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Items: 36

1.

Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria.

Miller TE, Henkels KM, Huddleston M, Salisbury R, Hussain SM, Sasaki AT, Cho KJ.

J Cell Sci. 2019 Jul 22. pii: jcs.231886. doi: 10.1242/jcs.231886. [Epub ahead of print]

PMID:
31331963
2.

Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence.

Ganesan R, Henkels KM, Wrenshall LE, Kanaho Y, Di Paolo G, Frohman MA, Gomez-Cambronero J.

J Leukoc Biol. 2018 May;103(5):867-883. doi: 10.1002/JLB.2A1017-407RR. Epub 2018 Apr 14.

3.

Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury.

Abdulnour RE, Howrylak JA, Tavares AH, Douda DN, Henkels KM, Miller TE, Fredenburgh LE, Baron RM, Gomez-Cambronero J, Levy BD.

J Leukoc Biol. 2018 May;103(5):919-932. doi: 10.1002/JLB.3A0617-252RR. Epub 2018 Feb 13.

4.

PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA.

Gomez-Cambronero J, Morris AJ, Henkels KM.

Methods Enzymol. 2017;583:327-357. doi: 10.1016/bs.mie.2016.09.042. Epub 2016 Nov 11.

PMID:
28063497
5.

PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases.

Henkels KM, Muppani NR, Gomez-Cambronero J.

PLoS One. 2016 Nov 16;11(11):e0166553. doi: 10.1371/journal.pone.0166553. eCollection 2016.

6.

A Phosphatidic Acid (PA) conveyor system of continuous intracellular transport from cell membrane to nucleus maintains EGF receptor homeostasis.

Henkels KM, Miller TE, Ganesan R, Wilkins BA, Fite K, Gomez-Cambronero J.

Oncotarget. 2016 Jul 26;7(30):47002-47017. doi: 10.18632/oncotarget.9685.

7.

Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor.

Hatton N, Lintz E, Mahankali M, Henkels KM, Gomez-Cambronero J.

Mol Cell Biol. 2015 Sep;35(18):3131-44. doi: 10.1128/MCB.00286-15. Epub 2015 Jun 29.

8.

S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding.

Henkels KM, Mallets ER, Dennis PB, Gomez-Cambronero J.

FASEB J. 2015 Apr;29(4):1299-313. doi: 10.1096/fj.14-260992. Epub 2014 Dec 15.

9.

A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src.

Mahankali M, Henkels KM, Speranza F, Gomez-Cambronero J.

J Cell Sci. 2015 Feb 1;128(3):516-26.

10.

The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.

Speranza F, Mahankali M, Henkels KM, Gomez-Cambronero J.

J Biol Chem. 2014 Oct 17;289(42):28885-97. doi: 10.1074/jbc.M114.597146. Epub 2014 Sep 2.

11.

Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model.

Henkels KM, Boivin GP, Dudley ES, Berberich SJ, Gomez-Cambronero J.

Oncogene. 2013 Dec 5;32(49):5551-62. doi: 10.1038/onc.2013.207. Epub 2013 Jun 10.

12.

A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.

Ye Q, Kantonen S, Henkels KM, Gomez-Cambronero J.

J Biol Chem. 2013 Apr 5;288(14):9881-91. doi: 10.1074/jbc.M113.450593. Epub 2013 Feb 12.

13.

A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration.

Mahankali M, Henkels KM, Gomez-Cambronero J.

J Cell Sci. 2013 Mar 15;126(Pt 6):1416-28. doi: 10.1242/jcs.117960. Epub 2013 Feb 1.

14.

Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity.

Mahankali M, Henkels KM, Alter G, Gomez-Cambronero J.

J Biol Chem. 2012 Nov 30;287(49):41417-31. doi: 10.1074/jbc.M112.383596. Epub 2012 Oct 3.

15.

Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras.

Henkels KM, Mahankali M, Gomez-Cambronero J.

Cell Signal. 2013 Jan;25(1):198-205. doi: 10.1016/j.cellsig.2012.08.010. Epub 2012 Aug 31.

16.

Cloning of PLD2 from baculovirus for studies in inflammatory responses.

Gomez-Cambronero J, Henkels KM.

Methods Mol Biol. 2012;861:201-25. doi: 10.1007/978-1-61779-600-5_13.

PMID:
22426721
17.

Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.

Mahankali M, Peng HJ, Henkels KM, Dinauer MC, Gomez-Cambronero J.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19617-22. doi: 10.1073/pnas.1114692108. Epub 2011 Nov 21.

18.

Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action.

Di Fulvio M, Frondorf K, Henkels KM, Grunwald WC Jr, Cool D, Gomez-Cambronero J.

J Biol Chem. 2012 Jan 2;287(1):393-407. doi: 10.1074/jbc.M111.259465. Epub 2011 Nov 17.

19.

A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism.

Kantonen S, Hatton N, Mahankali M, Henkels KM, Park H, Cox D, Gomez-Cambronero J.

Mol Cell Biol. 2011 Nov;31(22):4524-37. doi: 10.1128/MCB.05684-11. Epub 2011 Sep 19.

20.

The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis.

Peng HJ, Henkels KM, Mahankali M, Marchal C, Bubulya P, Dinauer MC, Gomez-Cambronero J.

Mol Cell Biol. 2011 Jun;31(11):2227-40. doi: 10.1128/MCB.01348-10. Epub 2011 Mar 28.

21.

Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).

Henkels KM, Farkaly T, Mahankali M, Segall JE, Gomez-Cambronero J.

J Mol Biol. 2011 May 20;408(5):850-62. doi: 10.1016/j.jmb.2011.03.017. Epub 2011 Mar 22.

22.

Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.

Peng HJ, Henkels KM, Mahankali M, Dinauer MC, Gomez-Cambronero J.

J Biol Chem. 2011 May 6;286(18):16308-20. doi: 10.1074/jbc.M110.206672. Epub 2011 Mar 4.

23.

IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3).

Henkels KM, Frondorf K, Gonzalez-Mejia ME, Doseff AL, Gomez-Cambronero J.

FEBS Lett. 2011 Jan 3;585(1):159-66. doi: 10.1016/j.febslet.2010.11.031. Epub 2010 Nov 21.

24.

Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling.

Frondorf K, Henkels KM, Frohman MA, Gomez-Cambronero J.

J Biol Chem. 2010 May 21;285(21):15837-47. doi: 10.1074/jbc.M109.070524. Epub 2010 Mar 19.

25.

A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation.

Henkels KM, Peng HJ, Frondorf K, Gomez-Cambronero J.

Mol Cell Biol. 2010 May;30(9):2251-63. doi: 10.1128/MCB.01239-09. Epub 2010 Feb 22.

26.

PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation.

Henkels KM, Short S, Peng HJ, Di Fulvio M, Gomez-Cambronero J.

Biochem Biophys Res Commun. 2009 Nov 13;389(2):224-8. doi: 10.1016/j.bbrc.2009.08.109. Epub 2009 Aug 26.

27.

Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis.

Di Fulvio M, Henkels KM, Gomez-Cambronero J.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):737-42. Epub 2007 Apr 10.

28.

The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF.

Di Fulvio M, Frondorf K, Henkels KM, Lehman N, Gomez-Cambronero J.

J Mol Biol. 2007 Mar 30;367(3):814-24. Epub 2007 Jan 12.

29.

Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK.

Turchi JJ, Henkels KM, Zhou Y.

Nucleic Acids Res. 2000 Dec 1;28(23):4634-41.

30.

Interactions of mammalian proteins with cisplatin-damaged DNA.

Turchi JJ, Henkels KM, Hermanson IL, Patrick SM.

J Inorg Biochem. 1999 Oct;77(1-2):83-7. Review.

PMID:
10626358
31.

Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines.

Henkels KM, Turchi JJ.

Cancer Res. 1999 Jul 1;59(13):3077-83. Erratum in: Cancer Res 2000 Feb 15;60(4):1150.

32.

High-mobility group 1 protein inhibits helicase catalyzed displacement of cisplatin-damaged DNA.

Patrick SM, Henkels KM, Turchi JJ.

Biochim Biophys Acta. 1997 Nov 20;1354(3):279-90.

PMID:
9427537
33.
34.

Mechanism of DNA-dependent protein kinase inhibition by cis-diamminedichloroplatinum(II)-damaged DNA.

Turchi JJ, Patrick SM, Henkels KM.

Biochemistry. 1997 Jun 17;36(24):7586-93.

PMID:
9200710
35.

Synthesis of the mammalian telomere lagging strand in vitro.

Reveal PM, Henkels KM, Turchi JJ.

J Biol Chem. 1997 May 2;272(18):11678-81.

36.

Cisplatin-DNA binding specificity of calf high-mobility group 1 protein.

Turchi JJ, Li M, Henkels KM.

Biochemistry. 1996 Mar 5;35(9):2992-3000.

PMID:
8608137

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