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Items: 1 to 50 of 91

1.

RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling.

Evans PR, Parra-Bueno P, Smirnov MS, Lustberg DJ, Dudek SM, Hepler JR, Yasuda R.

eNeuro. 2018 Jun 4;5(3). pii: ENEURO.0353-17.2018. doi: 10.1523/ENEURO.0353-17.2018. eCollection 2018 May-Jun.

2.

Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease.

Squires KE, Montañez-Miranda C, Pandya RR, Torres MP, Hepler JR.

Pharmacol Rev. 2018 Jul;70(3):446-474. doi: 10.1124/pr.117.015354. Review.

PMID:
29871944
3.

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.

Evans PR, Gerber KJ, Dammer EB, Duong DM, Goswami D, Lustberg DJ, Zou J, Yang JJ, Dudek SM, Griffin PR, Seyfried NT, Hepler JR.

J Proteome Res. 2018 Apr 6;17(4):1700-1711. doi: 10.1021/acs.jproteome.8b00027. Epub 2018 Mar 20.

PMID:
29518331
4.

Direct visualization of interaction between calmodulin and connexin45.

Zou J, Salarian M, Chen Y, Zhuo Y, Brown NE, Hepler JR, Yang JJ.

Biochem J. 2017 Nov 27;474(24):4035-4051. doi: 10.1042/BCJ20170426.

5.

Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus.

Branch MR, Hepler JR.

PLoS One. 2017 Sep 21;12(9):e0184497. doi: 10.1371/journal.pone.0184497. eCollection 2017.

6.

Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain.

Squires KE, Gerber KJ, Pare JF, Branch MR, Smith Y, Hepler JR.

Brain Struct Funct. 2018 Jan;223(1):233-253. doi: 10.1007/s00429-017-1487-y. Epub 2017 Aug 3.

PMID:
28776200
7.

RGS14 regulates the lifetime of Gα-GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells.

Brown NE, Lambert NA, Hepler JR.

Pharmacol Res Perspect. 2016 Aug 18;4(5):e00249. eCollection 2016 Oct.

8.

Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.

Gerber KJ, Squires KE, Hepler JR.

Mol Pharmacol. 2016 Feb;89(2):273-86. doi: 10.1124/mol.115.102210. Epub 2015 Dec 11. Review.

9.

Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory.

Evans PR, Dudek SM, Hepler JR.

Prog Mol Biol Transl Sci. 2015;133:169-206. doi: 10.1016/bs.pmbts.2015.03.006. Epub 2015 Apr 27. Review.

PMID:
26123307
10.

Bioluminescence resonance energy transfer to detect protein-protein interactions in live cells.

Brown NE, Blumer JB, Hepler JR.

Methods Mol Biol. 2015;1278:457-65. doi: 10.1007/978-1-4939-2425-7_30.

11.

Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14).

Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR.

J Biol Chem. 2015 Apr 3;290(14):9037-49. doi: 10.1074/jbc.M114.634329. Epub 2015 Feb 9.

12.

G protein coupled receptor signaling complexes in live cells.

Hepler JR.

Cell Logist. 2014 Jun 4;4:e29392. eCollection 2014.

13.

Regulator of G protein signaling 2 (RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1) in live cells.

Ghil S, McCoy KL, Hepler JR.

PLoS One. 2014 Apr 17;9(4):e95355. doi: 10.1371/journal.pone.0095355. eCollection 2014.

14.

Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain.

Evans PR, Lee SE, Smith Y, Hepler JR.

J Comp Neurol. 2014 Jan 1;522(1):186-203. doi: 10.1002/cne.23395.

15.

The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.

Zhao P, Nunn C, Ramineni S, Hepler JR, Chidiac P.

J Cell Biochem. 2013 Jun;114(6):1414-23. doi: 10.1002/jcb.24483.

16.

Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.

Vellano CP, Brown NE, Blumer JB, Hepler JR.

J Biol Chem. 2013 Feb 1;288(5):3620-31. doi: 10.1074/jbc.M112.440057. Epub 2012 Dec 17.

17.

Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop.

McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, Hepler JR.

Cell Signal. 2012 Jun;24(6):1351-60. doi: 10.1016/j.cellsig.2012.01.011. Epub 2012 Jan 28.

18.

RGS14 at the interface of hippocampal signaling and synaptic plasticity.

Vellano CP, Lee SE, Dudek SM, Hepler JR.

Trends Pharmacol Sci. 2011 Nov;32(11):666-74. doi: 10.1016/j.tips.2011.07.005. Epub 2011 Sep 8. Review.

19.

G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.

Vellano CP, Maher EM, Hepler JR, Blumer JB.

J Biol Chem. 2011 Nov 4;286(44):38659-69. doi: 10.1074/jbc.M111.274928. Epub 2011 Aug 31.

20.

Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.

Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR.

Biochemistry. 2011 Feb 8;50(5):752-62. doi: 10.1021/bi101910n. Epub 2011 Jan 11.

21.

RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory.

Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16994-8. doi: 10.1073/pnas.1005362107. Epub 2010 Sep 13.

22.

Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.

Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E.

Sci Signal. 2010 May 11;3(121):ra37. doi: 10.1126/scisignal.2000647.

23.

PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.

McCoy KL, Traynelis SF, Hepler JR.

Mol Pharmacol. 2010 Jun;77(6):1005-15. doi: 10.1124/mol.109.062018. Epub 2010 Mar 9.

24.

RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.

Shu FJ, Ramineni S, Hepler JR.

Cell Signal. 2010 Mar;22(3):366-76. doi: 10.1016/j.cellsig.2009.10.005.

25.

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors.

Yuan H, Vance KM, Junge CE, Geballe MT, Snyder JP, Hepler JR, Yepes M, Low CM, Traynelis SF.

J Biol Chem. 2009 May 8;284(19):12862-73. doi: 10.1074/jbc.M805123200. Epub 2009 Feb 24.

26.

Regulators of G protein signaling proteins as central components of G protein-coupled receptor signaling complexes.

McCoy KL, Hepler JR.

Prog Mol Biol Transl Sci. 2009;86:49-74. doi: 10.1016/S1877-1173(09)86003-1. Epub 2009 Oct 7. Review.

PMID:
20374713
27.

Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.

Mannaioni G, Orr AG, Hamill CE, Yuan H, Pedone KH, McCoy KL, Berlinguer Palmini R, Junge CE, Lee CJ, Yepes M, Hepler JR, Traynelis SF.

J Biol Chem. 2008 Jul 18;283(29):20600-11. doi: 10.1074/jbc.M803015200. Epub 2008 May 12.

28.

Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members.

Gu S, He J, Ho WT, Ramineni S, Thal DM, Natesh R, Tesmer JJ, Hepler JR, Heximer SP.

J Biol Chem. 2007 Nov 9;282(45):33064-75. Epub 2007 Sep 11.

30.

RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.

Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH.

Cell Signal. 2007 Apr;19(4):723-30. Epub 2006 Oct 7.

PMID:
17126529
31.

Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization.

Shu FJ, Ramineni S, Amyot W, Hepler JR.

Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25.

PMID:
16870394
32.

Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling.

Neitzel KL, Hepler JR.

Semin Cell Dev Biol. 2006 Jun;17(3):383-9. Epub 2006 Mar 16. Review.

PMID:
16647283
33.

Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins.

Hubbard KB, Hepler JR.

Cell Signal. 2006 Feb;18(2):135-50. Epub 2005 Sep 22. Review.

PMID:
16182515
34.

RGS2 interacts with Gs and adenylyl cyclase in living cells.

Roy AA, Baragli A, Bernstein LS, Hepler JR, Hébert TE, Chidiac P.

Cell Signal. 2006 Mar;18(3):336-48. Epub 2005 Aug 10.

PMID:
16095880
35.
36.

Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop.

Hague C, Bernstein LS, Ramineni S, Chen Z, Minneman KP, Hepler JR.

J Biol Chem. 2005 Jul 22;280(29):27289-95. Epub 2005 May 24.

37.

Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.

Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF.

J Neurosci. 2005 Apr 27;25(17):4319-29.

38.

Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity.

Hepler JR, Cladman W, Ramineni S, Hollinger S, Chidiac P.

Biochemistry. 2005 Apr 12;44(14):5495-502.

PMID:
15807543
39.

Differential effects of Gq alpha, G14 alpha, and G15 alpha on vascular smooth muscle cell survival and gene expression profiles.

Peavy RD, Hubbard KB, Lau A, Fields RB, Xu K, Lee CJ, Lee TT, Gernert K, Murphy TJ, Hepler JR.

Mol Pharmacol. 2005 Jun;67(6):2102-14. Epub 2005 Mar 23.

40.

Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes.

Junge CE, Lee CJ, Hubbard KB, Zhang Z, Olson JJ, Hepler JR, Brat DJ, Traynelis SF.

Exp Neurol. 2004 Jul;188(1):94-103.

PMID:
15191806
41.

RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.

Bernstein LS, Ramineni S, Hague C, Cladman W, Chidiac P, Levey AI, Hepler JR.

J Biol Chem. 2004 May 14;279(20):21248-56. Epub 2004 Feb 19.

42.

Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

Sorensen SD, Nicole O, Peavy RD, Montoya LM, Lee CJ, Murphy TJ, Traynelis SF, Hepler JR.

Mol Pharmacol. 2003 Nov;64(5):1199-209.

43.

Methods for measuring RGS protein phosphorylation by G protein-regulated kinases.

Hollinger S, Hepler JR.

Methods Mol Biol. 2004;237:205-19. Review.

PMID:
14501052
44.

Analysis of RGS protein palmitoylation.

Bernstein LS, Linder ME, Hepler JR.

Methods Mol Biol. 2004;237:195-204. Review.

PMID:
14501051
45.

RGS protein and G protein interactions: a little help from their friends.

Hepler JR.

Mol Pharmacol. 2003 Sep;64(3):547-9. Review. No abstract available.

46.

Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.

Hollinger S, Ramineni S, Hepler JR.

Biochemistry. 2003 Jan 28;42(3):811-9.

PMID:
12534294
47.

Cellular regulation of RGS proteins: modulators and integrators of G protein signaling.

Hollinger S, Hepler JR.

Pharmacol Rev. 2002 Sep;54(3):527-59. Review.

48.

Measuring RGS protein interactions with Gq alpha.

Chidiac P, Gadd ME, Hepler JR.

Methods Enzymol. 2002;344:686-702. No abstract available.

PMID:
11771420
49.

RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain.

Hollinger S, Taylor JB, Goldman EH, Hepler JR.

J Neurochem. 2001 Dec;79(5):941-9.

50.

Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.

Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK.

J Biol Chem. 2001 Feb 23;276(8):5438-44. Epub 2000 Nov 3.

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