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Items: 1 to 50 of 229


Synchrotron microcrystal native-SAD phasing at a low energy.

Guo G, Zhu P, Fuchs MR, Shi W, Andi B, Gao Y, Hendrickson WA, McSweeney S, Liu Q.

IUCrJ. 2019 May 3;6(Pt 4):532-542. doi: 10.1107/S2052252519004536. eCollection 2019 Jul 1.


Structural basis for activity of TRIC counter-ion channels in calcium release.

Wang XH, Su M, Gao F, Xie W, Zeng Y, Li DL, Liu XL, Zhao H, Qin L, Li F, Liu Q, Clarke OB, Lam SM, Shui GH, Hendrickson WA, Chen YH.

Proc Natl Acad Sci U S A. 2019 Feb 15. pii: 201817271. doi: 10.1073/pnas.1817271116. [Epub ahead of print]


Structure and activity of lipid bilayer within a membrane-protein transporter.

Qiu W, Fu Z, Xu GG, Grassucci RA, Zhang Y, Frank J, Hendrickson WA, Guo Y.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12985-12990. doi: 10.1073/pnas.1812526115. Epub 2018 Dec 3.


Structure-based analysis of CysZ-mediated cellular uptake of sulfate.

Assur Sanghai Z, Liu Q, Clarke OB, Belcher-Dufrisne M, Wiriyasermkul P, Giese MH, Leal-Pinto E, Kloss B, Tabuso S, Love J, Punta M, Banerjee S, Rajashankar KR, Rost B, Logothetis D, Quick M, Hendrickson WA, Mancia F.

Elife. 2018 May 24;7. pii: e27829. doi: 10.7554/eLife.27829.


Sample manipulation and data assembly for robust microcrystal synchrotron crystallography.

Guo G, Fuchs MR, Shi W, Skinner J, Berman E, Ogata CM, Hendrickson WA, McSweeney S, Liu Q.

IUCrJ. 2018 Apr 19;5(Pt 3):238-246. doi: 10.1107/S2052252518005389. eCollection 2018 May 1.


Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes.

Hartel AJW, Ong P, Schroeder I, Giese MH, Shekar S, Clarke OB, Zalk R, Marks AR, Hendrickson WA, Shepard KL.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1789-E1798. doi: 10.1073/pnas.1712313115. Epub 2018 Feb 5.


2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update.

Trewhella J, Duff AP, Durand D, Gabel F, Guss JM, Hendrickson WA, Hura GL, Jacques DA, Kirby NM, Kwan AH, Pérez J, Pollack L, Ryan TM, Sali A, Schneidman-Duhovny D, Schwede T, Svergun DI, Sugiyama M, Tainer JA, Vachette P, Westbrook J, Whitten AE.

Acta Crystallogr D Struct Biol. 2017 Sep 1;73(Pt 9):710-728. doi: 10.1107/S2059798317011597. Epub 2017 Aug 18.


Contemporary Use of Anomalous Diffraction in Biomolecular Structure Analysis.

Liu Q, Hendrickson WA.

Methods Mol Biol. 2017;1607:377-399. doi: 10.1007/978-1-4939-7000-1_16. Review.


Structural basis for conductance through TRIC cation channels.

Su M, Gao F, Yuan Q, Mao Y, Li DL, Guo Y, Yang C, Wang XH, Bruni R, Kloss B, Zhao H, Zeng Y, Zhang FB, Marks AR, Hendrickson WA, Chen YH.

Nat Commun. 2017 May 19;8:15103. doi: 10.1038/ncomms15103.


Structures of the colossal RyR1 calcium release channel.

Clarke OB, Hendrickson WA.

Curr Opin Struct Biol. 2016 Aug;39:144-152. doi: 10.1016/ Epub 2016 Sep 27. Review.


Structural Basis for Gating and Activation of RyR1.

des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J.

Cell. 2016 Sep 22;167(1):145-157.e17. doi: 10.1016/j.cell.2016.08.075.


Structure of the STRA6 receptor for retinol uptake.

Chen Y, Clarke OB, Kim J, Stowe S, Kim YK, Assur Z, Cavalier M, Godoy-Ruiz R, von Alpen DC, Manzini C, Blaner WS, Frank J, Quadro L, Weber DJ, Shapiro L, Hendrickson WA, Mancia F.

Science. 2016 Aug 26;353(6302). pii: aad8266. doi: 10.1126/science.aad8266.


Atomic-level analysis of membrane-protein structure.

Hendrickson WA.

Nat Struct Mol Biol. 2016 Jun 7;23(6):464-7. doi: 10.1038/nsmb.3215. Review.


Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.

Melillo B, Liang S, Park J, Schön A, Courter JR, LaLonde JM, Wendler DJ, Princiotto AM, Seaman MS, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB 3rd.

ACS Med Chem Lett. 2016 Jan 19;7(3):330-4. doi: 10.1021/acsmedchemlett.5b00471. eCollection 2016 Mar 10.


Structural basis for phosphatidylinositol-phosphate biosynthesis.

Clarke OB, Tomasek D, Jorge CD, Dufrisne MB, Kim M, Banerjee S, Rajashankar KR, Shapiro L, Hendrickson WA, Santos H, Mancia F.

Nat Commun. 2015 Oct 16;6:8505. doi: 10.1038/ncomms9505.


Crystallographic phasing from weak anomalous signals.

Liu Q, Hendrickson WA.

Curr Opin Struct Biol. 2015 Oct;34:99-107. doi: 10.1016/ Epub 2015 Sep 30. Review.


Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.

Ranaivoson FM, Liu Q, Martini F, Bergami F, von Daake S, Li S, Lee D, Demeler B, Hendrickson WA, Comoletti D.

Structure. 2015 Sep 1;23(9):1665-1677. doi: 10.1016/j.str.2015.06.022. Epub 2015 Jul 30.


Protein structure. Structure and activity of tryptophan-rich TSPO proteins.

Guo Y, Kalathur RC, Liu Q, Kloss B, Bruni R, Ginter C, Kloppmann E, Rost B, Hendrickson WA.

Science. 2015 Jan 30;347(6221):551-5. doi: 10.1126/science.aaa1534.


Structural insights into mis-regulation of protein kinase A in human tumors.

Cheung J, Ginter C, Cassidy M, Franklin MC, Rudolph MJ, Robine N, Darnell RB, Hendrickson WA.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1374-9. doi: 10.1073/pnas.1424206112. Epub 2015 Jan 20.


Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels.

Yang T, Hendrickson WA, Colecraft HM.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18213-8. doi: 10.1073/pnas.1420984111. Epub 2014 Dec 8.


Structure of a mammalian ryanodine receptor.

Zalk R, Clarke OB, des Georges A, Grassucci RA, Reiken S, Mancia F, Hendrickson WA, Frank J, Marks AR.

Nature. 2015 Jan 1;517(7532):44-9. doi: 10.1038/nature13950. Epub 2014 Dec 1.


Structure and selectivity in bestrophin ion channels.

Yang T, Liu Q, Kloss B, Bruni R, Kalathur RC, Guo Y, Kloppmann E, Rost B, Colecraft HM, Hendrickson WA.

Science. 2014 Oct 17;346(6207):355-9. doi: 10.1126/science.1259723. Epub 2014 Sep 25.


Multi-crystal native SAD analysis at 6 keV.

Liu Q, Guo Y, Chang Y, Cai Z, Assur Z, Mancia F, Greene MI, Hendrickson WA.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2544-57. doi: 10.1107/S1399004714013376. Epub 2014 Sep 30.


Crystal structures of apparent saccharide sensors from histidine kinase receptors prevalent in a human gut symbiont.

Zhang Z, Liu Q, Hendrickson WA.

FEBS J. 2014 Sep;281(18):4263-79. doi: 10.1111/febs.12904. Epub 2014 Aug 4.


Structural basis for a pH-sensitive calcium leak across membranes.

Chang Y, Bruni R, Kloss B, Assur Z, Kloppmann E, Rost B, Hendrickson WA, Liu Q.

Science. 2014 Jun 6;344(6188):1131-5. doi: 10.1126/science.1252043.


Anomalous diffraction in crystallographic phase evaluation.

Hendrickson WA.

Q Rev Biophys. 2014 Feb;47(1):49-93. doi: 10.1017/S0033583514000018. Review.


Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.

Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, LaLonde JM, Smith AB 3rd.

Acc Chem Res. 2014 Apr 15;47(4):1228-37. doi: 10.1021/ar4002735. Epub 2014 Feb 6. Review.


Jerome Karle (1918-2013).

Hendrickson WA.

Nature. 2013 Jul 25;499(7459):410. doi: 10.1038/499410a. No abstract available.


Robust structural analysis of native biological macromolecules from multi-crystal anomalous diffraction data.

Liu Q, Liu Q, Hendrickson WA.

Acta Crystallogr D Biol Crystallogr. 2013 Jul;69(Pt 7):1314-32. doi: 10.1107/S0907444913001479. Epub 2013 Jun 13.


Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB.

Trewhella J, Hendrickson WA, Kleywegt GJ, Sali A, Sato M, Schwede T, Svergun DI, Tainer JA, Westbrook J, Berman HM.

Structure. 2013 Jun 4;21(6):875-81. doi: 10.1016/j.str.2013.04.020. Review.


Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.

Qi R, Sarbeng EB, Liu Q, Le KQ, Xu X, Xu H, Yang J, Wong JL, Vorvis C, Hendrickson WA, Zhou L, Liu Q.

Nat Struct Mol Biol. 2013 Jul;20(7):900-7. doi: 10.1038/nsmb.2583. Epub 2013 May 26.


Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization.

Lalonde JM, Le-Khac M, Jones DM, Courter JR, Park J, Schön A, Princiotto AM, Wu X, Mascola JR, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB 3rd.

ACS Med Chem Lett. 2013 Mar 14;4(3):338-343.


Characterization of prion-like conformational changes of the neuronal isoform of Aplysia CPEB.

Raveendra BL, Siemer AB, Puthanveettil SV, Hendrickson WA, Kandel ER, McDermott AE.

Nat Struct Mol Biol. 2013 Apr;20(4):495-501. doi: 10.1038/nsmb.2503. Epub 2013 Feb 24.


Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.

Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A.

Nat Struct Mol Biol. 2013 Feb;20(2):135-8. doi: 10.1038/nsmb.2508. No abstract available.


Structural plasticity and conformational transitions of HIV envelope glycoprotein gp120.

Korkut A, Hendrickson WA.

PLoS One. 2012;7(12):e52170. doi: 10.1371/journal.pone.0052170. Epub 2012 Dec 27.


Evolution of diffraction methods for solving crystal structures.

Hendrickson WA.

Acta Crystallogr A. 2013 Jan;69(Pt 1):51-9. doi: 10.1107/S0108767312050453. Epub 2012 Dec 18.


Structure and design of broadly-neutralizing antibodies against HIV.

Ryu SE, Hendrickson WA.

Mol Cells. 2012 Sep;34(3):231-7. Epub 2012 Jun 25.


Structures from anomalous diffraction of native biological macromolecules.

Liu Q, Dahmane T, Zhang Z, Assur Z, Brasch J, Shapiro L, Mancia F, Hendrickson WA.

Science. 2012 May 25;336(6084):1033-7. doi: 10.1126/science.1218753.


An asymmetry-to-symmetry switch in signal transmission by the histidine kinase receptor for TMAO.

Moore JO, Hendrickson WA.

Structure. 2012 Apr 4;20(4):729-41. doi: 10.1016/j.str.2012.02.021. Epub 2012 Apr 3.


Definitive answers. Interview by Kristie Nybo.

Hendrickson WA.

Biotechniques. 2012 Mar;52(3):129. doi: 10.2144/000113815. No abstract available.


Tools for coproducing multiple proteins in mammalian cells.

Assur Z, Hendrickson WA, Mancia F.

Methods Mol Biol. 2012;801:173-87. doi: 10.1007/978-1-61779-352-3_12.


Optics Concept for a Pair of Undulator Beamlines for MX.

Berman LE, Allaire M, Chance MR, Hendrickson WA, Héroux A, Jakoncic J, Liu Q, Orville AM, Robinson HH, Schneider DK, Shi W, Soares AS, Stojanoff V, Stoner-Ma D, Sweet RM.

Nucl Instrum Methods Phys Res A. 2011 Sep 1;649(1):131-135.


What is 'current opinion' in structural biology?

Blundell TL, Hendrickson WA.

Curr Opin Struct Biol. 2011 Aug;21(4):447-9. doi: 10.1016/ Epub 2011 Jul 26. No abstract available.


Crystal structure of a phosphorylation-coupled saccharide transporter.

Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M.

Nature. 2011 May 5;473(7345):50-4. doi: 10.1038/nature09939. Epub 2011 Apr 6.


Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type β propeller domains.

Collins MN, Hendrickson WA.

Structure. 2011 Mar 9;19(3):324-36. doi: 10.1016/j.str.2010.11.017.


Crystal structure of a potassium ion transporter, TrkH.

Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, Hendrickson WA, Rost B, Javitch JA, Rajashankar KR, Jiang Y, Zhou M.

Nature. 2011 Mar 17;471(7338):336-40. doi: 10.1038/nature09731. Epub 2011 Feb 13.


Structural analysis of protein folding by the long-chain archaeal chaperone FKBP26.

Martinez-Hackert E, Hendrickson WA.

J Mol Biol. 2011 Apr 1;407(3):450-64. doi: 10.1016/j.jmb.2011.01.027. Epub 2011 Jan 22.


Multi-crystal anomalous diffraction for low-resolution macromolecular phasing.

Liu Q, Zhang Z, Hendrickson WA.

Acta Crystallogr D Biol Crystallogr. 2011 Jan;67(Pt 1):45-59. doi: 10.1107/S0907444910046573. Epub 2010 Dec 16.


Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins.

Fiumara F, Fioriti L, Kandel ER, Hendrickson WA.

Cell. 2010 Dec 23;143(7):1121-35. doi: 10.1016/j.cell.2010.11.042.


Homologue structure of the SLAC1 anion channel for closing stomata in leaves.

Chen YH, Hu L, Punta M, Bruni R, Hillerich B, Kloss B, Rost B, Love J, Siegelbaum SA, Hendrickson WA.

Nature. 2010 Oct 28;467(7319):1074-80. doi: 10.1038/nature09487.

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