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Satirical contributions in toxicology.

Bolt HM, Hengstler JG.

Arch Toxicol. 2019 Jun;93(6):1471. doi: 10.1007/s00204-019-02482-x. Epub 2019 Jun 27. No abstract available.


Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27.


Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation.

Wang Y, Tatham MH, Schmidt-Heck W, Swann C, Singh-Dolt K, Meseguer-Ripolles J, Lucendo-Villarin B, Kunath T, Rudd TR, Smith AJH, Hengstler JG, Godoy P, Hay RT, Hay DC.

iScience. 2019 Jun 28;16:206-217. doi: 10.1016/j.isci.2019.05.028. Epub 2019 May 24.


Hepatic Osteodystrophy-Molecular Mechanisms Proposed to Favor Its Development.

Ehnert S, Aspera-Werz RH, Ruoß M, Dooley S, Hengstler JG, Nadalin S, Relja B, Badke A, Nussler AK.

Int J Mol Sci. 2019 May 24;20(10). pii: E2555. doi: 10.3390/ijms20102555. Review.


Road Map for Development of Stem Cell-Based Alternative Test Methods.

Sachinidis A, Albrecht W, Nell P, Cherianidou A, Hewitt NJ, Edlund K, Hengstler JG.

Trends Mol Med. 2019 Jun;25(6):470-481. doi: 10.1016/j.molmed.2019.04.003. Epub 2019 May 23. Review.


Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis.

Damle-Vartak A, Begher-Tibbe B, Gunther G, Geisler F, Vartak N, Hengstler JG.

Methods Mol Biol. 2019;1981:25-53. doi: 10.1007/978-1-4939-9420-5_3.


Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.

Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, Hardick J, Ladigan S, Lindemann M, Smith S, Quambusch L, Scheinpflug R, Depta L, Gontla R, Unger A, Müller H, Baumann M, Schultz-Fademrecht C, Günther G, Maghnouj A, Müller MP, Pohl M, Teschendorf C, Wolters H, Viebahn R, Tannapfel A, Uhl W, Hengstler JG, Hahn SA, Siveke JT, Rauh D.

Cancer Res. 2019 May 1;79(9):2367-2378. doi: 10.1158/0008-5472.CAN-18-2861. Epub 2019 Mar 11.


Identification of interactions of binary variables associated with survival time using survivalFS.

Tietz T, Selinski S, Golka K, Hengstler JG, Gripp S, Ickstadt K, Ruczinski I, Schwender H.

Arch Toxicol. 2019 Mar;93(3):585-602. doi: 10.1007/s00204-019-02398-6. Epub 2019 Jan 29.


HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer.

Gogiashvili M, Nowacki J, Hergenröder R, Hengstler JG, Lambert J, Edlund K.

Metabolites. 2019 Jan 22;9(2). pii: E19. doi: 10.3390/metabo9020019. Review.


LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.

Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Pontén F, Mardinoglu A, Zhang C, Käfferlein HU, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG.

Int J Cancer. 2019 Aug 15;145(4):901-915. doi: 10.1002/ijc.32138. Epub 2019 Feb 7.


Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC.

Edlund K, Madjar K, Mattsson JSM, Djureinovic D, Lindskog C, Brunnström H, Koyi H, Brandén E, Jirström K, Pontén F, Rahnenführer J, Micke P, Hengstler JG.

J Thorac Oncol. 2019 Apr;14(4):628-640. doi: 10.1016/j.jtho.2018.12.022. Epub 2019 Jan 9.


Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit.

Birch Kristensen E, Yakimov V, Bjorn-Mortensen K, Soborg B, Koch A, Andersson M, Birch Kristensen K, Michelsen SW, Skotte L, Ahrendt Bjerregaard A, Blaszkewicz M, Golka K, Hengstler JG, Feenstra B, Melbye M, Geller F.

EXCLI J. 2018 Nov 2;17:1043-1053. doi: 10.17179/excli2018-1671. eCollection 2018.


Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.

Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3.


In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism.

Braeuning A, Oberemm A, Heise T, Gundert-Remy U, Hengstler JG, Lampen A.

Arch Toxicol. 2019 Feb;93(2):369-383. doi: 10.1007/s00204-018-2360-3. Epub 2018 Nov 22.


Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells.

Ebmeyer J, Behrend J, Lorenz M, Günther G, Reif R, Hengstler JG, Braeuning A, Lampen A, Hessel-Pras S.

Chem Biol Interact. 2019 Jan 25;298:104-111. doi: 10.1016/j.cbi.2018.11.007. Epub 2018 Nov 19.


Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease.

Hudert CA, Selinski S, Rudolph B, Bläker H, Loddenkemper C, Thielhorn R, Berndt N, Golka K, Cadenas C, Reinders J, Henning S, Bufler P, Jansen PLM, Holzhütter HG, Meierhofer D, Hengstler JG, Wiegand S.

Liver Int. 2019 Mar;39(3):540-556. doi: 10.1111/liv.14006. Epub 2018 Dec 21.


Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.

Gu X, Albrecht W, Edlund K, Kappenberg F, Rahnenführer J, Leist M, Moritz W, Godoy P, Cadenas C, Marchan R, Brecklinghaus T, Pardo LT, Castell JV, Gardner I, Han B, Hengstler JG, Stoeber R.

Arch Toxicol. 2018 Dec;92(12):3505-3515. doi: 10.1007/s00204-018-2302-0. Epub 2018 Oct 13.


The MAK-commission: finding solutions to society's future challenges.

Hengstler JG.

Arch Toxicol. 2018 Nov;92(11):3247-3249. doi: 10.1007/s00204-018-2313-x. Epub 2018 Sep 24. No abstract available.


Contemporary trends in toxicological research on arsenic.

Bolt HM, Hengstler JG.

Arch Toxicol. 2018 Nov;92(11):3251-3253. doi: 10.1007/s00204-018-2311-z. Epub 2018 Sep 22. No abstract available.


Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity.

Köppert S, Büscher A, Babler A, Ghallab A, Buhl EM, Latz E, Hengstler JG, Smith ER, Jahnen-Dechent W.

Front Immunol. 2018 Sep 4;9:1991. doi: 10.3389/fimmu.2018.01991. eCollection 2018.


Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells.

Knaack H, Lenk L, Philipp LM, Miarka L, Rahn S, Viol F, Hauser C, Egberts JH, Gundlach JP, Will O, Tiwari S, Mikulits W, Schumacher U, Hengstler JG, Sebens S.

Oncotarget. 2018 Aug 3;9(60):31771-31786. doi: 10.18632/oncotarget.25884. eCollection 2018 Aug 3.


β-Heregulin impairs EGF induced PLC-γ1 signalling in human breast cancer cells.

Rommerswinkel N, Keil S, Adawy A, Hengstler JG, Niggemann B, Zänker KS, Dittmar T.

Cell Signal. 2018 Dec;52:23-34. doi: 10.1016/j.cellsig.2018.08.016. Epub 2018 Aug 27.


Characterization of hepatocyte-based in vitro systems for reliable toxicity testing.

Vinken M, Hengstler JG.

Arch Toxicol. 2018 Oct;92(10):2981-2986. doi: 10.1007/s00204-018-2297-6. Epub 2018 Aug 23.


Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R.

Hepatology. 2019 Feb;69(2):666-683. doi: 10.1002/hep.30213. Epub 2018 Nov 19.


Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.

Sezgin S, Hassan R, Zühlke S, Kuepfer L, Hengstler JG, Spiteller M, Ghallab A.

Arch Toxicol. 2018 Sep;92(9):2963-2977. doi: 10.1007/s00204-018-2271-3. Epub 2018 Jul 23.


Essential components of methods papers.

Leist M, Hengstler JG.

ALTEX. 2018;35(3):429-432. doi: 10.14573/altex.1807031.


Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation.

Hammad S, Othman A, Meyer C, Telfah A, Lambert J, Dewidar B, Werle J, Nwosu ZC, Mahli A, Dormann C, Gao Y, Gould K, Han M, Yuan X, Gogiashvili M, Hergenröder R, Hellerbrand C, Thomas M, Ebert MP, Amasheh S, Hengstler JG, Dooley S.

Arch Toxicol. 2018 Aug;92(8):2549-2561. doi: 10.1007/s00204-018-2254-4. Epub 2018 Jul 4.


Assessment of stem cell differentiation based on genome-wide expression profiles.

Godoy P, Schmidt-Heck W, Hellwig B, Nell P, Feuerborn D, Rahnenführer J, Kattler K, Walter J, Blüthgen N, Hengstler JG.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170221. doi: 10.1098/rstb.2017.0221. Review.


Model Prediction and Validation of an Order Mechanism Controlling the Spatiotemporal Phenotype of Early Hepatocellular Carcinoma.

Hoehme S, Bertaux F, Weens W, Grasl-Kraupp B, Hengstler JG, Drasdo D.

Bull Math Biol. 2018 May;80(5):1134-1171. doi: 10.1007/s11538-017-0375-1. Epub 2018 Mar 22.


Prognostic impact of CD4-positive T cell subsets in early breast cancer: a study based on the FinHer trial patient population.

Schmidt M, Weyer-Elberich V, Hengstler JG, Heimes AS, Almstedt K, Gerhold-Ay A, Lebrecht A, Battista MJ, Hasenburg A, Sahin U, Kalogeras KT, Kellokumpu-Lehtinen PL, Fountzilas G, Wirtz RM, Joensuu H.

Breast Cancer Res. 2018 Feb 26;20(1):15. doi: 10.1186/s13058-018-0942-x.


Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.

Nemade H, Chaudhari U, Acharya A, Hescheler J, Hengstler JG, Papadopoulos S, Sachinidis A.

Arch Toxicol. 2018 Apr;92(4):1507-1524. doi: 10.1007/s00204-018-2170-7. Epub 2018 Feb 3.


Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy.

Gogiashvili M, Horsch S, Marchan R, Gianmoena K, Cadenas C, Tanner B, Naumann S, Ersova D, Lippek F, Rahnenführer J, Andersson JT, Hergenröder R, Lambert J, Hengstler JG, Edlund K.

NMR Biomed. 2018 Feb;31(2). doi: 10.1002/nbm.3862. Epub 2017 Dec 5.


Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.

Jabs V, Edlund K, König H, Grinberg M, Madjar K, Rahnenführer J, Ekman S, Bergkvist M, Holmberg L, Ickstadt K, Botling J, Hengstler JG, Micke P.

PLoS One. 2017 Nov 7;12(11):e0187246. doi: 10.1371/journal.pone.0187246. eCollection 2017.


Adverse outcome pathways: opportunities, limitations and open questions.

Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG.

Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Review.


Third symposium on Environmental Toxicology in North Rhine-Westphalia, Germany: Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine : Meeting report on a symposium held in Dortmund May 7-8, 2015.

Golka K, Ickstadt K, Selinski S, Hengstler JG, Wilhelm M.

Arch Toxicol. 2017 Nov;91(11):3711-3715. doi: 10.1007/s00204-017-2093-8. Epub 2017 Oct 13. No abstract available.


Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer.

Selinski S, Blaszkewicz M, Ickstadt K, Gerullis H, Otto T, Roth E, Volkert F, Ovsiannikov D, Moormann O, Banfi G, Nyirady P, Vermeulen SH, Garcia-Closas M, Figueroa JD, Johnson A, Karagas MR, Kogevinas M, Malats N, Schwenn M, Silverman DT, Koutros S, Rothman N, Kiemeney LA, Hengstler JG, Golka K.

Carcinogenesis. 2017 Dec 7;38(12):1167-1179. doi: 10.1093/carcin/bgx102.


Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes.

Chaudhari U, Nemade H, Sureshkumar P, Vinken M, Ates G, Rogiers V, Hescheler J, Hengstler JG, Sachinidis A.

Arch Toxicol. 2018 Jan;92(1):371-381. doi: 10.1007/s00204-017-2065-z. Epub 2017 Sep 22.


P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway.

Han D, Gao J, Gu X, Hengstler JG, Zhang L, Shahid M, Ali T, Han B.

Arch Toxicol. 2018 Feb;92(2):679-692. doi: 10.1007/s00204-017-2070-2. Epub 2017 Sep 22.


Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.

Engel J, Smith S, Lategahn J, Tumbrink HL, Goebel L, Becker C, Hennes E, Keul M, Unger A, Müller H, Baumann M, Schultz-Fademrecht C, Günther G, Hengstler JG, Rauh D.

J Med Chem. 2017 Sep 28;60(18):7725-7744. doi: 10.1021/acs.jmedchem.7b00515. Epub 2017 Sep 18.


A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein.

Hammad S, Braeuning A, Meyer C, Mohamed FEZA, Hengstler JG, Dooley S.

Arch Toxicol. 2017 Nov;91(11):3689-3692. doi: 10.1007/s00204-017-2040-8. Epub 2017 Aug 19.


Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage.

Schenk A, Ghallab A, Hofmann U, Hassan R, Schwarz M, Schuppert A, Schwen LO, Braeuning A, Teutonico D, Hengstler JG, Kuepfer L.

Sci Rep. 2017 Jul 24;7(1):6224. doi: 10.1038/s41598-017-04574-z.


Micro-brushing-based technique to gain fresh urothelial cells for gene expression analysis.

Kuhn C, Lehmann ML, Kress A, Truss MC, Hermes M, Blaszkewicz M, Hengstler JG, Golka K.

J Toxicol Environ Health A. 2017;80(7-8):411-416. doi: 10.1080/10937404.2017.1304723. Epub 2017 Jul 11.


N-acetyltransferase 1*10 genotype in bladder cancer patients.

Höhne S, Gerullis H, Blaszkewicz M, Selinski S, Hengstler JG, Otto T, Golka K.

J Toxicol Environ Health A. 2017;80(7-8):417-422. doi: 10.1080/10937404.2017.1304727. Epub 2017 Jul 11.


Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary.

Ebbinghaus D, Bánfi G, Selinski S, Blaszkewicz M, Bürger H, Hengstler JG, Nyirády P, Golka K.

J Toxicol Environ Health A. 2017;80(7-8):423-429. doi: 10.1080/10937404.2017.1304736. Epub 2017 Jul 11.


Urinary bladder cancer risk factors in an area of former coal, iron, and steel industries in Germany.

Krech E, Selinski S, Blaszkewicz M, Bürger H, Kadhum T, Hengstler JG, Truss MC, Golka K.

J Toxicol Environ Health A. 2017;80(7-8):430-438. doi: 10.1080/10937404.2017.1304719. Epub 2017 Jul 11.


Occupational bladder cancer: Polymorphisms of xenobiotic metabolizing enzymes, exposures, and prognosis.

Lukas C, Selinski S, Prager HM, Blaszkewicz M, Hengstler JG, Golka K.

J Toxicol Environ Health A. 2017;80(7-8):439-452. doi: 10.1080/10937404.2017.1304731. Epub 2017 Jul 11.


Urinary cadmium levels in active and retired coal miners.

Isermann J, Prager HM, Ebbinghaus R, Janasik B, Wasowicz W, Dufaux B, Meyer HF, Widera A, Selinski S, Hengstler JG, Golka K.

J Toxicol Environ Health A. 2017;80(7-8):405-410. doi: 10.1080/10937404.2017.1304710. Epub 2017 Jul 11.


Adverse outcome pathways: a concise introduction for toxicologists.

Vinken M, Knapen D, Vergauwen L, Hengstler JG, Angrish M, Whelan M.

Arch Toxicol. 2017 Nov;91(11):3697-3707. doi: 10.1007/s00204-017-2020-z. Epub 2017 Jun 28. Review.


Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma.

Marchan R, Büttner B, Lambert J, Edlund K, Glaeser I, Blaszkewicz M, Leonhardt G, Marienhoff L, Kaszta D, Anft M, Watzl C, Madjar K, Grinberg M, Rempel E, Hergenröder R, Selinski S, Rahnenführer J, Lesjak MS, Stewart JD, Cadenas C, Hengstler JG.

Cancer Res. 2017 Sep 1;77(17):4589-4601. doi: 10.1158/0008-5472.CAN-16-2065. Epub 2017 Jun 26.


Third Symposium on Interdisciplinary Activities in Environmental Toxicology in North Rhine-Westphalia, Germany.

Golka K, Ickstadt K, Selinski S, Hengstler JG, Wilhelm M.

J Toxicol Environ Health A. 2017;80(7-8):395. doi: 10.1080/10937404.2017.1304744. Epub 2017 Jun 23. No abstract available.


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