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Items: 29

1.

Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway.

Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L.

J Nat Prod. 2018 Mar 23;81(3):506-514. doi: 10.1021/acs.jnatprod.7b00734. Epub 2017 Dec 7.

2.

Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens.

Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H Jr, Corriden R, Rohde M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G, Nizet V.

EBioMedicine. 2015 Jun 10;2(7):690-8. doi: 10.1016/j.ebiom.2015.05.021. eCollection 2015 Jul.

3.

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis.

Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR Jr, Schultz PG, Wang F.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4453-8. doi: 10.1073/pnas.1504022112. Epub 2015 Mar 23.

4.

Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria.

Fair RJ, McCoy LS, Hensler ME, Aguilar B, Nizet V, Tor Y.

ChemMedChem. 2014 Sep;9(9):2164-71. doi: 10.1002/cmdc.201402175. Epub 2014 Jul 23.

5.

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus.

Hensler ME, Jang KH, Thienphrapa W, Vuong L, Tran DN, Soubih E, Lin L, Haste NM, Cunningham ML, Kwan BP, Shaw KJ, Fenical W, Nizet V.

J Antibiot (Tokyo). 2014 Aug;67(8):549-53. doi: 10.1038/ja.2014.36. Epub 2014 Apr 16.

6.

Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus.

Sakoulas G, Okumura CY, Thienphrapa W, Olson J, Nonejuie P, Dam Q, Dhand A, Pogliano J, Yeaman MR, Hensler ME, Bayer AS, Nizet V.

J Mol Med (Berl). 2014 Feb;92(2):139-49. doi: 10.1007/s00109-013-1100-7. Epub 2013 Dec 3.

7.

Antibacterial drug leads targeting isoprenoid biosynthesis.

Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. Epub 2012 Dec 17.

8.

Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus.

Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME.

J Antibiot (Tokyo). 2012 Dec;65(12):593-8. doi: 10.1038/ja.2012.77. Epub 2012 Oct 10.

9.

The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity.

Bebien M, Hensler ME, Davanture S, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T.

PLoS Pathog. 2012;8(7):e1002812. doi: 10.1371/journal.ppat.1002812. Epub 2012 Jul 19.

10.

Selectively guanidinylated aminoglycosides as antibiotics.

Fair RJ, Hensler ME, Thienphrapa W, Dam QN, Nizet V, Tor Y.

ChemMedChem. 2012 Jul;7(7):1237-44. doi: 10.1002/cmdc.201200150. Epub 2012 May 25.

11.

Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp.

Sun P, Maloney KN, Nam SJ, Haste NM, Raju R, Aalbersberg W, Jensen PR, Nizet V, Hensler ME, Fenical W.

Bioorg Med Chem. 2011 Nov 15;19(22):6557-62. doi: 10.1016/j.bmc.2011.06.053. Epub 2011 Jun 26.

12.

Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus.

Haste NM, Farnaes L, Perera VR, Fenical W, Nizet V, Hensler ME.

Mar Drugs. 2011;9(4):680-9. doi: 10.3390/md9040680. Epub 2011 Apr 21.

13.

Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus.

Haste NM, Hughes CC, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME.

Antimicrob Agents Chemother. 2011 Jul;55(7):3305-12. doi: 10.1128/AAC.01211-10. Epub 2011 Apr 18.

14.

Streptococcus gallolyticus, infective endocarditis, and colon carcinoma: new light on an intriguing coincidence.

Hensler ME.

J Infect Dis. 2011 Apr 15;203(8):1040-2. doi: 10.1093/infdis/jiq170. No abstract available.

PMID:
21450993
15.

Statins enhance formation of phagocyte extracellular traps.

Chow OA, von Köckritz-Blickwede M, Bright AT, Hensler ME, Zinkernagel AS, Cogen AL, Gallo RL, Monestier M, Wang Y, Glass CK, Nizet V.

Cell Host Microbe. 2010 Nov 18;8(5):445-54. doi: 10.1016/j.chom.2010.10.005.

16.

Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum.

Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC.

J Biol Chem. 2010 Sep 3;285(36):28220-8. doi: 10.1074/jbc.M110.118554. Epub 2010 Jun 25.

17.

Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus.

Haste NM, Perera VR, Maloney KN, Tran DN, Jensen P, Fenical W, Nizet V, Hensler ME.

J Antibiot (Tokyo). 2010 May;63(5):219-24. doi: 10.1038/ja.2010.22. Epub 2010 Mar 26.

18.

Group B streptococcal beta-hemolysin/cytolysin directly impairs cardiomyocyte viability and function.

Hensler ME, Miyamoto S, Nizet V.

PLoS One. 2008 Jun 18;3(6):e2446. doi: 10.1371/journal.pone.0002446.

19.

Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.

Dahesh S, Hensler ME, Van Sorge NM, Gertz RE Jr, Schrag S, Nizet V, Beall BW.

Antimicrob Agents Chemother. 2008 Aug;52(8):2915-8. doi: 10.1128/AAC.00461-08. Epub 2008 Jun 9.

20.

Discovery of a widely distributed toxin biosynthetic gene cluster.

Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE.

Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84. doi: 10.1073/pnas.0801338105. Epub 2008 Mar 28.

21.

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.

Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E.

Science. 2008 Mar 7;319(5868):1391-4. doi: 10.1126/science.1153018. Epub 2008 Feb 14.

22.

A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence.

Maisey HC, Quach D, Hensler ME, Liu GY, Gallo RL, Nizet V, Doran KS.

FASEB J. 2008 Jun;22(6):1715-24. doi: 10.1096/fj.07-093963. Epub 2008 Jan 15.

23.

CAMP factor is not essential for systemic virulence of Group B Streptococcus.

Hensler ME, Quach D, Hsieh CJ, Doran KS, Nizet V.

Microb Pathog. 2008 Jan;44(1):84-8. Epub 2007 Aug 14.

24.

Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug-resistant Gram-positive pathogens identified from a mixture-based combinatorial library.

Hensler ME, Bernstein G, Nizet V, Nefzi A.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5073-9. Epub 2006 Aug 4.

PMID:
16890437
25.
26.

Virulence role of group B Streptococcus beta-hemolysin/cytolysin in a neonatal rabbit model of early-onset pulmonary infection.

Hensler ME, Liu GY, Sobczak S, Benirschke K, Nizet V, Heldt GP.

J Infect Dis. 2005 Apr 15;191(8):1287-91. Epub 2005 Mar 10.

PMID:
15776375
27.

Molecular characterization of human zyxin.

Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kalff-Suske M, Grzeschik KH, von der Ahe D, Beckerle MC.

J Biol Chem. 1996 Dec 6;271(49):31470-8.

28.

Talin distribution and phosphorylation in thrombin-activated platelets.

Bertagnolli ME, Locke SJ, Hensler ME, Bray PF, Beckerle MC.

J Cell Sci. 1993 Dec;106 ( Pt 4):1189-99.

29.

Platelet morphologic changes and fibrinogen receptor localization. Initial responses in ADP-activated human platelets.

Hensler ME, Frojmovic M, Taylor RG, Hantgan RR, Lewis JC.

Am J Pathol. 1992 Sep;141(3):707-19.

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