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Items: 1 to 50 of 287

1.

Calcium signaling and secretory granule pool dynamics underlie biphasic insulin secretion and its amplification by glucose: experiments and modeling.

Pedersen MG, Tagliavini A, Henquin JC.

Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E475-E486. doi: 10.1152/ajpendo.00380.2018. Epub 2019 Jan 8.

PMID:
30620637
3.

Insulin secretion in response to high extracellular calcium is not a pathognomonic feature of insulinoma cells.

Henquin JC, Pattou F, Nenquin M.

Diabetes Metab. 2019 Jan;45(1):76-78. doi: 10.1016/j.diabet.2017.07.008. Epub 2017 Oct 31. No abstract available.

PMID:
29097005
4.
5.

Misunderstandings and controversies about the insulin-secreting properties of antidiabetic sulfonylureas.

Henquin JC.

Biochimie. 2017 Dec;143:3-9. doi: 10.1016/j.biochi.2017.07.002. Epub 2017 Jul 12. Review.

PMID:
28711685
6.

Immaturity of insulin secretion by pancreatic islets isolated from one human neonate.

Henquin JC, Nenquin M.

J Diabetes Investig. 2018 Mar;9(2):270-273. doi: 10.1111/jdi.12701. Epub 2017 Jul 17.

7.

Pharmacological approach to understanding the control of insulin secretion in human islets.

Henquin JC, Dufrane D, Gmyr V, Kerr-Conte J, Nenquin M.

Diabetes Obes Metab. 2017 Aug;19(8):1061-1070. doi: 10.1111/dom.12887. Epub 2017 Mar 31.

PMID:
28116849
8.

Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children.

Henquin JC, Nenquin M.

PLoS One. 2016 Nov 2;11(11):e0165961. doi: 10.1371/journal.pone.0165961. eCollection 2016.

9.

Sulphonylurea receptor-1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells.

Nenquin M, Henquin JC.

Diabetes Obes Metab. 2016 Jul;18(7):698-701. doi: 10.1111/dom.12607. Epub 2016 Jan 8.

PMID:
26584950
10.

Dynamics of glucose-induced insulin secretion in normal human islets.

Henquin JC, Dufrane D, Kerr-Conte J, Nenquin M.

Am J Physiol Endocrinol Metab. 2015 Oct 1;309(7):E640-50. doi: 10.1152/ajpendo.00251.2015. Epub 2015 Aug 11.

11.

Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro.

Henquin JC, Nenquin M, Guiot Y, Rahier J, Sempoux C.

Diabetes. 2015 Oct;64(10):3543-53. doi: 10.2337/db15-0527. Epub 2015 Jun 26.

12.

Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide.

Henquin JC, Nenquin M.

Endocrinology. 2014 Sep;155(9):3274-87. doi: 10.1210/en.2014-1247. Epub 2014 Jun 30.

13.

Focal congenital hyperinsulinism managed by medical treatment: a diagnostic algorithm based on molecular genetic screening.

Maiorana A, Barbetti F, Boiani A, Rufini V, Pizzoferro M, Francalanci P, Faletra F, Nichols CG, Grimaldi C, de Ville de Goyet J, Rahier J, Henquin JC, Dionisi-Vici C.

Clin Endocrinol (Oxf). 2014 Nov;81(5):679-88. doi: 10.1111/cen.12400. Epub 2014 Jan 30.

PMID:
24383515
14.

Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells.

Henquin JC, Sempoux C, Marchandise J, Godecharles S, Guiot Y, Nenquin M, Rahier J.

Diabetes. 2013 May;62(5):1689-96. doi: 10.2337/db12-1414. Epub 2012 Dec 28.

15.

Amplification of insulin secretion by acetylcholine or phorbol ester is independent of β-cell microfilaments and distinct from metabolic amplification.

Mourad NI, Nenquin M, Henquin JC.

Mol Cell Endocrinol. 2013 Mar 10;367(1-2):11-20. doi: 10.1016/j.mce.2012.12.002. Epub 2012 Dec 11.

PMID:
23246352
16.

cAMP-mediated and metabolic amplification of insulin secretion are distinct pathways sharing independence of β-cell microfilaments.

Mourad NI, Nenquin M, Henquin JC.

Endocrinology. 2012 Oct;153(10):4644-54. Epub 2012 Sep 4.

PMID:
22948217
17.

Do pancreatic β cells "taste" nutrients to secrete insulin?

Henquin JC.

Sci Signal. 2012 Aug 28;5(239):pe36. doi: 10.1126/scisignal.2003325.

PMID:
22932700
18.

Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.

Dubois E, Jacoby M, Blockmans M, Pernot E, Schiffmann SN, Foukas LC, Henquin JC, Vanhaesebroeck B, Erneux C, Schurmans S.

Cell Signal. 2012 Nov;24(11):1971-80. doi: 10.1016/j.cellsig.2012.06.012. Epub 2012 Jun 30.

PMID:
22750293
19.

Disruption and stabilization of β-cell actin microfilaments differently influence insulin secretion triggered by intracellular Ca2+ mobilization or store-operated Ca2+ entry.

Henquin JC, Mourad NI, Nenquin M.

FEBS Lett. 2012 Jan 2;586(1):89-95. doi: 10.1016/j.febslet.2011.11.030. Epub 2011 Dec 3.

20.

In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions.

Henquin JC, Nenquin M, Sempoux C, Guiot Y, Bellanné-Chantelot C, Otonkoski T, de Lonlay P, Nihoul-Fékété C, Rahier J.

J Clin Invest. 2011 Oct;121(10):3932-42. doi: 10.1172/JCI58400. Epub 2011 Sep 26.

21.

Long in the shade, glucagon re-occupies centre court.

Henquin JC, Accili D, Ahrén B, Boitard C, Seino S, Cerasi E.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:v-viii. doi: 10.1111/j.1463-1326.2011.01476.x. No abstract available.

PMID:
21824249
22.

The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells.

Henquin JC.

Diabetes Res Clin Pract. 2011 Aug;93 Suppl 1:S27-31. doi: 10.1016/S0168-8227(11)70010-9. Review.

PMID:
21864748
23.

Pancreatic alpha cell mass in European subjects with type 2 diabetes.

Henquin JC, Rahier J.

Diabetologia. 2011 Jul;54(7):1720-5. doi: 10.1007/s00125-011-2118-4. Epub 2011 Apr 5.

24.

Metabolic amplification of insulin secretion by glucose is independent of β-cell microtubules.

Mourad NI, Nenquin M, Henquin JC.

Am J Physiol Cell Physiol. 2011 Mar;300(3):C697-706. doi: 10.1152/ajpcell.00329.2010. Epub 2010 Dec 22.

25.

What ails the β-cell?

Accili D, Ahrén B, Boitard C, Cerasi E, Henquin JC, Seino S.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:1-3. doi: 10.1111/j.1463-1326.2010.01296.x. No abstract available.

PMID:
21029293
26.

Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments.

Mourad NI, Nenquin M, Henquin JC.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C389-98. doi: 10.1152/ajpcell.00138.2010. Epub 2010 May 19.

27.

Subplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretion.

Ravier MA, Cheng-Xue R, Palmer AE, Henquin JC, Gilon P.

Diabetologia. 2010 Sep;53(9):1947-57. doi: 10.1007/s00125-010-1775-z. Epub 2010 May 13.

28.

Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels.

Szollosi A, Nenquin M, Henquin JC.

Br J Pharmacol. 2010 Feb 1;159(3):669-77. doi: 10.1111/j.1476-5381.2009.00588.x. Epub 2010 Jan 28.

29.

Shortcomings of current models of glucose-induced insulin secretion.

Henquin JC, Nenquin M, Ravier MA, Szollosi A.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:168-79. doi: 10.1111/j.1463-1326.2009.01109.x. Review.

PMID:
19817799
30.

β-Cell research - A decade of rapid growth.

Ahrén B, Accili D, Boitard C, Efendic S, Henquin JC, Seino S, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:iv-ix. doi: 10.1111/j.1463-1326.2009.01143.x. No abstract available.

PMID:
19817782
31.

Regulation of insulin secretion: a matter of phase control and amplitude modulation.

Henquin JC.

Diabetologia. 2009 May;52(5):739-51. doi: 10.1007/s00125-009-1314-y. Epub 2009 Mar 14. Review.

PMID:
19288076
32.

Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells.

Quoix N, Cheng-Xue R, Mattart L, Zeinoun Z, Guiot Y, Beauvois MC, Henquin JC, Gilon P.

Diabetes. 2009 Feb;58(2):412-21. doi: 10.2337/db07-1298. Epub 2008 Nov 13.

33.

Pancreatic beta-cell mass in European subjects with type 2 diabetes.

Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:32-42. doi: 10.1111/j.1463-1326.2008.00969.x.

PMID:
18834431
34.

Pancreatic beta-cell mass or beta-cell function? That is the question!

Henquin JC, Cerasi E, Efendic S, Steiner DF, Boitard C.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:1-4. doi: 10.1111/j.1463-1326.2008.00968.x. No abstract available.

PMID:
18834427
35.

Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2.

Ravier MA, Nenquin M, Miki T, Seino S, Henquin JC.

Endocrinology. 2009 Jan;150(1):33-45. doi: 10.1210/en.2008-0617. Epub 2008 Sep 11.

PMID:
18787024
36.

Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.

Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL.

J Endocrinol. 2008 Mar;196(3):573-81. doi: 10.1677/JOE-07-0496.

PMID:
18310453
37.

Of mighty mice and diabetic men: animal models of islet dysfunction.

Efendic S, Boitard C, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:1-4. No abstract available.

PMID:
17919172
38.

The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.

Quoix N, Cheng-Xue R, Guiot Y, Herrera PL, Henquin JC, Gilon P.

FEBS Lett. 2007 Sep 4;581(22):4235-40. Epub 2007 Aug 7.

39.

Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: studies in islets lacking the Na+/H+ exchangeR NHE1.

Stiernet P, Nenquin M, Moulin P, Jonas JC, Henquin JC.

J Biol Chem. 2007 Aug 24;282(34):24538-46. Epub 2007 Jun 28.

40.

Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas.

Guiot Y, Stevens M, Marhfour I, Stiernet P, Mikhailov M, Ashcroft SJH, Rahier J, Henquin JC, Sempoux C.

Diabetologia. 2007 Sep;50(9):1889-1899. doi: 10.1007/s00125-007-0731-z. Epub 2007 Jun 26.

PMID:
17593344
41.

Nutrient control of insulin secretion in perifused adult pig islets.

Dufrane D, Nenquin M, Henquin JC.

Diabetes Metab. 2007 Dec;33(6):430-8. Epub 2007 Jun 20.

PMID:
17584514
42.
43.

Identification and subcellular localization of the Na+/H+ exchanger and a novel related protein in the endocrine pancreas and adrenal medulla.

Moulin P, Guiot Y, Jonas JC, Rahier J, Devuyst O, Henquin JC.

J Mol Endocrinol. 2007 Mar;38(3):409-22.

PMID:
17339404
44.

Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.

Szollosi A, Nenquin M, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2007 Jan 19;282(3):1747-56. Epub 2006 Nov 30.

45.

Nutrient control of insulin secretion in isolated normal human islets.

Henquin JC, Dufrane D, Nenquin M.

Diabetes. 2006 Dec;55(12):3470-7.

46.

Glucose acutely decreases pH of secretory granules in mouse pancreatic islets. Mechanisms and influence on insulin secretion.

Stiernet P, Guiot Y, Gilon P, Henquin JC.

J Biol Chem. 2006 Aug 4;281(31):22142-51. Epub 2006 Jun 7.

47.

Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk.

Khaldi MZ, Elouil H, Guiot Y, Henquin JC, Jonas JC.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E137-46. Epub 2006 Feb 7.

49.

Glucose-induced mixed [Ca2+]c oscillations in mouse beta-cells are controlled by the membrane potential and the SERCA3 Ca2+-ATPase of the endoplasmic reticulum.

Beauvois MC, Merezak C, Jonas JC, Ravier MA, Henquin JC, Gilon P.

Am J Physiol Cell Physiol. 2006 Jun;290(6):C1503-11. Epub 2005 Dec 28.

50.

A tale of two cousins: type 1 and type 2 diabetes.

Boitard C, Efendic S, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes. 2005 Dec;54 Suppl 2:S1-3. No abstract available.

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