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Items: 1 to 50 of 303

1.

MRI to Assess Neurological Function.

Nieman BJ, van Eede MC, Spring S, Dazai J, Henkelman RM, Lerch JP.

Curr Protoc Mouse Biol. 2018 Jun;8(2):e44. doi: 10.1002/cpmo.44. Epub 2018 May 22.

PMID:
29927554
2.

Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging.

Ellegood J, Yee Y, Kerr TM, Muller CL, Blakely RD, Henkelman RM, Veenstra-VanderWeele J, Lerch JP.

Mol Autism. 2018 Apr 10;9:24. doi: 10.1186/s13229-018-0210-z. eCollection 2018.

3.

P63 expression plays a role in developmental rate, embryo size, and local morphogenesis.

Boughner JC, van Eede MC, Spring S, Yu LX, Rostampour N, Henkelman RM.

Dev Dyn. 2018 May;247(5):779-787. doi: 10.1002/dvdy.24622. Epub 2018 Mar 1.

PMID:
29396915
4.

Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.

Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA.

Circ Res. 2018 Feb 2;122(3):405-416. doi: 10.1161/CIRCRESAHA.117.311194. Epub 2017 Dec 22.

PMID:
29273600
5.

Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function.

Sun X, Hota SK, Zhou YQ, Novak S, Miguel-Perez D, Christodoulou D, Seidman CE, Seidman JG, Gregorio CC, Henkelman RM, Rossant J, Bruneau BG.

Biol Open. 2018 Jan 5;7(1). pii: bio029512. doi: 10.1242/bio.029512.

6.

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie Helmut Fuchs SM, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Nutter SNLMJ, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium, Wurst W, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SDM, Adams DJ, Lloyd KCK, McKerlie C, Beaudet AL, Murray MBSA.

Nature. 2017 Nov 16;551(7680):398. doi: 10.1038/nature24643. Epub 2017 Nov 8.

7.

Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.

Sheybani-Deloui S, Chi L, Staite MV, Cain JE, Nieman BJ, Henkelman RM, Wainwright BJ, Potter SS, Bagli DJ, Lorenzo AJ, Rosenblum ND.

J Am Soc Nephrol. 2018 Feb;29(2):532-544. doi: 10.1681/ASN.2017050482. Epub 2017 Nov 6.

PMID:
29109083
8.

Partitioning k-space for cylindrical three-dimensional rapid acquisition with relaxation enhancement imaging in the mouse brain.

Spencer Noakes TL, Henkelman RM, Nieman BJ.

NMR Biomed. 2017 Nov;30(11). doi: 10.1002/nbm.3802. Epub 2017 Sep 13.

PMID:
28902423
9.

Spatial gene expression analysis of neuroanatomical differences in mouse models.

Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Henkelman RM, Lerch JP.

Neuroimage. 2017 Dec;163:220-230. doi: 10.1016/j.neuroimage.2017.08.065. Epub 2017 Sep 4.

PMID:
28882630
10.

Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition.

Arbogast T, Iacono G, Chevalier C, Afinowi NO, Houbaert X, van Eede MC, Laliberte C, Birling MC, Linda K, Meziane H, Selloum M, Sorg T, Nadif Kasri N, Koolen DA, Stunnenberg HG, Henkelman RM, Kopanitsa M, Humeau Y, De Vries BBA, Herault Y.

PLoS Genet. 2017 Jul 13;13(7):e1006886. doi: 10.1371/journal.pgen.1006886. eCollection 2017 Jul.

11.

High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium; Jackson Laboratory; Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource Center, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA.

Nature. 2016 Sep 22;537(7621):508-514. doi: 10.1038/nature19356. Epub 2016 Sep 14. Erratum in: Nature. 2017 Nov 16;551(7680):398.

12.

Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature.

Grimes DT, Boswell CW, Morante NF, Henkelman RM, Burdine RD, Ciruna B.

Science. 2016 Jun 10;352(6291):1341-4. doi: 10.1126/science.aaf6419.

13.

Comparing homologous microscopic sections from multiple embryos using HREM.

Henkelman RM, Friedel M, Lerch JP, Wilson R, Mohun T.

Dev Biol. 2016 Jul 1;415(1):1-5. doi: 10.1016/j.ydbio.2016.05.011. Epub 2016 May 18. No abstract available.

14.

Diffusible iodine-based contrast-enhanced computed tomography (diceCT): an emerging tool for rapid, high-resolution, 3-D imaging of metazoan soft tissues.

Gignac PM, Kley NJ, Clarke JA, Colbert MW, Morhardt AC, Cerio D, Cost IN, Cox PG, Daza JD, Early CM, Echols MS, Henkelman RM, Herdina AN, Holliday CM, Li Z, Mahlow K, Merchant S, Müller J, Orsbon CP, Paluh DJ, Thies ML, Tsai HP, Witmer LM.

J Anat. 2016 Jun;228(6):889-909. doi: 10.1111/joa.12449. Epub 2016 Mar 11. Review.

15.

Micro-CT imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A workshop report.

Solomon HM, Makris SL, Alsaid H, Bermudez O, Beyer BK, Chen A, Chen CL, Chen Z, Chmielewski G, DeLise AM, de Schaepdrijver L, Dogdas B, French J, Harrouk W, Helfgott J, Henkelman RM, Hesterman J, Hew KW, Hoberman A, Lo CW, McDougal A, Minck DR, Scott L, Stewart J, Sutherland V, Tatiparthi AK, Winkelmann CT, Wise LD, Wood SL, Ying X.

Regul Toxicol Pharmacol. 2016 Jun;77:100-8. doi: 10.1016/j.yrtph.2016.02.018. Epub 2016 Feb 27.

16.

4D atlas of the mouse embryo for precise morphological staging.

Wong MD, van Eede MC, Spring S, Jevtic S, Boughner JC, Lerch JP, Henkelman RM.

Development. 2015 Oct 15;142(20):3583-91. doi: 10.1242/dev.125872.

17.

Cardiovascular Patterning as Determined by Hemodynamic Forces and Blood Vessel Genetics.

Anderson GA, Udan RS, Dickinson ME, Henkelman RM.

PLoS One. 2015 Sep 4;10(9):e0137175. doi: 10.1371/journal.pone.0137175. eCollection 2015.

18.

Anisotropic stress orients remodelling of mammalian limb bud ectoderm.

Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S.

Nat Cell Biol. 2015 May;17(5):569-79. doi: 10.1038/ncb3156. Epub 2015 Apr 20.

19.

3D visualization of the regional differences.

Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP.

Mol Psychiatry. 2015 Feb;20(1):1. doi: 10.1038/mp.2014.168. No abstract available.

20.

Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse.

Cahill LS, Laliberté CL, Liu XJ, Bishop J, Nieman BJ, Mogil JS, Sorge RE, Jones CD, Salter MW, Henkelman RM.

Mol Pain. 2014 Sep 13;10:60. doi: 10.1186/1744-8069-10-60.

21.

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.

Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP.

Mol Psychiatry. 2015 Feb;20(1):118-25. doi: 10.1038/mp.2014.98. Epub 2014 Sep 9.

22.

ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease.

Hayes M, Gao X, Yu LX, Paria N, Henkelman RM, Wise CA, Ciruna B.

Nat Commun. 2014 Sep 3;5:4777. doi: 10.1038/ncomms5777.

23.

Inputs for subject-specific computational fluid dynamics simulation of blood flow in the mouse aorta.

Van Doormaal M, Zhou YQ, Zhang X, Steinman DA, Henkelman RM.

J Biomech Eng. 2014 Oct;136(10):101008. doi: 10.1115/1.4028104.

PMID:
25070260
24.

Automated pipeline for anatomical phenotyping of mouse embryos using micro-CT.

Wong MD, Maezawa Y, Lerch JP, Henkelman RM.

Development. 2014 Jun;141(12):2533-41. doi: 10.1242/dev.107722. Epub 2014 May 21.

25.

Differential HIF and NOS responses to acute anemia: defining organ-specific hemoglobin thresholds for tissue hypoxia.

Tsui AK, Marsden PA, Mazer CD, Sled JG, Lee KM, Henkelman RM, Cahill LS, Zhou YQ, Chan N, Liu E, Hare GM.

Am J Physiol Regul Integr Comp Physiol. 2014 Jul 1;307(1):R13-25. doi: 10.1152/ajpregu.00411.2013. Epub 2014 Apr 23.

26.

Whole-brain mapping of behaviourally induced neural activation in mice.

Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM.

Brain Struct Funct. 2015 Jul;220(4):2043-57. doi: 10.1007/s00429-014-0774-0. Epub 2014 Apr 24.

PMID:
24760545
27.

Magnetic Resonance in Medicine at 30.

Glover GH, Jones DK, Frahm J, Henkelman RM, Hennig J, Maudsley AA, Riederer SJ, Wehrli FW, Bernstein MA.

Magn Reson Med. 2014 Mar;71(3):901-2. doi: 10.1002/mrm.25160. No abstract available.

PMID:
24478240
28.

Structural stabilization of tissue for embryo phenotyping using micro-CT with iodine staining.

Wong MD, Spring S, Henkelman RM.

PLoS One. 2013 Dec 30;8(12):e84321. doi: 10.1371/journal.pone.0084321. eCollection 2013.

29.

A highly specific pattern of volumetric brain changes due to 22q11.2 deletions in both mice and humans.

Ellegood J, Markx S, Lerch JP, Steadman PE, Genç C, Provenzano F, Kushner SA, Henkelman RM, Karayiorgou M, Gogos JA.

Mol Psychiatry. 2014 Jan;19(1):6. doi: 10.1038/mp.2013.179. No abstract available.

PMID:
24362540
30.

Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas.

Steadman PE, Ellegood J, Szulc KU, Turnbull DH, Joyner AL, Henkelman RM, Lerch JP.

Autism Res. 2014 Feb;7(1):124-37. doi: 10.1002/aur.1344. Epub 2013 Oct 22.

31.

A coming of age: advanced imaging technologies for characterising the developing mouse.

Norris FC, Wong MD, Greene ND, Scambler PJ, Weaver T, Weninger WJ, Mohun TJ, Henkelman RM, Lythgoe MF.

Trends Genet. 2013 Dec;29(12):700-11. doi: 10.1016/j.tig.2013.08.004. Epub 2013 Sep 12. Review.

PMID:
24035368
32.

Design and implementation of a custom built optical projection tomography system.

Wong MD, Dazai J, Walls JR, Gale NW, Henkelman RM.

PLoS One. 2013 Sep 4;8(9):e73491. doi: 10.1371/journal.pone.0073491. eCollection 2013.

33.

Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion.

Ellegood J, Markx S, Lerch JP, Steadman PE, Genç C, Provenzano F, Kushner SA, Henkelman RM, Karayiorgou M, Gogos JA.

Mol Psychiatry. 2014 Jan;19(1):99-107. doi: 10.1038/mp.2013.112. Epub 2013 Sep 3.

34.

A method for 3D immunostaining and optical imaging of the mouse brain demonstrated in neural progenitor cells.

Gleave JA, Lerch JP, Henkelman RM, Nieman BJ.

PLoS One. 2013 Aug 6;8(8):e72039. doi: 10.1371/journal.pone.0072039. Print 2013.

35.

Mapping registration sensitivity in MR mouse brain images.

van Eede MC, Scholz J, Chakravarty MM, Henkelman RM, Lerch JP.

Neuroimage. 2013 Nov 15;82:226-36. doi: 10.1016/j.neuroimage.2013.06.004. Epub 2013 Jun 10.

PMID:
23756204
36.

Delayed myelination in a mouse model of fragile X syndrome.

Pacey LK, Xuan IC, Guan S, Sussman D, Henkelman RM, Chen Y, Thomsen C, Hampson DR.

Hum Mol Genet. 2013 Oct 1;22(19):3920-30. doi: 10.1093/hmg/ddt246. Epub 2013 Jun 4.

PMID:
23740941
37.

TRPV1 gates tissue access and sustains pathogenicity in autoimmune encephalitis.

Paltser G, Liu XJ, Yantha J, Winer S, Tsui H, Wu P, Maezawa Y, Cahill LS, Laliberté CL, Ramagopalan SV, DeLuca GC, Sadovnick AD, Astsaturov I, Ebers GC, Henkelman RM, Salter MW, Dosch HM.

Mol Med. 2013 Jul 24;19:149-59. doi: 10.2119/molmed.2012.00329.

38.

Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.

Sengar AS, Ellegood J, Yiu AP, Wang H, Wang W, Juneja SC, Lerch JP, Josselyn SA, Henkelman RM, Salter MW, Egan SE.

J Neurosci. 2013 Feb 27;33(9):4055-65. doi: 10.1523/JNEUROSCI.4428-12.2013.

39.

3D imaging, registration, and analysis of the early mouse embryonic vasculature.

Anderson GA, Wong MD, Yang J, Henkelman RM.

Dev Dyn. 2013 May;242(5):527-38. doi: 10.1002/dvdy.23947. Epub 2013 Mar 27.

40.

Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging.

Ellegood J, Babineau BA, Henkelman RM, Lerch JP, Crawley JN.

Neuroimage. 2013 Apr 15;70:288-300. doi: 10.1016/j.neuroimage.2012.12.029. Epub 2012 Dec 26.

41.

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.

Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR.

J Am Soc Nephrol. 2013 Jan;24(1):100-12. doi: 10.1681/ASN.2012050490.

42.

If the skull fits: magnetic resonance imaging and microcomputed tomography for combined analysis of brain and skull phenotypes in the mouse.

Nieman BJ, Blank MC, Roman BB, Henkelman RM, Millen KJ.

Physiol Genomics. 2012 Oct 17;44(20):992-1002. doi: 10.1152/physiolgenomics.00093.2012. Epub 2012 Sep 4.

43.

A novel 3D mouse embryo atlas based on micro-CT.

Wong MD, Dorr AE, Walls JR, Lerch JP, Henkelman RM.

Development. 2012 Sep;139(17):3248-56. doi: 10.1242/dev.082016.

44.

Neuroanatomical phenotyping of the mouse brain with three-dimensional autofluorescence imaging.

Gleave JA, Wong MD, Dazai J, Altaf M, Henkelman RM, Lerch JP, Nieman BJ.

Physiol Genomics. 2012 Aug 1;44(15):778-85. doi: 10.1152/physiolgenomics.00055.2012. Epub 2012 Jun 19.

45.

Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.

Yang J, Noyan-Ashraf MH, Meissner A, Voigtlaender-Bolz J, Kroetsch JT, Foltz W, Jaffray D, Kapoor A, Momen A, Heximer SP, Zhang H, van Eede M, Henkelman RM, Matthews SG, Lidington D, Husain M, Bolz SS.

Circulation. 2012 Jul 10;126(2):196-206. doi: 10.1161/CIRCULATIONAHA.111.039644. Epub 2012 Jun 5.

PMID:
22668972
46.

Neuroanatomical Assessment of the Integrin β3 Mouse Model Related to Autism and the Serotonin System Using High Resolution MRI.

Ellegood J, Henkelman RM, Lerch JP.

Front Psychiatry. 2012 Apr 26;3:37. doi: 10.3389/fpsyt.2012.00037. eCollection 2012.

47.

Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice.

Mansouri A, Min W, Cole CJ, Josselyn SA, Henderson JT, van Eede M, Henkelman RM, Ackerley C, Grunebaum E, Roifman CM.

Neurobiol Dis. 2012 Aug;47(2):201-9. doi: 10.1016/j.nbd.2012.04.001. Epub 2012 Apr 11.

PMID:
22521465
48.

Wanted dead or alive? The tradeoff between in-vivo versus ex-vivo MR brain imaging in the mouse.

Lerch JP, Gazdzinski L, Germann J, Sled JG, Henkelman RM, Nieman BJ.

Front Neuroinform. 2012 Mar 23;6:6. doi: 10.3389/fninf.2012.00006. eCollection 2012.

49.

Preparation of fixed mouse brains for MRI.

Cahill LS, Laliberté CL, Ellegood J, Spring S, Gleave JA, Eede MC, Lerch JP, Henkelman RM.

Neuroimage. 2012 Apr 2;60(2):933-9. doi: 10.1016/j.neuroimage.2012.01.100. Epub 2012 Jan 28.

PMID:
22305951
50.

Robust method for 3D arterial spin labeling in mice.

Chugh BP, Bishop J, Zhou YQ, Wu J, Henkelman RM, Sled JG.

Magn Reson Med. 2012 Jul;68(1):98-106. doi: 10.1002/mrm.23209. Epub 2011 Nov 18.

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