med. 2012 Dec;18(12):1812-9. doi: 10.1038/nm.2965. Epub 2012 Nov 25.

PMID:
23178247
50.

Impaired Pten expression in human malignant peripheral nerve sheath tumours.

Bradtmöller M, Hartmann C, Zietsch J, Jäschke S, Mautner VF, Kurtz A, Park SJ, Baier M, Harder A, Reuss D, von Deimling A, Heppner FL, Holtkamp N.

PLoS One. 2012;7(11):e47595. doi: 10.1371/journal.pone.0047595. Epub 2012 Nov 6.

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