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Items: 1 to 50 of 175

1.

CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model.

Nitsch L, Zimmermann J, Krauthausen M, Hofer MJ, Saggu R, Petzold GC, Heneka MT, Getts DR, Becker A, Campbell IL, Müller M.

Mol Neurobiol. 2019 Jun 2. doi: 10.1007/s12035-019-1640-0. [Epub ahead of print]

PMID:
31154574
2.

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.

Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M.

Mol Psychiatry. 2019 Mar 21. doi: 10.1038/s41380-019-0404-6. [Epub ahead of print]

PMID:
30899092
3.

Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression.

Herrera-Rivero M, Santarelli F, Brosseron F, Kummer MP, Heneka MT.

Mol Neurobiol. 2019 Mar 9. doi: 10.1007/s12035-019-1540-3. [Epub ahead of print]

PMID:
30852796
4.

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease.

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2019 Mar;20(3):187. doi: 10.1038/s41583-019-0137-1.

PMID:
30742056
5.

Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples.

Wolfsgruber S, Molinuevo JL, Wagner M, Teunissen CE, Rami L, Coll-Padrós N, Bouwman FH, Slot RER, Wesselman LMP, Peters O, Luther K, Buerger K, Priller J, Laske C, Teipel S, Spottke A, Heneka MT, Düzel E, Drzezga A, Wiltfang J, Sikkes SAM, van der Flier WM, Jessen F; Euro-SCD working group.

Alzheimers Res Ther. 2019 Jan 17;11(1):8. doi: 10.1186/s13195-018-0463-y.

6.

Microglia take centre stage in neurodegenerative disease.

Heneka MT.

Nat Rev Immunol. 2019 Feb;19(2):79-80. doi: 10.1038/s41577-018-0112-5. No abstract available.

PMID:
30610221
7.

Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies.

Hu X, Teunissen CE, Spottke A, Heneka MT, Düzel E, Peters O, Li S, Priller J, Buerger K, Teipel S, Laske C, Verfaillie SCJ, Barkhof F, Coll-Padrós N, Rami L, Molinuevo JL, van der Flier WM, Jessen F.

Alzheimers Dement. 2019 Feb;15(2):185-193. doi: 10.1016/j.jalz.2018.09.002. Epub 2018 Oct 12.

PMID:
30321506
8.

Inflammasome signalling in brain function and neurodegenerative disease.

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2018 Oct;19(10):610-621. doi: 10.1038/s41583-018-0055-7. Review. Erratum in: Nat Rev Neurosci. 2019 Mar;20(3):187.

PMID:
30206330
9.

Screening for Niemann-Pick Type C Disease in a Memory Clinic Cohort.

Traschütz A, Heneka MT.

JIMD Rep. 2019;44:109-114. doi: 10.1007/8904_2018_133. Epub 2018 Sep 6.

10.

Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.

Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9002-9007. doi: 10.1073/pnas.1801802115. Epub 2018 Aug 20.

11.

Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial.

Ludolph AC, Schuster J, Dorst J, Dupuis L, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Petri S, Meyer T, Grosskreutz J, Schrank B, Boentert M, Emmer A, Hermann A, Zeller D, Prudlo J, Winkler AS, Grehl T, Heneka MT, Wollebæk Johannesen S, Göricke B; RAS-ALS Study Group.

Lancet Neurol. 2018 Aug;17(8):681-688. doi: 10.1016/S1474-4422(18)30176-5. Epub 2018 Jun 19.

PMID:
29934198
12.

Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease.

Teipel SJ, Metzger CD, Brosseron F, Buerger K, Brueggen K, Catak C, Diesing D, Dobisch L, Fliebach K, Franke C, Heneka MT, Kilimann I, Kofler B, Menne F, Peters O, Polcher A, Priller J, Schneider A, Spottke A, Spruth EJ, Thelen M, Thyrian RJ, Wagner M, Düzel E, Jessen F, Dyrba M; DELCODE study group.

J Alzheimers Dis. 2018;64(3):801-813. doi: 10.3233/JAD-180106.

13.

A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.

Lehmer C, Schludi MH, Ransom L, Greiling J, Junghänel M, Exner N, Riemenschneider H, van der Zee J, Van Broeckhoven C, Weydt P, Heneka MT, Edbauer D.

EMBO Mol Med. 2018 Jun;10(6). pii: e8558. doi: 10.15252/emmm.201708558.

14.

Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.

Kalinin S, González-Prieto M, Scheiblich H, Lisi L, Kusumo H, Heneka MT, Madrigal JLM, Pandey SC, Feinstein DL.

J Neuroinflammation. 2018 May 14;15(1):141. doi: 10.1186/s12974-018-1184-7.

15.

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Roßner S, Heneka MT, Couillard-Despres S, Rockenstein E, Masliah E, Attems J, Aigner L.

Alzheimers Dement. 2018 Aug;14(8):1022-1037. doi: 10.1016/j.jalz.2018.02.017. Epub 2018 Apr 7.

16.

The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease.

Enkirch SJ, Traschütz A, Müller A, Widmann CN, Gielen GH, Heneka MT, Jurcoane A, Schild HH, Hattingen E.

Radiology. 2018 Jul;288(1):226-333. doi: 10.1148/radiol.2018171888. Epub 2018 Mar 7.

PMID:
29514015
17.

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.

Brosseron F, Traschütz A, Widmann CN, Kummer MP, Tacik P, Santarelli F, Jessen F, Heneka MT.

Alzheimers Res Ther. 2018 Feb 26;10(1):25. doi: 10.1186/s13195-018-0353-3.

18.

Microglia: You'll Never Walk Alone!

Villacampa N, Heneka MT.

Immunity. 2018 Feb 20;48(2):195-197. doi: 10.1016/j.immuni.2018.02.009.

19.

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease.

Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M.

Brain. 2018 Apr 1;141(4):1186-1200. doi: 10.1093/brain/awy008.

20.

Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE).

Jessen F, Spottke A, Boecker H, Brosseron F, Buerger K, Catak C, Fliessbach K, Franke C, Fuentes M, Heneka MT, Janowitz D, Kilimann I, Laske C, Menne F, Nestor P, Peters O, Priller J, Pross V, Ramirez A, Schneider A, Speck O, Spruth EJ, Teipel S, Vukovich R, Westerteicher C, Wiltfang J, Wolfsgruber S, Wagner M, Düzel E.

Alzheimers Res Ther. 2018 Feb 7;10(1):15. doi: 10.1186/s13195-017-0314-2.

21.

Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration.

Ising C, Heneka MT.

Cell Death Dis. 2018 Jan 25;9(2):120. doi: 10.1038/s41419-017-0153-x. Review.

22.

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.

PMID:
29293211
23.

Neuroinflammatory responses in Alzheimer's disease.

Dansokho C, Heneka MT.

J Neural Transm (Vienna). 2018 May;125(5):771-779. doi: 10.1007/s00702-017-1831-7. Epub 2017 Dec 22. Review.

PMID:
29273951
24.

United Again: STING and the Police.

Tejera D, Heneka MT.

Neuron. 2017 Dec 20;96(6):1207-1208. doi: 10.1016/j.neuron.2017.12.015.

25.

Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease.

Kaczmarczyk R, Tejera D, Simon BJ, Heneka MT.

J Neurochem. 2017 Dec 21. doi: 10.1111/jnc.14284. [Epub ahead of print]

26.

Targeting Neuroinflammation to Treat Alzheimer's Disease.

Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y.

CNS Drugs. 2017 Dec;31(12):1057-1082. doi: 10.1007/s40263-017-0483-3. Review.

27.

Variability and temporal dynamics of novel object recognition in aging male C57BL/6 mice.

Traschütz A, Kummer MP, Schwartz S, Heneka MT.

Behav Processes. 2018 Dec;157:711-716. doi: 10.1016/j.beproc.2017.11.009. Epub 2017 Nov 15.

PMID:
29155004
28.

Innate Immunity and Neurodegeneration.

Labzin LI, Heneka MT, Latz E.

Annu Rev Med. 2018 Jan 29;69:437-449. doi: 10.1146/annurev-med-050715-104343. Epub 2017 Nov 6.

PMID:
29106805
29.

Activation of the NLRP3 inflammasome in microglia: the role of ceramide.

Scheiblich H, Schlütter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT.

J Neurochem. 2017 Dec;143(5):534-550. doi: 10.1111/jnc.14225. Epub 2017 Oct 26.

30.

Microglia in Alzheimer's disease.

Sarlus H, Heneka MT.

J Clin Invest. 2017 Sep 1;127(9):3240-3249. doi: 10.1172/JCI90606. Epub 2017 Sep 1. Review.

31.

Tau plasma levels in subjective cognitive decline: Results from the DELCODE study.

Müller S, Preische O, Göpfert JC, Yañez VAC, Joos TO, Boecker H, Düzel E, Falkai P, Priller J, Buerger K, Catak C, Janowitz D, Heneka MT, Brosseron F, Nestor P, Peters O, Menne F, Schipke CG, Schneider A, Spottke A, Fließbach K, Kilimann I, Teipel S, Wagner M, Wiltfang J, Jessen F, Laske C.

Sci Rep. 2017 Aug 25;7(1):9529. doi: 10.1038/s41598-017-08779-0.

32.

Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags.

Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Kummer MP, Brosseron F, Gieselmann V, Heneka MT.

J Neurosci Methods. 2017 Nov 1;291:95-100. doi: 10.1016/j.jneumeth.2017.08.005. Epub 2017 Aug 5. No abstract available.

33.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

34.

Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia.

Kemmerling N, Wunderlich P, Theil S, Linnartz-Gerlach B, Hersch N, Hoffmann B, Heneka MT, de Strooper B, Neumann H, Walter J.

Glia. 2017 Jul;65(7):1103-1118. doi: 10.1002/glia.23147. Epub 2017 Apr 3.

PMID:
28370426
35.

Personalized genetics of the cholinergic blockade of neuroinflammation.

Simchovitz A, Heneka MT, Soreq H.

J Neurochem. 2017 Aug;142 Suppl 2:178-187. doi: 10.1111/jnc.13928. Epub 2017 Mar 21. Review.

36.

Role of neuroinflammation in neurodegeneration: new insights.

McManus RM, Heneka MT.

Alzheimers Res Ther. 2017 Mar 4;9(1):14. doi: 10.1186/s13195-017-0241-2. Review.

37.

IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination.

Zimmermann J, Emrich M, Krauthausen M, Saxe S, Nitsch L, Heneka MT, Campbell IL, Müller M.

Mol Neurobiol. 2018 Feb;55(2):946-957. doi: 10.1007/s12035-016-0368-3. Epub 2017 Jan 13.

PMID:
28084589
38.

Danger-associated molecular patterns in Alzheimer's disease.

Venegas C, Heneka MT.

J Leukoc Biol. 2017 Jan;101(1):87-98. doi: 10.1189/jlb.3MR0416-204R. Epub 2016 Oct 21. Review.

PMID:
28049142
39.

Inflammasome activation and innate immunity in Alzheimer's disease.

Heneka MT.

Brain Pathol. 2017 Mar;27(2):220-222. doi: 10.1111/bpa.12483. Review.

PMID:
28019679
40.

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, Bäumer V, Engelborghs S, De Bleecker J, Baets J, Gelpi E, Rojas-García R, Clarimón J, Lleó A, Diehl-Schmid J, Alexopoulos P, Perneczky R, Synofzik M, Just J, Schöls L, Graff C, Thonberg H, Borroni B, Padovani A, Jordanova A, Sarafov S, Tournev I, de Mendonça A, Miltenberger-Miltényi G, Simões do Couto F, Ramirez A, Jessen F, Heneka MT, Gómez-Tortosa E, Danek A, Cras P, Vandenberghe R, De Jonghe P, De Deyn PP, Sleegers K, Cruts M, Van Broeckhoven C, Goeman J, Nuytten D, Smets K, Robberecht W, Damme PV, Bleecker J, Santens P, Dermaut B, Versijpt J, Michotte A, Ivanoiu A, Deryck O, Bergmans B, Delbeck J, Bruyland M, Willems C, Salmon E, Pastor P, Ortega-Cubero S, Benussi L, Ghidoni R, Binetti G, Hernández I, Boada M, Ruiz A, Sorbi S, Nacmias B, Bagnoli S, Sorbi S, Sanchez-Valle R, Llado A, Santana I, Rosário Almeida M, Frisoni GB, Maetzler W, Matej R, Fraidakis MJ, Kovacs GG, Fabrizi GM, Testi S.

Hum Mutat. 2017 Mar;38(3):297-309. doi: 10.1002/humu.23161. Epub 2017 Jan 19.

41.

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease.

Unger MS, Marschallinger J, Kaindl J, Höfling C, Rossner S, Heneka MT, Van der Linden A, Aigner L.

Mol Neurobiol. 2016 Oct;53(8):5796-806. doi: 10.1007/s12035-016-0018-9. Epub 2016 Aug 20.

42.

Thoughts on Obesity and Brain Glucose.

Heneka MT, Nicotera P.

Cell. 2016 May 5;165(4):773-5. doi: 10.1016/j.cell.2016.04.057.

43.

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E.

Sci Transl Med. 2016 Apr 6;8(333):333ra50. doi: 10.1126/scitranslmed.aad6100.

44.

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers.

Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, Fortea J, Lleó A, Blesa R, Gispert JD, Sánchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, Traschütz A, Heneka MT, Struyfs H, Engelborghs S, Sleegers K, Van Broeckhoven C, Zetterberg H, Nellgård B, Blennow K, Crispin A, Ewers M, Haass C.

EMBO Mol Med. 2016 May 2;8(5):466-76. doi: 10.15252/emmm.201506123. Print 2016 May.

45.

Microglia in Alzheimer's disease: the good, the bad and the ugly.

Tejera D, Heneka MT.

Curr Alzheimer Res. 2016;13(4):370-80. Review.

PMID:
26567746
46.

Reduction of microbleeds by immunosuppression in a patient with Aβ-related vascular inflammation.

Traschütz A, Tzaridis T, Penner AH, Kuchelmeister K, Urbach H, Hattingen E, Heneka MT.

Neurol Neuroimmunol Neuroinflamm. 2015 Oct 15;2(6):e165. doi: 10.1212/NXI.0000000000000165. eCollection 2015 Dec.

47.

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.

48.

Effects of macrophage-dependent peroxisome proliferator-activated receptor γ signalling on adhesion formation after abdominal surgery in an experimental model.

Hong GS, Schwandt T, Stein K, Schneiker B, Kummer MP, Heneka MT, Kitamura K, Kalff JC, Wehner S.

Br J Surg. 2015 Nov;102(12):1506-16. doi: 10.1002/bjs.9907. Epub 2015 Aug 27.

PMID:
26313905
49.

Effect of pioglitazone medication on the incidence of dementia.

Heneka MT, Fink A, Doblhammer G.

Ann Neurol. 2015 Aug;78(2):284-94. doi: 10.1002/ana.24439. Epub 2015 Jun 30.

PMID:
25974006
50.

PLD3 in non-familial Alzheimer's disease.

Heilmann S, Drichel D, Clarimon J, Fernández V, Lacour A, Wagner H, Thelen M, Hernández I, Fortea J, Alegret M, Blesa R, Mauleón A, Roca MR, Kornhuber J, Peters O, Heun R, Frölich L, Hüll M, Heneka MT, Rüther E, Riedel-Heller S, Scherer M, Wiltfang J, Jessen F, Becker T, Tárraga L, Boada M, Maier W, Lleó A, Ruiz A, Nöthen MM, Ramirez A.

Nature. 2015 Apr 2;520(7545):E3-5. doi: 10.1038/nature14039. No abstract available.

PMID:
25832411

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