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Items: 24

1.

Discovery of a subnanomolar and selective spirocyclic agonist of the glucocorticoid receptor.

Badarau E, Robert F, Massip S, Jakob F, Lucas S, Friebe D, Hennen S, Frormann S, Ghosez L.

Eur J Med Chem. 2019 Jan 1;161:354-363. doi: 10.1016/j.ejmech.2018.10.032. Epub 2018 Oct 15.

PMID:
30384041
2.

α-Helix or β-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.

Oddo A, Mortensen S, Thøgersen H, De Maria L, Hennen S, McGuire JN, Kofoed J, Linderoth L, Reedtz-Runge S.

Biochemistry. 2018 Jul 17;57(28):4148-4154. doi: 10.1021/acs.biochem.8b00105. Epub 2018 Jun 21.

PMID:
29877701
3.

Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation.

Merten N, Fischer J, Simon K, Zhang L, Schröder R, Peters L, Letombe AG, Hennen S, Schrage R, Bödefeld T, Vermeiren C, Gillard M, Mohr K, Lu QR, Brüstle O, Gomeza J, Kostenis E.

Cell Chem Biol. 2018 Jun 21;25(6):775-786.e5. doi: 10.1016/j.chembiol.2018.03.012. Epub 2018 Apr 26.

PMID:
29706593
4.

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.

Simon K, Merten N, Schröder R, Hennen S, Preis P, Schmitt NK, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E.

Mol Pharmacol. 2017 May;91(5):518-532. doi: 10.1124/mol.116.107904. Epub 2017 Mar 2. Erratum in: Mol Pharmacol. 2017 Jul;92 (1):100.

PMID:
28254957
5.

Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor.

Hennen S, Kodra JT, Soroka V, Krogh BO, Wu X, Kaastrup P, Ørskov C, Rønn SG, Schluckebier G, Barbateskovic S, Gandhi PS, Reedtz-Runge S.

Sci Rep. 2016 May 19;6:26236. doi: 10.1038/srep26236.

6.

The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.

Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, Gomeza J.

J Biol Chem. 2016 Jan 8;291(2):705-18. doi: 10.1074/jbc.M115.683953. Epub 2015 Nov 30.

7.

Photoacoustic tomography imaging and estimation of oxygen saturation of hemoglobin in ocular tissue of rabbits.

Hennen SN, Xing W, Shui YB, Zhou Y, Kalishman J, Andrews-Kaminsky LB, Kass MA, Beebe DC, Maslov KI, Wang LV.

Exp Eye Res. 2015 Sep;138:153-8. doi: 10.1016/j.exer.2015.05.022. Epub 2015 Jun 3.

8.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.

9.

Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.

Hennen S, Wang H, Peters L, Merten N, Simon K, Spinrath A, Blättermann S, Akkari R, Schrage R, Schröder R, Schulz D, Vermeiren C, Zimmermann K, Kehraus S, Drewke C, Pfeifer A, König GM, Mohr K, Gillard M, Müller CE, Lu QR, Gomeza J, Kostenis E.

Sci Signal. 2013 Oct 22;6(298):ra93. doi: 10.1126/scisignal.2004350.

10.

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.

Blättermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schröder R, Tyagi R, Luschnig P, Gäb J, Hennen S, Ulven T, Pardo L, Mohr K, Gütschow M, Heinemann A, Kostenis E.

Nat Chem Biol. 2012 Jul;8(7):631-8. doi: 10.1038/nchembio.962. Epub 2012 May 27.

PMID:
22634634
11.

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

Schröder R, Janssen N, Schmidt J, Kebig A, Merten N, Hennen S, Müller A, Blättermann S, Mohr-Andrä M, Zahn S, Wenzel J, Smith NJ, Gomeza J, Drewke C, Milligan G, Mohr K, Kostenis E.

Nat Biotechnol. 2010 Sep;28(9):943-9. doi: 10.1038/nbt.1671. Epub 2010 Aug 15.

PMID:
20711173
12.
13.

Robert W. Briggs 1911-1983.

Hennen S, Malacinski G.

Dev Biol. 1983 Aug;98(2):255-6. No abstract available.

PMID:
6347756
14.

Cytochrome oxidase deficiency during development of amphibian nucleocytoplasmic hybrids.

Liepins A, Hennen S.

Dev Biol. 1977 Jun;57(2):284-92. No abstract available.

PMID:
194804
15.
16.

Teratogenic evaluation of terpenoid derivatives.

Unsworth B, Hennen S, Krishnakumaran A, Ting P, Hoffman N.

Life Sci. 1974 Nov 1;15(9):1649-55. No abstract available.

PMID:
4550001
17.

Back-transfer of late gastrula nuclei of nucleocytoplasmic hybrids.

Hennen S.

Dev Biol. 1974 Feb;36(2):447-51. No abstract available.

PMID:
4544407
18.
19.

Morphological and cytological features of gene activity in an amphibian hybrid system.

Hennen S.

Dev Biol. 1972 Oct;29(2):241-9. No abstract available.

PMID:
4538575
20.

Ultrastructure of the "germ plasm" in eggs and embryos of Rana pipiens.

Mahowald AP, Hennen S.

Dev Biol. 1971 Jan;24(1):37-53. No abstract available.

PMID:
4107682
23.

THE KARYOTYPE OF RANA SYLVATICA AND ITS COMPARISON WITH THE KARYOTYPE OF RANA PIPIENS.

HENNEN S.

J Hered. 1964 May-Jun;55:124-8. No abstract available.

PMID:
14170402

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