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Items: 1 to 50 of 71

1.

Population pharmacokinetic modeling of plasma Δ9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration.

Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK.

Br J Clin Pharmacol. 2020 Mar;86(3):611-619. doi: 10.1111/bcp.14170. Epub 2020 Jan 20.

PMID:
31747464
2.

Opioid-induced Ventilatory Depression in Sleep Apnea: Reply.

Doufas AG, Shafer SL, Henthorn TK.

Anesthesiology. 2019 Oct;131(4):937-938. doi: 10.1097/ALN.0000000000002930. No abstract available.

PMID:
31403499
3.

Preoperative Vancomycin Administration for Surgical Site Prophylaxis: Plasma and Soft-Tissue Concentrations in Pediatric Neurosurgical and Orthopedic Patients.

Peterson MB, Cohen MN, O'Neill BR, Garg S, Child J, Henthorn TK, Galinkin JG.

Anesth Analg. 2019 Aug 6. doi: 10.1213/ANE.0000000000004340. [Epub ahead of print]

PMID:
31397701
4.

Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial.

Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN.

J Inherit Metab Dis. 2019 May;42(3):424-437. doi: 10.1002/jimd.12085. Epub 2019 Apr 11.

PMID:
30873612
5.

Where's the Beef?: How Much Can We Skimp on Pharmacokinetic-Pharmacodynamic Data?

Henthorn TK, Olofsen E.

Anesthesiology. 2019 Feb;130(2):186-188. doi: 10.1097/ALN.0000000000002552. No abstract available.

PMID:
30589650
6.

Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(-) Ketamine Concentrations.

Henthorn TK, Avram MJ, Dahan A, Gustafsson LL, Persson J, Krejcie TC, Olofsen E.

Anesthesiology. 2018 Aug;129(2):260-270. doi: 10.1097/ALN.0000000000002265.

PMID:
29771709
7.

μ-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain?

Henthorn TK, Mikulich-Gilbertson SK.

Anesthesiology. 2018 May;128(5):867-870. doi: 10.1097/ALN.0000000000002177. No abstract available.

8.

The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis.

McLay JS, Engelhardt T, Mohammed BS, Cameron G, Cohen MN, Galinkin JL, Christians U, Avram MJ, Henthorn TK, Dsida RM, Hawwa AF, Anderson BJ.

Paediatr Anaesth. 2018 Feb;28(2):80-86. doi: 10.1111/pan.13302. Epub 2017 Dec 21. Erratum in: Paediatr Anaesth. 2018 Dec;28(12):1159.

PMID:
29266539
9.

Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m.

Tissot van Patot MC, Serkova NJ, Haschke M, Kominsky DJ, Roach RC, Christians U, Henthorn TK, Honigman B.

Free Radic Biol Med. 2009 Jun 1;46(11):1551-7. doi: 10.1016/j.freeradbiomed.2009.03.009. Epub 2009 Mar 19.

PMID:
19303436
10.

Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats.

Elkiweri IA, Zhang YL, Christians U, Ng KY, Tissot van Patot MC, Henthorn TK.

Anesth Analg. 2009 Jan;108(1):149-59. doi: 10.1213/ane.0b013e31818e0bd1.

11.

The pharmacokinetics and bioavailability of prochlorperazine delivered as a thermally generated aerosol in a single breath to volunteers.

Avram MJ, Spyker DA, Henthorn TK, Cassella JV.

Clin Pharmacol Ther. 2009 Jan;85(1):71-7. doi: 10.1038/clpt.2008.184. Epub 2008 Oct 1.

PMID:
18830225
12.

Early drug distribution: a generally neglected aspect of pharmacokinetics of particular relevance to intravenously administered anesthetic agents.

Henthorn TK, Krejcie TC, Avram MJ.

Clin Pharmacol Ther. 2008 Jul;84(1):18-22. doi: 10.1038/clpt.2008.107. Review.

PMID:
18563069
13.

The effect of altered physiological states on intravenous anesthetics.

Henthorn TK.

Handb Exp Pharmacol. 2008;(182):363-77. doi: 10.1007/978-3-540-74806-9_17. Review.

PMID:
18175100
14.
15.

A survey of propofol abuse in academic anesthesia programs.

Wischmeyer PE, Johnson BR, Wilson JE, Dingmann C, Bachman HM, Roller E, Tran ZV, Henthorn TK.

Anesth Analg. 2007 Oct;105(4):1066-71, table of contents.

PMID:
17898389
16.

Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs.

Avram MJ, Henthorn TK, Spyker DA, Krejcie TC, Lloyd PM, Cassella JV, Rabinowitz JD.

Drug Metab Dispos. 2007 Feb;35(2):262-7. Epub 2006 Nov 1.

PMID:
17079359
17.

Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution.

Avram MJ, Krejcie TC, Henthorn TK, Niemann CU.

J Pharmacol Exp Ther. 2004 Nov;311(2):617-24. Epub 2004 Jun 14.

PMID:
15197245
18.

Recirculatory pharmacokinetics. Which covariates affect the pharmacokinetics of intravenous agents?

Henthorn TK.

Adv Exp Med Biol. 2003;523:27-33. Review. No abstract available.

PMID:
15088837
19.
20.

Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics.

Minto CF, Schnider TW, Gregg KM, Henthorn TK, Shafer SL.

Anesthesiology. 2003 Aug;99(2):324-33.

PMID:
12883405
21.

Elimination of indocyanine green in the perioperative evaluation of donor liver function.

Mandell MS, Wachs M, Niemann CU, Henthorn TK.

Anesth Analg. 2002 Nov;95(5):1182-4, table of contents.

PMID:
12401588
22.

Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells.

Cho CW, Liu Y, Cobb WN, Henthorn TK, Lillehei K, Christians U, Ng KY.

Pharm Res. 2002 Aug;19(8):1123-9.

PMID:
12240937
23.

The concordance of early antipyrine and thiopental distribution kinetics.

Avram MJ, Krejcie TC, Henthorn TK.

J Pharmacol Exp Ther. 2002 Aug;302(2):594-600.

PMID:
12130720
24.

Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients.

Niemann CU, Yost CS, Mandell S, Henthorn TK.

Liver Transpl. 2002 May;8(5):476-81.

25.

Ultrasound-Induced hyperthermia increases cellular uptake and cytotoxicity of P-glycoprotein substrates in multi-drug resistant cells.

Liu Y, Cho CW, Yan X, Henthorn TK, Lillehei KO, Cobb WN, Ng KY.

Pharm Res. 2001 Sep;18(9):1255-61.

PMID:
11683237
26.

Initial and subsequent dosing of rectal acetaminophen in children: a 24-hour pharmacokinetic study of new dose recommendations.

Birmingham PK, Tobin MJ, Fisher DM, Henthorn TK, Hall SC, Coté CJ.

Anesthesiology. 2001 Mar;94(3):385-9.

PMID:
11374595
27.

Isoflurane alters the recirculatory pharmacokinetics of physiologic markers.

Avram MJ, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Henthorn TK.

Anesthesiology. 2000 Jun;92(6):1757-68.

PMID:
10839928
28.

Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol.

Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ.

Clin Pharmacol Ther. 2000 Apr;67(4):342-50.

PMID:
10801242
29.

Treatment of patients with metastatic melanoma with bryostatin-1--a phase II study.

Gonzalez R, Ebbinghaus S, Henthorn TK, Miller D, Kraft AS.

Melanoma Res. 1999 Dec;9(6):599-606.

PMID:
10661772
30.

Ketamine distribution described by a recirculatory pharmacokinetic model is not stereoselective.

Henthorn TK, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ.

Anesthesiology. 1999 Dec;91(6):1733-43.

PMID:
10598617
31.

Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water.

Krejcie TC, Henthorn TK, Gentry WB, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ.

J Pharmacol Exp Ther. 1999 Dec;291(3):1308-16.

PMID:
10565856
32.

Active transport of fentanyl by the blood-brain barrier.

Henthorn TK, Liu Y, Mahapatro M, Ng KY.

J Pharmacol Exp Ther. 1999 May;289(2):1084-9.

PMID:
10215691
33.

Evaluation of urea kinetics utilizing stable isotope urea and pharmacokinetic modeling.

Kaplan B, Wang Z, Siddhom O, Henthorn TK, Mujais SK.

Artif Organs. 1999 Jan;23(1):44-50.

PMID:
9950178
34.

Uptake of fentanyl in pulmonary endothelium.

Waters CM, Avram MJ, Krejcie TC, Henthorn TK.

J Pharmacol Exp Ther. 1999 Jan;288(1):157-63.

PMID:
9862766
35.

Transporter-mediated pulmonary endothelial uptake of fentanyl.

Henthorn TK, Krejcie TC, Avram MJ, Jensen TR, Waters CM.

Int J Clin Pharmacol Ther. 1998 Feb;36(2):74-5. No abstract available.

PMID:
9520148
36.

Premedication of pediatric tonsillectomy patients with oral transmucosal fentanyl citrate.

Dsida RM, Wheeler M, Birmingham PK, Henthorn TK, Avram MJ, Enders-Klein C, Maddalozzo J, Coté CJ.

Anesth Analg. 1998 Jan;86(1):66-70.

PMID:
9428853
37.

The effect of halothane on the recirculatory pharmacokinetics of physiologic markers.

Avram MJ, Krejcie TC, Niemann CU, Klein C, Gentry WB, Shanks CA, Henthorn TK.

Anesthesiology. 1997 Dec;87(6):1381-93.

PMID:
9416724
38.

Twenty-four-hour pharmacokinetics of rectal acetaminophen in children: an old drug with new recommendations.

Birmingham PK, Tobin MJ, Henthorn TK, Fisher DM, Berkelhamer MC, Smith FA, Fanta KB, Coté CJ.

Anesthesiology. 1997 Aug;87(2):244-52.

PMID:
9286887
39.

The use of a PID controller to model vecuronium pharmacokinetics and pharmacodynamics during liver transplantation. Proportional-integral-derivative.

O'Hara DA, Hexem JG, Derbyshire GJ, Overdyk FJ, Chen B, Henthorn TK, Li KJ.

IEEE Trans Biomed Eng. 1997 Jul;44(7):610-9.

PMID:
9210821
40.

A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs.

Krejcie TC, Avram MJ, Gentry WB, Niemann CU, Janowski MP, Henthorn TK.

J Pharmacokinet Biopharm. 1997 Apr;25(2):169-90.

PMID:
9408858
41.

Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs.

Krejcie TC, Jacquez JA, Avram MJ, Niemann CU, Shanks CA, Henthorn TK.

J Pharmacokinet Biopharm. 1996 Dec;24(6):569-88.

42.

Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly.

Krejcie TC, Henthorn TK, Niemann CU, Klein C, Gupta DK, Gentry WB, Shanks CA, Avram MJ.

J Pharmacol Exp Ther. 1996 Sep;278(3):1050-7.

PMID:
8819485
43.

Induction and maintenance of anesthesia in dogs by intravenous administration of methohexital.

Gentry WB, Krejcie TC, Henthorn TK, Avram MJ.

Am J Vet Res. 1996 Jul;57(7):1044-9.

PMID:
8807019
44.

Calculation of an effect compartment rate constant using recovery indices obtained with an isolated arm technique.

Shanks CA, Avram MJ, Krejcie TC, Henthorn TK.

Br J Anaesth. 1995 Jul;75(1):109-12.

45.

Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model.

Gentry WB, Krejcie TC, Henthorn TK, Shanks CA, Howard KA, Gupta DK, Avram MJ.

Anesthesiology. 1994 Aug;81(2):316-24; discussion 25A.

PMID:
8053580
46.

A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in dogs.

Krejcie TC, Henthorn TK, Shanks CA, Avram MJ.

J Pharmacol Exp Ther. 1994 May;269(2):609-16.

PMID:
8182527
47.

A pharmacokinetic-pharmacodynamic model for quantal responses with thiopental.

Shanks CA, Avram MJ, Krejcie TC, Henthorn TK, Gentry WB.

J Pharmacokinet Biopharm. 1993 Jun;21(3):309-21.

PMID:
8258770
48.

Determinants of thiopental induction dose requirements.

Avram MJ, Sanghvi R, Henthorn TK, Krejcie TC, Shanks CA, Fragen RJ, Howard KA, Kaczynski DA.

Anesth Analg. 1993 Jan;76(1):10-7.

PMID:
8418708
49.

Time-dependent distribution volume and kinetics of the pharmacodynamic effector site.

Henthorn TK, Krejcie TC, Shanks CA, Avram MJ.

J Pharm Sci. 1992 Nov;81(11):1136-8. No abstract available.

PMID:
1447720
50.

The relationship between alfentanil distribution kinetics and cardiac output.

Henthorn TK, Krejcie TC, Avram MJ.

Clin Pharmacol Ther. 1992 Aug;52(2):190-6.

PMID:
1505154

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