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ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.

Carvalho D, Taylor KR, Olaciregui NG, Molinari V, Clarke M, Mackay A, Ruddle R, Henley A, Valenti M, Hayes A, Brandon AH, Eccles SA, Raynaud F, Boudhar A, Monje M, Popov S, Moore AS, Mora J, Cruz O, Vinci M, Brennan PE, Bullock AN, Carcaboso AM, Jones C.

Commun Biol. 2019 May 9;2(1):156. doi: 10.1038/s42003-019-0420-8.


An experimental and computational study of the effect of aqueous solution on the multiphoton ionisation photoelectron spectrum of phenol.

Henley A, Riley JW, Wang B, Fielding HH.

Faraday Discuss. 2019 Dec 16;221(0):202-218. doi: 10.1039/c9fd00079h.


ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.

Carvalho D, Taylor KR, Olaciregui NG, Molinari V, Clarke M, Mackay A, Ruddle R, Henley A, Valenti M, Hayes A, Brandon AH, Eccles SA, Raynaud F, Boudhar A, Monje M, Popov S, Moore AS, Mora J, Cruz O, Vinci M, Brennan PE, Bullock AN, Carcaboso AM, Jones C.

Commun Biol. 2019 May 9;2:156. doi: 10.1038/s42003-019-0420-8. eCollection 2019.


Photoelectron Imaging and Quantum Chemistry Study of Phenolate, Difluorophenolate, and Dimethoxyphenolate Anions.

Woodhouse JL, Henley A, Parkes MA, Fielding HH.

J Phys Chem A. 2019 Apr 4;123(13):2709-2718. doi: 10.1021/acs.jpca.8b11121. Epub 2019 Mar 18.


The Root of Physical Inactivity Among African-American Women: Identifying Exercise Friendly Hairstyles.

Williams WM, Alleyne R, Henley AT.

J Natl Black Nurses Assoc. 2017 Dec;28(2):26-31.


Role of Photoisomerization on the Photodetachment of the Photoactive Yellow Protein Chromophore.

Henley A, Patel AM, Parkes MA, Anderson JC, Fielding HH.

J Phys Chem A. 2018 Oct 18;122(41):8222-8228. doi: 10.1021/acs.jpca.8b07770. Epub 2018 Oct 3.


Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).

Woodward HL, Innocenti P, Cheung KJ, Hayes A, Roberts J, Henley AT, Faisal A, Mak GW, Box G, Westwood IM, Cronin N, Carter M, Valenti M, De Haven Brandon A, O'Fee L, Saville H, Schmitt J, Burke R, Broccatelli F, van Montfort RLM, Raynaud FI, Eccles SA, Linardopoulos S, Blagg J, Hoelder S.

J Med Chem. 2018 Sep 27;61(18):8226-8240. doi: 10.1021/acs.jmedchem.8b00690. Epub 2018 Sep 10.


Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer.

Kosgodage US, Mould R, Henley AB, Nunn AV, Guy GW, Thomas EL, Inal JM, Bell JD, Lange S.

Front Pharmacol. 2018 Aug 13;9:889. doi: 10.3389/fphar.2018.00889. eCollection 2018.


Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib.

Dyczynski M, Yu Y, Otrocka M, Parpal S, Braga T, Henley AB, Zazzi H, Lerner M, Wennerberg K, Viklund J, Martinsson J, Grandér D, De Milito A, Pokrovskaja Tamm K.

Cancer Lett. 2018 Oct 28;435:32-43. doi: 10.1016/j.canlet.2018.07.028. Epub 2018 Jul 25.


A photoelectron imaging and quantum chemistry study of the deprotonated indole anion.

Parkes MA, Crellin J, Henley A, Fielding HH.

Phys Chem Chem Phys. 2018 Jun 6;20(22):15543-15549. doi: 10.1039/c8cp01902a.


Enhancement of CO2 Uptake and Selectivity in a Metal-Organic Framework by the Incorporation of Thiophene Functionality.

Bolotov VA, Kovalenko KA, Samsonenko DG, Han X, Zhang X, Smith GL, McCormick LJ, Teat SJ, Yang S, Lennox MJ, Henley A, Besley E, Fedin VP, Dybtsev DN, Schröder M.

Inorg Chem. 2018 May 7;57(9):5074-5082. doi: 10.1021/acs.inorgchem.8b00138. Epub 2018 Apr 23.


Temporal framing and the hidden-zero effect: rate-dependent outcomes on delay discounting.

Naudé GP, Kaplan BA, Reed DD, Henley AJ, DiGennaro Reed FD.

J Exp Anal Behav. 2018 May;109(3):506-519. doi: 10.1002/jeab.328. Epub 2018 Apr 16.


MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling.

Dzieran J, Rodriguez Garcia A, Westermark UK, Henley AB, Eyre Sánchez E, Träger C, Johansson HJ, Lehtiö J, Arsenian-Henriksson M.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1229-E1238. doi: 10.1073/pnas.1710901115. Epub 2018 Jan 26.


Electronic structure and dynamics of torsion-locked photoactive yellow protein chromophores.

Henley A, Diveky ME, Patel AM, Parkes MA, Anderson JC, Fielding HH.

Phys Chem Chem Phys. 2017 Dec 6;19(47):31572-31580. doi: 10.1039/c7cp06950b.


Modulation of Plasma Metabolite Biomarkers of the MAPK Pathway with MEK Inhibitor RO4987655: Pharmacodynamic and Predictive Potential in Metastatic Melanoma.

Ang JE, Pal A, Asad YJ, Henley AT, Valenti M, Box G, de Haven Brandon A, Revell VL, Skene DJ, Venturi M, Rueger R, Meresse V, Eccles SA, de Bono JS, Kaye SB, Workman P, Banerji U, Raynaud FI.

Mol Cancer Ther. 2017 Oct;16(10):2315-2323. doi: 10.1158/1535-7163.MCT-16-0881. Epub 2017 Jun 21.


The MYCN Protein in Health and Disease.

Ruiz-Pérez MV, Henley AB, Arsenian-Henriksson M.

Genes (Basel). 2017 Mar 30;8(4). pii: E113. doi: 10.3390/genes8040113. Review.


Time constraints in the alcohol purchase task.

Kaplan BA, Reed DD, Murphy JG, Henley AJ, Reed FDD, Roma PG, Hursh SR.

Exp Clin Psychopharmacol. 2017 Jun;25(3):186-197. doi: 10.1037/pha0000110. Epub 2017 Feb 27.


Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'.

Henley AB, Yang L, Chuang KL, Sahuri-Arisoylu M, Wu LH, Bligh SW, Bell JD.

PLoS One. 2017 Jan 27;12(1):e0170917. doi: 10.1371/journal.pone.0170917. eCollection 2017.


Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.

Cheeseman MD, Chessum NE, Rye CS, Pasqua AE, Tucker MJ, Wilding B, Evans LE, Lepri S, Richards M, Sharp SY, Ali S, Rowlands M, O'Fee L, Miah A, Hayes A, Henley AT, Powers M, Te Poele R, De Billy E, Pellegrino L, Raynaud F, Burke R, van Montfort RL, Eccles SA, Workman P, Jones K.

J Med Chem. 2017 Jan 12;60(1):180-201. doi: 10.1021/acs.jmedchem.6b01055. Epub 2016 Dec 22.


Metabolic dysfunction following weight cycling in male mice.

Schofield SE, Parkinson JR, Henley AB, Sahuri-Arisoylu M, Sanchez-Canon GJ, Bell JD.

Int J Obes (Lond). 2017 Mar;41(3):402-411. doi: 10.1038/ijo.2016.193. Epub 2016 Nov 14.


Protective effect of Allium sativum (garlic) aqueous extract against lead-induced oxidative stress in the rat brain, liver, and kidney.

Manoj Kumar V, Henley AK, Nelson CJ, Indumati O, Prabhakara Rao Y, Rajanna S, Rajanna B.

Environ Sci Pollut Res Int. 2017 Jan;24(2):1544-1552. doi: 10.1007/s11356-016-7923-3. Epub 2016 Oct 26.


Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.

Rye CS, Chessum NE, Lamont S, Pike KG, Faulder P, Demeritt J, Kemmitt P, Tucker J, Zani L, Cheeseman MD, Isaac R, Goodwin L, Boros J, Raynaud F, Hayes A, Henley AT, de Billy E, Lynch CJ, Sharp SY, Te Poele R, Fee LO, Foote KM, Green S, Workman P, Jones K.

Medchemcomm. 2016 Aug 1;7(8):1580-1586. Epub 2016 Jun 13.


Function-Altering Effects of Rule Phrasing in the Modulation of Instructional Control.

Henley AJ, Hirst JM, DiGennaro Reed FD, Becirevic A, Reed DD.

Anal Verbal Behav. 2016 Sep 23;33(1):24-40. doi: 10.1007/s40616-016-0063-5. eCollection 2017 Jun.


Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.

Hayes A, Mok NY, Liu M, Thai C, Henley AT, Atrash B, Lanigan RM, Sejberg J, Le Bihan YV, Bavetsias V, Blagg J, Raynaud FI.

Xenobiotica. 2017 Sep;47(9):771-777. doi: 10.1080/00498254.2016.1230245. Epub 2016 Oct 26.


A crowdsourced nickel-and-dime approach to analog OBM research: A behavioral economic framework for understanding workforce attrition.

Henley AJ, DiGennaro Reed FD, Reed DD, Kaplan BA.

J Exp Anal Behav. 2016 Sep;106(2):134-44. doi: 10.1002/jeab.220. Epub 2016 Aug 26.


Pilot Randomized Trial of Active Music Engagement Intervention Parent Delivery for Young Children With Cancer.

Robb SL, Haase JE, Perkins SM, Haut PR, Henley AK, Knafl KA, Tong Y.

J Pediatr Psychol. 2017 Mar 1;42(2):208-219. doi: 10.1093/jpepsy/jsw050.


Volatile fatty acids platform from thermally hydrolysed secondary sewage sludge enhanced through recovered micronutrients from digested sludge.

Kumi PJ, Henley A, Shana A, Wilson V, Esteves SR.

Water Res. 2016 Sep 1;100:267-276. doi: 10.1016/j.watres.2016.05.030. Epub 2016 May 12.


Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).

Osborne JD, Matthews TP, McHardy T, Proisy N, Cheung KM, Lainchbury M, Brown N, Walton MI, Eve PD, Boxall KJ, Hayes A, Henley AT, Valenti MR, De Haven Brandon AK, Box G, Jamin Y, Robinson SP, Westwood IM, van Montfort RL, Leonard PM, Lamers MB, Reader JC, Aherne GW, Raynaud FI, Eccles SA, Garrett MD, Collins I.

J Med Chem. 2016 Jun 9;59(11):5221-37. doi: 10.1021/acs.jmedchem.5b01938. Epub 2016 May 23.


Effective Binding of Methane Using a Weak Hydrogen Bond.

Henley A, Bound M, Besley E.

J Phys Chem A. 2016 May 26;120(20):3701-9. doi: 10.1021/acs.jpca.6b03331. Epub 2016 May 12.


Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.

Innocenti P, Woodward HL, Solanki S, Naud S, Westwood IM, Cronin N, Hayes A, Roberts J, Henley AT, Baker R, Faisal A, Mak GW, Box G, Valenti M, De Haven Brandon A, O'Fee L, Saville H, Schmitt J, Matijssen B, Burke R, van Montfort RL, Raynaud FI, Eccles SA, Linardopoulos S, Blagg J, Hoelder S.

J Med Chem. 2016 Apr 28;59(8):3671-88. doi: 10.1021/acs.jmedchem.5b01811. Epub 2016 Apr 7.


Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.

Ang JE, Pandher R, Ang JC, Asad YJ, Henley AT, Valenti M, Box G, de Haven Brandon A, Baird RD, Friedman L, Derynck M, Vanhaesebroeck B, Eccles SA, Kaye SB, Workman P, de Bono JS, Raynaud FI.

Mol Cancer Ther. 2016 Jun;15(6):1412-24. doi: 10.1158/1535-7163.MCT-15-0815. Epub 2016 Apr 5.


The Patient as Text: Literary Scholarship and Medical Practice in Margaret Edson's Wit.

Henley A.

AMA J Ethics. 2015 Sep 1;17(9):858-64. doi: 10.1001/journalofethics.2015.17.9.imhl1-1509. No abstract available.


7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.

Bavetsias V, Pérez-Fuertes Y, McIntyre PJ, Atrash B, Kosmopoulou M, O'Fee L, Burke R, Sun C, Faisal A, Bush K, Avery S, Henley A, Raynaud FI, Linardopoulos S, Bayliss R, Blagg J.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4203-9. doi: 10.1016/j.bmcl.2015.08.003. Epub 2015 Aug 6.


The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.

Walton MI, Eve PD, Hayes A, Henley AT, Valenti MR, De Haven Brandon AK, Box G, Boxall KJ, Tall M, Swales K, Matthews TP, McHardy T, Lainchbury M, Osborne J, Hunter JE, Perkins ND, Aherne GW, Reader JC, Raynaud FI, Eccles SA, Collins I, Garrett MD.

Oncotarget. 2016 Jan 19;7(3):2329-42. doi: 10.18632/oncotarget.4919.


A Survey of Staff Training and Performance Management Practices: the Good, the Bad, and the Ugly.

Reed FD, Henley AJ.

Behav Anal Pract. 2015 Feb 20;8(1):16-26. eCollection 2015 May.


Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

Mallinger A, Crumpler S, Pichowicz M, Waalboer D, Stubbs M, Adeniji-Popoola O, Wood B, Smith E, Thai C, Henley AT, Georgi K, Court W, Hobbs S, Box G, Ortiz-Ruiz MJ, Valenti M, De Haven Brandon A, TePoele R, Leuthner B, Workman P, Aherne W, Poeschke O, Dale T, Wienke D, Esdar C, Rohdich F, Raynaud F, Clarke PA, Eccles SA, Stieber F, Schiemann K, Blagg J.

J Med Chem. 2015 Feb 26;58(4):1717-35. doi: 10.1021/jm501436m. Epub 2015 Feb 13.


Improving the Quality of Parent-Teacher Interactions in an Early Childhood Classroom.

Berc H, Doucette JL, DiGennaro Reed FD, Neidert PL, Henley AJ.

Behav Anal Pract. 2014 Jul 22;7(2):47-50. doi: 10.1007/s40617-014-0012-5. eCollection 2014 Oct. No abstract available.


Barriers to Independent Living for Individuals with Disabilities and Seniors.

DiGennaro Reed FD, Strouse MC, Jenkins SR, Price J, Henley AJ, Hirst JM.

Behav Anal Pract. 2014 Jun 11;7(2):70-7. doi: 10.1007/s40617-014-0011-6. eCollection 2014 Oct.


Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).

Naud S, Westwood IM, Faisal A, Sheldrake P, Bavetsias V, Atrash B, Cheung KM, Liu M, Hayes A, Schmitt J, Wood A, Choi V, Boxall K, Mak G, Gurden M, Valenti M, de Haven Brandon A, Henley A, Baker R, McAndrew C, Matijssen B, Burke R, Hoelder S, Eccles SA, Raynaud FI, Linardopoulos S, van Montfort RL, Blagg J.

J Med Chem. 2013 Dec 27;56(24):10045-65. doi: 10.1021/jm401395s. Epub 2013 Dec 2.


Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.

Bavetsias V, Faisal A, Crumpler S, Brown N, Kosmopoulou M, Joshi A, Atrash B, Pérez-Fuertes Y, Schmitt JA, Boxall KJ, Burke R, Sun C, Avery S, Bush K, Henley A, Raynaud FI, Workman P, Bayliss R, Linardopoulos S, Blagg J.

J Med Chem. 2013 Nov 27;56(22):9122-35. doi: 10.1021/jm401115g. Epub 2013 Nov 6.


Evidence for validity of five secondary data sources for enumerating retail food outlets in seven American Indian communities in North Carolina.

Fleischhacker SE, Rodriguez DA, Evenson KR, Henley A, Gizlice Z, Soto D, Ramachandran G.

Int J Behav Nutr Phys Act. 2012 Nov 22;9:137. doi: 10.1186/1479-5868-9-137.


Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.

Bavetsias V, Crumpler S, Sun C, Avery S, Atrash B, Faisal A, Moore AS, Kosmopoulou M, Brown N, Sheldrake PW, Bush K, Henley A, Box G, Valenti M, de Haven Brandon A, Raynaud FI, Workman P, Eccles SA, Bayliss R, Linardopoulos S, Blagg J.

J Med Chem. 2012 Oct 25;55(20):8721-34. doi: 10.1021/jm300952s. Epub 2012 Oct 8.


Patients' views on an education booklet following spinal surgery.

McGregor AH, Henley A, Morris TP, Doré CJ.

Eur Spine J. 2012 Aug;21(8):1609-15. doi: 10.1007/s00586-012-2242-y. Epub 2012 Mar 2.


Exploring the care experience of patients undergoing spinal surgery: a qualitative study.

Davis RE, Vincent C, Henley A, McGregor A.

J Eval Clin Pract. 2013 Feb;19(1):132-8. doi: 10.1111/j.1365-2753.2011.01783.x. Epub 2011 Oct 26.


An evaluation of a postoperative rehabilitation program after spinal surgery and its impact on outcome.

McGregor AH, Henley A, Morris TP, Doré CJ; FASTER team.

Spine (Phila Pa 1976). 2012 Apr 1;37(7):E417-22. doi: 10.1097/BRS.0b013e31823b00b2.


Implementing HES&S training in the oil & gas industry: a brief overview.

Henley A, Pinheiro A, Daly D.

Occup Health Saf. 2011 Jul;80(7):84, 87. No abstract available.


Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930.

Yap TA, Walton MI, Hunter LJ, Valenti M, de Haven Brandon A, Eve PD, Ruddle R, Heaton SP, Henley A, Pickard L, Vijayaraghavan G, Caldwell JJ, Thompson NT, Aherne W, Raynaud FI, Eccles SA, Workman P, Collins I, Garrett MD.

Mol Cancer Ther. 2011 Feb;10(2):360-71. doi: 10.1158/1535-7163.MCT-10-0760. Epub 2010 Dec 29.


After a late miscarriage, stillbirth or neonatal death.

Schott J, Henley A.

J Fam Health Care. 2010;20(4):116-8.


Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt).

McHardy T, Caldwell JJ, Cheung KM, Hunter LJ, Taylor K, Rowlands M, Ruddle R, Henley A, de Haven Brandon A, Valenti M, Davies TG, Fazal L, Seavers L, Raynaud FI, Eccles SA, Aherne GW, Garrett MD, Collins I.

J Med Chem. 2010 Mar 11;53(5):2239-49. doi: 10.1021/jm901788j.


Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941.

Raynaud FI, Eccles SA, Patel S, Alix S, Box G, Chuckowree I, Folkes A, Gowan S, De Haven Brandon A, Di Stefano F, Hayes A, Henley AT, Lensun L, Pergl-Wilson G, Robson A, Saghir N, Zhyvoloup A, McDonald E, Sheldrake P, Shuttleworth S, Valenti M, Wan NC, Clarke PA, Workman P.

Mol Cancer Ther. 2009 Jul;8(7):1725-38. doi: 10.1158/1535-7163.MCT-08-1200. Epub 2009 Jul 7.

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