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Items: 49


Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK.

Zhao A, Lee SH, Mojena M, Jenkins RG, Patrick DR, Huber HE, Goetz MA, Hensens OD, Zink DL, Vilella D, Dombrowski AW, Lingham RB, Huang L.

J Antibiot (Tokyo). 1999 Dec;52(12):1086-94.


Hyalodendrosides A and B, antifungal triterpenoid glycosides from a lignicolous hyphomycete, Hyalodendron species.

Bills G, Dombrowski A, Morris SA, Hensens O, Liesch JM, Zink DL, Onishi J, Meinz MS, Rosenbach M, Thompson JR, Schwartz RE.

J Nat Prod. 2000 Jan;63(1):90-4.


Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3.

Felix JP, Bugianesi RM, Schmalhofer WA, Borris R, Goetz MA, Hensens OD, Bao JM, Kayser F, Parsons WH, Rupprecht K, Garcia ML, Kaczorowski GJ, Slaughter RS.

Biochemistry. 1999 Apr 20;38(16):4922-30.


8-O-acetylharpagide is a nonsteroidal ecdysteroid agonist.

Elbrecht A, Chen Y, Jurgens T, Hensens OD, Zink DL, Beck HT, Balick MJ, Borris R.

Insect Biochem Mol Biol. 1996 Jun;26(6):519-23.


Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures.

Stevens-Miles S, Goetz MA, Bills GF, Giacobbe RA, Tkacz JS, Chang RS, Mojena M, Martin I, Diez MT, Pelaez F, Hensens OD, Jones T, Burg RW, Kong YL, Huang L.

J Antibiot (Tokyo). 1996 Feb;49(2):119-23.


L-735,334, a novel sesquiterpenoid potassium channel-agonist from Trichoderma virens.

Lee SH, Hensens OD, Helms GL, Liesch JM, Zink DL, Giacobbe RA, Bills GF, Stevens-Miles S, Garcia ML, Schmalhofer WA, et al.

J Nat Prod. 1995 Dec;58(12):1822-8.


Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

Bollag DM, McQueney PA, Zhu J, Hensens O, Koupal L, Liesch J, Goetz M, Lazarides E, Woods CM.

Cancer Res. 1995 Jun 1;55(11):2325-33.


Pneumocandin D0, a new antifungal agent and potent inhibitor of Pneumocystis carinii.

Morris SA, Schwartz RE, Sesin DF, Masurekar P, Hallada TC, Schmatz DM, Bartizal K, Hensens OD, Zink DL.

J Antibiot (Tokyo). 1994 Jul;47(7):755-64.


L-741,494, a fungal metabolite that is an inhibitor of interleukin-1 beta converting enzyme.

Salvatore MJ, Hensens OD, Zink DL, Liesch J, Dufresne C, Ondeyka JG, Jürgens TM, Borris RP, Raghoobar S, McCauley E, et al.

J Nat Prod. 1994 Jun;57(6):755-60.


Spontaneous generation of a biradical species of neocarzinostatin chromophore: role in DNA bulge-specific cleavage.

Hensens OD, Chin DH, Stassinopoulos A, Zink DL, Kappen LS, Goldberg IH.

Proc Natl Acad Sci U S A. 1994 May 10;91(10):4534-8.


Modern spectroscopic approaches to structure elucidation.

Hensens OD.

Biotechnology. 1994;26:389-444. Review. No abstract available.


Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

Bergstrom JD, Kurtz MM, Rew DJ, Amend AM, Karkas JD, Bostedor RG, Bansal VS, Dufresne C, VanMiddlesworth FL, Hensens OD, et al.

Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):80-4.


Pneumocandins from Zalerion arboricola. III. Structure elucidation.

Hensens OD, Liesch JM, Zink DL, Smith JL, Wichmann CF, Schwartz RE.

J Antibiot (Tokyo). 1992 Dec;45(12):1875-85.


Cochinmicins, novel and potent cyclodepsipeptide endothelin antagonists from a Microbispora sp. II. Structure determination.

Zink D, Hensens OD, Lam YK, Reamer R, Liesch JM.

J Antibiot (Tokyo). 1992 Nov;45(11):1717-22.


L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. II. Isolation and structure.

Ondeyka J, Hensens OD, Zink D, Ball R, Lingham RB, Bills G, Dombrowski A, Goetz M.

J Antibiot (Tokyo). 1992 May;45(5):679-85.


Analogs of cyclosporin A modified at the D-Ala8 position.

Patchett AA, Taub D, Hensens OD, Goegelman RT, Yang L, Dumont F, Peterson L, Sigal NH.

J Antibiot (Tokyo). 1992 Jan;45(1):94-102.


The preparation of [2-deutero-3-fluoro-D-Ala8]cyclosporin A by directed biosynthesis.

Hensens OD, White RF, Goegelman RT, Inamine ES, Patchett AA.

J Antibiot (Tokyo). 1992 Jan;45(1):133-5. No abstract available.


The structure of heneicomycin.

Dewey RS, Hensens OD, Douglas AW, Albers-Schönberg G.

J Antibiot (Tokyo). 1991 Aug;44(8):838-43.


Novel and potent gastrin and brain cholecystokinin antagonists from Streptomyces olivaceus. Taxonomy, fermentation, isolation, chemical conversions, and physico-chemical and biochemical properties.

Lam YK, Bogen D, Chang RS, Faust KA, Hensens OD, Zink DL, Schwartz CD, Zitano L, Garrity GM, Gagliardi MM, et al.

J Antibiot (Tokyo). 1991 Jun;44(6):613-25.


L-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from Streptomyces sp. MA6348. Fermentation, isolation and structure determination.

Hensens OD, Borris RP, Koupal LR, Caldwell CG, Currie SA, Haidri AA, Homnick CF, Honeycutt SS, Lindenmayer SM, Schwartz CD, et al.

J Antibiot (Tokyo). 1991 Feb;44(2):249-54. No abstract available.


L-681,572--a new antifungal agent. Isolation, characterization, and biological activity.

Chaiet L, Fromtling RA, Garrity GM, Monaghan RL, Hensens OD, Valiant ME, Zink DL.

J Antibiot (Tokyo). 1989 Nov;42(11):1718-21. No abstract available.


A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis.

Pettibone DJ, Clineschmidt BV, Anderson PS, Freidinger RM, Lundell GF, Koupal LR, Schwartz CD, Williamson JM, Goetz MA, Hensens OD, et al.

Endocrinology. 1989 Jul;125(1):217-22.


Directed biosynthesis of avermectins.

Chen TS, Inamine ES, Hensens OD, Zink D, Ostlind DA.

Arch Biochem Biophys. 1989 Mar;269(2):544-7.


L-657,398, a novel antifungal agent: fermentation, isolation, structural elucidation and biological properties.

Schwartz RE, Liesch J, Hensens O, Zitano L, Honeycutt S, Garrity G, Fromtling RA, Onishi J, Monaghan R.

J Antibiot (Tokyo). 1988 Dec;41(12):1774-9.


On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.

Houck DR, Ondeyka J, Zink DL, Inamine E, Goetz MA, Hensens OD.

J Antibiot (Tokyo). 1988 Jul;41(7):882-91.


Difficidin and oxydifficidin: novel broad spectrum antibacterial antibiotics produced by Bacillus subtilis. II. Isolation and physico-chemical characterization.

Wilson KE, Flor JE, Schwartz RE, Joshua H, Smith JL, Pelak BA, Liesch JM, Hensens OD.

J Antibiot (Tokyo). 1987 Dec;40(12):1682-91.


L-681,217, a new and novel member of the efrotomycin family of antibiotics.

Kempf AJ, Wilson KE, Hensens OD, Monaghan RL, Zimmerman SB, Dulaney EL.

J Antibiot (Tokyo). 1986 Oct;39(10):1361-7.


Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors.

Schulman MD, Valentino D, Hensens O.

J Antibiot (Tokyo). 1986 Apr;39(4):541-9.


Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Structure elucidation.

Liesch JM, Hensens OD, Springer JP, Chang RS, Lotti VJ.

J Antibiot (Tokyo). 1985 Dec;38(12):1638-41.


Demethylavermectins. Biosynthesis, isolation and characterization.

Schulman MD, Valentino D, Hensens OD, Zink D, Nallin M, Kaplan L, Ostlind DA.

J Antibiot (Tokyo). 1985 Nov;38(11):1494-8.


A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.

Chang RS, Lotti VJ, Monaghan RL, Birnbaum J, Stapley EO, Goetz MA, Albers-Schönberg G, Patchett AA, Liesch JM, Hensens OD, et al.

Science. 1985 Oct 11;230(4722):177-9.


L-155,175: a new antiparasitic macrolide. Fermentation, isolation and structure.

Goetz MA, McCormick PA, Monaghan RL, Ostlind DA, Hensens OD, Liesch JM, Albers-Schonberg G.

J Antibiot (Tokyo). 1985 Feb;38(2):161-8.


Discovery, production and purification of the Na+, K+ activated ATPase inhibitor, L-681,110 from the fermentation broth of Streptomyces sp. MA-5038.

Huang L, Albers-Schonberg G, Monaghan RL, Jakubas K, Pong SS, Hensens OD, Burg RW, Ostlind DA, Conroy J, Stapley EO.

J Antibiot (Tokyo). 1984 Sep;37(9):970-5.


13C NMR study of thiostrepton and thiopeptin components.

Hensens OD, Albers-Schönberg G.

J Antibiot (Tokyo). 1983 Jul;36(7):832-45.


Total structure of the highly modified peptide antibiotic components of thiopeptin.

Hensens OD, Albers-Schönberg G.

J Antibiot (Tokyo). 1983 Jul;36(7):814-31.


The solution conformation of the peptide antibiotic thiostrepton: a 1H NMR study.

Hensens OD, Albers-Schönberg G, Anderson BF.

J Antibiot (Tokyo). 1983 Jul;36(7):799-813.


Neocarzinostatin chromophore: presence of a highly strained ether ring and its reaction with mercaptan and sodium borohydride.

Hensens OD, Dewey RS, Liesch JM, Napier MA, Reamer RA, Smith JL, Albers-Schönberg G, Goldberg IH.

Biochem Biophys Res Commun. 1983 Jun 15;113(2):538-47.


Factumycin, a new antibiotic (A40A): fermentation, isolation and antibacterial spectrum.

Gullo VP, Zimmerman SB, Dewey RS, Hensens O, Cassidy PJ, Oiwa R, Omura S.

J Antibiot (Tokyo). 1982 Dec;35(12):1705-7. No abstract available.


Neocarzinostatin chromophore: presence of a cyclic carbonate subunit and its modification in the structure of other biologically active forms.

Napier MA, Goldberg IH, Hensens OD, Dewey RS, Liesch JM, Albers-Schönberg G.

Biochem Biophys Res Commun. 1981 Jun;100(4):1703-12. No abstract available.


Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus.

Albers-Schönberg G, Joshua H, Lopez MB, Hensens OD, Springer JP, Chen J, Ostrove S, Hoffman CH, Alberts AW, Patchett AA.

J Antibiot (Tokyo). 1981 May;34(5):507-12.


Urinary metabolites of timolol from humans and laboratory animals. Syntheses and beta-adrenergic blocking activities.

Wasson BK, Scheigetz J, Rooney CS, Hall RA, Share NN, VandenHeuvel WJ, Arison BH, Hensens OD, Ellsworth RL, Tocco DJ.

J Med Chem. 1980 Nov;23(11):1178-84.


Neocarzinostatin: chemical characterization and partial structure of the non-protein chromophore.

Albers-Schönberg G, Dewey RS, Hensens OD, Liesch JM, Napier MA, Goldberg IH.

Biochem Biophys Res Commun. 1980 Aug 14;95(3):1351-6. No abstract available.


Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Alberts AW, Chen J, Kuron G, Hunt V, Huff J, Hoffman C, Rothrock J, Lopez M, Joshua H, Harris E, Patchett A, Monaghan R, Currie S, Stapley E, Albers-Schonberg G, Hensens O, Hirshfield J, Hoogsteen K, Liesch J, Springer J.

Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.


5-Methyl-5,6,7,8-tetrahydrofolic acid. Conformation of the tetrahydropyrazine ring.

Poe M, Hensens OD, Hoogsteen K.

J Biol Chem. 1979 Nov 10;254(21):10881-4. No abstract available.


The structures of some cobalamins in solution.

Hensens OD, Hill HA, Thornton J, Turner AM, Williams RJ.

Philos Trans R Soc Lond B Biol Sci. 1976 Feb 5;273(924):353-7.


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