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Items: 1 to 50 of 172

1.

Prediction of Survival With Long-Term Disease Progression in Most Common Spinocerebellar Ataxia.

Diallo A, Jacobi H, Cook A, Giunti P, Parkinson MH, Labrum R, Durr A, Brice A, Charles P, Marelli C, Mariotti C, Nanetti L, Panzeri M, Castaldo A, Rakowicz M, Rola R, Sulek A, Schmitz-Hübsch T, Schöls L, Hengel H, Baliko L, Melegh B, Filla A, Antenora A, Infante J, Berciano J, van de Warrenburg BP, Timmann D, Boesch S, Nachbauer W, Pandolfo M, Schulz JB, Bauer P, Jun-Suk K, Klockgether T, Tezenas du Montcel S.

Mov Disord. 2019 Jun 18. doi: 10.1002/mds.27739. [Epub ahead of print]

PMID:
31211461
2.

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.

Železnjak J, Lisnić VJ, Popović B, Lisnić B, Babić M, Halenius A, L'Hernault A, Roviš TL, Hengel H, Erhard F, Redwood AJ, Vidal SM, Dölken L, Krmpotić A, Jonjić S.

J Exp Med. 2019 May 29. pii: jem.20182213. doi: 10.1084/jem.20182213. [Epub ahead of print]

PMID:
31142589
3.

A novel biallelic loss-of-function mutation in TMCO1 gene confirming and expanding the phenotype spectrum of cerebro-facio-thoracic dysplasia.

Sharkia R, Zalan A, Jabareen-Masri A, Hengel H, Schöls L, Kessel A, Azem A, Mahajnah M.

Am J Med Genet A. 2019 Jul;179(7):1338-1345. doi: 10.1002/ajmg.a.61168. Epub 2019 May 18.

PMID:
31102500
4.

Biallelic variants in the transcription factor PAX7 are a new genetic cause of myopathy.

Feichtinger RG, Mucha BE, Hengel H, Orfi Z, Makowski C, Dort J, D'Anjou G, Nguyen TTM, Buchert R, Juenger H, Freisinger P, Baumeister S, Schoser B, Ahting U, Keimer R, Nguyen CE, Fabre P, Gauthier J, Miguet M, Lopes F, AlHakeem A, AlHashem A, Tabarki B, Kandaswamy KK, Bauer P, Steinbacher P, Prokisch H, Sturm M, Strom TM, Ellezam B, Mayr JA, Schöls L, Michaud JL, Campeau PM, Haack TB, Dumont NA.

Genet Med. 2019 May 16. doi: 10.1038/s41436-019-0532-z. [Epub ahead of print]

PMID:
31092906
5.

Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity.

Lagassé HAD, Hengel H, Golding B, Sauna ZE.

AAPS J. 2019 May 6;21(4):62. doi: 10.1208/s12248-019-0336-8.

PMID:
31062128
6.

Human Fcγ receptors compete for TGN1412 binding that determines the antibody's effector function.

Dudek S, Weißmüller S, Anzaghe M, Miller L, Sterr S, Hoffmann K, Hengel H, Waibler Z.

Eur J Immunol. 2019 Jul;49(7):1117-1126. doi: 10.1002/eji.201847924. Epub 2019 Apr 29.

PMID:
31002172
7.

Background paper to the decision to recommend the vaccination with the inactivated herpes zoster subunit vaccine : Statement of the German Standing Committee on Vaccination (STIKO) at the Robert Koch Institute.

Siedler A, Koch J, Garbe E, Hengel H, von Kries R, Ledig T, Mertens T, Zepp F, Überla K.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Mar;62(3):352-376. doi: 10.1007/s00103-019-02882-5. No abstract available.

PMID:
30848293
8.

Clinical, radiological, and genetic characteristics of 16 patients with ACO2 gene defects: Delineation of an emerging neurometabolic syndrome.

Sharkia R, Wierenga KJ, Kessel A, Azem A, Bertini E, Carrozzo R, Torraco A, Goffrini P, Ceccatelli Berti C, McCormick ME, Plecko B, Klein A, Abela L, Hengel H, Schöls L, Shalev S, Khayat M, Mahajnah M, Spiegel R.

J Inherit Metab Dis. 2019 Mar;42(2):264-275. doi: 10.1002/jimd.12022. Epub 2019 Jan 28.

PMID:
30689204
9.

Identification and Functional Characterization of a Novel Fc Gamma-Binding Glycoprotein in Rhesus Cytomegalovirus.

Kolb P, Sijmons S, McArdle MR, Taher H, Womack J, Hughes C, Ventura A, Jarvis MA, Stahl-Hennig C, Hansen S, Picker LJ, Malouli D, Hengel H, Früh K.

J Virol. 2019 Feb 5;93(4). pii: e02077-18. doi: 10.1128/JVI.02077-18. Print 2019 Feb 15.

PMID:
30487278
10.

Post-exposure prophylaxis for measles with immunoglobulins revised recommendations of the standing committee on vaccination in Germany.

Matysiak-Klose D, Santibanez S, Schwerdtfeger C, Koch J, von Bernuth H, Hengel H, Littmann M, Terhardt M, Wicker S, Mankertz A, Heininger U.

Vaccine. 2018 Dec 18;36(52):7916-7922. doi: 10.1016/j.vaccine.2018.10.070. Epub 2018 Nov 23. Review.

PMID:
30478003
11.

A previously identified missense mutation in STYXL1 is likely benign.

Hengel H, Schelling Y, Keimer R, Deigendesch W, Bauer P, Schöls L.

Eur J Med Genet. 2018 Nov 22. pii: S1769-7212(18)30680-3. doi: 10.1016/j.ejmg.2018.11.016. [Epub ahead of print]

PMID:
30472486
12.

Nerve ultrasound characterizes AMN polyneuropathy as inhomogeneous and focal hypertrophic.

Rattay TW, Just J, Röben B, Hengel H, Schüle R, Synofzik M, Söhn AS, Winter N, Dammeier N, Schöls L, Grimm A.

Orphanet J Rare Dis. 2018 Nov 3;13(1):194. doi: 10.1186/s13023-018-0939-7.

13.

NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection.

Schuch A, Zecher BF, Müller PA, Correia MP, Daul F, Rennert C, Tauber C, Schlitt K, Boettler T, Neumann-Haefelin C, Hengel H, Pircher H, Cerwenka A, Thimme R, Hofmann M.

J Hepatol. 2019 Mar;70(3):351-360. doi: 10.1016/j.jhep.2018.10.006. Epub 2018 Oct 18.

14.

Kinetics of Torque Teno Virus-DNA Plasma Load Predict Rejection in Lung Transplant Recipients.

Frye BC, Bierbaum S, Falcone V, Köhler TC, Gasplmayr M, Hettich I, Dürk T, Idzko M, Zissel G, Hengel H, Müller-Quernheim J.

Transplantation. 2019 Apr;103(4):815-822. doi: 10.1097/TP.0000000000002436.

PMID:
30234787
15.

Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease.

Heeg M, Ammann S, Klemann C, Panning M, Falcone V, Hengel H, Lehmberg K, Zur Stadt U, Wustrau K, Janka G, Ehl S.

Pediatr Blood Cancer. 2018 Nov;65(11):e27344. doi: 10.1002/pbc.27344. Epub 2018 Aug 1.

PMID:
30070073
16.

Cytomegalovirus Infection: Mouse Model.

Brizić I, Lisnić B, Brune W, Hengel H, Jonjić S.

Curr Protoc Immunol. 2018 Jul 25:e51. doi: 10.1002/cpim.51. [Epub ahead of print]

PMID:
30044539
17.

Serum neurofilament light chain is increased in hereditary spastic paraplegias.

Wilke C, Rattay TW, Hengel H, Zimmermann M, Brockmann K, Schöls L, Kuhle J, Schüle R, Synofzik M.

Ann Clin Transl Neurol. 2018 May 21;5(7):876-882. doi: 10.1002/acn3.583. eCollection 2018 Jul.

18.

Long-term evolution of patient-reported outcome measures in spinocerebellar ataxias.

Jacobi H, du Montcel ST, Bauer P, Giunti P, Cook A, Labrum R, Parkinson MH, Durr A, Brice A, Charles P, Marelli C, Mariotti C, Nanetti L, Sarro L, Rakowicz M, Sulek A, Sobanska A, Schmitz-Hübsch T, Schöls L, Hengel H, Baliko L, Melegh B, Filla A, Antenora A, Infante J, Berciano J, van de Warrenburg BP, Timmann D, Szymanski S, Boesch S, Nachbauer W, Kang JS, Pandolfo M, Schulz JB, Melac AT, Diallo A, Klockgether T.

J Neurol. 2018 Sep;265(9):2040-2051. doi: 10.1007/s00415-018-8954-0. Epub 2018 Jun 29.

PMID:
29959555
19.

Anti-inflammatory consequences of bile acid accumulation in virus-infected bile duct ligated mice.

Rattay S, Graf D, Kislat A, Homey B, Herebian D, Häussinger D, Hengel H, Zimmermann A, Schupp AK.

PLoS One. 2018 Jun 28;13(6):e0199863. doi: 10.1371/journal.pone.0199863. eCollection 2018.

20.

Human MxB Protein Is a Pan-herpesvirus Restriction Factor.

Schilling M, Bulli L, Weigang S, Graf L, Naumann S, Patzina C, Wagner V, Bauersfeld L, Goujon C, Hengel H, Halenius A, Ruzsics Z, Schaller T, Kochs G.

J Virol. 2018 Aug 16;92(17). pii: e01056-18. doi: 10.1128/JVI.01056-18. Print 2018 Sep 1.

21.

GPT2 mutations cause developmental encephalopathy with microcephaly and features of complicated hereditary spastic paraplegia.

Hengel H, Keimer R, Deigendesch W, Rieß A, Marzouqa H, Zaidan J, Bauer P, Schöls L.

Clin Genet. 2018 Oct;94(3-4):356-361. doi: 10.1111/cge.13390. Epub 2018 Jul 10.

PMID:
29882329
22.

Survival in patients with spinocerebellar ataxia types 1, 2, 3, and 6 (EUROSCA): a longitudinal cohort study.

Diallo A, Jacobi H, Cook A, Labrum R, Durr A, Brice A, Charles P, Marelli C, Mariotti C, Nanetti L, Panzeri M, Rakowicz M, Sobanska A, Sulek A, Schmitz-Hübsch T, Schöls L, Hengel H, Melegh B, Filla A, Antenora A, Infante J, Berciano J, van de Warrenburg BP, Timmann D, Boesch S, Pandolfo M, Schulz JB, Bauer P, Giunti P, Kang JS, Klockgether T, Tezenas du Montcel S.

Lancet Neurol. 2018 Apr;17(4):327-334. doi: 10.1016/S1474-4422(18)30042-5. Epub 2018 Mar 13.

PMID:
29553382
23.

Influence of demographic changes on the impact of vaccination against varicella and herpes zoster in Germany - a mathematical modelling study.

Horn J, Damm O, Greiner W, Hengel H, Kretzschmar ME, Siedler A, Ultsch B, Weidemann F, Wichmann O, Karch A, Mikolajczyk RT.

BMC Med. 2018 Jan 9;16(1):3. doi: 10.1186/s12916-017-0983-5.

24.

Reply: POLR3A variants in hereditary spastic paraplegia and ataxia.

Minnerop M, Kurzwelly D, Rattay TW, Timmann D, Hengel H, Synofzik M, Stendel C, Horvath R, Schüle R, Ramirez A.

Brain. 2018 Jan 1;141(1):e2. doi: 10.1093/brain/awx291. No abstract available.

25.

Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6).

Fiebig U, Holzer A, Ivanusic D, Plotzki E, Hengel H, Neipel F, Denner J.

Viruses. 2017 Oct 28;9(11). pii: E317. doi: 10.3390/v9110317.

26.

Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System.

Pupuleku A, Costa-García M, Farré D, Hengel H, Angulo A, Muntasell A, López-Botet M.

Front Immunol. 2017 Oct 24;8:1317. doi: 10.3389/fimmu.2017.01317. eCollection 2017.

27.

An A/U-Rich Enhancer Region Is Required for High-Level Protein Secretion through the HlyA Type I Secretion System.

Khosa S, Scholz R, Schwarz C, Trilling M, Hengel H, Jaeger KE, Smits SHJ, Schmitt L.

Appl Environ Microbiol. 2017 Dec 15;84(1). pii: e01163-17. doi: 10.1128/AEM.01163-17. Print 2018 Jan 1.

28.

Body Mass Index Decline Is Related to Spinocerebellar Ataxia Disease Progression.

Diallo A, Jacobi H, Schmitz-Hübsch T, Cook A, Labrum R, Durr A, Brice A, Charles P, Marelli C, Mariotti C, Nanetti L, Panzeri M, Rakowicz M, Sobanska A, Sulek A, Schöls L, Hengel H, Melegh B, Filla A, Antenora A, Infante J, Berciano J, van de Warrenburg BP, Timmann D, Boesch S, Pandolfo M, Schulz JB, Bauer P, Giunti P, Baliko L, Parkinson MH, Kang JS, Klockgether T, Tezenas du Montcel S.

Mov Disord Clin Pract. 2017 Aug 11;4(5):689-697. doi: 10.1002/mdc3.12522. eCollection 2017 Sep-Oct.

29.

Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.

Romania P, Cifaldi L, Pignoloni B, Starc N, D'Alicandro V, Melaiu O, Li Pira G, Giorda E, Carrozzo R, Bergvall M, Bergström T, Alfredsson L, Olsson T, Kockum I, Seppälä I, Lehtimäki T, Hurme MA, Hengel H, Santoni A, Cerboni C, Locatelli F, D'Amato M, Fruci D.

Cell Rep. 2017 Jul 25;20(4):846-853. doi: 10.1016/j.celrep.2017.06.084.

30.

A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle.

Matschulla T, Berry R, Gerke C, Döring M, Busch J, Paijo J, Kalinke U, Momburg F, Hengel H, Halenius A.

Sci Rep. 2017 Jun 7;7(1):2933. doi: 10.1038/s41598-017-02994-5.

31.

Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany.

Wiese-Posselt M, Siedler A, Mankertz A, Sauerbrei A, Hengel H, Wichmann O, Poethko-Müller C.

BMC Infect Dis. 2017 May 19;17(1):356. doi: 10.1186/s12879-017-2461-2.

32.

Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia.

Minnerop M, Kurzwelly D, Wagner H, Soehn AS, Reichbauer J, Tao F, Rattay TW, Peitz M, Rehbach K, Giorgetti A, Pyle A, Thiele H, Altmüller J, Timmann D, Karaca I, Lennarz M, Baets J, Hengel H, Synofzik M, Atasu B, Feely S, Kennerson M, Stendel C, Lindig T, Gonzalez MA, Stirnberg R, Sturm M, Roeske S, Jung J, Bauer P, Lohmann E, Herms S, Heilmann-Heimbach S, Nicholson G, Mahanjah M, Sharkia R, Carloni P, Brüstle O, Klopstock T, Mathews KD, Shy ME, de Jonghe P, Chinnery PF, Horvath R, Kohlhase J, Schmitt I, Wolf M, Greschus S, Amunts K, Maier W, Schöls L, Nürnberg P, Zuchner S, Klockgether T, Ramirez A, Schüle R.

Brain. 2017 Jun 1;140(6):1561-1578. doi: 10.1093/brain/awx095. Erratum in: Brain. 2017 Dec 9;:.

33.

CNTNAP1 mutations cause CNS hypomyelination and neuropathy with or without arthrogryposis.

Hengel H, Magee A, Mahanjah M, Vallat JM, Ouvrier R, Abu-Rashid M, Mahamid J, Schüle R, Schulze M, Krägeloh-Mann I, Bauer P, Züchner S, Sharkia R, Schöls L.

Neurol Genet. 2017 Mar 22;3(2):e144. doi: 10.1212/NXG.0000000000000144. eCollection 2017 Apr.

34.

Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Van den Hoecke S, Ehrhardt K, Kolpe A, El Bakkouri K, Deng L, Grootaert H, Schoonooghe S, Smet A, Bentahir M, Roose K, Schotsaert M, Schepens B, Callewaert N, Nimmerjahn F, Staeheli P, Hengel H, Saelens X.

J Virol. 2017 Mar 13;91(7). pii: e02500-16. doi: 10.1128/JVI.02500-16. Print 2017 Apr 1.

35.

Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial.

Feil K, Adrion C, Teufel J, Bösch S, Claassen J, Giordano I, Hengel H, Jacobi H, Klockgether T, Klopstock T, Nachbauer W, Schöls L, Stendel C, Uslar E, van de Warrenburg B, Berger I, Naumann I, Bayer O, Müller HH, Mansmann U, Strupp M.

BMC Neurol. 2017 Jan 10;17(1):7. doi: 10.1186/s12883-016-0786-x.

36.

Individual changes in preclinical spinocerebellar ataxia identified via increased motor complexity.

Ilg W, Fleszar Z, Schatton C, Hengel H, Harmuth F, Bauer P, Timmann D, Giese M, Schöls L, Synofzik M.

Mov Disord. 2016 Dec;31(12):1891-1900. doi: 10.1002/mds.26835. Epub 2016 Oct 26.

PMID:
27782309
37.

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;39(4):1271-80. doi: 10.1159/000447832. Epub 2016 Sep 8.

38.

CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection.

Rölle A, Halenius A, Ewen EM, Cerwenka A, Hengel H, Momburg F.

Eur J Immunol. 2016 Oct;46(10):2420-2425. doi: 10.1002/eji.201646492. Epub 2016 Aug 29.

39.

[Adverse ocular effects of vaccinations].

Ness T, Hengel H.

Ophthalmologe. 2016 Jul;113(7):615-22. doi: 10.1007/s00347-016-0313-x. Review. German.

PMID:
27357302
40.

CEACAM1-Mediated Inhibition of Virus Production.

Vitenshtein A, Weisblum Y, Hauka S, Halenius A, Oiknine-Djian E, Tsukerman P, Bauman Y, Bar-On Y, Stern-Ginossar N, Enk J, Ortenberg R, Tai J, Markel G, Blumberg RS, Hengel H, Jonjic S, Wolf DG, Adler H, Kammerer R, Mandelboim O.

Cell Rep. 2016 Jun 14;15(11):2331-9. doi: 10.1016/j.celrep.2016.05.036. Epub 2016 Jun 2.

41.

Highly individual patterns of virus-immune IgG effector responses in humans.

Corrales-Aguilar E, Trilling M, Reinhard H, Falcone V, Zimmermann A, Adams O, Santibanez S, Hengel H.

Med Microbiol Immunol. 2016 Oct;205(5):409-24. doi: 10.1007/s00430-016-0457-y. Epub 2016 May 18.

42.

Bile Acids Act as Soluble Host Restriction Factors Limiting Cytomegalovirus Replication in Hepatocytes.

Schupp AK, Trilling M, Rattay S, Le-Trilling VTK, Haselow K, Stindt J, Zimmermann A, Häussinger D, Hengel H, Graf D.

J Virol. 2016 Jul 11;90(15):6686-6698. doi: 10.1128/JVI.00299-16. Print 2016 Aug 1.

43.

Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo.

Lavender KJ, Gibbert K, Peterson KE, Van Dis E, Francois S, Woods T, Messer RJ, Gawanbacht A, Müller JA, Münch J, Phillips K, Race B, Harper MS, Guo K, Lee EJ, Trilling M, Hengel H, Piehler J, Verheyen J, Wilson CC, Santiago ML, Hasenkrug KJ, Dittmer U.

J Virol. 2016 Jun 10;90(13):6001-6013. doi: 10.1128/JVI.00451-16. Print 2016 Jul 1.

44.

Pulmonary Cytomegalovirus Replication in Renal Transplant Patients with Late Onset Pneumonitis.

Königshausen E, Hengel H, Adams O, Bry H, Steiner S, Priegnitz C, Hansen A, Sellin L, Rump LC, Voiculescu A.

Ann Transplant. 2016 Apr 21;21:235-40.

45.

Parental mosaicism in another case of Dravet syndrome caused by a novel SCN1A deletion: a case report.

Sharkia R, Hengel H, Schöls L, Athamna M, Bauer P, Mahajnah M.

J Med Case Rep. 2016 Mar 29;10:67. doi: 10.1186/s13256-016-0854-2. Review.

46.

Eradication of measles: remaining challenges.

Holzmann H, Hengel H, Tenbusch M, Doerr HW.

Med Microbiol Immunol. 2016 Jun;205(3):201-8. doi: 10.1007/s00430-016-0451-4. Epub 2016 Mar 2. Review.

47.

Current and future effects of varicella and herpes zoster vaccination in Germany - Insights from a mathematical model in a country with universal varicella vaccination.

Horn J, Karch A, Damm O, Kretzschmar ME, Siedler A, Ultsch B, Weidemann F, Wichmann O, Hengel H, Greiner W, Mikolajczyk RT.

Hum Vaccin Immunother. 2016 Jul 2;12(7):1766-76. doi: 10.1080/21645515.2015.1135279. Epub 2016 Feb 2.

48.

Poultry food products--a source of avian influenza virus transmission to humans?

Harder TC, Buda S, Hengel H, Beer M, Mettenleiter TC.

Clin Microbiol Infect. 2016 Feb;22(2):141-146. doi: 10.1016/j.cmi.2015.11.015. Epub 2015 Dec 12. Review.

49.

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.

Nouri K, Moll JM, Milroy LG, Hain A, Dvorsky R, Amin E, Lenders M, Nagel-Steger L, Howe S, Smits SH, Hengel H, Schmitt L, Münk C, Brunsveld L, Ahmadian MR.

PLoS One. 2015 Dec 1;10(12):e0143634. doi: 10.1371/journal.pone.0143634. eCollection 2015.

50.

Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses.

Honke N, Shaabani N, Merches K, Gassa A, Kraft A, Ehrhardt K, Häussinger D, Löhning M, Dittmer U, Hengel H, Recher M, Lang PA, Lang KS.

Eur J Immunol. 2016 Feb;46(2):372-80. doi: 10.1002/eji.201545765. Epub 2015 Nov 17.

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