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Items: 47

1.

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

Williamson DS, Smith GP, Acheson-Dossang P, Bedford ST, Chell V, Chen IJ, Daechsel JCA, Daniels Z, David L, Dokurno P, Hentzer M, Herzig MC, Hubbard RE, Moore JD, Murray JB, Newland S, Ray SC, Shaw T, Surgenor AE, Terry L, Thirstrup K, Wang Y, Christensen KV.

J Med Chem. 2017 Nov 9;60(21):8945-8962. doi: 10.1021/acs.jmedchem.7b01186. Epub 2017 Oct 27.

PMID:
29023112
2.

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.

Smith GP, Badolo L, Chell V, Chen IJ, Christensen KV, David L, Daechsel JA, Hentzer M, Herzig MC, Mikkelsen GK, Watson SP, Williamson DS.

Bioorg Med Chem Lett. 2017 Sep 15;27(18):4500-4505. doi: 10.1016/j.bmcl.2017.07.072. Epub 2017 Aug 1.

PMID:
28802631
3.

Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity.

Bayer Andersen K, Leander Johansen J, Hentzer M, Smith GP, Dietz GP.

Front Cell Neurosci. 2016 Jun 28;10:164. doi: 10.3389/fncel.2016.00164. eCollection 2016.

4.

High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139.

Wang J, Zhu LY, Liu Q, Hentzer M, Smith GP, Wang MW.

Acta Pharmacol Sin. 2015 Jul;36(7):874-8. doi: 10.1038/aps.2015.12. Epub 2015 Jun 1.

5.

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.

Maeda K, Sugino H, Akazawa H, Amada N, Shimada J, Futamura T, Yamashita H, Ito N, McQuade RD, Mørk A, Pehrson AL, Hentzer M, Nielsen V, Bundgaard C, Arnt J, Stensbøl TB, Kikuchi T.

J Pharmacol Exp Ther. 2014 Sep;350(3):589-604. doi: 10.1124/jpet.114.213793. Epub 2014 Jun 19.

PMID:
24947465
6.

Abnormal visual gain control in a Parkinson's disease model.

Afsari F, Christensen KV, Smith GP, Hentzer M, Nippe OM, Elliott CJ, Wade AR.

Hum Mol Genet. 2014 Sep 1;23(17):4465-78. doi: 10.1093/hmg/ddu159. Epub 2014 Apr 9.

7.

Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.

Sams AG, Larsen K, Mikkelsen GK, Hentzer M, Christoffersen CT, Jensen KG, Frederiksen K, Bang-Andersen B.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5134-40. doi: 10.1016/j.bmcl.2012.05.048. Epub 2012 May 18.

PMID:
22677319
8.

Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa.

Rybtke MT, Borlee BR, Murakami K, Irie Y, Hentzer M, Nielsen TE, Givskov M, Parsek MR, Tolker-Nielsen T.

Appl Environ Microbiol. 2012 Aug;78(15):5060-9. doi: 10.1128/AEM.00414-12. Epub 2012 May 11.

9.

A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.

Sautter R, Ramos D, Schneper L, Ciofu O, Wassermann T, Koh CL, Heydorn A, Hentzer M, Høiby N, Kharazmi A, Molin S, Devries CA, Ohman DE, Mathee K.

Gene. 2012 May 1;498(2):242-53. doi: 10.1016/j.gene.2011.11.005. Epub 2011 Nov 9.

10.

Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.

Shi F, Shen JK, Chen D, Fog K, Thirstrup K, Hentzer M, Karlsson JJ, Menon V, Jones KA, Smith KE, Smith G.

ACS Med Chem Lett. 2011 Feb 28;2(4):303-6. doi: 10.1021/ml100293q. eCollection 2011 Apr 14.

11.

Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.

Sams AG, Hentzer M, Mikkelsen GK, Larsen K, Bundgaard C, Plath N, Christoffersen CT, Bang-Andersen B.

J Med Chem. 2010 Sep 9;53(17):6386-97. doi: 10.1021/jm100697g.

PMID:
20684563
12.

Quorum sensing regulation in Aeromonas hydrophila.

Garde C, Bjarnsholt T, Givskov M, Jakobsen TH, Hentzer M, Claussen A, Sneppen K, Ferkinghoff-Borg J, Sams T.

J Mol Biol. 2010 Mar 5;396(4):849-57. doi: 10.1016/j.jmb.2010.01.002. Epub 2010 Jan 11.

PMID:
20064524
13.

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.

Ritzén A, Sindet R, Hentzer M, Svendsen N, Brodbeck RM, Bundgaard C.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3275-8. doi: 10.1016/j.bmcl.2009.04.095. Epub 2009 Apr 24.

PMID:
19443216
14.

Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors.

Yang L, Rybtke MT, Jakobsen TH, Hentzer M, Bjarnsholt T, Givskov M, Tolker-Nielsen T.

Antimicrob Agents Chemother. 2009 Jun;53(6):2432-43. doi: 10.1128/AAC.01283-08. Epub 2009 Apr 13.

15.
16.

The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional.

Shrout JD, Chopp DL, Just CL, Hentzer M, Givskov M, Parsek MR.

Mol Microbiol. 2006 Dec;62(5):1264-77. Epub 2006 Oct 24.

17.

Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein.

Schreiber K, Boes N, Eschbach M, Jaensch L, Wehland J, Bjarnsholt T, Givskov M, Hentzer M, Schobert M.

J Bacteriol. 2006 Jan;188(2):659-68.

18.

Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections.

Bjarnsholt T, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Hougen HP, Rygaard J, Moser C, Eberl L, Høiby N, Givskov M.

Microbiology. 2005 Dec;151(Pt 12):3873-80.

PMID:
16339933
19.

Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model.

Bragonzi A, Worlitzsch D, Pier GB, Timpert P, Ulrich M, Hentzer M, Andersen JB, Givskov M, Conese M, Doring G.

J Infect Dis. 2005 Aug 1;192(3):410-9. Epub 2005 Jun 24.

20.

Identity and effects of quorum-sensing inhibitors produced by Penicillium species.

Rasmussen TB, Skindersoe ME, Bjarnsholt T, Phipps RK, Christensen KB, Jensen PO, Andersen JB, Koch B, Larsen TO, Hentzer M, Eberl L, Hoiby N, Givskov M.

Microbiology. 2005 May;151(Pt 5):1325-40.

PMID:
15870443
21.

Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis.

Hoffmann N, Rasmussen TB, Jensen PØ, Stub C, Hentzer M, Molin S, Ciofu O, Givskov M, Johansen HK, Høiby N.

Infect Immun. 2005 Apr;73(4):2504-14. Erratum in: Infect Immun. 2005 Aug;73(8):5290.

22.

Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector.

Rasmussen TB, Bjarnsholt T, Skindersoe ME, Hentzer M, Kristoffersen P, Köte M, Nielsen J, Eberl L, Givskov M.

J Bacteriol. 2005 Mar;187(5):1799-814.

23.

Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent.

Bjarnsholt T, Jensen PØ, Burmølle M, Hentzer M, Haagensen JA, Hougen HP, Calum H, Madsen KG, Moser C, Molin S, Høiby N, Givskov M.

Microbiology. 2005 Feb;151(Pt 2):373-83.

PMID:
15699188
24.
25.

Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation.

Stapper AP, Narasimhan G, Ohman DE, Barakat J, Hentzer M, Molin S, Kharazmi A, Høiby N, Mathee K.

J Med Microbiol. 2004 Jul;53(Pt 7):679-90.

PMID:
15184541
26.

Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice.

Wu H, Song Z, Hentzer M, Andersen JB, Molin S, Givskov M, Høiby N.

J Antimicrob Chemother. 2004 Jun;53(6):1054-61. Epub 2004 Apr 29.

PMID:
15117922
27.

Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.

Bagge N, Schuster M, Hentzer M, Ciofu O, Givskov M, Greenberg EP, Høiby N.

Antimicrob Agents Chemother. 2004 Apr;48(4):1175-87.

28.

Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.

Bagge N, Hentzer M, Andersen JB, Ciofu O, Givskov M, Høiby N.

Antimicrob Agents Chemother. 2004 Apr;48(4):1168-74.

29.

Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics.

Arevalo-Ferro C, Hentzer M, Reil G, Görg A, Kjelleberg S, Givskov M, Riedel K, Eberl L.

Environ Microbiol. 2003 Dec;5(12):1350-69.

PMID:
14641579
30.
31.

Quorum sensing : a novel target for the treatment of biofilm infections.

Hentzer M, Eberl L, Nielsen J, Givskov M.

BioDrugs. 2003;17(4):241-50. Review.

PMID:
12899641
32.

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors.

Hentzer M, Wu H, Andersen JB, Riedel K, Rasmussen TB, Bagge N, Kumar N, Schembri MA, Song Z, Kristoffersen P, Manefield M, Costerton JW, Molin S, Eberl L, Steinberg P, Kjelleberg S, Høiby N, Givskov M.

EMBO J. 2003 Aug 1;22(15):3803-15.

33.

Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.

Bagge N, Ciofu O, Hentzer M, Campbell JI, Givskov M, Høiby N.

Antimicrob Agents Chemother. 2002 Nov;46(11):3406-11.

34.

Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA.

Laux DC, Corson JM, Givskov M, Hentzer M, Møller A, Wosencroft KA, Olson JC, Krogfelt KA, Goldberg JB, Cohen PS.

Microbiology. 2002 Jun;148(Pt 6):1709-23.

PMID:
12055291
35.
36.

Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers.

Olsen JA, Severinsen R, Rasmussen TB, Hentzer M, Givskov M, Nielsen J.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):325-8.

PMID:
11814788
37.

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.

Hentzer M, Riedel K, Rasmussen TB, Heydorn A, Andersen JB, Parsek MR, Rice SA, Eberl L, Molin S, Høiby N, Kjelleberg S, Givskov M.

Microbiology. 2002 Jan;148(Pt 1):87-102.

PMID:
11782502
38.

N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms.

Riedel K, Hentzer M, Geisenberger O, Huber B, Steidle A, Wu H, Høiby N, Givskov M, Molin S, Eberl L.

Microbiology. 2001 Dec;147(Pt 12):3249-62.

PMID:
11739757
39.

The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility.

Huber B, Riedel K, Hentzer M, Heydorn A, Gotschlich A, Givskov M, Molin S, Eberl L.

Microbiology. 2001 Sep;147(Pt 9):2517-28.

PMID:
11535791
40.

Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function.

Hentzer M, Teitzel GM, Balzer GJ, Heydorn A, Molin S, Givskov M, Parsek MR.

J Bacteriol. 2001 Sep;183(18):5395-401.

41.

Genetic and chemical tools for investigating signaling processes in biofilms.

Charlton T, Givskov M, deNys R, Andersen JB, Hentzer M, Rice S, Kjelleberg S.

Methods Enzymol. 2001;336:108-28. No abstract available.

PMID:
11398393
42.

A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm.

Charlton TS, de Nys R, Netting A, Kumar N, Hentzer M, Givskov M, Kjelleberg S.

Environ Microbiol. 2000 Oct;2(5):530-41.

PMID:
11233161
43.

gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication.

Andersen JB, Heydorn A, Hentzer M, Eberl L, Geisenberger O, Christensen BB, Molin S, Givskov M.

Appl Environ Microbiol. 2001 Feb;67(2):575-85.

44.

Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa.

Wu H, Song Z, Hentzer M, Andersen JB, Heydorn A, Mathee K, Moser C, Eberl L, Molin S, Høiby N, Givskov M.

Microbiology. 2000 Oct;146 ( Pt 10):2481-93.

PMID:
11021924
45.

Experimental reproducibility in flow-chamber biofilms.

Heydorn A, Ersbøll BK, Hentzer M, Parsek MR, Givskov M, Molin S.

Microbiology. 2000 Oct;146 ( Pt 10):2409-15.

PMID:
11021917
46.

Quantification of biofilm structures by the novel computer program COMSTAT.

Heydorn A, Nielsen AT, Hentzer M, Sternberg C, Givskov M, Ersbøll BK, Molin S.

Microbiology. 2000 Oct;146 ( Pt 10):2395-407.

PMID:
11021916
47.

Antisense silencing of the creA gene in Aspergillus nidulans.

Bautista LF, Aleksenko A, Hentzer M, Santerre-Henriksen A, Nielsen J.

Appl Environ Microbiol. 2000 Oct;66(10):4579-81.

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