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Items: 37

1.

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity.

Ahmed SM, Ramani PD, Wong SQR, Zhao X, Ivanyi-Nagy R, Leong TC, Chua C, Li Z, Hentze H, Tan IB, Yan J, DasGupta R, Dröge P.

PLoS One. 2019 May 8;14(5):e0215696. doi: 10.1371/journal.pone.0215696. eCollection 2019.

2.

Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.

Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R.

Nat Commun. 2017 Sep 5;8(1):435. doi: 10.1038/s41467-017-00451-5.

3.

Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.

Chu X, Shih SJ, Shaw R, Hentze H, Chan GH, Owens K, Wang S, Cai X, Newton D, Castro-Perez J, Salituro G, Palamanda J, Fernandis A, Ng CK, Liaw A, Savage MJ, Evers R.

Drug Metab Dispos. 2015 Jun;43(6):851-63. doi: 10.1124/dmd.115.063347. Epub 2015 Mar 26.

PMID:
25813937
4.

Formation of ceramophilic chitin and biohybrid materials enabled by a genetically engineered bifunctional protein.

Malho JM, Heinonen H, Kontro I, Mushi NE, Serimaa R, Hentze HP, Linder MB, Szilvay GR.

Chem Commun (Camb). 2014 Jul 14;50(55):7348-51. doi: 10.1039/c4cc02170c.

PMID:
24871427
5.

Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI.

Rajendran R, Huang W, Tang AM, Liang JM, Choo S, Reese T, Hentze H, van Boxtel S, Cliffe A, Rogers K, Henry B, Chuang KH.

Cancer Med. 2014 Feb;3(1):47-60. doi: 10.1002/cam4.177. Epub 2014 Jan 6.

6.

Inverse relationship between LDL cholesterol and PCSK9 plasma levels in dyslipidemic cynomolgus monkeys: effects of LDL lowering by ezetimibe in the absence of statins.

Hentze H, Jensen KK, Chia SM, Johns DG, Shaw RJ, Davis HR Jr, Shih SJ, Wong KK.

Atherosclerosis. 2013 Nov;231(1):84-90. doi: 10.1016/j.atherosclerosis.2013.08.028. Epub 2013 Sep 5.

PMID:
24125416
7.

The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.

Novotny-Diermayr V, Hart S, Goh KC, Cheong A, Ong LC, Hentze H, Pasha MK, Jayaraman R, Ethirajulu K, Wood JM.

Blood Cancer J. 2012 May;2(5):e69. doi: 10.1038/bcj.2012.14. Epub 2012 May 4.

8.

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.

Hart S, Goh KC, Novotny-Diermayr V, Hu CY, Hentze H, Tan YC, Madan B, Amalini C, Loh YK, Ong LC, William AD, Lee A, Poulsen A, Jayaraman R, Ong KH, Ethirajulu K, Dymock BW, Wood JW.

Leukemia. 2011 Nov;25(11):1751-9. doi: 10.1038/leu.2011.148. Epub 2011 Jun 21.

PMID:
21691275
9.

Pharmacodynamic evaluation of the target efficacy of SB939, an oral HDAC inhibitor with selectivity for tumor tissue.

Novotny-Diermayr V, Sausgruber N, Loh YK, Pasha MK, Jayaraman R, Hentze H, Yong WP, Goh BC, Toh HC, Ethirajulu K, Zhu J, Wood JM.

Mol Cancer Ther. 2011 Jul;10(7):1207-17. doi: 10.1158/1535-7163.MCT-11-0044. Epub 2011 May 17.

10.

SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.

Novotny-Diermayr V, Sangthongpitag K, Hu CY, Wu X, Sausgruber N, Yeo P, Greicius G, Pettersson S, Liang AL, Loh YK, Bonday Z, Goh KC, Hentze H, Hart S, Wang H, Ethirajulu K, Wood JM.

Mol Cancer Ther. 2010 Mar;9(3):642-52. doi: 10.1158/1535-7163.MCT-09-0689. Epub 2010 Mar 2.

11.

Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies.

Hentze H, Soong PL, Wang ST, Phillips BW, Putti TC, Dunn NR.

Stem Cell Res. 2009 May;2(3):198-210. doi: 10.1016/j.scr.2009.02.002. Epub 2009 Feb 12.

12.

The generation of six clinical-grade human embryonic stem cell lines.

Crook JM, Peura TT, Kravets L, Bosman AG, Buzzard JJ, Horne R, Hentze H, Dunn NR, Zweigerdt R, Chua F, Upshall A, Colman A.

Cell Stem Cell. 2007 Nov;1(5):490-4. No abstract available.

13.

The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy.

Leist M, Bremer S, Brundin P, Hescheler J, Kirkeby A, Krause KH, Poerzgen P, Puceat M, Schmidt M, Schrattenholz A, Zak NB, Hentze H.

ALTEX. 2008;25(3):163-90.

14.

Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1.

Choo AB, Tan HL, Ang SN, Fong WJ, Chin A, Lo J, Zheng L, Hentze H, Philp RJ, Oh SK, Yap M.

Stem Cells. 2008 Jun;26(6):1454-63. doi: 10.1634/stemcells.2007-0576. Epub 2008 Mar 20.

15.

A UTF1-based selection system for stable homogeneously pluripotent human embryonic stem cell cultures.

Tan SM, Wang ST, Hentze H, Dröge P.

Nucleic Acids Res. 2007;35(18):e118. Epub 2007 Sep 12.

16.

Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage.

Phillips BW, Hentze H, Rust WL, Chen QP, Chipperfield H, Tan EK, Abraham S, Sadasivam A, Soong PL, Wang ST, Lim R, Sun W, Colman A, Dunn NR.

Stem Cells Dev. 2007 Aug;16(4):561-78.

PMID:
17784830
17.

ATP-depleting carbohydrates prevent tumor necrosis factor receptor 1-dependent apoptotic and necrotic liver injury in mice.

Latta M, Künstle G, Lucas R, Hentze H, Wendel A.

J Pharmacol Exp Ther. 2007 Jun;321(3):875-83. Epub 2007 Mar 16.

PMID:
17369282
18.

Cell therapy and the safety of embryonic stem cell-derived grafts.

Hentze H, Graichen R, Colman A.

Trends Biotechnol. 2007 Jan;25(1):24-32. Epub 2006 Nov 3. Review.

PMID:
17084475
19.

Kupffer cell-expressed membrane-bound TNF mediates melphalan hepatotoxicity via activation of both TNF receptors.

Kresse M, Latta M, Künstle G, Riehle HM, van Rooijen N, Hentze H, Tiegs G, Biburger M, Lucas R, Wendel A.

J Immunol. 2005 Sep 15;175(6):4076-83.

20.

Topoisomerase inhibitor camptothecin sensitizes mouse hepatocytes in vitro and in vivo to TNF-mediated apoptosis.

Hentze H, Latta M, Künstle G, Dhakshinamoorthy S, Ng PY, Porter AG, Wendel A.

Hepatology. 2004 May;39(5):1311-20.

PMID:
15122760
22.

Redox control of hepatic cell death.

Hentze H, Latta M, Künstle G, Lucas R, Wendel A.

Toxicol Lett. 2003 Apr 4;139(2-3):111-8.

PMID:
12628746
23.

EuroBionet: a pan-European biomonitoring network for urban air quality assessment.

Klumpp A, Ansel W, Klumpp G, Belluzzo N, Calatayud V, Chaplin N, Garrec JP, Gutsche HJ, Hayes M, Hentze HW, Kambezidis H, Laurent O, Peñuelas J, Rasmussen S, Ribas A, Ro-Poulsen H, Rossi S, Sanz MJ, Shang H, Sifakis N, Vergne P.

Environ Sci Pollut Res Int. 2002;9(3):199-203.

PMID:
12094534
24.

Porous polymers and resins for biotechnological and biomedical applications.

Hentze HP, Antonietti M.

J Biotechnol. 2002 Mar;90(1):27-53. Review.

PMID:
12069045
25.

Ajoene, an experimental anti-leukemic drug: mechanism of cell death.

Dirsch VM, Antlsperger DS, Hentze H, Vollmar AM.

Leukemia. 2002 Jan;16(1):74-83.

26.

Glutathione dependence of caspase-8 activation at the death-inducing signaling complex.

Hentze H, Schmitz I, Latta M, Krueger A, Krammer PH, Wendel A.

J Biol Chem. 2002 Feb 15;277(7):5588-95. Epub 2001 Dec 4.

27.

Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury.

Härter L, Keel M, Hentze H, Leist M, Ertel W.

J Neuroimmunol. 2001 Dec 3;121(1-2):76-8.

PMID:
11730942
28.

Spontaneous in contrast to CD95-induced neutrophil apoptosis is independent of caspase activity.

Härter L, Keel M, Hentze H, Steckholzer U, Ungethüm U, Trentz O, Ertel W.

J Trauma. 2001 Jun;50(6):982-8.

PMID:
11426111
29.

In vivo and in vitro evidence for extracellular caspase activity released from apoptotic cells.

Hentze H, Schwoebel F, Lund S, Keel M, Ertel W, Wendel A, Jäättelä M, Leist M.

Biochem Biophys Res Commun. 2001 May 25;283(5):1111-7. Erratum in: Biochem Biophys Res Commun 2001 Jul 27;285(4):1076. Kehl M [corrected to Keel M].

PMID:
11355887
30.

DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.

Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, Knippers R.

Cancer Res. 2001 Feb 15;61(4):1659-65.

31.

Sepsis after severe injury interrupts caspase-dependent processing of interleukin-18.

Oberholzer A, Feilner A, Hentze H, Steckholzer U, Kurimoto M, Trentz O, Ertel W.

J Trauma. 2000 Jul;49(1):11-6; discussion 16-7.

PMID:
10912852
32.
33.

Concanavalin A hepatotoxicity in mice: tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation.

Künstle G, Hentze H, Germann PG, Tiegs G, Meergans T, Wendel A.

Hepatology. 1999 Nov;30(5):1241-51.

PMID:
10534346
34.

CD95-Mediated murine hepatic apoptosis requires an intact glutathione status.

Hentze H, Künstle G, Volbracht C, Ertel W, Wendel A.

Hepatology. 1999 Jul;30(1):177-85.

PMID:
10385654
35.

Inhibition of caspase activity prevents CD95-mediated hepatic microvascular perfusion failure and restores Kupffer cell clearance capacity.

Wanner GA, Mica L, Wanner-Schmid E, Kolb SA, Hentze H, Trentz O, Ertel W.

FASEB J. 1999 Jul;13(10):1239-48.

PMID:
10385614
36.

Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury.

Tiegs G, Küsters S, Künstle G, Hentze H, Kiemer AK, Wendel A.

J Pharmacol Exp Ther. 1998 Dec;287(3):1098-104.

PMID:
9864298
37.

Apoptosis in the absence of poly-(ADP-ribose) polymerase.

Leist M, Single B, Künstle G, Volbracht C, Hentze H, Nicotera P.

Biochem Biophys Res Commun. 1997 Apr 17;233(2):518-22.

PMID:
9144569

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