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The miR-193a-3p-MAP3k3 Signaling Axis Regulates Substrate Topography-Induced Osteogenesis of Bone Marrow Stem Cells.

Lv Y, Huang Y, Xu M, Heng BC, Yang C, Cao C, Hu Z, Liu W, Chi X, Gao M, Zhang X, Wei Y, Deng X.

Adv Sci (Weinh). 2019 Nov 13;7(1):1901412. doi: 10.1002/advs.201901412. eCollection 2020 Jan.


Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress.

Halloran M, Ragagnin AMG, Vidal M, Parakh S, Yang S, Heng B, Grima N, Shahheydari H, Soo KY, Blair I, Guillemin GJ, Sundaramoorthy V, Atkin JD.

Cell Mol Life Sci. 2019 Dec 4. doi: 10.1007/s00018-019-03394-w. [Epub ahead of print]


Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes.

Tran C, Heng B, Teo JD, Humphrey SJ, Qi Y, Couttas TA, Stefen H, Brettle M, Fath T, Guillemin GJ, Don AS.

J Neurochem. 2019 Nov 19:e14917. doi: 10.1111/jnc.14917. [Epub ahead of print]


Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS.

J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22.


Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages.

He S, Ruan D, Chen Y, Ran J, Chen X, Yin Z, Tang C, Huang J, Heng BC, Chen J, Chen W, Shen W, Ouyang H.

Stem Cells Transl Med. 2019 Dec;8(12):1318-1329. doi: 10.1002/sctm.19-0125. Epub 2019 Oct 22.


Postnatal Expression Patterns of Estrogen Receptor Subtypes and Choline Acetyltransferase in Different Regions of the Papez Circuit.

Wang YX, Zhu L, Li LX, Xu HN, Wang HG, An D, Heng B, Zhao Q, Liu YQ.

Dev Neurosci. 2019 Sep 19:1-9. doi: 10.1159/000502686. [Epub ahead of print]


Diverse effects of pulsed electrical stimulation on cells - with a focus on chondrocytes and cartilage regeneration.

Ning T, Zhang K, Heng BC, Ge Z.

Eur Cell Mater. 2019 Sep 3;38:79-93. doi: 10.22203/eCM.v038a07.


Metformin inhibits Aβ25-35 -induced apoptotic cell death in SH-SY5Y cells.

Li LX, Liu MY, Jiang X, Xia ZH, Wang YX, An D, Wang HG, Heng B, Liu YQ.

Basic Clin Pharmacol Toxicol. 2019 Nov;125(5):439-449. doi: 10.1111/bcpt.13279. Epub 2019 Jul 9.


Understanding the Immunological Mechanisms of Mesenchymal Stem Cells in Allogeneic Transplantation: From the Aspect of Major Histocompatibility Complex Class I.

Wang Y, Tian M, Wang F, Heng BC, Zhou J, Cai Z, Liu H.

Stem Cells Dev. 2019 Sep 1;28(17):1141-1150. doi: 10.1089/scd.2018.0256. Epub 2019 Jul 31.


Genistein Inhibits Aβ25-35-Induced Neuronal Death with Changes in the Electrophysiological Properties of Voltage-Gated Sodium and Potassium Channels.

Wang YX, Xia ZH, Jiang X, Li LX, An D, Wang HG, Heng B, Liu YQ.

Cell Mol Neurobiol. 2019 Aug;39(6):809-822. doi: 10.1007/s10571-019-00680-w. Epub 2019 Apr 30.


EphrinB2/EphB4 Signaling Regulates DPSCs to Induce Sprouting Angiogenesis of Endothelial Cells.

Gong T, Xu J, Heng B, Qiu S, Yi B, Han Y, Lo ECM, Zhang C.

J Dent Res. 2019 Jul;98(7):803-812. doi: 10.1177/0022034519843886. Epub 2019 Apr 24.


Small molecules enhance neurogenic differentiation of dental-derived adult stem cells.

Heng BC, Jiang S, Yi B, Gong T, Lim LW, Zhang C.

Arch Oral Biol. 2019 Jun;102:26-38. doi: 10.1016/j.archoralbio.2019.03.024. Epub 2019 Mar 29.


Sema4D/PlexinB1 promotes endothelial differentiation of dental pulp stem cells via activation of AKT and ERK1/2 signaling.

Zou T, Jiang S, Dissanayaka WL, Heng BC, Xu J, Gong T, Huang X, Zhang C.

J Cell Biochem. 2019 Aug;120(8):13614-13624. doi: 10.1002/jcb.28635. Epub 2019 Apr 1.


Local Delivery of Silk-Cellulose Incorporated with Stromal Cell-Derived Factor-1α Functionally Improves the Uterus Repair.

Cai H, Wu B, Li Y, Liu Y, Shi L, Gong L, Xia Y, Heng BC, Wu H, Ouyang H, Zhu Z, Zou X.

Tissue Eng Part A. 2019 Nov;25(21-22):1514-1526. doi: 10.1089/ten.TEA.2018.0283. Epub 2019 Sep 3.


Is there scope for expanding the optometrist's scope of practice in Singapore? - A survey of optometrists, opticians in Singapore.

George PP, Yun OCS, Siow K, Saxena N, Heng BH, Car J, Lockwood C.

Cont Lens Anterior Eye. 2019 Jun;42(3):258-264. doi: 10.1016/j.clae.2019.02.008. Epub 2019 Feb 26.


Enhancement of the chondrogenic differentiation of mesenchymal stem cells and cartilage repair by ghrelin.

Fan L, Chen J, Tao Y, Heng BC, Yu J, Yang Z, Ge Z.

J Orthop Res. 2019 Jun;37(6):1387-1397. doi: 10.1002/jor.24224. Epub 2019 Feb 12.


Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor.

Engel M, Gee YS, Cross D, Maccarone A, Heng B, Hulme A, Smith G, Guillemin GJ, Stringer BW, Hyland CJT, Ooi L.

J Neurochem. 2019 May;149(4):535-550. doi: 10.1111/jnc.14655. Epub 2019 Feb 3.


Effects of chronic diseases on health-related quality of life and self-rated health among three adult age groups.

Ge L, Ong R, Yap CW, Heng BH.

Nurs Health Sci. 2019 Jun;21(2):214-222. doi: 10.1111/nhs.12585. Epub 2018 Dec 10.


Protective Effects of Myxobacterial Extracts on Hydrogen Peroxide-induced Toxicity on Human Primary Astrocytes.

Dehhaghi M, Tan V, Heng B, Mohammadipanah F, Guillemin GJ.

Neuroscience. 2019 Feb 10;399:1-11. doi: 10.1016/j.neuroscience.2018.11.033. Epub 2018 Nov 26.


A collagen-coated sponge silk scaffold for functional meniscus regeneration.

Yan R, Chen Y, Gu Y, Tang C, Huang J, Hu Y, Zheng Z, Ran J, Heng B, Chen X, Yin Z, Chen W, Shen W, Ouyang H.

J Tissue Eng Regen Med. 2019 Feb;13(2):156-173. doi: 10.1002/term.2777. Epub 2019 Jan 4.


Lipoteichoic acid of Enterococcus faecalis inhibits osteoclastogenesis via transcription factor RBP-J.

Wang S, Heng BC, Qiu S, Deng J, Shun Pan Cheung G, Jin L, Zhao B, Zhang C.

Innate Immun. 2019 Jan;25(1):13-21. doi: 10.1177/1753425918812646. Epub 2018 Nov 21.


Genistein inhibits Aβ25-35 -induced SH-SY5Y cell damage by modulating the expression of apoptosis-related proteins and Ca2+ influx through ionotropic glutamate receptors.

Xu HN, Li LX, Wang YX, Wang HG, An D, Heng B, Liu YQ.

Phytother Res. 2019 Feb;33(2):431-441. doi: 10.1002/ptr.6239. Epub 2018 Nov 19.


Lifetime trajectory simulation of chronic disease progression and comorbidity development.

Zhu Z, Heng BH, Teow KL.

J Biomed Inform. 2018 Dec;88:29-36. doi: 10.1016/j.jbi.2018.11.002. Epub 2018 Nov 7.


The relationship between substrate topography and stem cell differentiation in the musculoskeletal system.

Huang J, Chen Y, Tang C, Fei Y, Wu H, Ruan D, Paul ME, Chen X, Yin Z, Heng BC, Chen W, Shen W.

Cell Mol Life Sci. 2019 Feb;76(3):505-521. doi: 10.1007/s00018-018-2945-2. Epub 2018 Nov 2. Review.


Neuroprotective Effect of Myxobacterial Extracts on Quinolinic Acid-Induced Toxicity in Primary Human Neurons.

Dehhaghi M, Tan V, Heng B, Braidy N, Mohammadipanah F, Guillemin GJ.

Neurotox Res. 2019 Feb;35(2):281-290. doi: 10.1007/s12640-018-9945-8. Epub 2018 Sep 28.


Health Technology Disinvestment in Singapore.

Lim BP, Heng BH, Tai HY, Tham L, Chua HC.

Ann Acad Med Singapore. 2018 Aug;47(8):338-344.


The roles of inflammatory mediators and immunocytes in tendinopathy.

Tang C, Chen Y, Huang J, Zhao K, Chen X, Yin Z, Heng BC, Chen W, Shen W.

J Orthop Translat. 2018 Apr 14;14:23-33. doi: 10.1016/ eCollection 2018 Jul. Review.


Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation.

Shao J, Wang M, Yu G, Zhu S, Yu Y, Heng BC, Wu J, Ye H.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6722-E6730. doi: 10.1073/pnas.1802448115. Epub 2018 Jul 2.


EphrinB2 signalling modulates the neural differentiation of human dental pulp stem cells.

Heng BC, Gong T, Xu J, Lim LW, Zhang C.

Biomed Rep. 2018 Aug;9(2):161-168. doi: 10.3892/br.2018.1108. Epub 2018 Jun 1.


Sex differences in associations between multimorbidity and physical function domains among community-dwelling adults in Singapore.

Ge L, Yap CW, Heng BH.

PLoS One. 2018 May 14;13(5):e0197443. doi: 10.1371/journal.pone.0197443. eCollection 2018.


SFRP1 Promoter Methylation and Renal Carcinoma Risk: A Systematic Review and Meta-Analysis.

Mo S, Su Z, Heng B, Chen W, Shi L, Du X, Lai C.

J Nippon Med Sch. 2018;85(2):78-86. doi: 10.1272/jnms.2018_85-13. Review.


A comparison of food habits and prey preferences of Amur tiger (Panthera tigris altaica) at the southwest Primorskii Krai in Russia and Hunchun in China.

Gu J, Yu L, Hua Y, Ning Y, Heng B, Qi J, Long Z, Yao M, Huang C, Li Z, Lang J, Jiang G, Ma J.

Integr Zool. 2018 Sep;13(5):595-603. doi: 10.1111/1749-4877.12322.


Corrigendum to"Effects of compatibility of deproteinized antler cancellous bone with various bioactive factors on their osteogenic potential" [Biomaterials 34 (2013) 9103-9114].

Zhang X, Xu M, Song L, Wei Y, Lin Y, Liu W, Heng BC, Peng H, Wang Y, Deng X.

Biomaterials. 2018 Jul;170:136. doi: 10.1016/j.biomaterials.2018.04.018. Epub 2018 Apr 14. No abstract available.


Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption.

Zhou CH, Meng JH, Yang YT, Hu B, Hong JQ, Lv ZT, Chen K, Heng BC, Jiang GY, Zhu J, Cheng ZH, Zhang W, Cao L, Wang W, Shen WL, Yan SG, Wu HB.

Front Pharmacol. 2018 Mar 27;9:210. doi: 10.3389/fphar.2018.00210. eCollection 2018.


Concise Review: Stem Cell Fate Guided By Bioactive Molecules for Tendon Regeneration.

Zhang YJ, Chen X, Li G, Chan KM, Heng BC, Yin Z, Ouyang HW.

Stem Cells Transl Med. 2018 May;7(5):404-414. doi: 10.1002/sctm.17-0206. Epub 2018 Mar 23. Review.


Exogenous stromal derived factor-1 releasing silk scaffold combined with intra-articular injection of progenitor cells promotes bone-ligament-bone regeneration.

Hu Y, Ran J, Zheng Z, Jin Z, Chen X, Yin Z, Tang C, Chen Y, Huang J, Le H, Yan R, Zhu T, Wang J, Lin J, Xu K, Zhou Y, Zhang W, Cai Y, Dominique P, Heng BC, Chen W, Shen W, Ouyang HW.

Acta Biomater. 2018 Apr 15;71:168-183. doi: 10.1016/j.actbio.2018.02.019. Epub 2018 Mar 7.


Therapeutic effects of gefitinib-encapsulated thermosensitive injectable hydrogel in intervertebral disc degeneration.

Pan Z, Sun H, Xie B, Xia D, Zhang X, Yu D, Li J, Xu Y, Wang Z, Wu Y, Zhang X, Wang Y, Fu Q, Hu W, Yang Y, Bunpetch V, Shen W, Heng BC, Zhang S, Ouyang H.

Biomaterials. 2018 Apr;160:56-68. doi: 10.1016/j.biomaterials.2018.01.016. Epub 2018 Jan 11.


Prevalence of frailty and its association with depressive symptoms among older adults in Singapore.

Ge L, Yap CW, Heng BH.

Aging Ment Health. 2019 Mar;23(3):319-324. doi: 10.1080/13607863.2017.1416332. Epub 2018 Jan 16.


EphrinB2 signaling enhances osteogenic/odontogenic differentiation of human dental pulp stem cells.

Heng BC, Wang S, Gong T, Xu J, Yuan C, Zhang C.

Arch Oral Biol. 2018 Mar;87:62-71. doi: 10.1016/j.archoralbio.2017.12.014. Epub 2017 Dec 16.


Evaluation of an integrated primary care-led dementia shared care program in Singapore: An effectiveness and cost-effectiveness study.

Saxena N, George PP, Teo KW, Tan WS, Ng C, Heng BH, Yeo CYY, Anthony P, Tan C, Low KY, Wu V, Ali NB, Chong MS.

Geriatr Gerontol Int. 2018 Mar;18(3):479-486. doi: 10.1111/ggi.13196. Epub 2017 Nov 28.


Engrailed-2 promoter hyper-methylation is associated with its downregulation in clear cell renal cell carcinoma.

Lai CY, Yu GS, Xu Y, Wu X, Heng BL, Xue YJ, Su ZX.

Oncol Lett. 2017 Dec;14(6):6888-6894. doi: 10.3892/ol.2017.7000. Epub 2017 Sep 19.


Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption via suppression of the NF-κB signalling pathway in a rat model.

Zhou CH, Shi ZL, Meng JH, Hu B, Zhao CC, Yang YT, Yu W, Chen ZX, Heng BC, Parkman VA, Jiang S, Zhu HX, Wu HB, Shen WL, Yan SG.

Br J Pharmacol. 2018 Mar;175(6):859-876. doi: 10.1111/bph.14092. Epub 2018 Feb 14.


Re-examining the sensitivity of HbA1c to screen for diabetes mellitus.

Yap CW, Ang YG, Quek TPL, Heng BH, Chew DEK.

J Diabetes. 2018 May;10(5):380-385. doi: 10.1111/1753-0407.12615. Epub 2017 Dec 11.


Inhibition of TGF-β Signaling in SHED Enhances Endothelial Differentiation.

Xu JG, Gong T, Wang YY, Zou T, Heng BC, Yang YQ, Zhang CF.

J Dent Res. 2018 Feb;97(2):218-225. doi: 10.1177/0022034517733741. Epub 2017 Oct 3.


Medication adherence and glycemic control among newly diagnosed diabetes patients.

Lin LK, Sun Y, Heng BH, Chew DEK, Chong PN.

BMJ Open Diabetes Res Care. 2017 Jul 31;5(1):e000429. doi: 10.1136/bmjdrc-2017-000429. eCollection 2017.


Social isolation, loneliness and their relationships with depressive symptoms: A population-based study.

Ge L, Yap CW, Ong R, Heng BH.

PLoS One. 2017 Aug 23;12(8):e0182145. doi: 10.1371/journal.pone.0182145. eCollection 2017.


Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix.

Wang Y, Yu D, Liu Z, Zhou F, Dai J, Wu B, Zhou J, Heng BC, Zou XH, Ouyang H, Liu H.

Stem Cell Res Ther. 2017 Aug 14;8(1):189. doi: 10.1186/s13287-017-0632-0.


Human regulatory macrophages are potent in suppression of the xenoimmune response via indoleamine-2,3-dioxygenase-involved mechanism(s).

Guo F, Hu M, Huang D, Zhao Y, Heng B, Guillemin G, Lim CK, Hawthorne WJ, Yi S.

Xenotransplantation. 2017 Sep;24(5). doi: 10.1111/xen.12326. Epub 2017 Aug 2.


Delivery of epidermal growth factor receptor inhibitor via a customized collagen scaffold promotes meniscal defect regeneration in a rabbit model.

Pan Z, Wu Y, Zhang X, Fu Q, Li J, Yang Y, Yu D, Xu Y, Lu X, Sun H, Zhang X, Heng BC, Bunpetch V, Zhang S, Ouyang H.

Acta Biomater. 2017 Oct 15;62:210-221. doi: 10.1016/j.actbio.2017.07.008. Epub 2017 Jul 28.


Small molecule therapeutics for inflammation-associated chronic musculoskeletal degenerative diseases: Past, present and future.

Chen Y, Huang J, Tang C, Chen X, Yin Z, Heng BC, Chen W, Shen W.

Exp Cell Res. 2017 Oct 1;359(1):1-9. doi: 10.1016/j.yexcr.2017.07.027. Epub 2017 Jul 22. Review.


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