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Items: 1 to 50 of 452

1.

Influence of Liver Fibrosis on Lobular Zonation.

Ghallab A, Myllys M, Holland CH, Zaza A, Murad W, Hassan R, Ahmed YA, Abbas T, Abdelrahim EA, Schneider KM, Matz-Soja M, Reinders J, Gebhardt R, Berres ML, Hatting M, Drasdo D, Saez-Rodriguez J, Trautwein C, Hengstler JG.

Cells. 2019 Dec 2;8(12). pii: E1556. doi: 10.3390/cells8121556.

2.

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project.

Escher SE, Kamp H, Bennekou SH, Bitsch A, Fisher C, Graepel R, Hengstler JG, Herzler M, Knight D, Leist M, Norinder U, Ouédraogo G, Pastor M, Stuard S, White A, Zdrazil B, van de Water B, Kroese D.

Arch Toxicol. 2019 Dec;93(12):3643-3667. doi: 10.1007/s00204-019-02591-7. Epub 2019 Nov 28.

PMID:
31781791
3.

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver.

Klindt C, Reich M, Hellwig B, Stindt J, Rahnenführer J, Hengstler JG, Köhrer K, Schoonjans K, Häussinger D, Keitel V.

Cells. 2019 Nov 19;8(11). pii: E1467. doi: 10.3390/cells8111467.

4.

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances.

Dreser N, Madjar K, Holzer AK, Kapitza M, Scholz C, Kranaster P, Gutbier S, Klima S, Kolb D, Dietz C, Trefzer T, Meisig J, van Thriel C, Henry M, Berthold MR, Blüthgen N, Sachinidis A, Rahnenführer J, Hengstler JG, Waldmann T, Leist M.

Arch Toxicol. 2019 Nov 11. doi: 10.1007/s00204-019-02612-5. [Epub ahead of print]

PMID:
31712839
5.

CRUP: a comprehensive framework to predict condition-specific regulatory units.

Ramisch A, Heinrich V, Glaser LV, Fuchs A, Yang X, Benner P, Schöpflin R, Li N, Kinkley S, Römer-Hillmann A, Longinotto J, Heyne S, Czepukojc B, Kessler SM, Kiemer AK, Cadenas C, Arrigoni L, Gasparoni N, Manke T, Pap T, Pospisilik JA, Hengstler J, Walter J, Meijsing SH, Chung HR, Vingron M.

Genome Biol. 2019 Nov 8;20(1):227. doi: 10.1186/s13059-019-1860-7.

6.

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Krebs A, Waldmann T, Wilks MF, Van Vugt-Lussenburg BMA, Van der Burg B, Terron A, Steger-Hartmann T, Ruegg J, Rovida C, Pedersen E, Pallocca G, Luijten M, Leite SB, Kustermann S, Kamp H, Hoeng J, Hewitt P, Herzler M, Hengstler JG, Heinonen T, Hartung T, Hardy B, Gantner F, Fritsche E, Fant K, Ezendam J, Exner T, Dunkern T, Dietrich DR, Coecke S, Busquet F, Braeuning A, Bondarenko O, Bennekou SH, Beilmann M, Leist M.

ALTEX. 2019;36(4):682-699. doi: 10.14573/altex.1909271.

7.

The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice.

Hessel-Pras S, Braeuning A, Guenther G, Adawy A, Enge AM, Ebmeyer J, Henderson CJ, Hengstler JG, Lampen A, Reif R.

Arch Toxicol. 2019 Oct 12. doi: 10.1007/s00204-019-02582-8. [Epub ahead of print]

PMID:
31606820
8.

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis.

Czepukojc B, Abuhaliema A, Barghash A, Tierling S, Naß N, Simon Y, Körbel C, Cadenas C, van Hul N, Sachinidis A, Hengstler JG, Helms V, Laschke MW, Walter J, Haybaeck J, Leclercq I, Kiemer AK, Kessler SM.

Front Med (Lausanne). 2019 Sep 4;6:179. doi: 10.3389/fmed.2019.00179. eCollection 2019.

9.

Quality Criteria for Studies on Dietary Glycation Compounds and Human Health.

Hellwig M, Humpf HU, Hengstler J, Mally A, Vieths S, Henle T.

J Agric Food Chem. 2019 Oct 16;67(41):11307-11311. doi: 10.1021/acs.jafc.9b04172. Epub 2019 Oct 3.

PMID:
31514500
10.

Mechanical strain mimicking breathing amplifies alterations in gene expression induced by SiO2 NPs in lung epithelial cells.

Schmitz C, Welck J, Tavernaro I, Grinberg M, Rahnenführer J, Kiemer AK, van Thriel C, Hengstler JG, Kraegeloh A.

Nanotoxicology. 2019 Nov;13(9):1227-1243. doi: 10.1080/17435390.2019.1650971. Epub 2019 Aug 16.

PMID:
31418614
11.

Corrigendum to Essential components of methods papers.

Leist M, Hengstler JG.

ALTEX. 2019;36(3):506. doi: 10.14573/altex.1904114.

12.

Satirical contributions in toxicology.

Bolt HM, Hengstler JG.

Arch Toxicol. 2019 Jun;93(6):1471. doi: 10.1007/s00204-019-02482-x. Epub 2019 Jun 27. No abstract available.

PMID:
31250072
13.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27.

PMID:
31250071
14.

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation.

Wang Y, Tatham MH, Schmidt-Heck W, Swann C, Singh-Dolt K, Meseguer-Ripolles J, Lucendo-Villarin B, Kunath T, Rudd TR, Smith AJH, Hengstler JG, Godoy P, Hay RT, Hay DC.

iScience. 2019 Jun 28;16:206-217. doi: 10.1016/j.isci.2019.05.028. Epub 2019 May 24.

15.

Hepatic Osteodystrophy-Molecular Mechanisms Proposed to Favor Its Development.

Ehnert S, Aspera-Werz RH, Ruoß M, Dooley S, Hengstler JG, Nadalin S, Relja B, Badke A, Nussler AK.

Int J Mol Sci. 2019 May 24;20(10). pii: E2555. doi: 10.3390/ijms20102555. Review.

16.

Road Map for Development of Stem Cell-Based Alternative Test Methods.

Sachinidis A, Albrecht W, Nell P, Cherianidou A, Hewitt NJ, Edlund K, Hengstler JG.

Trends Mol Med. 2019 Jun;25(6):470-481. doi: 10.1016/j.molmed.2019.04.003. Epub 2019 May 23. Review.

PMID:
31130451
17.

Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis.

Damle-Vartak A, Begher-Tibbe B, Gunther G, Geisler F, Vartak N, Hengstler JG.

Methods Mol Biol. 2019;1981:25-53. doi: 10.1007/978-1-4939-9420-5_3.

PMID:
31016646
18.

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.

Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, Hardick J, Ladigan S, Lindemann M, Smith S, Quambusch L, Scheinpflug R, Depta L, Gontla R, Unger A, Müller H, Baumann M, Schultz-Fademrecht C, Günther G, Maghnouj A, Müller MP, Pohl M, Teschendorf C, Wolters H, Viebahn R, Tannapfel A, Uhl W, Hengstler JG, Hahn SA, Siveke JT, Rauh D.

Cancer Res. 2019 May 1;79(9):2367-2378. doi: 10.1158/0008-5472.CAN-18-2861. Epub 2019 Mar 11.

PMID:
30858154
19.

Identification of interactions of binary variables associated with survival time using survivalFS.

Tietz T, Selinski S, Golka K, Hengstler JG, Gripp S, Ickstadt K, Ruczinski I, Schwender H.

Arch Toxicol. 2019 Mar;93(3):585-602. doi: 10.1007/s00204-019-02398-6. Epub 2019 Jan 29.

PMID:
30694373
20.

HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer.

Gogiashvili M, Nowacki J, Hergenröder R, Hengstler JG, Lambert J, Edlund K.

Metabolites. 2019 Jan 22;9(2). pii: E19. doi: 10.3390/metabo9020019. Review.

21.

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.

Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Pontén F, Mardinoglu A, Zhang C, Käfferlein HU, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG.

Int J Cancer. 2019 Aug 15;145(4):901-915. doi: 10.1002/ijc.32138. Epub 2019 Feb 7.

22.

Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC.

Edlund K, Madjar K, Mattsson JSM, Djureinovic D, Lindskog C, Brunnström H, Koyi H, Brandén E, Jirström K, Pontén F, Rahnenführer J, Micke P, Hengstler JG.

J Thorac Oncol. 2019 Apr;14(4):628-640. doi: 10.1016/j.jtho.2018.12.022. Epub 2019 Jan 9.

23.

Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit.

Birch Kristensen E, Yakimov V, Bjorn-Mortensen K, Soborg B, Koch A, Andersson M, Birch Kristensen K, Michelsen SW, Skotte L, Ahrendt Bjerregaard A, Blaszkewicz M, Golka K, Hengstler JG, Feenstra B, Melbye M, Geller F.

EXCLI J. 2018 Nov 2;17:1043-1053. doi: 10.17179/excli2018-1671. eCollection 2018.

24.

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.

Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3.

PMID:
30511339
25.

In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism.

Braeuning A, Oberemm A, Heise T, Gundert-Remy U, Hengstler JG, Lampen A.

Arch Toxicol. 2019 Feb;93(2):369-383. doi: 10.1007/s00204-018-2360-3. Epub 2018 Nov 22.

PMID:
30467583
26.

Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells.

Ebmeyer J, Behrend J, Lorenz M, Günther G, Reif R, Hengstler JG, Braeuning A, Lampen A, Hessel-Pras S.

Chem Biol Interact. 2019 Jan 25;298:104-111. doi: 10.1016/j.cbi.2018.11.007. Epub 2018 Nov 19.

PMID:
30465738
27.

Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease.

Hudert CA, Selinski S, Rudolph B, Bläker H, Loddenkemper C, Thielhorn R, Berndt N, Golka K, Cadenas C, Reinders J, Henning S, Bufler P, Jansen PLM, Holzhütter HG, Meierhofer D, Hengstler JG, Wiegand S.

Liver Int. 2019 Mar;39(3):540-556. doi: 10.1111/liv.14006. Epub 2018 Dec 21.

PMID:
30444569
28.

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.

Gu X, Albrecht W, Edlund K, Kappenberg F, Rahnenführer J, Leist M, Moritz W, Godoy P, Cadenas C, Marchan R, Brecklinghaus T, Pardo LT, Castell JV, Gardner I, Han B, Hengstler JG, Stoeber R.

Arch Toxicol. 2018 Dec;92(12):3505-3515. doi: 10.1007/s00204-018-2302-0. Epub 2018 Oct 13.

PMID:
30317417
29.

The MAK-commission: finding solutions to society's future challenges.

Hengstler JG.

Arch Toxicol. 2018 Nov;92(11):3247-3249. doi: 10.1007/s00204-018-2313-x. Epub 2018 Sep 24. No abstract available.

PMID:
30251053
30.

Contemporary trends in toxicological research on arsenic.

Bolt HM, Hengstler JG.

Arch Toxicol. 2018 Nov;92(11):3251-3253. doi: 10.1007/s00204-018-2311-z. Epub 2018 Sep 22. No abstract available.

PMID:
30244273
31.

Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity.

Köppert S, Büscher A, Babler A, Ghallab A, Buhl EM, Latz E, Hengstler JG, Smith ER, Jahnen-Dechent W.

Front Immunol. 2018 Sep 4;9:1991. doi: 10.3389/fimmu.2018.01991. eCollection 2018.

32.

Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells.

Knaack H, Lenk L, Philipp LM, Miarka L, Rahn S, Viol F, Hauser C, Egberts JH, Gundlach JP, Will O, Tiwari S, Mikulits W, Schumacher U, Hengstler JG, Sebens S.

Oncotarget. 2018 Aug 3;9(60):31771-31786. doi: 10.18632/oncotarget.25884. eCollection 2018 Aug 3.

33.

β-Heregulin impairs EGF induced PLC-γ1 signalling in human breast cancer cells.

Rommerswinkel N, Keil S, Adawy A, Hengstler JG, Niggemann B, Zänker KS, Dittmar T.

Cell Signal. 2018 Dec;52:23-34. doi: 10.1016/j.cellsig.2018.08.016. Epub 2018 Aug 27.

PMID:
30165102
34.

Characterization of hepatocyte-based in vitro systems for reliable toxicity testing.

Vinken M, Hengstler JG.

Arch Toxicol. 2018 Oct;92(10):2981-2986. doi: 10.1007/s00204-018-2297-6. Epub 2018 Aug 23. Review.

PMID:
30141065
35.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R.

Hepatology. 2019 Feb;69(2):666-683. doi: 10.1002/hep.30213. Epub 2018 Nov 19.

36.

Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.

Sezgin S, Hassan R, Zühlke S, Kuepfer L, Hengstler JG, Spiteller M, Ghallab A.

Arch Toxicol. 2018 Sep;92(9):2963-2977. doi: 10.1007/s00204-018-2271-3. Epub 2018 Jul 23.

PMID:
30039229
37.

Essential components of methods papers.

Leist M, Hengstler JG.

ALTEX. 2018;35(3):429-432. doi: 10.14573/altex.1807031. Erratum in: ALTEX. 2019;36(3):506.

38.

Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation.

Hammad S, Othman A, Meyer C, Telfah A, Lambert J, Dewidar B, Werle J, Nwosu ZC, Mahli A, Dormann C, Gao Y, Gould K, Han M, Yuan X, Gogiashvili M, Hergenröder R, Hellerbrand C, Thomas M, Ebert MP, Amasheh S, Hengstler JG, Dooley S.

Arch Toxicol. 2018 Aug;92(8):2549-2561. doi: 10.1007/s00204-018-2254-4. Epub 2018 Jul 4.

PMID:
29974145
39.

Assessment of stem cell differentiation based on genome-wide expression profiles.

Godoy P, Schmidt-Heck W, Hellwig B, Nell P, Feuerborn D, Rahnenführer J, Kattler K, Walter J, Blüthgen N, Hengstler JG.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170221. doi: 10.1098/rstb.2017.0221. Review.

40.

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures.

Rodrigues RM, Kollipara L, Chaudhari U, Sachinidis A, Zahedi RP, Sickmann A, Kopp-Schneider A, Jiang X, Keun H, Hengstler J, Oorts M, Annaert P, Hoeben E, Gijbels E, De Kock J, Vanhaecke T, Rogiers V, Vinken M.

Arch Toxicol. 2018 Jun;92(6):1939-1952. doi: 10.1007/s00204-018-2214-z. Epub 2018 May 14.

41.

Children with mucopolysaccharidosis risk progressive visual dysfunction despite haematopoietic stem cell transplants.

Teär Fahnehjelm K, Olsson M, Chen E, Hengstler J, Naess K, Winiarski J.

Acta Paediatr. 2018 Nov;107(11):1995-2003. doi: 10.1111/apa.14368. Epub 2018 May 23.

PMID:
29683519
42.

Model Prediction and Validation of an Order Mechanism Controlling the Spatiotemporal Phenotype of Early Hepatocellular Carcinoma.

Hoehme S, Bertaux F, Weens W, Grasl-Kraupp B, Hengstler JG, Drasdo D.

Bull Math Biol. 2018 May;80(5):1134-1171. doi: 10.1007/s11538-017-0375-1. Epub 2018 Mar 22.

PMID:
29568983
43.

Prognostic impact of CD4-positive T cell subsets in early breast cancer: a study based on the FinHer trial patient population.

Schmidt M, Weyer-Elberich V, Hengstler JG, Heimes AS, Almstedt K, Gerhold-Ay A, Lebrecht A, Battista MJ, Hasenburg A, Sahin U, Kalogeras KT, Kellokumpu-Lehtinen PL, Fountzilas G, Wirtz RM, Joensuu H.

Breast Cancer Res. 2018 Feb 26;20(1):15. doi: 10.1186/s13058-018-0942-x.

44.

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.

Nemade H, Chaudhari U, Acharya A, Hescheler J, Hengstler JG, Papadopoulos S, Sachinidis A.

Arch Toxicol. 2018 Apr;92(4):1507-1524. doi: 10.1007/s00204-018-2170-7. Epub 2018 Feb 3.

45.

Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy.

Gogiashvili M, Horsch S, Marchan R, Gianmoena K, Cadenas C, Tanner B, Naumann S, Ersova D, Lippek F, Rahnenführer J, Andersson JT, Hergenröder R, Lambert J, Hengstler JG, Edlund K.

NMR Biomed. 2018 Feb;31(2). doi: 10.1002/nbm.3862. Epub 2017 Dec 5.

PMID:
29206323
46.

Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.

Jabs V, Edlund K, König H, Grinberg M, Madjar K, Rahnenführer J, Ekman S, Bergkvist M, Holmberg L, Ickstadt K, Botling J, Hengstler JG, Micke P.

PLoS One. 2017 Nov 7;12(11):e0187246. doi: 10.1371/journal.pone.0187246. eCollection 2017.

47.

Adverse outcome pathways: opportunities, limitations and open questions.

Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG.

Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Review.

PMID:
29051992
48.

Third symposium on Environmental Toxicology in North Rhine-Westphalia, Germany: Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine : Meeting report on a symposium held in Dortmund May 7-8, 2015.

Golka K, Ickstadt K, Selinski S, Hengstler JG, Wilhelm M.

Arch Toxicol. 2017 Nov;91(11):3711-3715. doi: 10.1007/s00204-017-2093-8. Epub 2017 Oct 13. No abstract available.

PMID:
29030651
49.

Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer.

Selinski S, Blaszkewicz M, Ickstadt K, Gerullis H, Otto T, Roth E, Volkert F, Ovsiannikov D, Moormann O, Banfi G, Nyirady P, Vermeulen SH, Garcia-Closas M, Figueroa JD, Johnson A, Karagas MR, Kogevinas M, Malats N, Schwenn M, Silverman DT, Koutros S, Rothman N, Kiemeney LA, Hengstler JG, Golka K.

Carcinogenesis. 2017 Dec 7;38(12):1167-1179. doi: 10.1093/carcin/bgx102.

50.

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes.

Chaudhari U, Nemade H, Sureshkumar P, Vinken M, Ates G, Rogiers V, Hescheler J, Hengstler JG, Sachinidis A.

Arch Toxicol. 2018 Jan;92(1):371-381. doi: 10.1007/s00204-017-2065-z. Epub 2017 Sep 22.

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