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Items: 1 to 50 of 201

1.

The Entorhinal Cortex Atrophy Score Is Diagnostic and Prognostic in Mild Cognitive Impairment.

Traschütz A, Enkirch SJ, Polomac N, Widmann CN, Schild HH, Heneka MT, Hattingen E.

J Alzheimers Dis. 2020 Apr 1. doi: 10.3233/JAD-181150. [Epub ahead of print]

PMID:
32250289
2.

T cells in Alzheimer's disease: space invaders.

McManus RM, Heneka MT.

Lancet Neurol. 2020 Apr;19(4):285-287. doi: 10.1016/S1474-4422(20)30076-4. Epub 2020 Mar 18. No abstract available.

PMID:
32199089
3.

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.

Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT.

Cell Rep. 2020 Mar 17;30(11):3743-3754.e6. doi: 10.1016/j.celrep.2020.02.025.

4.

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment.

Kleineidam L, Chouraki V, Próchnicki T, van der Lee SJ, Madrid-Márquez L, Wagner-Thelen H, Karaca I, Weinhold L, Wolfsgruber S, Boland A, Martino Adami PV, Lewczuk P, Popp J, Brosseron F, Jansen IE, Hulsman M, Kornhuber J, Peters O, Berr C, Heun R, Frölich L, Tzourio C, Dartigues JF, Hüll M, Espinosa A, Hernández I, de Rojas I, Orellana A, Valero S, Stringa N, van Schoor NM, Huisman M, Scheltens P; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Rüther E, Deleuze JF, Wiltfang J, Tarraga L, Schmid M, Scherer M, Riedel-Heller S, Heneka MT, Amouyel P, Jessen F, Boada M, Maier W, Schneider A, González-Pérez A, van der Flier WM, Wagner M, Lambert JC, Holstege H, Sáez ME, Latz E, Ruiz A, Ramirez A.

Acta Neuropathol. 2020 Mar 12. doi: 10.1007/s00401-020-02138-6. [Epub ahead of print]

PMID:
32166339
5.

Do infections have a role in the pathogenesis of Alzheimer disease?

Itzhaki RF, Golde TE, Heneka MT, Readhead B.

Nat Rev Neurol. 2020 Apr;16(4):193-197. doi: 10.1038/s41582-020-0323-9. Epub 2020 Mar 9. Review.

PMID:
32152461
6.

Neuroimmune Connections in Aging and Neurodegenerative Diseases.

Scheiblich H, Trombly M, Ramirez A, Heneka MT.

Trends Immunol. 2020 Apr;41(4):300-312. doi: 10.1016/j.it.2020.02.002. Epub 2020 Mar 5. Review.

PMID:
32147113
7.

Microglia in Alzheimer's disease: Local heroes!

Villacampa N, Heneka MT.

J Exp Med. 2020 Apr 6;217(4). pii: e20192311. doi: 10.1084/jem.20192311.

PMID:
32126139
8.

An immune-cell signature marks the brain in Alzheimer's disease.

Heneka MT.

Nature. 2020 Jan;577(7790):322-323. doi: 10.1038/d41586-019-03892-8. No abstract available.

PMID:
31937952
9.

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia.

Lučiūnaitė A, McManus RM, Jankunec M, Rácz I, Dansokho C, Dalgėdienė I, Schwartz S, Brosseron F, Heneka MT.

J Neurochem. 2019 Dec 23:e14945. doi: 10.1111/jnc.14945. [Epub ahead of print]

PMID:
31872431
10.

In vivo characterization of functional states of cortical microglia during peripheral inflammation.

Riester K, Brawek B, Savitska D, Fröhlich N, Zirdum E, Mojtahedi N, Heneka MT, Garaschuk O.

Brain Behav Immun. 2019 Dec 11. pii: S0889-1591(19)31294-2. doi: 10.1016/j.bbi.2019.12.007. [Epub ahead of print]

PMID:
31837418
11.

Vaccination with (1-11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice.

Mantile F, Capasso A, Villacampa N, Donnini M, Liguori GL, Constantin G, De Berardinis P, Heneka MT, Prisco A.

Aging Clin Exp Res. 2019 Nov 22. doi: 10.1007/s40520-019-01414-0. [Epub ahead of print]

PMID:
31758499
12.

NLRP3 inflammasome activation drives tau pathology.

Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT.

Nature. 2019 Nov;575(7784):669-673. doi: 10.1038/s41586-019-1769-z. Epub 2019 Nov 20.

PMID:
31748742
13.

Inflammasome-mediated innate immunity in Alzheimer's disease.

Venegas C, Heneka MT.

FASEB J. 2019 Dec;33(12):13075-13084. doi: 10.1096/fj.201900439. Epub 2019 Nov 8.

PMID:
31702392
14.

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease.

Webers A, Heneka MT, Gleeson PA.

Immunol Cell Biol. 2020 Jan;98(1):28-41. doi: 10.1111/imcb.12301. Epub 2019 Nov 20. Review.

PMID:
31654430
15.

Norepinephrine as a modulator of microglial dynamics.

Mercan D, Heneka MT.

Nat Neurosci. 2019 Nov;22(11):1745-1746. doi: 10.1038/s41593-019-0526-9. No abstract available.

PMID:
31636450
16.

Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.

Brosseron F, Kolbe CC, Santarelli F, Carvalho S, Antonell A, Castro-Gomez S, Tacik P, Namasivayam AA, Mangone G, Schneider R, Latz E, Wüllner U, Svenningsson P, Sánchez-Valle R, Molinuevo JL, Corvol JC, Heneka MT; AETIONOMY study group.

Alzheimers Dement. 2020 Feb;16(2):292-304. doi: 10.1016/j.jalz.2019.07.018. Epub 2020 Jan 6.

17.

Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer's Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness.

Teipel SJ, Kuper-Smith JO, Bartels C, Brosseron F, Buchmann M, Buerger K, Catak C, Janowitz D, Dechent P, Dobisch L, Ertl-Wagner B, Fließbach K, Haynes JD, Heneka MT, Kilimann I, Laske C, Li S, Menne F, Metzger CD, Priller J, Pross V, Ramirez A, Scheffler K, Schneider A, Spottke A, Spruth EJ, Wagner M, Wiltfang J, Wolfsgruber S, Düzel E, Jessen F, Dyrba M; DELCODE study group.

J Alzheimers Dis. 2019;72(2):455-465. doi: 10.3233/JAD-190446.

18.

Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults.

Berron D, Cardenas-Blanco A, Bittner D, Metzger CD, Spottke A, Heneka MT, Fliessbach K, Schneider A, Teipel SJ, Wagner M, Speck O, Jessen F, Düzel E.

J Neurosci. 2019 Oct 30;39(44):8788-8797. doi: 10.1523/JNEUROSCI.1279-19.2019. Epub 2019 Sep 20.

19.

Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.

Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Schwartz S, Santarelli F, Gieselmann V, Klockgether T, Brosseron F, Heneka MT.

J Neurochem. 2020 Mar;152(6):710-726. doi: 10.1111/jnc.14870. Epub 2019 Oct 21.

PMID:
31520481
20.

A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2.

Karsak M, Glebov K, Scheffold M, Bajaj T, Kawalia A, Karaca I, Rading S, Kornhuber J, Peters O, Diez-Fairen M, Frölich L, Hüll M, Wiltfang J, Scherer M, Riedel-Heller S, Schneider A, Heneka MT, Fliessbach K, Sharaf A, Thiele H, Lennarz M, Jessen F, Maier W, Kubisch C, Ignatova Z, Nürnberg P, Pastor P, Walter J, Ramirez A.

Hum Mutat. 2020 Jan;41(1):169-181. doi: 10.1002/humu.23904. Epub 2019 Sep 15.

PMID:
31464095
21.

[Neuroinflammation as motor of Alzheimer's disease].

Castro-Gomez S, Binder J, Heneka MT.

Nervenarzt. 2019 Sep;90(9):898-906. doi: 10.1007/s00115-019-0778-3. Review. German.

PMID:
31428829
22.

In Vivo Phagocytosis Analysis of Amyloid Beta.

Tejera D, Heneka MT.

Methods Mol Biol. 2019;2034:287-292. doi: 10.1007/978-1-4939-9658-2_21.

PMID:
31392693
23.

Microglia in Neurodegenerative Disorders.

Tejera D, Heneka MT.

Methods Mol Biol. 2019;2034:57-67. doi: 10.1007/978-1-4939-9658-2_5. Review.

PMID:
31392677
24.

Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study.

Miebach L, Wolfsgruber S, Polcher A, Peters O, Menne F, Luther K, Incesoy E, Priller J, Spruth E, Altenstein S, Buerger K, Catak C, Janowitz D, Perneczky R, Utecht J, Laske C, Buchmann M, Schneider A, Fliessbach K, Kalbhen P, Heneka MT, Brosseron F, Spottke A, Roy N, Teipel SJ, Kilimann I, Wiltfang J, Bartels C, Düzel E, Dobisch L, Metzger C, Meiberth D, Ramirez A, Jessen F, Wagner M.

Alzheimers Res Ther. 2019 Jul 31;11(1):66. doi: 10.1186/s13195-019-0515-y.

25.

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome.

Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, Latz E, Golenbock D, Heneka MT.

EMBO J. 2019 Sep 2;38(17):e101064. doi: 10.15252/embj.2018101064. Epub 2019 Jul 30.

26.

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.

Esteve P, Rueda-Carrasco J, Inés Mateo M, Martin-Bermejo MJ, Draffin J, Pereyra G, Sandonís Á, Crespo I, Moreno I, Aso E, Garcia-Esparcia P, Gomez-Tortosa E, Rábano A, Fortea J, Alcolea D, Lleo A, Heneka MT, Valpuesta JM, Esteban JA, Ferrer I, Domínguez M, Bovolenta P.

Nat Neurosci. 2019 Aug;22(8):1258-1268. doi: 10.1038/s41593-019-0432-1. Epub 2019 Jul 15.

PMID:
31308530
27.

CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model.

Nitsch L, Zimmermann J, Krauthausen M, Hofer MJ, Saggu R, Petzold GC, Heneka MT, Getts DR, Becker A, Campbell IL, Müller M.

Mol Neurobiol. 2019 Dec;56(12):7977-7993. doi: 10.1007/s12035-019-1640-0. Epub 2019 Jun 2.

PMID:
31154574
28.

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.

Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M.

Mol Psychiatry. 2019 Mar 21. doi: 10.1038/s41380-019-0404-6. [Epub ahead of print]

29.

Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression.

Herrera-Rivero M, Santarelli F, Brosseron F, Kummer MP, Heneka MT.

Mol Neurobiol. 2019 Sep;56(9):6539-6550. doi: 10.1007/s12035-019-1540-3. Epub 2019 Mar 9.

PMID:
30852796
30.

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease.

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2019 Mar;20(3):187. doi: 10.1038/s41583-019-0137-1.

PMID:
30742056
31.

Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples.

Wolfsgruber S, Molinuevo JL, Wagner M, Teunissen CE, Rami L, Coll-Padrós N, Bouwman FH, Slot RER, Wesselman LMP, Peters O, Luther K, Buerger K, Priller J, Laske C, Teipel S, Spottke A, Heneka MT, Düzel E, Drzezga A, Wiltfang J, Sikkes SAM, van der Flier WM, Jessen F; Euro-SCD working group.

Alzheimers Res Ther. 2019 Jan 17;11(1):8. doi: 10.1186/s13195-018-0463-y.

32.

Microglia take centre stage in neurodegenerative disease.

Heneka MT.

Nat Rev Immunol. 2019 Feb;19(2):79-80. doi: 10.1038/s41577-018-0112-5. Review. No abstract available.

PMID:
30610221
33.

Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies.

Hu X, Teunissen CE, Spottke A, Heneka MT, Düzel E, Peters O, Li S, Priller J, Buerger K, Teipel S, Laske C, Verfaillie SCJ, Barkhof F, Coll-Padrós N, Rami L, Molinuevo JL, van der Flier WM, Jessen F.

Alzheimers Dement. 2019 Feb;15(2):185-193. doi: 10.1016/j.jalz.2018.09.002. Epub 2018 Oct 12.

PMID:
30321506
34.

Inflammasome signalling in brain function and neurodegenerative disease.

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2018 Oct;19(10):610-621. doi: 10.1038/s41583-018-0055-7. Review. Erratum in: Nat Rev Neurosci. 2019 Mar;20(3):187.

PMID:
30206330
35.

Screening for Niemann-Pick Type C Disease in a Memory Clinic Cohort.

Traschütz A, Heneka MT.

JIMD Rep. 2019;44:109-114. doi: 10.1007/8904_2018_133. Epub 2018 Sep 6.

36.

Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.

Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9002-9007. doi: 10.1073/pnas.1801802115. Epub 2018 Aug 20.

37.

Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial.

Ludolph AC, Schuster J, Dorst J, Dupuis L, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Petri S, Meyer T, Grosskreutz J, Schrank B, Boentert M, Emmer A, Hermann A, Zeller D, Prudlo J, Winkler AS, Grehl T, Heneka MT, Wollebæk Johannesen S, Göricke B; RAS-ALS Study Group.

Lancet Neurol. 2018 Aug;17(8):681-688. doi: 10.1016/S1474-4422(18)30176-5. Epub 2018 Jun 19.

PMID:
29934198
38.

Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease.

Teipel SJ, Metzger CD, Brosseron F, Buerger K, Brueggen K, Catak C, Diesing D, Dobisch L, Fliebach K, Franke C, Heneka MT, Kilimann I, Kofler B, Menne F, Peters O, Polcher A, Priller J, Schneider A, Spottke A, Spruth EJ, Thelen M, Thyrian RJ, Wagner M, Düzel E, Jessen F, Dyrba M; DELCODE study group.

J Alzheimers Dis. 2018;64(3):801-813. doi: 10.3233/JAD-180106.

39.

A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.

Lehmer C, Schludi MH, Ransom L, Greiling J, Junghänel M, Exner N, Riemenschneider H, van der Zee J, Van Broeckhoven C, Weydt P, Heneka MT, Edbauer D.

EMBO Mol Med. 2018 Jun;10(6). pii: e8558. doi: 10.15252/emmm.201708558.

40.

Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.

Kalinin S, González-Prieto M, Scheiblich H, Lisi L, Kusumo H, Heneka MT, Madrigal JLM, Pandey SC, Feinstein DL.

J Neuroinflammation. 2018 May 14;15(1):141. doi: 10.1186/s12974-018-1184-7.

41.

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Roßner S, Heneka MT, Couillard-Despres S, Rockenstein E, Masliah E, Attems J, Aigner L.

Alzheimers Dement. 2018 Aug;14(8):1022-1037. doi: 10.1016/j.jalz.2018.02.017. Epub 2018 Apr 7.

42.

The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease.

Enkirch SJ, Traschütz A, Müller A, Widmann CN, Gielen GH, Heneka MT, Jurcoane A, Schild HH, Hattingen E.

Radiology. 2018 Jul;288(1):226-333. doi: 10.1148/radiol.2018171888. Epub 2018 Mar 7.

PMID:
29514015
43.

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.

Brosseron F, Traschütz A, Widmann CN, Kummer MP, Tacik P, Santarelli F, Jessen F, Heneka MT.

Alzheimers Res Ther. 2018 Feb 26;10(1):25. doi: 10.1186/s13195-018-0353-3.

44.

Microglia: You'll Never Walk Alone!

Villacampa N, Heneka MT.

Immunity. 2018 Feb 20;48(2):195-197. doi: 10.1016/j.immuni.2018.02.009.

45.

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease.

Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M.

Brain. 2018 Apr 1;141(4):1186-1200. doi: 10.1093/brain/awy008.

46.

Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE).

Jessen F, Spottke A, Boecker H, Brosseron F, Buerger K, Catak C, Fliessbach K, Franke C, Fuentes M, Heneka MT, Janowitz D, Kilimann I, Laske C, Menne F, Nestor P, Peters O, Priller J, Pross V, Ramirez A, Schneider A, Speck O, Spruth EJ, Teipel S, Vukovich R, Westerteicher C, Wiltfang J, Wolfsgruber S, Wagner M, Düzel E.

Alzheimers Res Ther. 2018 Feb 7;10(1):15. doi: 10.1186/s13195-017-0314-2.

47.

Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration.

Ising C, Heneka MT.

Cell Death Dis. 2018 Jan 25;9(2):120. doi: 10.1038/s41419-017-0153-x. Review.

48.

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.

PMID:
29293211
49.

Neuroinflammatory responses in Alzheimer's disease.

Dansokho C, Heneka MT.

J Neural Transm (Vienna). 2018 May;125(5):771-779. doi: 10.1007/s00702-017-1831-7. Epub 2017 Dec 22. Review.

PMID:
29273951
50.

United Again: STING and the Police.

Tejera D, Heneka MT.

Neuron. 2017 Dec 20;96(6):1207-1208. doi: 10.1016/j.neuron.2017.12.015.

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