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Items: 1 to 50 of 161

1.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.

Miner K, Labitzke K, Liu B, Wang P, Henckels K, Gaida K, Elliott R, Chen JJ, Liu L, Leith A, Trueblood E, Hensley K, Xia XZ, Homann O, Bennett B, Fiorino M, Whoriskey J, Yu G, Escobar S, Wong M, Born TL, Budelsky A, Comeau M, Smith D, Phillips J, Johnston JA, McGivern JG, Weikl K, Powers D, Kunzelmann K, Mohn D, Hochheimer A, Sullivan JK.

Front Pharmacol. 2019 Feb 14;10:51. doi: 10.3389/fphar.2019.00051. eCollection 2019.

2.

PAC1 receptor mRNA and protein distribution in rat and human trigeminal and sphenopalatine ganglia, spinal trigeminal nucleus and in dura mater.

Hensley K, Pretorius J, Chan B, Page K, Liu H, Choi C, Shi D, Xu C, Edvinsson L, Miller S.

Cephalalgia. 2019 Jun;39(7):827-840. doi: 10.1177/0333102418821621. Epub 2018 Dec 24.

PMID:
30582714
3.

Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's model mice.

Togashi K, Hasegawa M, Nagai J, Tonouchi A, Masukawa D, Hensley K, Goshima Y, Ohshima T.

Genes Cells. 2019 Jan;24(1):31-40. doi: 10.1111/gtc.12651. Epub 2018 Nov 18.

4.

Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system.

Murphy K, Llewellyn K, Wakser S, Pontasch J, Samanich N, Flemer M, Hensley K, Kim DS, Park J.

J Biol Chem. 2018 Nov 23;293(47):18242-18269. doi: 10.1074/jbc.RA117.001245. Epub 2018 Oct 3.

5.

Development and applications of solid-phase extraction and liquid chromatography-mass spectrometry methods for quantification of microcystins in urine, plasma, and serum.

Palagama DSW, Baliu-Rodriguez D, Lad A, Levison BS, Kennedy DJ, Haller ST, Westrick J, Hensley K, Isailovic D.

J Chromatogr A. 2018 Oct 26;1573:66-77. doi: 10.1016/j.chroma.2018.08.023. Epub 2018 Aug 17.

PMID:
30201162
6.

Analysis of lanthionine ketimine ethyl ester in mouse serum, whole blood and tissues using ultrahigh-pressure liquid chromatography/tandem mass spectrometry.

Muchiri RN, Kowal KE, Hensley K, Feinstein DL, van Breemen RB.

Rapid Commun Mass Spectrom. 2018 Nov 30;32(22):1941-1948. doi: 10.1002/rcm.8263.

PMID:
30117207
7.

Lanthionine ketimine-5-ethyl ester provides neuroprotection in a zebrafish model of okadaic acid-induced Alzheimer's disease.

Koehler D, Shah ZA, Hensley K, Williams FE.

Neurochem Int. 2018 May;115:61-68. doi: 10.1016/j.neuint.2018.02.002. Epub 2018 Feb 21.

8.

Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters.

Shen D, Hensley K, Denton TT.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):562-565. doi: 10.1016/j.bmcl.2018.01.052. Epub 2018 Feb 1.

9.

Neuroprotective and neurotrophic effects of Lanthionine Ketimine Ester.

Marangoni N, Kowal K, Deliu Z, Hensley K, Feinstein DL.

Neurosci Lett. 2018 Jan 18;664:28-33. doi: 10.1016/j.neulet.2017.11.018. Epub 2017 Nov 8.

PMID:
29128626
10.

Etelcalcetide, A Novel Calcimimetic, Prevents Vascular Calcification in A Rat Model of Renal Insufficiency with Secondary Hyperparathyroidism.

Yu L, Tomlinson JE, Alexander ST, Hensley K, Han CY, Dwyer D, Stolina M, Dean C Jr, Goodman WG, Richards WG, Li X.

Calcif Tissue Int. 2017 Dec;101(6):641-653. doi: 10.1007/s00223-017-0319-7. Epub 2017 Oct 16.

11.

Multiple non-catalytic ADAMs are novel integrin α4 ligands.

Wang L, Hoggard JA, Korleski ED, Long GV, Ree BC, Hensley K, Bond SR, Wolfsberg TG, Chen J, Zeczycki TN, Bridges LC.

Mol Cell Biochem. 2018 May;442(1-2):29-38. doi: 10.1007/s11010-017-3190-y. Epub 2017 Sep 14.

PMID:
28913673
12.

Etelcalcetide (AMG 416), a peptide agonist of the calcium-sensing receptor, preserved cortical bone structure and bone strength in subtotal nephrectomized rats with established secondary hyperparathyroidism.

Li X, Yu L, Asuncion F, Grisanti M, Alexander S, Hensley K, Han CY, Niu QT, Dwyer D, Villasenor K, Stolina M, Dean C Jr, Ominsky MS, Ke HZ, Tomlinson JE, Richards WG.

Bone. 2017 Dec;105:163-172. doi: 10.1016/j.bone.2017.08.026. Epub 2017 Sep 1.

13.

Salivary protein changes in response to acute stress in medical residents performing advanced clinical simulations: a pilot proteomics study.

Marvin RK, Saepoo MB, Ye S, White DB, Liu R, Hensley K, Rega P, Kazan V, Giovannucci DR, Isailovic D.

Biomarkers. 2017 May - Jun;22(3-4):372-382. doi: 10.1080/1354750X.2017.1279215. Epub 2017 Jan 25.

14.

Collapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, and conformational flexibility.

Myllykoski M, Baumann A, Hensley K, Kursula P.

Amino Acids. 2017 Apr;49(4):747-759. doi: 10.1007/s00726-016-2376-z. Epub 2017 Jan 2.

PMID:
28044206
15.

In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.

Rulifson IC, Collins P, Miao L, Nojima D, Lee KJ, Hardy M, Gupte J, Hensley K, Samayoa K, Cam C, Rottman JB, Ollmann M, Richards WG, Li Y.

J Biol Chem. 2017 Feb 3;292(5):1951-1969. doi: 10.1074/jbc.M116.751404. Epub 2016 Dec 23.

16.

Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth.

Kotaka K, Nagai J, Hensley K, Ohshima T.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):759-764. doi: 10.1016/j.bbrc.2016.12.069. Epub 2016 Dec 11.

PMID:
27965088
17.

Comparing student performance on paper- and computer-based math curriculum-based measures.

Hensley K, Rankin A, Hosp J.

Assist Technol. 2017 Fall;29(3):140-145. doi: 10.1080/10400435.2016.1212129. Epub 2016 Jul 22.

PMID:
27449699
19.

BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR.

Makani V, Jang YG, Christopher K, Judy W, Eckstein J, Hensley K, Chiaia N, Kim DS, Park J.

PLoS One. 2016 Mar 3;11(3):e0149715. doi: 10.1371/journal.pone.0149715. eCollection 2016.

20.

Autophagy Modulation by Lanthionine Ketimine Ethyl Ester Improves Long-Term Outcome after Central Fluid Percussion Injury in the Mouse.

Hensley K, Poteshkina A, Johnson MF, Eslami P, Gabbita SP, Hristov AM, Venkova-Hristova KM, Harris-White ME.

J Neurotrauma. 2016 Aug 15;33(16):1501-13. doi: 10.1089/neu.2015.4196. Epub 2016 Jan 28.

PMID:
26530250
21.

Molecular combing compared to Southern blot for measuring D4Z4 contractions in FSHD.

Vasale J, Boyar F, Jocson M, Sulcova V, Chan P, Liaquat K, Hoffman C, Meservey M, Chang I, Tsao D, Hensley K, Liu Y, Owen R, Braastad C, Sun W, Walrafen P, Komatsu J, Wang JC, Bensimon A, Anguiano A, Jaremko M, Wang Z, Batish S, Strom C, Higgins J.

Neuromuscul Disord. 2015 Dec;25(12):945-51. doi: 10.1016/j.nmd.2015.08.008. Epub 2015 Aug 21.

PMID:
26420234
22.

Detection of Protein Carbonyls by Means of Biotin Hydrazide-Streptavidin Affinity Methods.

Hensley K.

Methods Mol Biol. 2015;1314:95-100. doi: 10.1007/978-1-4939-2718-0_11.

PMID:
26139258
23.

The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.

Martins-de-Souza D, Cassoli JS, Nascimento JM, Hensley K, Guest PC, Pinzon-Velasco AM, Turck CW.

Proteomics Clin Appl. 2015 Oct;9(9-10):817-31. doi: 10.1002/prca.201500004. Epub 2015 Sep 10. Review.

PMID:
25921334
24.

Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis.

Dupree JL, Polak PE, Hensley K, Pelligrino D, Feinstein DL.

J Neurochem. 2015 Jul;134(2):302-14. doi: 10.1111/jnc.13114. Epub 2015 Apr 22.

25.

A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies.

Harris-White ME, Ferbas KG, Johnson MF, Eslami P, Poteshkina A, Venkova K, Christov A, Hensley K.

Neurobiol Dis. 2015 Dec;84:60-8. doi: 10.1016/j.nbd.2015.03.007. Epub 2015 Mar 14.

26.

Redox regulation of autophagy in healthy brain and neurodegeneration.

Hensley K, Harris-White ME.

Neurobiol Dis. 2015 Dec;84:50-9. doi: 10.1016/j.nbd.2015.03.002. Epub 2015 Mar 11. Review.

27.

Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress.

Kadiiska MB, Peddada S, Herbert RA, Basu S, Hensley K, Jones DP, Hatch GE, Mason RP.

Free Radic Biol Med. 2015 Apr;81:100-6. doi: 10.1016/j.freeradbiomed.2015.01.006. Epub 2015 Jan 19.

28.

Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement.

Hensley K, Denton TT.

Free Radic Biol Med. 2015 Jan;78:123-34. doi: 10.1016/j.freeradbiomed.2014.10.581. Epub 2014 Nov 6. Review.

29.

Semaphorin 3A signaling through neuropilin-1 is an early trigger for distal axonopathy in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Venkova K, Christov A, Kamaluddin Z, Kobalka P, Siddiqui S, Hensley K.

J Neuropathol Exp Neurol. 2014 Jul;73(7):702-13. doi: 10.1097/NEN.0000000000000086.

30.

A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease.

Hensley K, Gabbita SP, Venkova K, Hristov A, Johnson MF, Eslami P, Harris-White ME.

J Neuropathol Exp Neurol. 2013 Oct;72(10):955-69. doi: 10.1097/NEN.0b013e3182a74372.

PMID:
24042198
31.

Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells.

Makani V, Hall J, Qamar K, Jain P, Jang Y, Hensley K, Park JJ.

Mol Cell Endocrinol. 2013 Dec 5;381(1-2):175-87. doi: 10.1016/j.mce.2013.07.033. Epub 2013 Aug 7.

32.

Lanthionine ketimine ethyl ester partially rescues neurodevelopmental defects in unc-33 (DPYSL2/CRMP2) mutants.

Hubbard C, Benda E, Hardin T, Baxter T, St John E, O'Brien S, Hensley K, Holgado AM.

J Neurosci Res. 2013 Sep;91(9):1183-90. doi: 10.1002/jnr.23239. Epub 2013 Jul 3.

PMID:
23825043
33.

In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis.

Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K.

Free Radic Biol Med. 2013 Oct;63:351-60. doi: 10.1016/j.freeradbiomed.2013.05.026. Epub 2013 May 28.

PMID:
23722162
34.

Immuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals.

Gomez-Mejiba SE, Zhai Z, Della-Vedova MC, Muñoz MD, Chatterjee S, Towner RA, Hensley K, Floyd RA, Mason RP, Ramirez DC.

Biochim Biophys Acta. 2014 Feb;1840(2):722-9. doi: 10.1016/j.bbagen.2013.04.039. Epub 2013 May 2. Review.

35.

Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines.

Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA.

Free Radic Biol Med. 2013 Sep;62:145-156. doi: 10.1016/j.freeradbiomed.2013.01.033. Epub 2013 Feb 16. Review.

36.

Amyotrophic lateral sclerosis and novel therapeutic strategies.

Morrison B, Hensley K, Pioro EP, Petri S, Kiaei M.

Neurol Res Int. 2012;2012:798028. doi: 10.1155/2012/798028. Epub 2012 Dec 19. No abstract available.

37.

Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.

Khanna R, Wilson SM, Brittain JM, Weimer J, Sultana R, Butterfield A, Hensley K.

Future Neurol. 2012 Nov 1;7(6):749-771.

38.

A derivative of the CRMP2 binding compound lanthionine ketimine provides neuroprotection in a mouse model of cerebral ischemia.

Nada SE, Tulsulkar J, Raghavan A, Hensley K, Shah ZA.

Neurochem Int. 2012 Dec;61(8):1357-63. doi: 10.1016/j.neuint.2012.09.013. Epub 2012 Oct 2.

39.

Progress in therapy development for amyotrophic lateral sclerosis.

Venkova-Hristova K, Christov A, Kamaluddin Z, Kobalka P, Hensley K.

Neurol Res Int. 2012;2012:187234. doi: 10.1155/2012/187234. Epub 2012 Jul 4. Erratum in: Neurol Res Int. 2012;2012:853030.

40.

A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease.

Stansley B, Post J, Hensley K.

J Neuroinflammation. 2012 May 31;9:115. doi: 10.1186/1742-2094-9-115. Review.

41.

Off-target platelet activation in macaques unique to a therapeutic monoclonal antibody.

Santostefano MJ, Kirchner J, Vissinga C, Fort M, Lear S, Pan WJ, Prince PJ, Hensley KM, Tran D, Rock D, Vargas HM, Narayanan P, Jawando R, Rees W, Reindel JF, Reynhardt K, Everds N.

Toxicol Pathol. 2012 Aug;40(6):899-917. doi: 10.1177/0192623312444029. Epub 2012 May 2.

PMID:
22552394
42.

Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid.

Kadiiska MB, Hatch GE, Nyska A, Jones DP, Hensley K, Stocker R, George MM, Van Thiel DH, Stadler K, Barrett JC, Mason RP.

Free Radic Biol Med. 2011 Nov 1;51(9):1636-42. doi: 10.1016/j.freeradbiomed.2011.07.013. Epub 2011 Jul 22.

43.

Translational research involving oxidative stress and diseases of aging.

Floyd RA, Towner RA, He T, Hensley K, Maples KR.

Free Radic Biol Med. 2011 Sep 1;51(5):931-41. doi: 10.1016/j.freeradbiomed.2011.04.014. Epub 2011 Apr 14. Review.

44.

Analysis of postmortem ventricular cerebrospinal fluid from patients with and without dementia indicates association of vitamin E with neuritic plaques and specific measures of cognitive performance.

Hensley K, Barnes LL, Christov A, Tangney C, Honer WG, Schneider JA, Bennett DA, Morris MC.

J Alzheimers Dis. 2011;24(4):767-74. doi: 10.3233/JAD-2011-101995.

45.

Collapsin response mediator protein-2: an emerging pathologic feature and therapeutic target for neurodisease indications.

Hensley K, Venkova K, Christov A, Gunning W, Park J.

Mol Neurobiol. 2011 Jun;43(3):180-91. doi: 10.1007/s12035-011-8166-4. Epub 2011 Jan 28. Review.

PMID:
21271304
46.

Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce Sjögren syndrome or systemic lupus erythematosus in BALB/c mice.

Kurien BT, Porter A, Dorri Y, Iqbal S, D'Souza A, Singh A, Asfa S, Cartellieri M, Mathias K, Matsumoto H, Bachmann M, Hensley K, Scofield RH.

Free Radic Biol Med. 2011 May 15;50(10):1222-33. doi: 10.1016/j.freeradbiomed.2010.10.687. Epub 2010 Oct 12.

47.

Emerging biological importance of central nervous system lanthionines.

Hensley K, Venkova K, Christov A.

Molecules. 2010 Aug 13;15(8):5581-94. doi: 10.3390/molecules15085581. Review.

48.
49.

Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures.

Hensley K, Christov A, Kamat S, Zhang XC, Jackson KW, Snow S, Post J.

J Neurosci. 2010 Feb 24;30(8):2979-88. doi: 10.1523/JNEUROSCI.5247-09.2010.

50.

Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis.

Neymotin A, Petri S, Calingasan NY, Wille E, Schafer P, Stewart C, Hensley K, Beal MF, Kiaei M.

Exp Neurol. 2009 Nov;220(1):191-7. doi: 10.1016/j.expneurol.2009.08.028. Epub 2009 Sep 4.

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