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Simultaneous targeting of linked loci in mouse embryos using base editing.

Lee HK, Willi M, Smith HE, Miller SM, Liu DR, Liu C, Hennighausen L.

Sci Rep. 2019 Feb 7;9(1):1662. doi: 10.1038/s41598-018-33533-5.


Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia.

Kollmann S, Grundschober E, Maurer B, Warsch W, Grausenburger R, Edlinger L, Huuhtanen J, Lagger S, Hennighausen L, Valent P, Decker T, Strobl B, Mueller M, Mustjoki S, Hoelbl-Kovacic A, Sexl V.

Leukemia. 2019 Jul;33(7):1583-1597. doi: 10.1038/s41375-018-0369-5. Epub 2019 Jan 24.


Targeting fidelity of adenine and cytosine base editors in mouse embryos.

Lee HK, Willi M, Miller SM, Kim S, Liu C, Liu DR, Hennighausen L.

Nat Commun. 2018 Nov 15;9(1):4804. doi: 10.1038/s41467-018-07322-7.


STAT5-Driven Enhancers Tightly Control Temporal Expression of Mammary-Specific Genes.

Shin HY, Hennighausen L, Yoo KH.

J Mammary Gland Biol Neoplasia. 2019 Mar;24(1):61-71. doi: 10.1007/s10911-018-9418-y. Epub 2018 Oct 17. Review.


Dissecting Tissue-Specific Super-Enhancers by Integrating Genome-Wide Analyses and CRISPR/Cas9 Genome Editing.

Yoo KH, Hennighausen L, Shin HY.

J Mammary Gland Biol Neoplasia. 2019 Mar;24(1):47-59. doi: 10.1007/s10911-018-9417-z. Epub 2018 Oct 6. Review.


Progressing super-enhancer landscape during mammary differentiation controls tissue-specific gene regulation.

Lee HK, Willi M, Shin HY, Liu C, Hennighausen L.

Nucleic Acids Res. 2018 Nov 16;46(20):10796-10809. doi: 10.1093/nar/gky891.


Mutation frequency is not increased in CRISPR-Cas9-edited mice.

Willi M, Smith HE, Wang C, Liu C, Hennighausen L.

Nat Methods. 2018 Oct;15(10):756-758. doi: 10.1038/s41592-018-0148-2. No abstract available.


Octopus-toolkit: a workflow to automate mining of public epigenomic and transcriptomic next-generation sequencing data.

Kim T, Seo HD, Hennighausen L, Lee D, Kang K.

Nucleic Acids Res. 2018 May 18;46(9):e53. doi: 10.1093/nar/gky083.


Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells.

Villarino AV, Sciumè G, Davis FP, Iwata S, Zitti B, Robinson GW, Hennighausen L, Kanno Y, O'Shea JJ.

J Exp Med. 2017 Oct 2;214(10):2999-3014. doi: 10.1084/jem.20150907. Epub 2017 Sep 15.


Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

Fu SP, Hong H, Lu SF, Hu CJ, Xu HX, Li Q, Yu ML, Ou C, Meng JZ, Wang TL, Hennighausen L, Zhu BM.

PLoS One. 2017 Aug 14;12(8):e0181948. doi: 10.1371/journal.pone.0181948. eCollection 2017.


Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells.

Willi M, Yoo KH, Reinisch F, Kuhns TM, Lee HK, Wang C, Hennighausen L.

Nat Commun. 2017 Jul 17;8:16069. doi: 10.1038/ncomms16069.


CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome.

Shin HY, Wang C, Lee HK, Yoo KH, Zeng X, Kuhns T, Yang CM, Mohr T, Liu C, Hennighausen L.

Nat Commun. 2017 May 31;8:15464. doi: 10.1038/ncomms15464.


Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice.

Lee HK, Willi M, Wang C, Yang CM, Smith HE, Liu C, Hennighausen L.

Nucleic Acids Res. 2017 May 5;45(8):4606-4618. doi: 10.1093/nar/gkx185.


Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial.

Heratizadeh A, Werfel T, Wollenberg A, Abraham S, Plank-Habibi S, Schnopp C, Sticherling M, Apfelbacher C, Biedermann T, Breuer K, Fell I, Fölster-Holst R, Heine G, Grimm J, Hennighausen L, Kugler C, Reese I, Ring J, Schäkel K, Schmitt J, Seikowski K, von Stebut E, Wagner N, Waßmann-Otto A, Wienke-Graul U, Weisshaar E, Worm M, Gieler U, Kupfer J; Arbeitsgemeinschaft Neurodermitisschulung für Erwachsene (ARNE) Study Group.

J Allergy Clin Immunol. 2017 Sep;140(3):845-853.e3. doi: 10.1016/j.jaci.2017.01.029. Epub 2017 Feb 24.


Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5.

Zeng X, Willi M, Shin HY, Hennighausen L, Wang C.

Cell Rep. 2016 Dec 20;17(12):3333-3346. doi: 10.1016/j.celrep.2016.11.079.


STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.

Hidano S, Randall LM, Dawson L, Dietrich HK, Konradt C, Klover PJ, John B, Harris TH, Fang Q, Turek B, Kobayashi T, Hennighausen L, Beiting DP, Koshy AA, Hunter CA.

MBio. 2016 Nov 8;7(6). pii: e01881-16. doi: 10.1128/mBio.01881-16.


Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression.

Hosui A, Tatsumi T, Hikita H, Saito Y, Hiramatsu N, Tsujii M, Hennighausen L, Takehara T.

Hepatol Res. 2017 Jul;47(8):813-825. doi: 10.1111/hepr.12816. Epub 2016 Oct 18.


Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation.

Willi M, Yoo KH, Wang C, Trajanoski Z, Hennighausen L.

Nucleic Acids Res. 2016 Dec 1;44(21):10277-10291. Epub 2016 Sep 30.


STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis.

Lee J, Seong S, Kim JH, Kim K, Kim I, Jeong BC, Nam KI, Kim KK, Hennighausen L, Kim N.

Sci Rep. 2016 Aug 3;6:30977. doi: 10.1038/srep30977.


Hierarchy within the mammary STAT5-driven Wap super-enhancer.

Shin HY, Willi M, HyunYoo K, Zeng X, Wang C, Metser G, Hennighausen L.

Nat Genet. 2016 Aug;48(8):904-911. doi: 10.1038/ng.3606. Epub 2016 Jul 4.


Primary cancer cell culture: mammary-optimized vs conditional reprogramming.

Alamri AM, Kang K, Groeneveld S, Wang W, Zhong X, Kallakury B, Hennighausen L, Liu X, Furth PA.

Endocr Relat Cancer. 2016 Jul;23(7):535-54. doi: 10.1530/ERC-16-0071. Epub 2016 Jun 7.


Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms.

Yoo KH, Oh S, Kang K, Wang C, Robinson GW, Ge K, Hennighausen L.

Mol Cell Biol. 2016 Jul 29;36(16):2108-20. doi: 10.1128/MCB.00089-16. Print 2016 Aug 15.


Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype.

Müller TA, Grundler R, Istvanffy R, Rudelius M, Hennighausen L, Illert AL, Duyster J.

Leukemia. 2016 Aug;30(8):1725-33. doi: 10.1038/leu.2016.72. Epub 2016 Apr 5.


Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Sakamoto K, Wehde BL, Yoo KH, Kim T, Rajbhandari N, Shin HY, Triplett AA, Rädler PD, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner KU.

Mol Cell Biol. 2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15. Print 2016 Jun 1.


Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

Villarino A, Laurence A, Robinson GW, Bonelli M, Dema B, Afzali B, Shih HY, Sun HW, Brooks SR, Hennighausen L, Kanno Y, O'Shea JJ.

Elife. 2016 Mar 21;5. pii: e08384. doi: 10.7554/eLife.08384.


STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.

Haetscher N, Feuermann Y, Wingert S, Rehage M, Thalheimer FB, Weiser C, Bohnenberger H, Jung K, Schroeder T, Serve H, Oellerich T, Hennighausen L, Rieger MA.

Nat Commun. 2015 Nov 25;6:8928. doi: 10.1038/ncomms9928.


Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet.

Baik M, Lee MS, Kang HJ, Park SJ, Piao MY, Nguyen TH, Hennighausen L.

Eur J Nutr. 2017 Mar;56(2):569-579. doi: 10.1007/s00394-015-1101-0. Epub 2015 Nov 18.


An autoregulatory enhancer controls mammary-specific STAT5 functions.

Metser G, Shin HY, Wang C, Yoo KH, Oh S, Villarino AV, O'Shea JJ, Kang K, Hennighausen L.

Nucleic Acids Res. 2016 Feb 18;44(3):1052-63. doi: 10.1093/nar/gkv999. Epub 2015 Oct 7.


Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes.

Yoo KH, Oh S, Kang K, Hensel T, Robinson GW, Hennighausen L.

Nucleic Acids Res. 2015 Oct 15;43(18):8774-89. doi: 10.1093/nar/gkv776. Epub 2015 Aug 6.


The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.

Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A.

Cell Death Differ. 2016 Jan;23(1):41-51. doi: 10.1038/cdd.2015.61. Epub 2015 Jun 5.


Neuronal STAT5 signaling is required for maintaining lactation but not for postpartum maternal behaviors in mice.

Buonfiglio DC, Ramos-Lobo AM, Silveira MA, Furigo IC, Hennighausen L, Frazão R, Donato J Jr.

Horm Behav. 2015 May;71:60-8. doi: 10.1016/j.yhbeh.2015.04.004. Epub 2015 Apr 17.


Genome-wide target site triplication of Alu elements in the human genome.

Lee W, Mun S, Kang K, Hennighausen L, Han K.

Gene. 2015 May 1;561(2):283-91. doi: 10.1016/j.gene.2015.02.052. Epub 2015 Feb 19.


The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration.

Bae WK, Kang K, Yu JH, Yoo KH, Factor VM, Kaji K, Matter M, Thorgeirsson S, Hennighausen L.

FASEB J. 2015 May;29(5):1653-62. doi: 10.1096/fj.14-261537. Epub 2014 Dec 4.


Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.

Dabydeen SA, Kang K, Díaz-Cruz ES, Alamri A, Axelrod ML, Bouker KB, Al-Kharboosh R, Clarke R, Hennighausen L, Furth PA.

Carcinogenesis. 2015 Jan;36(1):122-32. doi: 10.1093/carcin/bgu237. Epub 2014 Nov 23.


The STAT5-regulated miR-193b locus restrains mammary stem and progenitor cell activity and alveolar differentiation.

Yoo KH, Kang K, Feuermann Y, Jang SJ, Robinson GW, Hennighausen L.

Dev Biol. 2014 Nov 15;395(2):245-54. doi: 10.1016/j.ydbio.2014.09.012. Epub 2014 Sep 16.


Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD.

Capitini CM, Nasholm NM, Chien CD, Larabee SM, Qin H, Song YK, Klover PJ, Hennighausen L, Khan J, Fry TJ.

Blood. 2014 Sep 18;124(12):1976-86. doi: 10.1182/blood-2013-05-500876. Epub 2014 Jul 25.


Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells.

Thalheimer FB, Wingert S, De Giacomo P, Haetscher N, Rehage M, Brill B, Theis FJ, Hennighausen L, Schroeder T, Rieger MA.

Stem Cell Reports. 2014 Jun 19;3(1):34-43. doi: 10.1016/j.stemcr.2014.05.010. eCollection 2014 Jul 8.


The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers.

Bae WK, Yoo KH, Lee JS, Kim Y, Chung IJ, Park MH, Yoon JH, Furth PA, Hennighausen L.

Mol Carcinog. 2015 Oct;54(10):1172-80. doi: 10.1002/mc.22188. Epub 2014 Jul 7.


Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer.

Assefnia S, Kang K, Groeneveld S, Yamaji D, Dabydeen S, Alamri A, Liu X, Hennighausen L, Furth PA.

Endocr Relat Cancer. 2014 May 6;21(3):443-57. doi: 10.1530/ERC-14-0032. Print 2014 Jun.


Coregulation of genetic programs by the transcription factors NFIB and STAT5.

Robinson GW, Kang K, Yoo KH, Tang Y, Zhu BM, Yamaji D, Colditz V, Jang SJ, Gronostajski RM, Hennighausen L.

Mol Endocrinol. 2014 May;28(5):758-67. doi: 10.1210/me.2012-1387. Epub 2014 Mar 28.


MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

Feuermann Y, Kang K, Shamay A, Robinson GW, Hennighausen L.

PLoS One. 2014 Jan 30;9(1):e85123. doi: 10.1371/journal.pone.0085123. eCollection 2014.


Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast.

Hirose J, Masuda H, Tokuyama N, Omata Y, Matsumoto T, Yasui T, Kadono Y, Hennighausen L, Tanaka S.

J Exp Med. 2014 Jan 13;211(1):153-63. doi: 10.1084/jem.20130538. Epub 2013 Dec 23.


MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.

Feuermann Y, Kang K, Gavrilova O, Haetscher N, Jang SJ, Yoo KH, Jiang C, Gonzalez FJ, Robinson GW, Hennighausen L.

RNA Biol. 2013 Dec;10(12):1807-14. doi: 10.4161/rna.27239. Epub 2013 Nov 22.


Mammary-specific gene activation is defined by progressive recruitment of STAT5 during pregnancy and the establishment of H3K4me3 marks.

Kang K, Yamaji D, Yoo KH, Robinson GW, Hennighausen L.

Mol Cell Biol. 2014 Feb;34(3):464-73. doi: 10.1128/MCB.00988-13. Epub 2013 Nov 25.


Canonical and non-canonical roles of the histone methyltransferase EZH2 in mammary development and cancer.

Bae WK, Hennighausen L.

Mol Cell Endocrinol. 2014 Jan 25;382(1):593-597. doi: 10.1016/j.mce.2013.05.002. Epub 2013 May 17. Review.


The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.

Bell BD, Kitajima M, Larson RP, Stoklasek TA, Dang K, Sakamoto K, Wagner KU, Kaplan DH, Reizis B, Hennighausen L, Ziegler SF.

Nat Immunol. 2013 Apr;14(4):364-71. doi: 10.1038/ni.2541. Epub 2013 Feb 24. Erratum in: Nat Immunol. 2014 Mar;15(3):305. Kaplan, Daniel H [added].


Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

Yamaji D, Kang K, Robinson GW, Hennighausen L.

Nucleic Acids Res. 2013 Feb 1;41(3):1622-36. doi: 10.1093/nar/gks1310. Epub 2012 Dec 28.


STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.

Tam WF, Hähnel PS, Schüler A, Lee BH, Okabe R, Zhu N, Pante SV, Raffel G, Mercher T, Wernig G, Bockamp E, Sasca D, Kreft A, Robinson GW, Hennighausen L, Gilliland DG, Kindler T.

Cancer Res. 2013 Jan 1;73(1):373-84. doi: 10.1158/0008-5472.CAN-12-0255. Epub 2012 Nov 13.


Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection.

Page C, Goicochea L, Matthews K, Zhang Y, Klover P, Holtzman MJ, Hennighausen L, Frieman M.

J Virol. 2012 Dec;86(24):13334-49. doi: 10.1128/JVI.01689-12. Epub 2012 Sep 26.

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